Show Advanced Search
""
""

Advanced Search (alpha)

""
 
Search By
Section
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS
Search by expression pattern


FYN Gene

protein-coding   GIFtS: 73

GC06M111981
FYN oncogene related to SRC, FGR, YES
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
"" "" "" "" "" "" "" "" "" "" "" "" "" "" "" ""Services    
 "" "" "" "" "" "" "" "" "" "" "" "" ""

Aliases &
Descriptions
for FYN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

  User Feedback
Aliases & Descriptions
FYN oncogene related to SRC, FGR, YES1 2     OKT3-induced calcium influx regulator2
SLK1 2 3     protein-tyrosine kinase fyn2
MGC453501 2     proto-oncogene tyrosine-protein kinase fyn2
SYN1 2     tyrosine-protein kinase Fyn2
Proto-oncogene Syn2 3     c-syn protooncogene2
Proto-oncogene c-Fyn2 3     tyrosine kinase p59fyn(T)2
p59-Fyn2 3     src/yes-related novel2
src-like kinase2     EC 2.7.10.23

External Ids:    HGNC: 40371   Entrez Gene: 25342   Ensembl: ENSG000000108107   UniProtKB: P062413   

Search outside databases for aliases for FYN gene

Previous GC identifers: GC06M111817 GC06M112005 GC06M112028 GC06M112089

Summaries
for FYN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for FYN:
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase
that has been implicated in the control of cell growth. The protein associates with the p85 subunit of
phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants
encoding distinct isoforms exist. (provided by RefSeq)

UniProtKB/Swiss-Prot: FYN_HUMAN, P06241
Function: Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels,
with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in
brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and
neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC

"" summary for FYN:
Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that
interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of
the Src kinase family have a very similar domain structure with a high degree of homology in the SH1
(catalytic), linker, SH2 (p-Tyr binding), SH3 (protein-protein interaction) and SH4 (membrane association)
domains. c-Src, Fyn and Yes are ubiquitously expressed, although high levels of c-Src are found in
platelets, neural tissue and osteoclasts. For c-Src, autophosphorylation of Tyr418 and dephosphorylation of
Tyr530 is required to switch the kinase from the inactive closed formation to the active open formation.
c-Src can be inactivated by two kinases, c-Src kinase (CSK) and CSK homologous kinase (CHK), both of which
phosphorylate Tyr530 of c-Src. The activity of the Src kinase family can also be regulated by phosphatases
(e.g. SHP1), binding to adaptor proteins (e.g. Cbp) and proteasomal degradation. Src kinases are key
upstream mediators of both the PI 3-K and MAPK signaling pathways, and have been shown to have important
roles in cell proliferation, migration and survival.

Gene Wiki entry for FYN

Genomic Views
for FYN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the FYN gene upstream (promoter) region "":
AP-1   NF-kappaB1   NF-kappaB   STAT5A   c-Fos   c-Jun   SRF   ATF   AP-2gamma   CUTL1   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for FYN:  ""
MePH28285-1A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

FYN Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M111981:  view genomic region     (about GC identifiers)

Start:
 111,981,535 bp from pter
End:
 112,194,655 bp from pter
Size:
 213,121 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  

Proteins
for FYN gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

  User Feedback		 UniProtKB/Swiss-Prot: FYN_HUMAN, P06241 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Fyn  
Size: 537 amino acids; 60762 Da
Cofactor: Manganese
Subunit: Interacts (via its SH3 domain) with PIK3R1 and PRMT8. Interacts with FYB, PAG1, and SH2D1A. Interacts with
CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity (By similarity). Interacts with TOM1L1
(phosphorylated form) (By similarity). Interacts with SH2D1A and SLAMF1. Interacts (via its SH3 domain) with HEV ORF3
protein. Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity
Subcellular location: Cell membrane. Note=Present and active in lipid rafts. Present in cell body and along the process
of mature and developing oligodendroyctes
PDB structures from "" and Proteopedia "" :
1A0N (3D) ""    1AOT (3D) ""    1AOU (3D) ""    1AVZ (3D) ""    1AZG (3D) ""    1EFN (3D) ""    1FYN (3D) ""    1G83 (3D) ""    
1M27 (3D) ""    1NYF (3D) ""    1NYG (3D) ""    1SHF (3D) ""    1ZBJ (3D) ""    2DQ7 (3D) ""    
Secondary accessions: B5BU57 Q16248 Q5R3A6 Q5R3A7 Q8N5D7
Alternative splicing: 3 isoforms:  P06241-1   P06241-2   P06241-3   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (3 alternative transcripts): 
    NP_002028.1  NP_694592.1  NP_694593.1  


    ENSEMBL proteins: 
    ENSP00000357667 ENSP00000357671 ENSP00000346671 ENSP00000357656 ENSP00000229470 ENSP00000348295 
    ENSP00000229471 


    Human Recombinant Proteins 
    ""Millipore Purified and/or Recombinant FYN Protein
    ""Sigma-Aldrich Proteins and AQUA Peptides for FYN
    "" Browse R&D Systems for human recombinant proteins
    ""Enzo Life Sciences proteins for FYN
    ""HuPro® and/or Recombinant Proteins from Abnova for FYN ""
    "" Origene Purified Recombinant Human Proteins (see all 3): FYN
    ""Novus Biologicals Proteins for FYN  ""
    Novus Biologicals Lysates for FYN
    ""Browse Sino Biological Recombinant Proteins  ""

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005740 mitochondrial envelope IEA--
    GO:0005768 endosome IDA15611048
    GO:0005829 cytosol EXP8493579 9028946 9032261 9295288 10858437 11604131 11943772 12660731 16818765
    GO:0005886 plasma membrane IDA15611048
    About this table

    "" FYN for ontologies           About GeneDecksing



    Antibodies for FYN: 
    ""Millipore Mono- and Polyclonal Antibodies for the study of FYN
    ""Sigma-Aldrich Antibodies for FYN
    ""R&D Systems Antibodies for FYN
    ""Cell Signaling Technology (CST) Antibodies for FYN 
    ""Monoclonal and Polyclonal Antibodies from Abnova (FYN)
    "" Origene Antibodies (see all 2): FYN ""
    ""Novus Biologicals Antibodies for FYN
    ""Epitomics antibodies for FYN

    Assays for FYN: 
    ""Millipore Kits and Assays for the Analysis of FYN
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Enzo Life Sciences assays for FYN

    Protein Domains/
    Families
    for FYN gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

      User Feedback
    "" FYN for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11 ):
     IPR017441 Protein_kinase_ATP_BS
     IPR020745 Tyr_kinase_non-rcpt_Fyn
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P06241

    ProtoNet protein and cluster: P06241

    3 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FYN_HUMAN, P06241
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain

    Gene Function
    for FYN gene

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Millipore RNAi Products for the Analysis of FYN Gene knock-down
    ""Abnova Chimera RNAi Products for Gene knock-down (FYN)
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 3): FYN
    Origene shRNA RFP (see all 3): FYN
    Origene basic RS shRNA (see all 3): FYN

    ""Applied Biosystems Silencer® siRNAs for FYN
    ""Sigma-Aldrich siRNA Panels and siRNA for FYN
    Sigma-Aldrich shRNA Panels and shRNA for FYN
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector (see all 3): FYN
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): FYN
    Origene untagged cDNA clones in CMV expression vector (see all 4): FYN
    ""Browse Sino Biological Human cDNA Clones  ""

    UniProtKB/Swiss-Prot: FYN_HUMAN, P06241
    Function: Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels,
    with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in
    brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and
    neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by
    dephosphorylation of this site
    Enzyme Number (IUBMB): EC 2.7.10.2 

    Genatlas biochemistry entry for FYN:
    SRC/YES-related oncogene homolog,involved in T cell signaling regulation,STAR (signal transduction and activator of
    RNA) family

    5/13 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 13 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0001948 glycoprotein binding IPI16831868
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity ----
    GO:0004713 protein tyrosine kinase activity EXP10858437
    About this table

    "" FYN for ontologies           About GeneDecksing

    Animal Models: 15/16 MGI mutant phenotypes (inferred from 5 alleles"") (MGI details for Fyn) (see all 16 ):

    behavior/neurologicalendocrine/exocrine glandgrowth/sizehearing/vestibular/earhematopoietic system
    homeostasis/metabolismimmune systemlethality-postnatallife span-post-weaning/agingnervous system
    no phenotypic analysisrenal/urinary systemreproductive systemskin/coat/nailstaste/olfaction

    "" FYN for phenotypes           About GeneDecksing

    Pathways & Interactions
    for FYN gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
    About This Section

      User Feedback
    "" FYN for pathways           About GeneDecksing

    5/15 "" Millipore Pathways for FYN (see all 15 )
      ""  G-protein signaling Regulation of CDC42 activity
    Chemotaxis CXCR4 signaling pathway
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Immune response Role of DAP12 receptors in NK cells
    Cytoskeleton remodeling Slit-Robo signaling

    5/22 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  FYN  (Your Favorite Gene powered by Ingenuity) (see all 22 )
      ""  Reelin Signaling in Neurons
    Prolactin Signaling
    Role of NFAT in Regulation of the Immune Response
    Natural Killer Cell Signaling
    Molecular Mechanisms of Cancer

    5/28 "" GeneAssist Pathways for FYN (see all 28 )
      ""  PKC-Theta Pathway
    CD28 Signaling in T-Helper Cell
    Inhibition of Angiogenesis by TSP1
    Prolactin Signaling
    Phospholipase-C Pathway

    4 "" Cell Signaling Technology (CST) Pathways for FYN: 
      ""  Insulin Receptor Signaling
    Translational Control: Regulation of eIF4E and p70 S6 Kinase
    Protein Acetylation
    MAPK/Erk in Growth and Differentiation

    5/9 "" Kegg Pathways  (Kegg details for FYN) (see all 9 ):
      ""  hsa04360 Axon guidance
    hsa04510 Focal adhesion
    hsa04520 Adherens junction
    hsa04650 Natural killer cell mediated cytotoxicity
    hsa04660 T cell receptor signaling pathway

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FYN

    5/339 Interacting proteins for FYN (ENSP000003576563 P062411, 2) via UniProtKB, MINT, and/or STRING (see all 339 ) ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYBO151171, 2STRING: ENSP00000263405 EBI-515315,EBI-1753267 MINT-16564 MINT-16566 MINT-16565 MINT-7247494 EBI-515315,EBI-1753267 MINT-16564 MINT-16566 MINT-16565 MINT-7247494
    ABL1P005191, 2STRING: ENSP00000361423 EBI-515315,EBI-375543 MINT-7246522 EBI-515315,EBI-375543 MINT-7246522
    BCAR1P569451, 2STRING: ENSP00000162330 EBI-515315,EBI-702093 MINT-7247002 EBI-515315,EBI-702093 MINT-7247002
    CD2APQ9Y5K61, 2STRING: ENSP00000352264 EBI-515315,EBI-298152 MINT-7246306 EBI-515315,EBI-298152 MINT-7246306
    HTR6P504061, 2EBI-515315,EBI-1182222 MINT-7214635 MINT-7214669 MINT-7214596 MINT-7214580 MINT-7214683 MINT-7214655 EBI-515315,EBI-1182222 MINT-7214635 MINT-7214669 MINT-7214596 MINT-7214580 MINT-7214683 MINT-7214655
    About this table

    5/17 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 17 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764 neuron migration IEA--
    GO:0006468 protein amino acid phosphorylation NAS7822789
    GO:0006816 calcium ion transport NAS7822789
    GO:0007166 cell surface receptor linked signaling pathway IEA--
    GO:0007243 intracellular protein kinase cascade TAS1361685
    About this table

    "" FYN for ontologies           About GeneDecksing


    Drugs & Compounds
    for FYN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

      User Feedback
    "" FYN for compounds           About GeneDecksing

    "" Enzo Life Sciences drugs & compounds for FYN
    ""Browse Small Molecules at Sigma-Aldrich

    "" Compounds for FYN available from Tocris Bioscience
    CompoundAction CAS number
    1-Naphthyl PP1Src family kinase inhibitor; also inhibits c-Abl[221243-82-9]
    About this table


    10/167 ""Novoseek chemical compound relationships for FYN gene (see all 167 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 100.00 821 9104812 (6), 1465444 (5), 11005864 (5), 9892651 (4) (see all 100)
    phosphatidylinositol 30.86 53 10848967 (6), 9890970 (3), 1652056 (3), 1465444 (3) (see all 39)
    nmda 20.92 69 9892651 (5), 12524444 (5), 7488151 (3), 16407246 (3) (see all 37)
    phosphotyrosine 16.11 19 9890970 (2), 9674711 (1), 8995358 (1), 8985339 (1) (see all 18)
    2-bromopalmitate 5.63 3 10617614 (3)
    sphingosylphosphorylcholine 5.54 5 17950286 (3), 12433841 (2)
    pd166326 4.75 2 19567819 (2)
    myricetin 4.37 4 18632659 (4)
    4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 3.80 2 19046409 (1), 18632659 (1)
    ifenprodil 3.69 4 12399115 (2), 15813945 (1), 14634488 (1)
    About this table


    Transcripts
    for FYN gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Millipore RNAi Products for the Analysis of FYN Gene knock-down
    ""Abnova Chimera RNAi Products for Gene knock-down (FYN)
    ""Applied Biosystems Silencer® siRNAs:  NM_002037  NM_153047  NM_153048  
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 3): FYN
    Origene shRNA RFP (see all 3): FYN
    Origene basic RS shRNA (see all 3): FYN

    ""Sigma-Aldrich siRNA Panels and siRNA for FYN
    Sigma-Aldrich shRNA Panels and shRNA for FYN
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""4 SABiosciences microRNAs that regulate FYN: ""
    hsa-miR-369-3p hsa-miR-27a hsa-miR-27b hsa-miR-96
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_002037  NM_153047  NM_153048  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector (see all 3): FYN
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): FYN
    Origene untagged cDNA clones in CMV expression vector (see all 4): FYN
    Primers:"" Origene genome-wide validated SYBR primer pairs: FYN
    ""SABiosciences RT2 qPCR Primer Assay for FYN: PPH00147A ""

    REFSEQ mRNAs for FYN gene (3 alternative transcripts): 

    NM_002037.3  NM_153047.1  NM_153048.1  

    Additional cDNA sequence: 

    AB451293.1 AB451426.1 AK056699.1 AK090692.1 AK097134.1 AK124011.1 AY429536.1 BC032496.1 
    BX537571.1 M14333.1 M14676.1 S74774.1 

    24/33 DOTS entries (see all 33 ):

    DT.86843886  DT.95289422  DT.92435837  DT.95132434  DT.121320948  DT.75101275  DT.95264558  DT.121321042 
    DT.91802035  DT.424307  DT.121320911  DT.121320995  DT.436784  DT.100880796  DT.121321045  DT.100744689 
    DT.121320926  DT.100687227  DT.100880804  DT.100880805  DT.86800269  DT.92435828  DT.95131340  DT.100707610 

    24/304 AceView cDNA sequences (see all 304 ):

    BM738560 N44762 BF931843 AU141939 AU185836 BI468586 AI498268 BI552534 
    BI763851 H46981 CB162527 BX099778 AK097134 CB156965 AA314371 AI493204 
    BQ638774 NM_002037 F03232 AY429536 AW162423 BE466553 BC032496 AA894844 

    "" highest scoring ESTs for FYN:

    M14333 AA749232 AI239995 AI476651 AI498268 AW028899 AW131781 AW418644 BE041606 BE221421 

    Unigene Cluster for FYN:

    FYN oncogene related to SRC, FGR, YES
    Hs.390567  [show with all ESTs]
    Unigene Representative Sequence: BX537571


    GeneLoc Exon Structure

    18/19 Ensembl transcripts including schematic representations (see all 19 ):
    ENST00000368678  ENST00000368682  ENST00000354650  ENST00000496864  ENST00000467899  ENST00000495927  
    ENST00000495935  ENST00000471959  ENST00000467921  ENST00000462598  ENST00000462856  ENST00000484067  
    ENST00000487824  ENST00000368667  ENST00000491885  ENST00000476769  ENST00000229470  ENST00000356013  

    Expression
    for FYN gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

      User Feedback

    FYN expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for FYN

    1""  / 2""  / 3""

    9 probe-sets matching FYN gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    40480_s_at2, 3 U95-A 1 1.00 1.00 0.99 1.12 M14333 1.00 1.00 1.00 1
    2039_s_at2, 3 U95-A 1 1.00 1.00 0.98 1.23 M14333 1.00 1.00 1.00 1
    40479_at2, 3 U95-A 1 0.50 1.00 0.97 0.66 Z97989 0.20 1.00 0.72 1
    210105_s_at2, 3 U133-A 1 1.00 1.00 -- -- M14333 1.00 1.00 1.00 1
    216033_s_at2, 3 U133-A 1 1.00 1.00 -- -- S74774 0.60 1.00 0.82 1
    212486_s_at2, 3 U133-A 1 0.46 1.00 -- -- N20923 0.20 1.00 0.72 1
    210105_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    216033_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    212486_s_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table

    "" FYN for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTTTAACAAA

    SOURCE GeneReport for Unigene cluster: Hs.390567

    Expression variation in blood from EXPOLDB for FYN

    UniProtKB/Swiss-Prot: FYN_HUMAN, P06241
    Tissue specificity: Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic
    lineages, especially T lymphocytes

    Primers:"" Origene genome-wide validated SYBR primer pairs: FYN ""
    ""SABiosciences RT2 qPCR Primer Assay for FYN: PPH00147A ""

    Orthologs
    for FYN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

      User Feedback
    Orthologs for FYN gene from 5/11 species (see all 11 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 FYN1   -- FYN oncogene related to SRC, FGR, YES 88.89(n)
    93.45(a)    		 475032  XM_863422.1  XP_868515.1 
    chimpanzee
    (Pan troglodytes)    		 FYN1   -- FYN oncogene related to SRC, FGR, YES 99.13(n)
    98.88(a)    		 462944  XM_001158524.1  XP_001158524.1 
    cow
    (Bos taurus)    		 FYN1   -- FYN oncogene related to SRC, FGR, YES 94.54(n)
    99.63(a)    		 527263  XM_001251202.1  XP_001251203.1 
    rat
    (Rattus norvegicus)    		 Fyn1   -- FYN oncogene related to SRC, FGR, YES 92.86(n)
    99.63(a)    		 25150  NM_012755.1  NP_036887.1 
    mouse
    (Mus musculus)    		 Fyn1, 5 10 (25.00 cM)5
    		 Fyn proto-oncogene1, 5 88.83(n)1
    94.19(a)1    		 143601  NM_008054.11  NP_032080.11 
     AI4483205  AK1565845  (see all 27)
    About this table        Species with no ortholog for FYN

    ENSEMBL Gene Tree for FYN

    Paralogs
    for FYN gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      User Feedback
    Paralogs for FYN gene
    TEC2  FRK2  LCK2  BLK2  LYN2  ITK2  FGR2  PTK62  
    YES12  HCK2  TXK2  ABL12  SRC2  BMX2  ABL22  SRMS2  
    BTK2  

    "" FYN for paralogs           About GeneDecksing


    Genomic Variants
    for FYN gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
    About This Section

      User Feedback
    10/1138 NCBI SNPs in FYN are shown (see all 1138 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 447)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    ""
    rs7068951,2
    		C,F,O,A,H109613955(+) CTCACT/CGTTGG 3 -- int1 ng51""22Minor allele frequency- C:0.45MN NA EA NS WA 2008""
    ""
    rs129101,2
    		C,F,A,H112101775(-) GCGGAA/CATTTT 1 -- ut51 ese3""21Minor allele frequency- C:0.29EA NA NS WA 1684""
    ""
    rs19655831,2
    		C,F,A,H109654395(+) GTGGCG/ATGTGT 2 -- int1 ng51""3Minor allele frequency- A:0.32NA EA WA 210""
    ""
    rs14650611,2
    		C,F,A,H109654212(+) CCTAAG/ATGCCT 2 -- int1 ng51""7Minor allele frequency- A:0.32NS EA NA WA 630""
    ""
    rs65687061,2
    		C,F,A,H109654454(+) TCCCCC/TCAAGC 2 -- int1 ng51""4Minor allele frequency- T:0.48NA EA WA 212""
    ""
    rs17403771,2
    		C,F,A,H109615715(+) AATCAC/AATAAG 3 -- int1 ng51""9Minor allele frequency- A:0.45NS EA NA 586""
    ""
    rs69168611,2
    		C,F,A,H109554845(+) TGAAAA/CAATTC 3 -- ng31""15Minor allele frequency- C:0.28EA NA NS WA 1260""
    ""
    rs17261131,2
    		C,F,A,H109615730(+) ACATGC/ACATCA 3 -- int1 ng51""8Minor allele frequency- A:0.45NS EA NA 576""
    ""
    rs69140911,2
    		C,F,A,H109654331(+) AGCTCT/CCCTGG 2 -- int1 ng51""11Minor allele frequency- C:0.49NA NS EA WA 730""
    ""
    rs14098371,2
    		C,F,O109768016(+) CACTTT/CGGCTT 1 -- ng51""16Minor allele frequency- C:0.06NA EA NS WA 1352""
    About this table

    HapMap Linkage Disequilibrium images for FYN (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
    Database of Genomic Variants (DGV): 4 variations for FYN
         1 CNV: 8527
         3 Indels: 81548 93961 93960

    Disorders & Mutations
    for FYN gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      User Feedback
    "" FYN for disorders           About GeneDecksing

    OMIM: 137025

    10/124 ""Novoseek disease relationships for FYN gene (see all 124 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    brain; ischemic 4.57 9 12419528 (4), 12759180 (2), 12932824 (1), 12850569 (1) (see all 5)
    graft-versus-host reaction 4.21 5 7758119 (5)
    neuropathogenesis 3.59 3 9763511 (1), 15615649 (1), 15082191 (1)
    hypomyelination 3.50 3 15528192 (1), 15504915 (1), 11007902 (1)
    dominant-negative mutant 3.31 4 9822663 (1), 16614081 (1), 16337776 (1), 15537652 (1)
    skin carcinogenesis 2.43 3 19934324 (1), 19073879 (1), 18632659 (1)
    cml progression 2.20 1 19131339 (1)
    catalepsies 2.09 4 16407246 (4)
    central nervous system demyelination 1.72 1 17290413 (1)
    syndrome, wiskott-aldrich 1.71 3 8810341 (1), 14707117 (1), 10532312 (1)
    About this table

    1 PharmGKB disease relationship for FYN gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872 12730115
    About this table

    Genetic Association Database: FYN
    Human Genome Epidemiology Navigator: FYN (17 documents)
    Tumor Gene Database: FYN

    Medical News
    for FYN gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      User Feedback

    Publications
    for FYN gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

      User Feedback    		10/870 PubMed articles for FYN gene (see all 870 ):

    Search for FYN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

      User Feedback
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FYN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

      User Feedback
    Entrez Gene: 2534 HGNC: 4037 AceView: FYN Ensembl:ENSG00000010810 euGenes: HUgn2534
    ECgene: FYN Kegg: 2534 H-InvDB: FYN

    Other Databases showing FYN gene

    (According to HUGE)
    About This Section

      User Feedback    		   --

    Specialized Databases showing FYN gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      User Feedback
    NameDescription
    ATLAS Chromosomes in Cancer entry for FYN Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for FYN gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section

      User Feedback    		Patent Information for FYN gene: ""
    Search GeneIP for patents involving FYN

    GeneCards and IP: ""
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


    Services
    for FYN gene

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
    Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section

      User Feedback    		""
    ""
    Products for FYN:
    "" TaqMan ® Gene Expression Assays
    "" TaqMan ® Genotyping Assays
    		 "" Free SNP selection tool

    ""
    "" Millipore Custom Antibody & Bulk Services
    "" Millipore Preclinical / Clinical Development Services
    "" Millipore Immunoassay Services
    "" Millipore Target Screening & Profiling Services

    ""
    "" Predesigned and custom siRNAs for FYN"" Antibodies for FYN
    "" Explore super-pooled esiRNAs"" Proteins for FYN
    "" Lentivirus-delivered shRNAs for FYN"" Browse small molecules at Sigma-Aldrich
    "" "Your Favorite Gene" Pathways"" Browse ELISAs at Sigma-Aldrich
    "" Browse iPSC Reprogramming Factors at Sigma-Aldrichfeedback


     ""  ""
    "" Antibodies  "" Primer Pairs  
    "" Cell Culture Products  "" ELISAs  
    "" Flow Cytometry Kits  "" Protease Activity Assays & Reagents  
    "" Cell Selection/Detection Kits & Reagents  "" ELISA/Assay Development Kits & Reagents  
    "" Multiplex/Array Assay Kits & Reagents  "" ELISpot Kits & Development Modules  
    "" Recombinant & Natural Proteins  

    "" Recombinant Proteins (FYN)
    "" Antibodies (FYN)
    "" Chimera RNAi (FYN)
    "" Custom Service for Mouse Mab
    "" Custom Service for Rabbit Pab from Full-length Protein


    """"""""
    "" Antibodies & Assays for FYN 

    "" Tagged/untagged cDNA clones
    "" Validated SYBR primer pairs
    "" Purified proteins from HEK293T cells
    "" Western blot validated antibodies
    "" shRNA in GFP-retroviral vector
    "" Custom immunoassay development
    "" Tocris compounds for FYN
    "" Regulatory tfbs in FYN upstream (promoter) region
    "" Search Chromatin IP Primers for FYN
    "" DNA Methylation qPCR Primer Assays for FYN
    "" RT2 qPCR Primer Assay for FYN
    "" GNC Network for FYN
    "" microRNAs that regulate FYN
    """"""""
    "" Assays/Drugs/Proteins for FYN
    "" Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
    "" Novus Tissue Slides
    "" Antibodies for FYN
    "" Proteins for FYN
    "" Lysates for FYN
    "" Antibodies for FYN
    "" Browse Sino Biological Proteins and Antibodies
    "" Browse Sino Biological cDNA Clones
    "" Antibodies/Proteins Production Services
    "" Rabbit Monoclonal Antibody Platform
    "" Bulk Purchasing
      User Feedback        

    GeneCards Homepage - Last full update: 21 May 2010 - Incremental updates: 24 May 2010 , 20 Jun 2010

    View Random Gene

    Category
    acyl-CoA synthetase family member 3
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2010 , Weizmann Institute of Science. All Rights Reserved.
    FYN gene at Home site.
    hostname: server4.xennexinc.com db build: 72 index build: 72d solr: 1.4