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Aliases for SLC4A10 Gene

Aliases for SLC4A10 Gene

  • Solute Carrier Family 4 Member 10 2 3 4 5
  • Solute Carrier Family 4, Sodium Bicarbonate Transporter, Member 10 2 3
  • NCBE 3 4
  • Solute Carrier Family 4, Sodium Bicarbonate Cotransporter-Like, Member 10 3
  • Solute Carrier Family 4, Sodium Bicarbonate Transporter-Like, Member 10 2
  • Sodium-Driven Chloride Bicarbonate Exchanger 3
  • NBCn2 3

External Ids for SLC4A10 Gene

Previous GeneCards Identifiers for SLC4A10 Gene

  • GC02P160534
  • GC02P161009
  • GC02P162444
  • GC02P162683
  • GC02P162306
  • GC02P162189
  • GC02P162281
  • GC02P154363

Summaries for SLC4A10 Gene

Entrez Gene Summary for SLC4A10 Gene

  • This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

GeneCards Summary for SLC4A10 Gene

SLC4A10 (Solute Carrier Family 4 Member 10) is a Protein Coding gene. Diseases associated with SLC4A10 include Complex Partial Epilepsy. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and inorganic anion exchanger activity. An important paralog of this gene is SLC4A8.

UniProtKB/Swiss-Prot for SLC4A10 Gene

  • Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).

Additional gene information for SLC4A10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A10 Gene

Genomics for SLC4A10 Gene

GeneHancer (GH) Regulatory Elements for SLC4A10 Gene

Promoters and enhancers for SLC4A10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I161627 Promoter 0.9 EPDnew 550.1 +200.1 200065 0.1 MXI1 USF1 SIN3A KLF4 ZNF217 GATA3 CTBP1 POLR2A SLC4A10 KRT18P46 LOC105373722
GH02I161423 Enhancer 0.4 Ensembl 550.8 -0.4 -391 1.8 RING1 SUZ12 EZH2 ENSG00000224076 SLC4A10 ENSG00000251621 LINC01806 TBR1
GH02I162117 Enhancer 0.7 Ensembl ENCODE 10.7 +694.2 694222 2.3 SMARCE1 CTBP1 JUND HLF DPF2 FOS RAD21 DPP4 ENSG00000224076 ENSG00000251621 SLC4A10 TIMM8AP1 ENSG00000230918 LOC101929532 GC02M162149 GC02M162150
GH02I162123 Enhancer 0.7 ENCODE 10.7 +699.7 699664 0.1 GATAD2A CTCF ZNF654 ZNF511 FOXA3 TRIM22 ARID4B REST RAD21 ZNF592 ENSG00000224076 ENSG00000251621 SLC4A10 LOC101929532 GC02M162150 GC02M162149
GH02I161237 Enhancer 2.2 VISTA UCNEbase FANTOM5 Ensembl ENCODE 3.3 -185.8 -185792 2.7 RB1 ZSCAN4 SIN3A NFXL1 ZNF335 GLIS2 ZNF366 SCRT2 ZNF143 BCLAF1 GC02M161238 GC02M161236 TBR1 LINC01806 AHCTF1P1 SLC4A10 LOC101929512
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC4A10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC4A10 gene promoter:

Genomic Locations for SLC4A10 Gene

Genomic Locations for SLC4A10 Gene
560,951 bases
Plus strand

Genomic View for SLC4A10 Gene

Genes around SLC4A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC4A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC4A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A10 Gene

Proteins for SLC4A10 Gene

  • Protein details for SLC4A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium-driven chloride bicarbonate exchanger
    Protein Accession:
    Secondary Accessions:
    • B7Z1R0
    • B7Z2J0
    • B7ZLC5
    • B9EG69
    • F8W675
    • Q4ZFX6
    • Q8TCP2
    • Q9HCQ6

    Protein attributes for SLC4A10 Gene

    1118 amino acids
    Molecular mass:
    125946 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC4A10 Gene


neXtProt entry for SLC4A10 Gene

Post-translational modifications for SLC4A10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC4A10 Gene

Domains & Families for SLC4A10 Gene

Gene Families for SLC4A10 Gene

Suggested Antigen Peptide Sequences for SLC4A10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the anion exchanger (TC 2.A.31) family.
  • Belongs to the anion exchanger (TC 2.A.31) family.
genes like me logo Genes that share domains with SLC4A10: view

Function for SLC4A10 Gene

Molecular function for SLC4A10 Gene

UniProtKB/Swiss-Prot Function:
Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).

Phenotypes From GWAS Catalog for SLC4A10 Gene

Gene Ontology (GO) - Molecular Function for SLC4A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity TAS --
GO:0008509 anion transmembrane transporter activity IEA --
GO:0008510 sodium:bicarbonate symporter activity IBA --
GO:0015293 symporter activity IEA --
GO:0015297 antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC4A10: view
genes like me logo Genes that share phenotypes with SLC4A10: view

Animal Models for SLC4A10 Gene

MGI Knock Outs for SLC4A10:

Animal Model Products

miRNA for SLC4A10 Gene

miRTarBase miRNAs that target SLC4A10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC4A10 Gene

Localization for SLC4A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A10 Gene

Cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC4A10 gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC4A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 10993873
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC4A10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC4A10 Gene

Pathways & Interactions for SLC4A10 Gene

genes like me logo Genes that share pathways with SLC4A10: view

Gene Ontology (GO) - Biological Process for SLC4A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006820 anion transport IEA --
GO:0006821 chloride transport NAS 10993873
genes like me logo Genes that share ontologies with SLC4A10: view

No data available for SIGNOR curated interactions for SLC4A10 Gene

Drugs & Compounds for SLC4A10 Gene

(1) Drugs for SLC4A10 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sodium bicarbonate Approved Pharma Transporter, substrate 0

(3) Additional Compounds for SLC4A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC4A10: view

Transcripts for SLC4A10 Gene

Unigene Clusters for SLC4A10 Gene

Solute carrier family 4, sodium bicarbonate transporter, member 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A10 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -

Relevant External Links for SLC4A10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC4A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC4A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC4A10 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.5), Brain - Anterior cingulate cortex (BA24) (x8.5), and Brain - Cortex (x6.0).

Protein differential expression in normal tissues from HIPED for SLC4A10 Gene

This gene is overexpressed in Frontal cortex (38.4), Brain (23.0), and Retina (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC4A10 Gene

Protein tissue co-expression partners for SLC4A10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC4A10 Gene:


SOURCE GeneReport for Unigene cluster for SLC4A10 Gene:


Evidence on tissue expression from TISSUES for SLC4A10 Gene

  • Nervous system(4.6)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with SLC4A10: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC4A10 Gene

Orthologs for SLC4A10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC4A10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC4A10 33 34
  • 99.79 (n)
(Monodelphis domestica)
Mammalia SLC4A10 34
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia SLC4A10 34
  • 96 (a)
(Canis familiaris)
Mammalia SLC4A10 33 34
  • 95.67 (n)
(Bos Taurus)
Mammalia SLC4A10 33 34
  • 94.07 (n)
(Mus musculus)
Mammalia Slc4a10 33 16 34
  • 90.27 (n)
(Rattus norvegicus)
Mammalia Slc4a10 33
  • 89.43 (n)
(Gallus gallus)
Aves SLC4A10 33 34
  • 82.9 (n)
(Anolis carolinensis)
Reptilia SLC4A10 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc4a10 33
  • 78.49 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19338 33
(Danio rerio)
Actinopterygii slc4a10b 34
  • 82 (a)
SLC4A10 (2 of 2) 34
  • 81 (a)
LOC557642 33
  • 72.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ndae1 35 34
  • 53 (a)
(Caenorhabditis elegans)
Secernentea F52B5.1 35
  • 47 (a)
abts-1 34
  • 42 (a)
R03E9.3 35
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
Species where no ortholog for SLC4A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC4A10 Gene

Gene Tree for SLC4A10 (if available)
Gene Tree for SLC4A10 (if available)

Paralogs for SLC4A10 Gene

Paralogs for SLC4A10 Gene

genes like me logo Genes that share paralogs with SLC4A10: view

Variants for SLC4A10 Gene

Sequence variations from dbSNP and Humsavar for SLC4A10 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs142943771 uncertain-significance, not specified 161,974,255(+) C/G coding_sequence_variant, missense_variant
rs201351567 uncertain-significance, not specified 161,949,250(+) A/G coding_sequence_variant, missense_variant
rs779428686 uncertain-significance, not specified 161,974,272(+) G/A coding_sequence_variant, missense_variant
rs929159822 uncertain-significance, not specified 161,839,848(+) A/G/T 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs1000001203 -- 161,920,053(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC4A10 Gene

Variant ID Type Subtype PubMed ID
esv1338019 CNV deletion 17803354
esv2646896 CNV deletion 19546169
esv2721050 CNV deletion 23290073
esv3304328 CNV mobile element insertion 20981092
esv3304423 CNV mobile element insertion 20981092
esv3380375 CNV insertion 20981092
esv3381795 CNV insertion 20981092
esv3584140 CNV loss 25503493
esv3593162 CNV loss 21293372
esv3593163 CNV loss 21293372
esv3593164 CNV loss 21293372
esv3593165 CNV loss 21293372
esv3593168 CNV loss 21293372
esv3593173 CNV loss 21293372
nsv1127776 CNV deletion 24896259
nsv3006 CNV insertion 18451855
nsv3007 CNV deletion 18451855
nsv3008 CNV insertion 18451855
nsv476511 CNV novel sequence insertion 20440878
nsv519410 CNV gain 19592680
nsv819853 CNV gain 19587683
nsv834438 CNV gain 17160897

Variation tolerance for SLC4A10 Gene

Residual Variation Intolerance Score: 6.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC4A10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A10 Gene

Disorders for SLC4A10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC4A10 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
complex partial epilepsy
  • complex partial epileptic seizure
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC4A10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC4A10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC4A10 Gene

Publications for SLC4A10 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58
  3. AQP1 and SLC4A10 as candidate genes for primary open-angle glaucoma. (PMID: 20101282) Liu W … Allingham RR (Molecular vision 2010) 3 44 58
  4. Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity. (PMID: 18319254) Parker MD … Boron WF (The Journal of biological chemistry 2008) 2 3 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58

Products for SLC4A10 Gene

Sources for SLC4A10 Gene

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