Using EnrichNet from GeneCards
EnrichNet (Network-based gene set enrichment analysis), from The University of Nottingham, measures the association between gene sets and functional pathways/processes based on the distances between corresponding proteins in a protein-protein interaction network, instead of only using the overlap of gene sets to estimate their association. The approach maps gene and protein sets of interest onto a protein interaction network and computes the distribution of shortest path distances between all protein pairs from different sets. This distribution is then compared against the distribution across all pathway/process protein sets from a chosen database (KEGG, BioCarta, Reactome, etc.).
After executing a search in GeneCards, the results page provides a EnrichNet button. Clicking on it causes the set of gene symbols found by the search to be translated to Ensembl identifiers which are sent to the EnrichNet server for further analysis and visualization.
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