Aliases for PON2 Gene
External Ids for PON2 Gene
Previous GeneCards Identifiers for PON2 Gene
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for PON2 Gene
PON2 (Paraoxonase 2) is a Protein Coding gene. Diseases associated with PON2 include Amyotrophic Lateral Sclerosis 1 and Multiple Chemical Sensitivity. Among its related pathways are Arachidonic acid metabolism and Phase I biotransformations, non P450. Gene Ontology (GO) annotations related to this gene include identical protein binding and arylesterase activity. An important paralog of this gene is PON1.
UniProtKB/Swiss-Prot Summary for PON2 Gene
Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.