Aliases for P2RY12 Gene
External Ids for P2RY12 Gene
Previous GeneCards Identifiers for P2RY12 Gene
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
GeneCards Summary for P2RY12 Gene
P2RY12 (Purinergic Receptor P2Y12) is a Protein Coding gene. Diseases associated with P2RY12 include Bleeding Disorder, Platelet-Type, 8 and Drug Metabolism, Poor, Cyp2c19-Related. Among its related pathways are GPCR Pathway and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled adenosine receptor activity. An important paralog of this gene is P2RY13.
UniProtKB/Swiss-Prot Summary for P2RY12 Gene
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.