Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRNP Gene

Aliases for PRNP Gene

  • Prion Protein 2 3
  • PRIP 3 4 6
  • CD230 Antigen 3 4
  • PrP33-35C 3 4
  • PrP27-30 3 4
  • P27-30 2 3
  • AltPrP 3 4
  • KURU 3 6
  • ASCR 3 4
  • PRP 3 4
  • CJD 3 6
  • Gerstmann-Strausler-Scheinker Syndrome 2
  • Creutzfeldt-Jakob Disease 2
  • Fatal Familial Insomnia 2
  • Prion Protein (P27-30) 2
  • Prion-Related Protein 3
  • Major Prion Protein 3
  • CD230 3
  • PrPc 3
  • GSS 3

External Ids for PRNP Gene

Previous HGNC Symbols for PRNP Gene

  • PRIP
  • GSS
  • CJD

Previous GeneCards Identifiers for PRNP Gene

  • GC20P004655
  • GC20P004662

Summaries for PRNP Gene

Entrez Gene Summary for PRNP Gene

  • The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for PRNP Gene

PRNP (Prion Protein) is a Protein Coding gene. Diseases associated with PRNP include creutzfeldt-jakob disease and prion disease. Among its related pathways are L1CAM interactions and Glypican 1 network. GO annotations related to this gene include identical protein binding and copper ion binding.

UniProtKB/Swiss-Prot for PRNP Gene

  • May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

Tocris Summary for PRNP Gene

Gene Wiki entry for PRNP Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRNP Gene

Genomics for PRNP Gene

Regulatory Elements for PRNP Gene

Genomic Location for PRNP Gene

Start:
4,686,151 bp from pter
End:
4,701,590 bp from pter
Size:
15,440 bases
Orientation:
Plus strand

Genomic View for PRNP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRNP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRNP Gene

Proteins for PRNP Gene

  • Protein details for PRNP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    F7VJQ1-APRIO_HUMAN
    Recommended name:
    Alternative prion protein
    Protein Accession:
    F7VJQ1
    Secondary Accessions:

    Protein attributes for PRNP Gene

    Size:
    73 amino acids
    Molecular mass:
    8691 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The alternative prion protein/AltPrP and PRNP (AC P04156) have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP. In mouse and hamster, the alternative initiation AUG codon is absent and is replaced by a GUG codon (PubMed:21478263).
    • This protein is produced by a bicistronic gene which also produces the major prion protein/PRNP from an overlapping reading frame.

    Alternative splice isoforms for PRNP Gene

    UniProtKB/Swiss-Prot:
  • Protein details for PRNP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04156-PRIO_HUMAN
    Recommended name:
    Major prion protein
    Protein Accession:
    P04156
    Secondary Accessions:
    • O60489
    • P78446
    • Q15216
    • Q15221
    • Q27H91
    • Q5QPB4
    • Q8TBG0
    • Q96E70
    • Q9UP19

    Protein attributes for PRNP Gene

    Size:
    253 amino acids
    Molecular mass:
    27661 Da
    Quaternary structure:
    • Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with GRB2, APP, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement (By similarity). Interacts with KIAA1191.
    Miscellaneous:
    • The alternative prion protein/AltPrP (AC F7VJQ1) and PRNP have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP. In mouse and hamster, the alternative initiation AUG codon is absent and is replaced by a GUG codon
    • This protein is produced by a bicistronic gene which also produces the The alternative prion protein/AltPrP from an overlapping reading frame

    Three dimensional structures from OCA and Proteopedia for PRNP Gene

    Alternative splice isoforms for PRNP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRNP Gene

Proteomics data for PRNP Gene at MOPED

Post-translational modifications for PRNP Gene

  • Isoform 2 is sumoylated with SUMO1.
  • The glycosylation pattern (the amount of mono-, di- and non-glycosylated forms or glycoforms) seems to differ in normal and CJD prion.
  • Glycosylation at Thr95, Asn181, Thr193, and Asn197
  • Modification sites at PhosphoSitePlus

Other Protein References for PRNP Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRNP (PRNP)

No data available for DME Specific Peptides for PRNP Gene

Domains for PRNP Gene

Gene Families for PRNP Gene

HGNC:
  • CD :CD molecules

Protein Domains for PRNP Gene

Graphical View of Domain Structure for InterPro Entry

P04156

UniProtKB/Swiss-Prot:

PRIO_HUMAN :
  • P04156
Domain:
  • The normal, monomeric form, PRPN(C), has a mainly alpha-helical structure. Misfolding of this form produces a disease-associated, protease-resistant form, PRPN (Sc), accompanied by a large increase of the beta-sheet content and formation of amyloid fibrils. These fibrils consist of a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization. In addition, the heparan-sulfate proteoglycan, GPC1, promotes the association of PRPN (C) to lipid rafts and appears to facilitate the conversion to PRPN (Sc)
  • Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization
Family:
  • Belongs to the prion family.
genes like me logo Genes that share domains with PRNP: view

Function for PRNP Gene

Molecular function for PRNP Gene

GENATLAS Biochemistry: prion protein (p27-30)
UniProtKB/Swiss-Prot Induction: Up-regulated by endoplasmic reticulum stress and proteasomal inhibition.
UniProtKB/Swiss-Prot Function: May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

Gene Ontology (GO) - Molecular Function for PRNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding TAS 16294306
GO:0005515 protein binding IPI 16286452
GO:0008017 microtubule binding IDA 16004966
GO:0015631 tubulin binding IDA 16004966
GO:0042802 identical protein binding IPI 16286452
genes like me logo Genes that share ontologies with PRNP: view
genes like me logo Genes that share phenotypes with PRNP: view

Animal Models for PRNP Gene

MGI Knock Outs for PRNP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRNP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PRNP Gene

Localization for PRNP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRNP Gene

Mitochondrion outer membrane; Single-pass membrane protein.
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of CU(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Isoform 2: Cytoplasm. Nucleus. Note=Accumulates outside the secretory route in the cytoplasm, from where it relocates to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRNP Gene COMPARTMENTS Subcellular localization image for PRNP gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
endoplasmic reticulum 4
cytoskeleton 2
cytosol 2
endosome 2
extracellular 2
lysosome 2
mitochondrion 2
vacuole 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 16004966
GO:0005741 mitochondrial outer membrane IDA 21478263
GO:0005783 endoplasmic reticulum ISS --
GO:0005794 Golgi apparatus ISS --
genes like me logo Genes that share ontologies with PRNP: view

Pathways for PRNP Gene

genes like me logo Genes that share pathways with PRNP: view

Pathways by source for PRNP Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PRNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation ISS --
GO:0006878 cellular copper ion homeostasis NAS 16004966
GO:0006979 response to oxidative stress ISS --
GO:0007050 cell cycle arrest IEA --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with PRNP: view

Compounds for PRNP Gene

(5) Tocris Compounds for PRNP Gene

Compound Action Cas Number
MOG (35-55) Encephalitogenic myelin oligodendrocyte glycoprotein fragment [149635-73-4]
Myelin Basic Protein (87-99) Major antigenic component implicated in the pathophysiology of multiple sclerosis [118506-26-6]
Nogo-66 (1-40) Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration [475221-20-6]
ONO 2506 Inhibits S100B synthesis; neuroprotective [185517-21-9]
PLP (139-151) Encephalitogenic myelin proteolipid fragment [122018-58-0]

(1) Drugbank Compounds for PRNP Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Tetracycline
60-54-8 target inhibitor

(58) Novoseek inferred chemical compound relationships for PRNP Gene

Compound -log(P) Hits PubMed IDs
methionine 75.9 99
valine 74.9 62
copper 48.2 64
clds 45.8 4
guanidine thiocyanate 44.4 1
genes like me logo Genes that share compounds with PRNP: view

Transcripts for PRNP Gene

Unigene Clusters for PRNP Gene

Prion protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRNP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRNP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4
SP1: - - - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7:

Relevant External Links for PRNP Gene

GeneLoc Exon Structure for
PRNP
ECgene alternative splicing isoforms for
PRNP

Expression for PRNP Gene

mRNA expression in normal human tissues for PRNP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRNP Gene

SOURCE GeneReport for Unigene cluster for PRNP Gene Hs.472010

mRNA Expression by UniProt/SwissProt for PRNP Gene

F7VJQ1-APRIO_HUMAN
Tissue specificity: Detected in brain homogenate, primary neurons, and peripheral blood mononuclear cells (at protein level).
genes like me logo Genes that share expressions with PRNP: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PRNP Gene

Orthologs for PRNP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRNP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRNP 35
  • 99.21 (n)
  • 99.21 (a)
PRNP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRNP 35
  • 86.9 (n)
  • 90.87 (a)
PRP 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRNP 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prnp 35
  • 84.13 (n)
  • 87.7 (a)
Prnp 16
Prnp 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRNP 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRNP 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prnp 35
  • 86.82 (n)
  • 89.72 (a)
chicken
(Gallus gallus)
Aves PRNP 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
Species with no ortholog for PRNP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRNP Gene

ENSEMBL:
Gene Tree for PRNP (if available)
TreeFam:
Gene Tree for PRNP (if available)

Paralogs for PRNP Gene

No data available for Paralogs for PRNP Gene

Variants for PRNP Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PRNP Gene

P04156-PRIO_HUMAN
The five tandem octapeptide repeats region is highly unstable. Insertions or deletions of octapeptide repeat units are associated to prion disease

Sequence variations from dbSNP and Humsavar for PRNP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs14521 -- 4,701,472(+) TGAAA(A/T)ATGCA utr-variant-3-prime
rs1799990 Pathogenic, - 4,699,605(+) GCTAC(A/G)TGCTG reference, missense, utr-variant-3-prime
rs1800014 Uncertain significance, - 4,699,875(+) AGTAC(A/G)AGAGG missense, reference, utr-variant-3-prime
rs1894281 -- 4,686,791(+) GAGCC(A/C)CGTTA intron-variant
rs1894282 -- 4,687,017(+) GGCAA(A/G)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRNP Gene

Variant ID Type Subtype PubMed ID
nsv912627 CNV Gain 21882294

Relevant External Links for PRNP Gene

HapMap Linkage Disequilibrium report
PRNP
Human Gene Mutation Database (HGMD)
PRNP
Locus Specific Mutation Databases (LSDB)
PRNP

Disorders for PRNP Gene

(6) OMIM Diseases for PRNP Gene (176640)

UniProtKB/Swiss-Prot

PRIO_HUMAN
  • Note=PrP is found in high quantity in the brain of humans and animals infected with neurodegenerative diseases known as transmissible spongiform encephalopathies or prion diseases, like: Creutzfeldt-Jakob disease (CJD), fatal familial insomnia (FFI), Gerstmann-Straussler disease (GSD), Huntington disease-like type 1 (HDL1) and kuru in humans; scrapie in sheep and goat; bovine spongiform encephalopathy (BSE) in cattle; transmissible mink encephalopathy (TME); chronic wasting disease (CWD) of mule deer and elk; feline spongiform encephalopathy (FSE) in cats and exotic ungulate encephalopathy (EUE) in nyala and greater kudu. The prion diseases illustrate three manifestations of CNS degeneration: (1) infectious (2) sporadic and (3) dominantly inherited forms. TME, CWD, BSE, FSE, EUE are all thought to occur after consumption of prion-infected foodstuffs.
  • Creutzfeldt-Jakob disease (CJD) [MIM:123400]: Occurs primarily as a sporadic disorder (1 per million), while 10-15% are familial. Accidental transmission of CJD to humans appears to be iatrogenic (contaminated human growth hormone (HGH), corneal transplantation, electroencephalographic electrode implantation, etc.). Epidemiologic studies have failed to implicate the ingestion of infected animal meat in the pathogenesis of CJD in human. The triad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration of neurons, (2) severe astrocytic gliosis that often appears to be out of proportion to the degree of nerve cell loss, and (3) amyloid plaque formation. CJD is characterized by progressive dementia and myoclonic seizures, affecting adults in mid-life. Some patients present sleep disorders, abnormalities of high cortical function, cerebellar and corticospinal disturbances. The disease ends in death after a 3-12 months illness. {ECO:0000269 PubMed:10790216, ECO:0000269 PubMed:1671440, ECO:0000269 PubMed:1975028, ECO:0000269 PubMed:7902693, ECO:0000269 PubMed:7906019, ECO:0000269 PubMed:7913755, ECO:0000269 PubMed:8461023, ECO:0000269 PubMed:8909447, ECO:0000269 PubMed:9266722}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Fatal familial insomnia (FFI) [MIM:600072]: Autosomal dominant disorder and is characterized by neuronal degeneration limited to selected thalamic nuclei and progressive insomnia. {ECO:0000269 PubMed:1347910}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Gerstmann-Straussler disease (GSD) [MIM:137440]: A rare inherited prion disease characterized by adult onset of memory loss, dementia, ataxia, and pathologic deposition of amyloid-like plaques in the brain. GSD presents with progressive limb and truncal ataxia, dysarthria, and cognitive decline in the thirties and forties, and the average disease duration is 7 years. {ECO:0000269 PubMed:10581485, ECO:0000269 PubMed:11709001, ECO:0000269 PubMed:1363810, ECO:0000269 PubMed:2564168, ECO:0000269 PubMed:7699395, ECO:0000269 PubMed:7783876, ECO:0000269 PubMed:7902972, ECO:0000269 PubMed:8797472, ECO:0000269 PubMed:9786248}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Huntington disease-like 1 (HDL1) [MIM:603218]: Autosomal dominant, early-onset neurodegenerative disorder with prominent psychiatric features. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Kuru (KURU) [MIM:245300]: Kuru is transmitted during ritualistic cannibalism, among natives of the New Guinea highlands. Patients exhibit various movement disorders like cerebellar abnormalities, rigidity of the limbs, and clonus. Emotional lability is present, and dementia is conspicuously absent. Death usually occurs from 3 to 12 month after onset. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Spongiform encephalopathy with neuropsychiatric features (SENF) [MIM:606688]: Autosomal dominant presenile dementia with a rapidly progressive and protracted clinical course. The dementia was characterized clinically by frontotemporal features, including early personality changes. Some patients had memory loss, several showed aggressiveness, hyperorality and verbal stereotypy, others had parkinsonian symptoms. Note=The disease is caused by mutations affecting the gene represented in this entry.

(84) Novoseek inferred disease relationships for PRNP Gene

Disease -log(P) Hits PubMed IDs
prion diseases 98 195
creutzfeldt-jakob disease 97.6 122
gerstmann-straussler-scheinker disease 95.5 43
insomnia fatal familial 94.6 34
scrapie 94.4 135

Relevant External Links for PRNP

GeneTests
PRNP
GeneReviews
PRNP
Genetic Association Database (GAD)
PRNP
Human Genome Epidemiology (HuGE) Navigator
PRNP
genes like me logo Genes that share disorders with PRNP: view

Publications for PRNP Gene

  1. Mutant prion proteins in Gerstmann-Straussler-Scheinker disease with neurofibrillary tangles. (PMID: 1363810) Hsiao K. … Prusiner S.B. (Nat. Genet. 1992) 3 4 23
  2. Genomic structure of the human prion protein gene. (PMID: 1678248) Puckett C. … Hood L.E. (Am. J. Hum. Genet. 1991) 3 4 23
  3. Transmissible familial Creutzfeldt-Jakob disease associated with five, seven, and eight extra octapeptide coding repeats in the PRNP gene. (PMID: 1683708) Goldfarb L.G. … Gajdusek D.C. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 23
  4. A variant of Gerstmann-Straussler-Scheinker disease carrying codon 105 mutation with codon 129 polymorphism of the prion protein gene: a clinicopathological study. (PMID: 7699395) Itoh Y. … Otomo E. (J. Neurol. Sci. 1994) 3 4 23
  5. Mutation in codon 200 and polymorphism in codon 129 of the prion protein gene in Libyan Jews with Creutzfeldt-Jakob disease. (PMID: 7913755) Gabizon R. … Prusiner S.B. (Philos. Trans. R. Soc. Lond., B, Biol. Sci. 1994) 3 4 23

Products for PRNP Gene

  • Addgene plasmids for PRNP

Sources for PRNP Gene

Back to Top

Content