Aliases for AMDHD2 Gene
External Ids for AMDHD2 Gene
Previous GeneCards Identifiers for AMDHD2 Gene
GeneCards Summary for AMDHD2 Gene
AMDHD2 (Amidohydrolase Domain Containing 2) is a Protein Coding gene. Diseases associated with AMDHD2 include Tick-Borne Relapsing Fever. Among its related pathways are Metabolism of proteins and Amino sugar and nucleotide sugar metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and N-acetylglucosamine-6-phosphate deacetylase activity. An important paralog of this gene is ENSG00000259784.
UniProtKB/Swiss-Prot Summary for AMDHD2 Gene
Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.