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Aliases for SUOX Gene

Aliases for SUOX Gene

  • Sulfite Oxidase 2 3 5
  • EC 1.8.3.1 4 56

External Ids for SUOX Gene

Previous GeneCards Identifiers for SUOX Gene

  • GC12M056183
  • GC12P056958
  • GC12P056107
  • GC12P054681
  • GC12P054651
  • GC12P054677
  • GC12P056391
  • GC12P053429

Summaries for SUOX Gene

Entrez Gene Summary for SUOX Gene

  • Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for SUOX Gene

SUOX (Sulfite Oxidase) is a Protein Coding gene. Diseases associated with SUOX include Sulfite Oxidase Deficiency, Isolated and Encephalomalacia. Among its related pathways are Viral mRNA Translation and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and electron transfer activity.

Gene Wiki entry for SUOX Gene

Additional gene information for SUOX Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUOX Gene

Genomics for SUOX Gene

GeneHancer (GH) Regulatory Elements for SUOX Gene

Promoters and enhancers for SUOX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I055995 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 582.6 -0.4 -439 3.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B SUOX RAB5B DNAJC14 ZC3H10 ENSG00000258317 PRIM1 BAZ2A PMEL GC12P055992
GH12I056040 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.1 +44.8 44819 3.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS26 LOC105369780 BAZ2A RN7SL809P STAT2 PAN2 ENSG00000258199 ZC3H10 CDK2 ENSG00000257740
GH12I056078 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.5 +84.1 84115 6.1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ZNF610 ERBB3 SUOX ANKRD52 RAB5B IKZF4 BAZ2A PHC1P1 ENSG00000257740 PAN2 SMARCC2
GH12I056006 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 28.1 +10.5 10528 1.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B IKZF4 SUOX DNAJC14 ZC3H10 ENSG00000258317 HSPD1P4 ZBTB39 ENSG00000257740 PA2G4 ENSG00000258199
GH12I055970 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.3 -24.2 -24243 5.1 ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 PMEL RAB5B BAZ2A DNAJC14 ZC3H10 ENSG00000258199 ENSG00000258317 TMEM198B CDK2 ENSG00000257740
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SUOX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SUOX gene promoter:

Genomic Locations for SUOX Gene

Genomic Locations for SUOX Gene
chr12:55,997,180-56,006,641
(GRCh38/hg38)
Size:
9,462 bases
Orientation:
Plus strand
chr12:56,390,964-56,400,425
(GRCh37/hg19)

Genomic View for SUOX Gene

Genes around SUOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUOX Gene

Proteins for SUOX Gene

  • Protein details for SUOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51687-SUOX_HUMAN
    Recommended name:
    Sulfite oxidase, mitochondrial
    Protein Accession:
    P51687

    Protein attributes for SUOX Gene

    Size:
    545 amino acids
    Molecular mass:
    60283 Da
    Cofactor:
    Name=heme b; Xref=ChEBI:CHEBI:60344;
    Cofactor:
    Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAA74886.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL08048.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SUOX Gene

neXtProt entry for SUOX Gene

Selected DME Specific Peptides for SUOX Gene

P51687:
  • GYAWSGGGR
  • LEPFWALYAVH
  • VAPIWNLRGVLS
  • FFTRNHLPVP
  • RVVVPGV
  • VLLAYEMNG
  • GAISTARW

Post-translational modifications for SUOX Gene

No Post-translational modifications

Domains & Families for SUOX Gene

Gene Families for SUOX Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SUOX Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SUOX: view

No data available for UniProtKB/Swiss-Prot for SUOX Gene

Function for SUOX Gene

Molecular function for SUOX Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Sulfite + O(2) + H(2)O = sulfate + H(2)O(2).

Enzyme Numbers (IUBMB) for SUOX Gene

Phenotypes From GWAS Catalog for SUOX Gene

Gene Ontology (GO) - Molecular Function for SUOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25910212
GO:0008482 sulfite oxidase activity TAS --
GO:0016491 oxidoreductase activity IEA --
GO:0020037 heme binding IEA --
GO:0030151 molybdenum ion binding IEA --
genes like me logo Genes that share ontologies with SUOX: view
genes like me logo Genes that share phenotypes with SUOX: view

Human Phenotype Ontology for SUOX Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SUOX Gene

Localization for SUOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUOX Gene

Mitochondrion intermembrane space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUOX gene
Compartment Confidence
mitochondrion 5
peroxisome 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SUOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005758 mitochondrial intermembrane space IEA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with SUOX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SUOX Gene

Pathways & Interactions for SUOX Gene

genes like me logo Genes that share pathways with SUOX: view

UniProtKB/Swiss-Prot P51687-SUOX_HUMAN

  • Pathway: Energy metabolism; sulfur metabolism.

Gene Ontology (GO) - Biological Process for SUOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006790 sulfur compound metabolic process IEA --
GO:0042128 nitrate assimilation IEA --
GO:0055114 oxidation-reduction process IEA --
GO:0070221 sulfide oxidation, using sulfide:quinone oxidoreductase TAS --
genes like me logo Genes that share ontologies with SUOX: view

No data available for SIGNOR curated interactions for SUOX Gene

Drugs & Compounds for SUOX Gene

(16) Drugs for SUOX Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Molybdenum Approved Pharma 31
Oxygen Approved, Vet_approved Pharma 0
Hydrogen peroxide Approved, Vet_approved Pharma 73
Water Approved Pharma 0
(Molybdopterin-S,S)-Dioxo-Thio-Molybdenum(V) Experimental Pharma Target 0

(24) Additional Compounds for SUOX Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Sulfate
  • Sulfate (ion 2-)
  • Sulfate anion
  • Sulfate anion(2-)
  • Sulfate dianion
  • Sulfate ion
14808-79-8
Sulfite
  • Bisulfite
  • Sulfite dianion
  • Sulfite ion
  • Sulfite ions
  • Sulfonate
14265-45-3
Sulfurous acid
  • Sulfur dioxide solution
  • Sulfuric(IV) acid (H2SO3)
7782-99-2
genes like me logo Genes that share compounds with SUOX: view

Transcripts for SUOX Gene

Unigene Clusters for SUOX Gene

Sulfite oxidase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUOX Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e · 9f ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - -
SP10: - - - - - - - -
SP11: - - - - - -
SP12: - -
SP13: -
SP14: - - - - - - - - - - -
SP15: - - - - - -
SP16: -
SP17: -
SP18:

ExUns: 9g · 9h · 9i · 9j ^ 10a · 10b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for SUOX Gene

GeneLoc Exon Structure for
SUOX
ECgene alternative splicing isoforms for
SUOX

Expression for SUOX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUOX Gene

Protein differential expression in normal tissues from HIPED for SUOX Gene

This gene is overexpressed in Liver (9.8), Kidney (8.2), Liver, secretome (7.6), and Gallbladder (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUOX Gene



Protein tissue co-expression partners for SUOX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SUOX Gene:

SUOX

SOURCE GeneReport for Unigene cluster for SUOX Gene:

Hs.558403

Evidence on tissue expression from TISSUES for SUOX Gene

  • Liver(4.6)
  • Nervous system(4.2)
  • Pancreas(4.1)
  • Kidney(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SUOX Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • immune
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • skull
  • tooth
Abdomen:
  • kidney
Limb:
  • lower limb
  • upper limb
General:
  • blood
  • hair
  • peripheral nervous system
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with SUOX: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SUOX Gene

Orthologs for SUOX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUOX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUOX 33 34
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia SUOX 33 34
  • 89.4 (n)
cow
(Bos Taurus)
Mammalia SUOX 33 34
  • 88.38 (n)
mouse
(Mus musculus)
Mammalia Suox 33 16 34
  • 85.5 (n)
rat
(Rattus norvegicus)
Mammalia Suox 33
  • 84.99 (n)
lizard
(Anolis carolinensis)
Reptilia SUOX 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia suox 33
  • 61.13 (n)
zebrafish
(Danio rerio)
Actinopterygii suox 33
  • 60.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010877 33
  • 56.6 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7280 35 33 34
  • 56.22 (n)
worm
(Caenorhabditis elegans)
Secernentea suox-1 33 34
  • 54.73 (n)
H13N06.4 35
  • 48 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SOX 33
  • 52.9 (n)
rice
(Oryza sativa)
Liliopsida Os08g0530400 33
  • 54.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU06931 33
  • 51.95 (n)
Species where no ortholog for SUOX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUOX Gene

ENSEMBL:
Gene Tree for SUOX (if available)
TreeFam:
Gene Tree for SUOX (if available)

Paralogs for SUOX Gene

(2) SIMAP similar genes for SUOX Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SUOX Gene

genes like me logo Genes that share paralogs with SUOX: view

No data available for Paralogs for SUOX Gene

Variants for SUOX Gene

Sequence variations from dbSNP and Humsavar for SUOX Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1041681662 sulfite oxidase deficiency (ISOD) [MIM:272300] 56,004,192(+) G/A coding_sequence_variant, missense_variant
rs121908007 pathogenic, Sulfite oxidase deficiency, isolated, Isolated sulfite oxidase deficiency (ISOD) [MIM:272300] 56,004,039(+) G/A coding_sequence_variant, missense_variant
rs121908008 pathogenic, Sulfite oxidase deficiency, isolated, Isolated sulfite oxidase deficiency (ISOD) [MIM:272300] 56,004,183(+) C/A coding_sequence_variant, missense_variant
rs121908009 pathogenic, Sulfite oxidase deficiency, isolated, Isolated sulfite oxidase deficiency (ISOD) [MIM:272300] 56,004,978(+) G/A coding_sequence_variant, missense_variant
rs139170103 uncertain-significance, Sulfite oxidase deficiency 55,999,336(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SUOX Gene

Variant ID Type Subtype PubMed ID
nsv832427 CNV loss 17160897
nsv832424 CNV loss 17160897
nsv1051961 CNV gain 25217958

Variation tolerance for SUOX Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SUOX Gene

Human Gene Mutation Database (HGMD)
SUOX
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUOX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUOX Gene

Disorders for SUOX Gene

MalaCards: The human disease database

(10) MalaCards diseases for SUOX Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sulfite oxidase deficiency, isolated
  • isod
encephalomalacia
molybdenum cofactor deficiency
  • combined deficiency of sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase
xanthinuria, type i
  • xan1
fructose intolerance, hereditary
  • fructosemia
- elite association - COSMIC cancer census association via MalaCards
Search SUOX in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SUOX_HUMAN
  • Isolated sulfite oxidase deficiency (ISOD) [MIM:272300]: Characterized by neurological abnormalities including multicystic leukoencephalopathy with brain atrophy. Patients often suffer from seizures. Often leads to death at an early age. {ECO:0000269 PubMed:10519592, ECO:0000269 PubMed:12112661, ECO:0000269 PubMed:12368985, ECO:0000269 PubMed:9428520, ECO:0000269 PubMed:9600976}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SUOX

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SUOX: view

No data available for Genatlas for SUOX Gene

Publications for SUOX Gene

  1. Molecular cloning of human liver sulfite oxidase. (PMID: 7599189) Garrett RM … Rajagopalan KV (Biochimica et biophysica acta 1995) 2 3 4 22 58
  2. The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain. (PMID: 12832761) Rudolph MJ … Kisker C (Acta crystallographica. Section D, Biological crystallography 2003) 3 4 22 58
  3. A novel mutation in neonatal isolated sulphite oxidase deficiency. (PMID: 12368985) Lee HF … Shu SG (Neuropediatrics 2002) 3 4 22 58
  4. Isolated sulfite oxidase deficiency: review of two cases in one family. (PMID: 10519592) Edwards MC … MacDonald IM (Ophthalmology 1999) 3 4 22 58
  5. Human sulfite oxidase R160Q: identification of the mutation in a sulfite oxidase-deficient patient and expression and characterization of the mutant enzyme. (PMID: 9600976) Garrett RM … Rajagopalan KV (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 22 58

Products for SUOX Gene

Sources for SUOX Gene

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