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GeneCard: IL17A   interleukin 17A (GC06P052160; Chromosome 6:52,159,144-52,163,395) The following 8 records in the GeneCard text contribute to matching your query: - ALIASES: OTTHUMP00000016597 (EG)| cytotoxic T-lymphocyte-associated antigen 8 (EG)| cytotoxic T-lymphocyte-associated protein 8 (EG)| cytotoxic T-lymphocyte-associated serine esterase 8 (EG)| interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) (HGNC)| interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) (EG)| IL-17 (HGNC)| IL-17 (SP)| IL-17 (EG)| IL-17A (HGNC)| IL-17A (SP)| IL-17A (EG)| CTLA-8 (SP)| Cytotoxic T-lymphocyte-associated antigen 8 (SP)| CTLA8 (SP)| CTLA8 (EG)| IL17 (SP)| IL17 (EG) - SWISSPROT: WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il17/"; SWISSPROT: IL17 | |GENE: IL17A| [155 amino acids; 17504 D] | Q16552 |FUNCTION: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts|SUBUNIT: Homodimer|SUBCELLULAR LOCATION: Secreted|TISSUE SPECIFICITY: Restricted to activated memory T-cells|PTM: Found both in glycosylated and nonglycosylated forms|SIMILARITY: Belongs to the IL-17 family|WEB RESOURCE: Name=R&D Systems' cytokine mini-reviews: IL-17; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1674";|WEB RESOURCE: Name=Wikipedia; Note=Interleukin-17 entry; URL="http://en.wikipedia.org/wiki/Interleukin_17";|WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il17/"; |RECOMMENDED_NAME: Interleukin-17A precursor && minedVia: UniProt - LITERATURE: The role of the IL23/IL17 axis in bronchiolitis obliterans syndrome after lung transplantation. . . . - ENTREZGENE: chr=6 | contig= | cytoLoc=6p12 | dbXrefs=HGNC:5981,MIM:603149,Ensembl:ENSG00000112115,HPRD:04396 | egHugo= | egId=3605 | end=52163395 | geneName=interleukin 17A | genomicNucAcc=AY460616.1 AL391221.15 CH471081.1 AC_000049.1 AC_000138.1 NC_000006.10 NT_007592.14 NW_001838981.2 NW_923073.1 | go=GO:0006486 GO:0005615 GO:0005125 GO:0007267 GO:0008219 GO:0006954 GO:0006915 GO:0045944 GO:0005576 GO:0006955 | protAcc=AAR23263.1 CAI16678.1 EAX04362.1 Q16552.1 Q5T2P0 Q6NZ94 AAH66251.1 AAH66252.1 AAH66253.1 AAH67503.1 AAH67504.1 AAH67505.1 AAC50341.1 CAA91233.1 NP_002181.1 | proteinAliases=OTTHUMP00000016597|cytotoxic T-lymphocyte-associated antigen 8|cytotoxic T-lymphocyte-associated protein 8|cytotoxic T-lymphocyte-associated serine esterase 8|interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) | refseq=NM_002190.2(REVIEWED) | rnaNucAcc=BC066251.1 BC066252.1 BC066253.1 BC067503.1 BC067504.1 BC067505.1 U32659.1 Z58820.1 NM_002190.2 | start=52159144 | status=O | summary=The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq] | symbol=IL17A | synonyms=CTLA8 IL-17 IL-17A IL17 | type=protein-coding - HGNC: accs=U32659 | aliases=IL-17A, IL-17 | dateApproved=1993-10-25 | dateModified=2008-02-05 | dateNameChanged=2006-04-26 | description=interleukin 17A | egCuratedId=3605 | egMappedId=3605 | enzymeIds= | geneFamName=IL | hgnc=5981 | loc=6p12 | mgdId= | omimId=603149 | prevNames="interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)" | prevSymbols=CTLA8, IL17 | pubmedIds=8390535 | refseqId=NM_002190 | refseqMappedId=NM_002190 | status=Approved | symbol=IL17A | uniprotId=Q16552 - InterPro: entry_id: IPR010345 entry_name: IL17 - ACEVIEW: aceviewSymbol = IL17 | acc=CD559442;quality=1,acc=BC066252;quality=1,acc=BC067503;quality=1,acc=NM_002190;quality=1,acc=BC067505;quality=1,acc=CD559595;quality=1,acc=CD559598;quality=2,acc=U32659;quality=2,acc=CD559599;quality=2,acc=BC067504;quality=2,acc=Z58820;quality=2,acc=CD559600;quality=2,acc=BC066251;quality=2,acc=CK130280;quality=2,acc=CD559596;quality=2,acc=BC066253;quality=2,acc=CD559601;quality=3,acc=CD559597;quality=3,acc=CD559443;quality=4,acc=CD559447;quality=4 - ABCAM: proteins: protein=IL17;tid=1371 | antibodies: protein=IL17;tid=1371 GeneCard: IL17B   interleukin 17B (GC05M148734; Chromosome 5:148,734,023-148,739,031) The following 3 records in the GeneCard text contribute to matching your query: - GENATLAS: biochem: interleukin 17B,expressed in adult pancreas,small intestine stomach,not expressed in activated T cells,not binding to the IL17 receptor | disease: - ENTREZGENE: chr=5 | contig= | cytoLoc=5q32-q34 | dbXrefs=HGNC:5982,MIM:604627,Ensembl:ENSG00000127743,HPRD:05217 | egHugo= | egId=27190 | end=148739031 | geneName=interleukin 17B | genomicNucAcc=AC131025.1 AF386077.2 CH471062.2 AC_000048.1 AC_000137.1 NC_000005.8 NT_029289.10 NW_001838953.2 NW_922784.1 | go=GO:0005615 GO:0005125 GO:0007267 GO:0006955 GO:0005576 GO:0004871 GO:0006954 | protAcc=AAK60336.1 EAW61781.1 EAW61782.1 Q6IAG3 Q9UHF5.1 AAG39637.1 AAF28104.1 AAF01318.1 AAF78775.1 AAG44136.1 AAQ89290.1 AAI13926.1 AAI13947.1 CAG33473.1 NP_055258.1 | proteinAliases=cytokine-like protein ZCYTO7|interleukin 20|interleukin-17 beta|neuronal interleukin-17 related factor | refseq=NM_014443.2(REVIEWED) | rnaNucAcc=AF110385.1 AF152098.1 AF184969.1 AF212311.1 AF218727.1 AY358931.1 BC113925.1 BC113946.1 CR457192.1 NM_014443.2 | start=148734023 | status=O | summary=The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. [provided by RefSeq] | symbol=IL17B | synonyms=IL-17B IL-20 MGC138900 MGC138901 ZCYTO7 | type=protein-coding - InterPro: entry_id: IPR010345 entry_name: IL17 GeneCard: IL17C   interleukin 17C (GC16P087232; Chromosome 16:87,232,502-87,234,385) The following 3 records in the GeneCard text contribute to matching your query: - GENATLAS: biochem: interleukin 17C,not detected in several adult tissues,not in activated T cells,not binding to the IL17 receptor | disease: - ENTREZGENE: chr=16 | contig= | cytoLoc=16q24 | dbXrefs=HGNC:5983,MIM:604628,Ensembl:ENSG00000124391,HPRD:06863 | egHugo= | egId=27189 | end=87234383 | geneName=interleukin 17C | genomicNucAcc=AC116552.2 CQ847631.1 CH471184.2 AC_000059.1 AC_000148.1 NC_000016.8 NT_010542.15 NW_001838333.1 NW_926561.1 | go=GO:0005615 GO:0005125 GO:0030223 GO:0007267 GO:0007166 GO:0005625 GO:0006954 GO:0005576 | protAcc=CAH18037.1 EAW66798.1 Q9P0M4.1 AAF28105.1 AAQ88835.1 AAH69152.1 AAI01836.1 AAI12197.1 NP_037410.1 | proteinAliases=cytokine CX2 | refseq=NM_013278.3(REVIEWED) | rnaNucAcc=AF152099.1 AY358471.1 BC069152.1 BC101835.1 BC112196.1 NM_013278.3 | start=87232502 | status=O | summary=The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq] | symbol=IL17C | synonyms=CX2 IL-17C IL-21 MGC126884 MGC138401 | type=protein-coding - InterPro: entry_id: IPR010345 entry_name: IL17 GeneCard: IL17RC   interleukin 17 receptor C (GC03P009933; Chromosome 3:9,933,782-9,950,314) The following 3 records in the GeneCard text contribute to matching your query: - ALIASES: FLJ95963 (EG)| FLJ96005 (EG)| IL17F receptor (EG)| MGC10763 (EG)| interleukin 17 receptor-like (EG)| IL17-RL (HGNC)| IL17-RL (EG)| IL17RL (OMIM)| IL17RL (EG)| IL-17 receptor C (SP)| IL-17RC (SP)| IL-17RL (SP)| IL17Rhom (SP)| Interleukin-17 receptor homolog (SP)| Interleukin-17 receptor-like protein (SP) - ENTREZGENE: chr=3 | contig= | cytoLoc=3p25.3|3p25.3-p24.1 | dbXrefs=HGNC:18358,MIM:610925,Ensembl:ENSG00000163702,HPRD:17142 | egHugo= | egId=84818 | end=9950314 | geneName=interleukin 17 receptor C | genomicNucAcc=AC018809.5 CH471055.1 AC_000046.1 AC_000135.1 NC_000003.10 NT_022517.17 NW_001838876.2 NW_921651.1 | go=GO:0004872 GO:0016021 GO:0005886 | protAcc=EAW64021.1 EAW64022.1 EAW64023.1 EAW64024.1 EAW64025.1 EAW64026.1 EAW64027.1 EAW64028.1 EAW64029.1 EAW64030.1 EAW64031.1 EAW64032.1 Q8N2D7 Q8NAC3.2 AAM77569.1 BAC11677.1 BAC04001.1 BAF83359.1 BAG57799.1 BAG58336.1 BAG64270.1 AAQ89199.1 AAQ89456.1 ABV44615.1 ABV44616.1 ABV44617.1 NP_116121.2 NP_703190.1 NP_703191.1 | proteinAliases=IL17F receptor|interleukin 17 receptor-like | refseq=NM_032732.4(REVIEWED) NM_153460.2(REVIEWED) NM_153461.2(REVIEWED) | rnaNucAcc=AF458065.1 AK075534.1 AK092907.1 AK094746.1 AK096824.1 AK225650.1 AK290670.1 AK294616.1 AK295377.1 AK303171.1 AK308241.1 AK315024.1 AK315053.1 AY358840.1 AY359098.1 BC006411.1 DC381087.1 EF676032.1 EF676033.1 EF676034.1 NM_032732.4 NM_153460.2 NM_153461.2 | start=9933782 | status=O | summary=This gene encodes a single-pass transmembrane protein that shares limited similarity with the interleukin-17 receptor. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only three have been determined to date. [provided by RefSeq] | symbol=IL17RC | synonyms=FLJ95963 FLJ96005 IL17-RL IL17RL MGC10763 | type=protein-coding - HGNC: accs=BC006411 | aliases=IL17-RL | dateApproved=2003-07-07 | dateModified=2008-02-05 | dateNameChanged= | description=interleukin 17 receptor C | egCuratedId=84818 | egMappedId=84818 | enzymeIds= | geneFamName=IL | hgnc=18358 | loc=3p25.3 | mgdId=MGI:2159336 | omimId=610925 | prevNames= | prevSymbols= | pubmedIds=11706037 | refseqId=NM_032732 | refseqMappedId=NM_032732 | status=Approved | symbol=IL17RC | uniprotId=Q8NAC3 GeneCard: IL17D   interleukin 17D (GC13P020175; Chromosome 13:20,175,479-20,195,237) The following 2 records in the GeneCard text contribute to matching your query: - ENTREZGENE: chr=13 | contig= | cytoLoc=13q12.11 | dbXrefs=HGNC:5984,MIM:607587,Ensembl:ENSG00000172458,HPRD:16251 | egHugo= | egId=53342 | end=20195237 | geneName=interleukin 17D | genomicNucAcc=AL161772.17 AL512652.18 CH471075.1 AC_000056.1 AC_000145.1 NC_000013.9 NT_024524.13 NW_001838069.1 NW_925473.1 | go=GO:0005615 GO:0005125 GO:0005576 GO:0006954 | protAcc=CAH70875.1 CAH71796.1 EAX08274.1 EAX08275.1 EAX08276.1 Q8TAD2.1 AAM77566.1 AAM12734.1 AAL86911.1 AAQ89471.1 AAH36243.1 ABM81646.1 NP_612141.1 | proteinAliases=OTTHUMP00000018104|interleukin 27 | refseq=NM_138284.1(REVIEWED) | rnaNucAcc=AF458062.1 AF479775.1 AK123964.1 AY078238.1 AY359113.1 BC036243.1 DQ890720.2 NM_138284.1 | start=20175482 | status=O | summary=The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq] | symbol=IL17D | synonyms=FLJ30846 IL-17D IL-22 IL-27 IL27 | type=protein-coding - InterPro: entry_id: IPR010345 entry_name: IL17 GeneCard: IL17F   interleukin 17F (GC06M052209; Chromosome 6:52,209,438-52,217,257) The following 2 records in the GeneCard text contribute to matching your query: - ENTREZGENE: chr=6 | contig= | cytoLoc=6p12 | dbXrefs=HGNC:16404,MIM:606496,Ensembl:ENSG00000112116,HPRD:16224 | egHugo= | egId=112744 | end=52217257 | geneName=interleukin 17F | genomicNucAcc=AL034343.17 CH471081.1 AC_000049.1 AC_000138.1 NC_000006.10 NT_007592.14 NW_001838981.2 NW_923073.1 | go=GO:0005615 GO:0045423 GO:0051216 GO:0042109 GO:0017015 GO:0045414 GO:0005576 GO:0045408 GO:0045076 GO:0019955 GO:0005125 GO:0016525 GO:0006029 GO:0042803 GO:0006954 GO:0045944 | protAcc=CAD92646.1 EAX04363.1 EAX04364.1 Q6NSI0 Q96PD4.2 AAL14427.1 AAK83350.1 AAH70124.1 NP_443104.1 | proteinAliases=cytokine ML-1 | refseq=NM_052872.3(REVIEWED) | rnaNucAcc=AF332389.1 AF384857.1 BC070124.1 NM_052872.3 | start=52209443 | status=O | summary=The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq] | symbol=IL17F | synonyms=IL-17F ML-1 ML1 | type=protein-coding - InterPro: entry_id: IPR010345 entry_name: IL17 GeneCard: IL17RB   interleukin 17 receptor B (GC03P053855; Chromosome 3:53,855,617-53,874,867) The following 2 records in the GeneCard text contribute to matching your query: - LITERATURE: Evi27 encodes a novel membrane protein with homology to the IL17 receptor. . . . - ENTREZGENE: chr=3 | contig= | cytoLoc=3p21.1 | dbXrefs=HGNC:18015,MIM:605458,Ensembl:ENSG00000056736,HPRD:05677 | egHugo= | egId=55540 | end=53874867 | geneName=interleukin 17 receptor B | genomicNucAcc=AC012467.9 AY518533.1 CS135264.1 CH471055.1 AC_000046.1 AC_000135.1 NC_000003.10 NT_022517.17 NW_001838877.2 NW_921651.1 | go=GO:0001558 GO:0004872 GO:0004896 GO:0005737 GO:0009986 GO:0005887 GO:0006952 GO:0005576 GO:0005886 | protAcc=AAR89910.1 CAJ21520.1 EAW65298.1 EAW65299.1 Q9NRM6.2 AAF86051.1 AAF86052.1 AAF78776.1 AAK37428.1 AAQ89956.1 AAH00980.1 ABM81855.1 ABM85016.1 NP_061195.2 | proteinAliases=IL-17B receptor|cytokine receptor CRL4|interleukin 17 receptor homolog 1|interleukin 17B receptor | refseq=NM_018725.3(REVIEWED) | rnaNucAcc=AF208110.1 AF208111.1 AF212365.1 AF250309.1 AK307749.1 AY359122.1 BC000980.1 BI458542.1 CR615594.1 DA093617.1 DQ890929.2 DQ894090.2 NM_018725.3 | start=53855617 | status=O | summary=The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq] | symbol=IL17RB | synonyms=CRL4 EVI27 IL17BR IL17RH1 MGC5245 | type=protein-coding GeneCard: IL25   interleukin 25 (GC14P022912; Chromosome 14:22,911,858-22,915,452) The following 2 records in the GeneCard text contribute to matching your query: - ENTREZGENE: chr=14 | contig= | cytoLoc=14q11.2 | dbXrefs=HGNC:13765,MIM:605658,Ensembl:ENSG00000166090,HPRD:05742 | egHugo= | egId=64806 | end=22915452 | geneName=interleukin 25 | genomicNucAcc=AL049829.4 CH471078.2 AC_000057.1 AC_000146.1 NC_000014.7 NT_026437.11 NW_001838110.1 NW_925539.1 | go=GO:0016020 GO:0005615 GO:0030380 GO:0005125 GO:0005576 GO:0008150 GO:0006954 | protAcc=EAW66161.1 EAW66162.1 Q2M3F0 Q9H293.1 AAG40848.1 AAL57622.1 AAN39038.1 AAQ89484.1 AAH69565.1 AAI04930.1 AAI04932.1 ACE87341.1 ACE86659.1 NP_073626.1 NP_758525.1 | proteinAliases=interleukin 17E | refseq=NM_022789.2(REVIEWED) NM_172314.1(REVIEWED) | rnaNucAcc=AF305200.1 AF458059.1 AF461739.1 AY359127.1 BC069565.1 BC104929.1 BC104931.1 EU831823.1 EU831900.1 NM_022789.2 NM_172314.1 | start=22911858 | status=O | summary=The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. This cytokine can induce NF-kappaB activation, and stimulate the production of IL8. Both this cytokine and IL17B are ligands for the cytokine receptor IL17BR. Studies of the similar gene in mice suggested that this cytokine may be a proinflammatory cytokine favoring Th2-type immune response. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq] | symbol=IL25 | synonyms=IL-17E IL-25 IL17E | type=protein-coding - InterPro: entry_id: IPR010345 entry_name: IL17 GeneCard: EBI3   Epstein-Barr virus induced 3 (GC19P004180; Chromosome 19:4,180,495-4,188,525) The following 1 record in the GeneCard text contributes to matching your query: - SWISSPROT: FUNCTION: Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokinesSWISSPROT: IL27B | |GENE: EBI3| [229 amino acids; 25396 D] | Q14213 |FUNCTION: Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines|SUBUNIT: Heterodimer with IL27. IL-27 is an heterodimer composed IL27 and EBI3. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1|SUBCELLULAR LOCATION: Secreted|INDUCTION: By EBV|SIMILARITY: Belongs to the type I cytokine receptor family. Type 3 subfamily|SIMILARITY: Contains 2 fibronectin type-III domains|WEB RESOURCE: Name=Wikipedia; Note=Interleukin-27 entry; URL="http://en.wikipedia.org/wiki/Interleukin_27"; |SECONDARY ACCESSIONS: O75269 |RECOMMENDED_NAME: Interleukin-27 subunit beta precursor && minedVia: UniProt GeneCard: FASLG   Fas ligand (TNF superfamily, member 6) (GC01P170894; Chromosome 1:170,894,777-170,902,637) The following 1 record in the GeneCard text contributes to matching your query: - LITERATURE: High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas. . . . GeneCard: FOXP3   forkhead box P3 (GC0XM048993; Chromosome X:48,994,354-49,008,232) The following 1 record in the GeneCard text contributes to matching your query: - LITERATURE: High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas. . . . GeneCard: GZMB   granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (GC14M024170; Chromosome 14:24,170,000-24,173,313) The following 1 record in the GeneCard text contributes to matching your query: - LITERATURE: High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas. . . . GeneCard: IFNG   interferon, gamma (GC12M066834; Chromosome 12:66,834,816-66,839,790) The following 1 record in the GeneCard text contributes to matching your query: - LITERATURE: IL17 and IFNgamma production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis. . . . GeneCard: IL10   interleukin 10 (GC01M205007; Chromosome 1:205,007,571-205,012,462) The following 1 record in the GeneCard text contributes to matching your query: - LITERATURE: IL17 and IFNgamma production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis. . . . GeneCard: IL17RA   interleukin 17 receptor A (GC22P015947; Chromosome 22:15,945,849-15,971,405) The following 1 record in the GeneCard text contributes to matching your query: - LITERATURE: Evi27 encodes a novel membrane protein with homology to the IL17 receptor. . . . GeneCard: IL18R1   interleukin 18 receptor 1 (GC02P102345; Chromosome 2:102,294,421-102,381,650) The following 1 record in the GeneCard text contributes to matching your query: - LITERATURE: Evi27 encodes a novel membrane protein with homology to the IL17 receptor. . . . GeneCard: IL1B   interleukin 1, beta (GC02M113303; Chromosome 2:113,303,808-113,310,827) The following 1 record in the GeneCard text contributes to matching your query: - LITERATURE: High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas. . . . GeneCard: IL23A   interleukin 23, alpha subunit p19 (GC12P055021; Chromosome 12:55,018,926-55,020,461) The following 1 record in the GeneCard text contributes to matching your query: - LITERATURE: The role of the IL23/IL17 axis in bronchiolitis obliterans syndrome after lung transplantation. . . . GeneCard: IL27   interleukin 27 (GC16M028418; Chromosome 16:28,418,184-28,425,656) The following 1 record in the GeneCard text contributes to matching your query: - SWISSPROT: FUNCTION: Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL-27 subunit p28 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replivationSWISSPROT: IL27A | |GENE: IL27| [243 amino acids; 27493 D] | Q8NEV9 |FUNCTION: Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL-27 subunit p28 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replivation|SUBUNIT: Heterodimer with IL27B/EBI3. IL-27 is an heterodimer composed IL27 and EBI3. EBI3 is also a component of the IL-12 heterodimer|SUBCELLULAR LOCATION: Secreted. Note=Does not seem to be secreted without coexpression of EBI3|TISSUE SPECIFICITY: Expressed in monocytes and in placenta|INDUCTION: Transiently induced by LPS stimulation in monocytes|PTM: O-glycosylated (Probable)|SIMILARITY: Belongs to the IL-6 superfamily|WEB RESOURCE: Name=Wikipedia; Note=Interleukin-27 entry; URL="http://en.wikipedia.org/wiki/Interleukin_27"; |SECONDARY ACCESSIONS: A0N0L2 Q6P676 |RECOMMENDED_NAME: Interleukin-27 subunit alpha precursor && minedVia: UniProt GeneCard: IL6   interleukin 6 (interferon, beta 2) (GC07P022732; Chromosome 7:22,732,028-22,738,146) The following 1 record in the GeneCard text contributes to matching your query: - LITERATURE: High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas. . . . GeneCard: IL8   interleukin 8 (GC04P074845; Chromosome 4:74,825,122-74,828,297) The following 1 record in the GeneCard text contributes to matching your query: - LITERATURE: Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells. . . .

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