The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obes... See more...

Aliases for HSD11B1 Gene

Aliases for HSD11B1 Gene

  • Hydroxysteroid 11-Beta Dehydrogenase 1 2 3 5
  • SDR26C1 2 3 4
  • Short Chain Dehydrogenase/Reductase Family 26C Member 1 3 4
  • Corticosteroid 11-Beta-Dehydrogenase Isozyme 1 3 4
  • 11-Beta-HSD1 3 4
  • EC 1.1.1.146 4 51
  • HSD11L 3 4
  • 11-DH 3 4
  • HSD11 3 4
  • Short Chain Dehydrogenase/Reductase Family 26C, Member 1 2
  • Hydroxysteroid (11-Beta) Dehydrogenase 1 2
  • 11-Beta-Hydroxysteroid Dehydrogenase 1 4
  • EC 1.1.1 51
  • CORTRD2 3
  • HSD11B1 5
  • HSD11B 3
  • HDL 3

External Ids for HSD11B1 Gene

Previous HGNC Symbols for HSD11B1 Gene

  • HSD11B
  • HSD11

Previous GeneCards Identifiers for HSD11B1 Gene

  • GC01P208517
  • GC01P205584
  • GC01P206517
  • GC01P206938
  • GC01P206247
  • GC01P207926
  • GC01P209859
  • GC01P180534

Summaries for HSD11B1 Gene

Entrez Gene Summary for HSD11B1 Gene

  • The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]

GeneCards Summary for HSD11B1 Gene

HSD11B1 (Hydroxysteroid 11-Beta Dehydrogenase 1) is a Protein Coding gene. Diseases associated with HSD11B1 include Cortisone Reductase Deficiency 2 and Hyperandrogenism Due To Cortisone Reductase Deficiency. Among its related pathways are Drug metabolism - cytochrome P450 and Metabolism of steroid hormones. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and 11-beta-hydroxysteroid dehydrogenase (NADP+) activity. An important paralog of this gene is HSD11B1L.

UniProtKB/Swiss-Prot Summary for HSD11B1 Gene

  • Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).

Tocris Summary for HSD11B1 Gene

  • 11beta-Hydroxysteroid Dehydrogenases (11beta-HSD) isozymes 11beta-HSD1 and 11beta-HSD2 catalyze the interconversion of cortisol and cortisone. 11beta-HSD1 converts cortisone to cortisol, the active hormone; and 11beta-HSD2 converts cortisol to cortisone, the inactive form.

Gene Wiki entry for HSD11B1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSD11B1 Gene

Genomics for HSD11B1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HSD11B1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSD11B1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSD11B1

Top Transcription factor binding sites by QIAGEN in the HSD11B1 gene promoter:
  • C/EBPalpha
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • TBP

Genomic Locations for HSD11B1 Gene

Genomic Locations for HSD11B1 Gene
chr1:209,686,178-209,734,950
(GRCh38/hg38)
Size:
48,773 bases
Orientation:
Plus strand
chr1:209,859,510-209,908,295
(GRCh37/hg19)
Size:
48,786 bases
Orientation:
Plus strand

Genomic View for HSD11B1 Gene

Genes around HSD11B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSD11B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSD11B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSD11B1 Gene

Proteins for HSD11B1 Gene

  • Protein details for HSD11B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28845-DHI1_HUMAN
    Recommended name:
    Corticosteroid 11-beta-dehydrogenase isozyme 1
    Protein Accession:
    P28845
    Secondary Accessions:
    • B2R9Z1
    • D3DT89

    Protein attributes for HSD11B1 Gene

    Size:
    292 amino acids
    Molecular mass:
    32401 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for HSD11B1 Gene

neXtProt entry for HSD11B1 Gene

Selected DME Specific Peptides for HSD11B1 Gene

P28845:
  • NVSITLC
  • IVTGASKG
  • MGAHVVVTARS
  • MEDMTFAE

Post-translational modifications for HSD11B1 Gene

  • Glycosylated.
  • Glycosylation at Asn123, Asn162, and Asn207
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for HSD11B1 Gene

Domains & Families for HSD11B1 Gene

Gene Families for HSD11B1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for HSD11B1 Gene

InterPro:
Blocks:
  • Short-chain dehydrogenase/reductase SDR
ProtoNet:

Suggested Antigen Peptide Sequences for HSD11B1 Gene

GenScript: Design optimal peptide antigens:
  • 11-beta-hydroxysteroid dehydrogenase 1 (DHI1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P28845

UniProtKB/Swiss-Prot:

DHI1_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with HSD11B1: view

Function for HSD11B1 Gene

Molecular function for HSD11B1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + H(+) + NADPH; Xref=Rhea:RHEA:11388, ChEBI:CHEBI:15378, ChEBI:CHEBI:35346, ChEBI:CHEBI:47787, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.146; Evidence={ECO:0000269|PubMed:10497248, ECO:0000269|PubMed:15152005, ECO:0000269|PubMed:17070044, ECO:0000269|PubMed:17919905};.
GENATLAS Biochemistry:
hydroxysteroid dehydrogenase 11-beta 1,NADP dependent,expressed in liver,lung,testis,catalyzing the interconversion of cortisol and cortisone,glucocorticoid metabolism liver

Enzyme Numbers (IUBMB) for HSD11B1 Gene

Phenotypes From GWAS Catalog for HSD11B1 Gene

Gene Ontology (GO) - Molecular Function for HSD11B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity IBA 21873635
GO:0005496 steroid binding IBA 21873635
GO:0016491 oxidoreductase activity IEA --
GO:0042803 protein homodimerization activity IDA 15513927
GO:0050661 NADP binding IDA 15513927
genes like me logo Genes that share ontologies with HSD11B1: view
genes like me logo Genes that share phenotypes with HSD11B1: view

Human Phenotype Ontology for HSD11B1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HSD11B1 Gene

MGI Knock Outs for HSD11B1:

Animal Model Products

  • Taconic Biosciences Mouse Models for HSD11B1

CRISPR Products

miRNA for HSD11B1 Gene

miRTarBase miRNAs that target HSD11B1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSD11B1

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for HSD11B1 Gene

Localization for HSD11B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSD11B1 Gene

Endoplasmic reticulum membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSD11B1 gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 3
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HSD11B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IDA 10497248
genes like me logo Genes that share ontologies with HSD11B1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSD11B1 Gene

Pathways & Interactions for HSD11B1 Gene

genes like me logo Genes that share pathways with HSD11B1: view

Gene Ontology (GO) - Biological Process for HSD11B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006704 glucocorticoid biosynthetic process TAS --
GO:0006706 steroid catabolic process IBA 21873635
GO:0008202 steroid metabolic process IEA --
GO:0030324 lung development IEA --
genes like me logo Genes that share ontologies with HSD11B1: view

No data available for SIGNOR curated interactions for HSD11B1 Gene

Drugs & Compounds for HSD11B1 Gene

(60) Drugs for HSD11B1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrocortisone Approved, Vet_approved Pharma Agonist, Enzyme, substrate 897
NADH Approved Nutra Target 0
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist, Enzyme, substrate Anti-inflammatory glucocorticoid 2886
glycyrrhizin Approved, Experimental Pharma Inhibitor, Inhibition, Target, antagonist 26
Dexamethasone acetate Approved, Investigational, Vet_approved Pharma Enzyme, substrate 2886

(34) Additional Compounds for HSD11B1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11-Dehydrocorticosterone
  • 11-dehydro-Corticosterone
  • 11-Dehydrocorticosteron
  • 11-oxo-11-Deoxycorticosterone
  • 11-Oxocorticosterone
  • 17-(1-keto-2-Hydroxyethyl)-D4-androsten-3,11-dione
72-23-1
7-Ketocholesterol
  • 3b-Hydroxycholest-5-en-7-one
  • 7-Oxocholesterol
  • Cholest-5-en-3b-ol-7-one
  • Delta5-Cholesten-3b-ol-7-one
  • 3beta-Hydroxy-5-cholestene-7-one
566-28-9
11b-Hydroxyandrost-4-ene-3,17-dione
  • 11beta-Hydroxy-4-androstene-3,17-dione
  • 4-Androsten-11beta-ol-3,17-dione
  • Androst-4-ene-3,17-dione-11beta-ol
  • 11b-Hydroxy-4-androstene-3,17-dione
  • 11β-hydroxy-4-androstene-3,17-dione
382-44-5
3a,21-Dihydroxy-5b-pregnane-11,20-dione
  • 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione
  • 5beta-Pregnane-3alpha,21-diol-11,20-dione
566-03-0
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
  • NNAL
  • 4-(methylnitrosamino)-1-(3-Pyridyl)-1-butan-1-ol
  • NNAL CPD
76014-81-8

(1) Tocris Compounds for HSD11B1 Gene

Compound Action Cas Number
PF 915275 Potent and selective 11beta-hydroxysteroid dehydrogenase inhibitor 857290-04-1

(2) ApexBio Compounds for HSD11B1 Gene

Compound Action Cas Number
Carbenoxolone disodium 7421-40-1
PF 915275 857290-04-1
genes like me logo Genes that share compounds with HSD11B1: view

Drug Products

Transcripts for HSD11B1 Gene

mRNA/cDNA for HSD11B1 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSD11B1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSD11B1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
SP1:
SP2: - -
SP3: - -
SP4: - -

Relevant External Links for HSD11B1 Gene

GeneLoc Exon Structure for
HSD11B1

Expression for HSD11B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSD11B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSD11B1 Gene

This gene is overexpressed in Liver (x23.6).

Protein differential expression in normal tissues from HIPED for HSD11B1 Gene

This gene is overexpressed in Liver (58.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HSD11B1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSD11B1

SOURCE GeneReport for Unigene cluster for HSD11B1 Gene:

Hs.195040

mRNA Expression by UniProt/SwissProt for HSD11B1 Gene:

P28845-DHI1_HUMAN
Tissue specificity: Widely expressed. Highest expression in liver.

Evidence on tissue expression from TISSUES for HSD11B1 Gene

  • Liver(4.8)
  • Nervous system(4.6)
  • Adrenal gland(3)
  • Blood(2.7)
  • Skin(2.7)
  • Kidney(2.6)
  • Heart(2.6)
  • Muscle(2.5)
  • Intestine(2.5)
  • Lung(2.3)
  • Spleen(2.2)
  • Pancreas(2.1)
  • Urine(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HSD11B1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • reproductive
Regions:
Head and neck:
  • brain
  • face
  • head
  • pituitary gland
Pelvis:
  • ovary
  • testicle
  • uterus
General:
  • hair
  • skin
genes like me logo Genes that share expression patterns with HSD11B1: view

No data available for Protein tissue co-expression partners for HSD11B1 Gene

Orthologs for HSD11B1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSD11B1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HSD11B1 30 31
  • 99.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HSD11B1 30 31
  • 86.71 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HSD11B1 30 31
  • 84.54 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hsd11b1 30
  • 79.91 (n)
Mouse
(Mus musculus)
Mammalia Hsd11b1 30 17 31
  • 79.73 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia HSD11B1 31
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC771930 30
  • 63.55 (n)
-- 31
  • 57 (a)
OneToMany
-- 31
  • 55 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia HSD11B1 31
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hsd11b1 30
  • 59.76 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC64545 30
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 33
-- 33
-- 33
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
OneToOne
Species where no ortholog for HSD11B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for HSD11B1 Gene

ENSEMBL:
Gene Tree for HSD11B1 (if available)
TreeFam:
Gene Tree for HSD11B1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSD11B1: view image

Paralogs for HSD11B1 Gene

(1) SIMAP similar genes for HSD11B1 Gene using alignment to 1 proteins:

  • DHI1_HUMAN
genes like me logo Genes that share paralogs with HSD11B1: view

Variants for HSD11B1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSD11B1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
31589 Pathogenic: Cortisone reductase deficiency 2 209,732,479(+) G/T MISSENSE_VARIANT
743453 Benign: not provided 209,705,839(+) C/T SYNONYMOUS_VARIANT
787221 Benign: not provided 209,732,427(+) G/A INTRON_VARIANT
rs387907168 Pathogenic: Cortisone reductase deficiency 2 209,707,020(+) C/T MISSENSE_VARIANT
rs41283132 Benign/Likely Benign: not specified; not provided 209,734,386(+) G/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for HSD11B1 Gene

Structural Variations from Database of Genomic Variants (DGV) for HSD11B1 Gene

Variant ID Type Subtype PubMed ID
nsv1004343 CNV gain 25217958
nsv1006632 CNV gain 25217958
nsv478363 CNV novel sequence insertion 20440878
nsv525445 CNV loss 19592680

Variation tolerance for HSD11B1 Gene

Residual Variation Intolerance Score: 20.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSD11B1 Gene

Human Gene Mutation Database (HGMD)
HSD11B1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSD11B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSD11B1 Gene

Disorders for HSD11B1 Gene

MalaCards: The human disease database

(22) MalaCards diseases for HSD11B1 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

DHI1_HUMAN
  • Cortisone reductase deficiency 2 (CORTRD2) [MIM:614662]: An autosomal dominant error of cortisone metabolism characterized by a failure to regenerate cortisol from cortisone, resulting in increased cortisol clearance, activation of the hypothalamic- pituitary axis and ACTH-mediated adrenal androgen excess. Clinical features include hyperandrogenism resulting in hirsutism, oligo- amenorrhea, and infertility in females and premature pseudopuberty in males. {ECO:0000269 PubMed:12858176}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for HSD11B1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with HSD11B1: view

No data available for Genatlas for HSD11B1 Gene

Publications for HSD11B1 Gene

  1. Regulatory effect of common promoter polymorphisms on the expression of the 11beta-hydroxysteroid dehydrogenase type 1 gene. (PMID: 19571556) Ku YH … Park KS (Hormone research 2009) 3 23 41
  2. Association study of 11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in urban Japanese cohort. (PMID: 19535162) Miyamoto Y … Morisaki T (Diabetes research and clinical practice 2009) 3 23 41
  3. Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model. (PMID: 18553955) Julian LD … Powers JP (Journal of medicinal chemistry 2008) 3 4 23
  4. [Possible pathogenetic role of 11 beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) gene polymorphisms in arterial hypertension]. (PMID: 18769825) Morales MA … Fardella CE (Revista medica de Chile 2008) 3 23 41
  5. Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes. (PMID: 17467270) Hennebert O … Morfin R (The Journal of steroid biochemistry and molecular biology 2007) 3 23 26

Products for HSD11B1 Gene

Sources for HSD11B1 Gene