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Aliases for CYP3A43 Gene

Aliases for CYP3A43 Gene

  • Cytochrome P450 Family 3 Subfamily A Member 43 2 3 5
  • EC 1.14.14.1 4 58
  • Cytochrome P450, Family 3, Subfamily A, Polypeptide 43 2
  • Cytochrome P450, Subfamily IIIA, Polypeptide 43 2

External Ids for CYP3A43 Gene

Previous GeneCards Identifiers for CYP3A43 Gene

  • GC07P097960
  • GC07P099023
  • GC07P099037
  • GC07P099070
  • GC07P099263
  • GC07P099426
  • GC07P094062

Summaries for CYP3A43 Gene

Entrez Gene Summary for CYP3A43 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for CYP3A43 Gene

CYP3A43 (Cytochrome P450 Family 3 Subfamily A Member 43) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP3A5.

UniProtKB/Swiss-Prot for CYP3A43 Gene

  • Exhibits low testosterone 6-beta-hydroxylase activity.

Gene Wiki entry for CYP3A43 Gene

Additional gene information for CYP3A43 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A43 Gene

Genomics for CYP3A43 Gene

Regulatory Elements for CYP3A43 Gene

Enhancers for CYP3A43 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H099794 1.2 ENCODE dbSUPER 6.1 -32.8 -32802 1 ELF3 FOXA2 ARID4B DMAP1 ZSCAN9 RAD21 RARA YY1 ATF7 CREM LOC101927550 GIGYF1 CYP3A43 CYP3A4 CYP3A137P
GH07H099692 1.9 FANTOM5 Ensembl ENCODE dbSUPER 3.3 -133.8 -133765 2 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF766 CBX5 PDAP1 PTCD1 C7orf43 CYP3A5 SAP25 ZSCAN25 TMEM225B CYP3A43 CYP3A4 AZGP1
GH07H099791 1.3 FANTOM5 ENCODE dbSUPER 2.5 -35.5 -35497 2 FOXA2 MAX CEBPG RAD21 RARA ZNF7 YY1 IRF9 HNF4G ATF7 SAP25 CYP3A43 CYP3A5 CYP3A4 CYP3A137P
GH07H099826 1 ENCODE 0.7 +0.7 727 5 PKNOX1 FOXA2 MLX ARID4B YY1 REST PPARG NFIL3 ZNF184 RCOR2 OR2AE1 PILRB ATP5J2 CNPY4 GATS TRIM4 CYP3A43 ENSG00000260445
GH07H099834 0.9 ENCODE 0.7 +3.8 3800 0 HDAC1 PKNOX1 ATF1 TCF12 GATA2 ATF7 CEBPB NCOA1 ZNF592 SMARCA4 CYP3A43 ENSG00000260445
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYP3A43 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP3A43 Gene

Chromosome:
7
Start:
99,828,013 bp from pter
End:
99,867,092 bp from pter
Size:
39,080 bases
Orientation:
Plus strand

Genomic View for CYP3A43 Gene

Genes around CYP3A43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP3A43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP3A43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP3A43 Gene

Proteins for CYP3A43 Gene

  • Protein details for CYP3A43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB55-CP343_HUMAN
    Recommended name:
    Cytochrome P450 3A43
    Protein Accession:
    Q9HB55
    Secondary Accessions:
    • Q495Y1
    • Q75MK2
    • Q75MK3
    • Q9HB52
    • Q9HB53
    • Q9HB54
    • Q9HB57

    Protein attributes for CYP3A43 Gene

    Size:
    503 amino acids
    Molecular mass:
    57670 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 or CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. CYP3A43-CYP3A4 chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. CYP3A43-CYP3A5 chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).

    Alternative splice isoforms for CYP3A43 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP3A43 Gene

Selected DME Specific Peptides for CYP3A43 Gene

Q9HB55:
  • LFPFLTP
  • VLVKECYSVFTN
  • PGPTPLP
  • PCKETQIPLK
  • EEWKRIR
  • KESRLKD
  • SHKALSD
  • PERFSKKN

Post-translational modifications for CYP3A43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for CYP3A43

Domains & Families for CYP3A43 Gene

Gene Families for CYP3A43 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

Q9HB55

UniProtKB/Swiss-Prot:

CP343_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP3A43: view

Function for CYP3A43 Gene

Molecular function for CYP3A43 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Exhibits low testosterone 6-beta-hydroxylase activity.
UniProtKB/Swiss-Prot Induction:
By rifampicin.

Enzyme Numbers (IUBMB) for CYP3A43 Gene

Phenotypes From GWAS Catalog for CYP3A43 Gene

Gene Ontology (GO) - Molecular Function for CYP3A43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS --
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA --
genes like me logo Genes that share ontologies with CYP3A43: view
genes like me logo Genes that share phenotypes with CYP3A43: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CYP3A43
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP3A43 Gene

Localization for CYP3A43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A43 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP3A43 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 1
extracellular 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CYP3A43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP3A43: view

Pathways & Interactions for CYP3A43 Gene

genes like me logo Genes that share pathways with CYP3A43: view

Pathways by source for CYP3A43 Gene

Gene Ontology (GO) - Biological Process for CYP3A43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP3A43: view

No data available for SIGNOR curated interactions for CYP3A43 Gene

Drugs & Compounds for CYP3A43 Gene

(50) Drugs for CYP3A43 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist, Enzyme, inducer 2239
Ethosuximide Approved Pharma Enzyme, substrate 9
Oxazepam Approved Pharma Enzyme, substrate 9
Phenelzine Approved Pharma Enzyme, inhibitor 7
Praziquantel Approved, Vet_approved Pharma Enzyme, substrate 39

(23) Additional Compounds for CYP3A43 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
219535-29-2
12,13-EpOME
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate
genes like me logo Genes that share compounds with CYP3A43: view

Transcripts for CYP3A43 Gene

Unigene Clusters for CYP3A43 Gene

Cytochrome P450, family 3, subfamily A, polypeptide 43:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CYP3A43
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A43 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - - - -

Relevant External Links for CYP3A43 Gene

GeneLoc Exon Structure for
CYP3A43
ECgene alternative splicing isoforms for
CYP3A43

Expression for CYP3A43 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP3A43 Gene

mRNA differential expression in normal tissues according to GTEx for CYP3A43 Gene

This gene is overexpressed in Liver (x23.8) and Pancreas (x16.5).

Protein differential expression in normal tissues from HIPED for CYP3A43 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP3A43 Gene



Protein tissue co-expression partners for CYP3A43 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP3A43 Gene:

CYP3A43

SOURCE GeneReport for Unigene cluster for CYP3A43 Gene:

Hs.306220

mRNA Expression by UniProt/SwissProt for CYP3A43 Gene:

Q9HB55-CP343_HUMAN
Tissue specificity: Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.

Evidence on tissue expression from TISSUES for CYP3A43 Gene

  • Liver(4.6)
genes like me logo Genes that share expression patterns with CYP3A43: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP3A43 Gene

Orthologs for CYP3A43 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CYP3A43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP3A43 33 34
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia CYP3A12 34
  • 74 (a)
ManyToMany
-- 34
  • 71 (a)
ManyToMany
CYP3A26 34
  • 71 (a)
ManyToMany
-- 34
  • 70 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 69 (a)
ManyToMany
CYP3A5 34 34
  • 67 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp3a13 34
  • 67 (a)
ManyToMany
Cyp3a25 34
  • 66 (a)
ManyToMany
Cyp3a57 34
  • 66 (a)
ManyToMany
Cyp3a11 34
  • 64 (a)
ManyToMany
Cyp3a59 34
  • 64 (a)
ManyToMany
Cyp3a16 34
  • 63 (a)
ManyToMany
Cyp3a41a 34
  • 63 (a)
ManyToMany
Cyp3a41b 34
  • 63 (a)
ManyToMany
Cyp3a44 34
  • 63 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
ManyToMany
-- 34
  • 59 (a)
ManyToMany
-- 34
  • 59 (a)
ManyToMany
-- 34
  • 52 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
ManyToMany
-- 34
  • 52 (a)
ManyToMany
-- 34
  • 50 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CYP3A37 34
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii cyp3a65 34
  • 51 (a)
ManyToMany
cyp3c1l2 34
  • 45 (a)
ManyToMany
cyp3c4 34
  • 44 (a)
ManyToMany
si:dkey-21n8.3 34
  • 44 (a)
ManyToMany
cyp3c1 34
  • 43 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp6g1 35
  • 33 (a)
Cyp9f2 35
  • 33 (a)
Cyp6a17 35
  • 32 (a)
Cyp6a23 35
  • 32 (a)
Cyp6a14 35
  • 31 (a)
Cyp6a20 35
  • 31 (a)
Cyp6a9 35
  • 31 (a)
Cyp6a13 35
  • 30 (a)
Cyp6a18 35
  • 30 (a)
Cyp6a19 35
  • 30 (a)
Cyp6a22 35
  • 30 (a)
Cyp6d4 35
  • 30 (a)
Cyp6v1 35
  • 30 (a)
Cyp6a2 35
  • 29 (a)
Cyp9b2 35
  • 29 (a)
Cyp9c1 35
  • 29 (a)
Cyp9h1 35
  • 29 (a)
Cyp28d2 35
  • 28 (a)
Cyp6a21 35
  • 28 (a)
Cyp6d5 35
  • 28 (a)
Cyp6g2 35
  • 28 (a)
Cyp6w1 35
  • 28 (a)
Cyp9b1 35
  • 28 (a)
Cyp313a2 35
  • 27 (a)
Cyp6a8 35
  • 27 (a)
Cyp6t3 35
  • 27 (a)
Cyp28d1 35
  • 26 (a)
Cyp309a2 35
  • 26 (a)
Cyp6d2 35
  • 26 (a)
Cyp6u1 35
  • 26 (a)
Cyp28a5 35
  • 25 (a)
Cyp6t1 35
  • 25 (a)
Cyp28c1 35
  • 24 (a)
Cyp309a1 35
  • 24 (a)
worm
(Caenorhabditis elegans)
Secernentea C36A4.2 35
  • 30 (a)
F14F7.2 35
  • 30 (a)
T10B9.1 35
  • 30 (a)
T10B9.7 35
  • 30 (a)
C36A4.1 35
  • 29 (a)
F14F7.3 35
  • 29 (a)
T10B9.2 35
  • 29 (a)
C36A4.6 35
  • 28 (a)
F42A6.4 35
  • 28 (a)
T10B9.3 35
  • 28 (a)
T10B9.5 35
  • 28 (a)
T10B9.8 35
  • 28 (a)
ZK1320.4 35
  • 26 (a)
K06G5.2 35
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG5 36
Species where no ortholog for CYP3A43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYP3A43 Gene

ENSEMBL:
Gene Tree for CYP3A43 (if available)
TreeFam:
Gene Tree for CYP3A43 (if available)

Paralogs for CYP3A43 Gene

Variants for CYP3A43 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP3A43 Gene

CP343_HUMAN-Q9HB55
At protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is that of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional.

Sequence variations from dbSNP and Humsavar for CYP3A43 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000030886 -- 99,831,932(+) CTGTA(A/G)TTTAT intron-variant
rs1000040878 -- 99,830,441(+) TGAAC(C/T)CTGGA intron-variant
rs1000066249 -- 99,861,007(+) TAGCT(-/G)GGATT intron-variant
rs1000182365 -- 99,843,222(+) CACTC(C/G/T)CCTTC intron-variant
rs1000296903 -- 99,856,722(+) ACTTC(C/T)GAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP3A43 Gene

Variant ID Type Subtype PubMed ID
dgv11526n54 CNV loss 21841781
dgv11527n54 CNV loss 21841781
esv2670223 CNV deletion 23128226
esv29538 CNV loss 19812545
esv3542152 CNV deletion 23714750
esv3614284 CNV loss 21293372
esv3614285 CNV loss 21293372

Variation tolerance for CYP3A43 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.37; 90.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP3A43 Gene

Human Gene Mutation Database (HGMD)
CYP3A43
The Human Cytochrome P450 Allele Nomenclature Database
CYP3A43
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP3A43

Disorders for CYP3A43 Gene

Relevant External Links for CYP3A43

Genetic Association Database (GAD)
CYP3A43
Human Genome Epidemiology (HuGE) Navigator
CYP3A43
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP3A43

No disorders were found for CYP3A43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP3A43 Gene

Publications for CYP3A43 Gene

  1. First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant. (PMID: 14695544) Cauffiez C … Broly F (Human mutation 2004) 3 4 22 45 60
  2. Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. (PMID: 11266076) Gellner K … Wojnowski L (Pharmacogenetics 2001) 2 3 4 22 60
  3. cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. (PMID: 11160876) Domanski TL … Zaphiropoulos PG (Molecular pharmacology 2001) 2 3 4 22 60
  4. Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A43*1B allele in europeoid residents of West Siberia. (PMID: 16848237) Shchepotina EG … Lyakhovich VV (Bulletin of experimental biology and medicine 2005) 3 22 45 60
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 45 60

Products for CYP3A43 Gene

Sources for CYP3A43 Gene

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