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Aliases for CYP2A13 Gene

Aliases for CYP2A13 Gene

  • Cytochrome P450 Family 2 Subfamily A Member 13 2 3 5
  • Cytochrome P450, Subfamily IIA (Phenobarbital-Inducible), Polypeptide 13 2 3
  • Cytochrome P450, Family 2, Subfamily A, Polypeptide 13 2 3
  • EC 4 61
  • CYPIIA13 3 4
  • Cytochrome P450 2A13 3
  • CYP2A 3
  • CPAD 3

External Ids for CYP2A13 Gene

Previous GeneCards Identifiers for CYP2A13 Gene

  • GC19P042233
  • GC19P041986
  • GC19P046108
  • GC19P046126
  • GC19P046130
  • GC19P046286
  • GC19P041594
  • GC19P038026

Summaries for CYP2A13 Gene

Entrez Gene Summary for CYP2A13 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2A13 Gene

CYP2A13 (Cytochrome P450 Family 2 Subfamily A Member 13) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2A6.

UniProtKB/Swiss-Prot for CYP2A13 Gene

  • Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.

Gene Wiki entry for CYP2A13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2A13 Gene

Genomics for CYP2A13 Gene

Regulatory Elements for CYP2A13 Gene

Enhancers for CYP2A13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F041126 1.1 Ensembl ENCODE 5.7 +39.2 39151 2.0 SIN3A THRB RAD21 ZNF121 GLIS2 ZNF138 EGR2 ZNF263 ZNF362 ZNF654 CYP2F1 CYP2A13 CYP2T3P
GH19F041288 1 FANTOM5 ENCODE 6.1 +200.8 200841 0.9 CTCF ZFP64 RAD21 ZFHX2 ZNF143 PRDM10 ZBTB20 EGR2 ZNF654 YY2 CYP2A13 HNRNPUL1 B9D2 RN7SL34P LOC105372401
GH19F041120 0.8 Ensembl ENCODE 4.5 +32.8 32792 1.9 ZNF121 KLF1 ZNF316 NR2F1 EMSY CYP2F1 RNU6-195P PCAT19 CYP2A13 ZNF574 CYP2T3P
GH19F040747 1.6 FANTOM5 ENCODE 2 -335.7 -335690 9.8 MLX CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SNRPA FBL ENSG00000269843 COQ8B ITPKC CCDC97 SERTAD3 ENSG00000269069 CYP2G2P ENSG00000271299
GH19F041095 0.5 Ensembl 5.9 +7.5 7517 0.6 L3MBTL2 E2F6 MGA CYP2F1 CYP2A13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYP2A13 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP2A13 Gene

41,088,451 bp from pter
41,096,195 bp from pter
7,745 bases
Plus strand

Genomic View for CYP2A13 Gene

Genes around CYP2A13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2A13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2A13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2A13 Gene

Proteins for CYP2A13 Gene

  • Protein details for CYP2A13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome P450 2A13
    Protein Accession:
    Secondary Accessions:
    • Q53YR8
    • Q6R569
    • Q6R570
    • Q9H2X2

    Protein attributes for CYP2A13 Gene

    494 amino acids
    Molecular mass:
    56688 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2A13 Gene

neXtProt entry for CYP2A13 Gene

Selected DME Specific Peptides for CYP2A13 Gene


Post-translational modifications for CYP2A13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2A13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CYP2A13 Gene

Gene Families for CYP2A13 Gene

Suggested Antigen Peptide Sequences for CYP2A13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome P450 family.
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2A13: view

Function for CYP2A13 Gene

Molecular function for CYP2A13 Gene

GENATLAS Biochemistry:
cytochrome P450,subfamily IIA (phenobarbital-inducible),polypeptide 13
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=10.7 uM for phenacetin {ECO:0000269 PubMed:18779312};
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.

Enzyme Numbers (IUBMB) for CYP2A13 Gene

Gene Ontology (GO) - Molecular Function for CYP2A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0008389 coumarin 7-hydroxylase activity TAS --
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0008395 steroid hydroxylase activity IBA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with CYP2A13: view
genes like me logo Genes that share phenotypes with CYP2A13: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP2A13 Gene

Localization for CYP2A13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2A13 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP2A13 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CYP2A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with CYP2A13: view

Pathways & Interactions for CYP2A13 Gene

genes like me logo Genes that share pathways with CYP2A13: view

Gene Ontology (GO) - Biological Process for CYP2A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0009804 coumarin metabolic process TAS --
GO:0019373 epoxygenase P450 pathway IBA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP2A13: view

No data available for SIGNOR curated interactions for CYP2A13 Gene

Drugs & Compounds for CYP2A13 Gene

(24) Drugs for CYP2A13 Gene - From: DrugBank, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotine Approved Pharma Antagonist, Enzyme, substrate 1050
Methoxsalen Approved Pharma Enzyme, inhibitor 36
Testosterone Approved, Investigational Pharma Enzyme, substrate Endogenous androgen receptor agonist 546
UVADEX Approved February 1999 Pharma 0
Citalopram Approved Pharma 503

(26) Additional Compounds for CYP2A13 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate
genes like me logo Genes that share compounds with CYP2A13: view

Transcripts for CYP2A13 Gene

mRNA/cDNA for CYP2A13 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP2A13 Gene

Cytochrome P450, family 2, subfamily A, polypeptide 13:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2A13 Gene

No ASD Table

Relevant External Links for CYP2A13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYP2A13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYP2A13 Gene

mRNA differential expression in normal tissues according to GTEx for CYP2A13 Gene

This gene is overexpressed in Liver (x19.9), Cervix - Ectocervix (x5.5), Testis (x5.3), Minor Salivary Gland (x5.3), and Vagina (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of CYP2A13 Gene:


SOURCE GeneReport for Unigene cluster for CYP2A13 Gene:


mRNA Expression by UniProt/SwissProt for CYP2A13 Gene:

Tissue specificity: Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle.
genes like me logo Genes that share expression patterns with CYP2A13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CYP2A13 Gene

Orthologs for CYP2A13 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2A13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 35
  • 92 (a)
(Canis familiaris)
Mammalia CYP2A13 35 35
  • 88 (a)
(Mus musculus)
Mammalia Cyp2a4 35
  • 87 (a)
Cyp2a5 34 35
  • 85.49 (n)
Cyp2a12 35
  • 74 (a)
Cyp2a22 35
  • 73 (a)
(Pan troglodytes)
Mammalia -- 35
  • 87 (a)
(Rattus norvegicus)
Mammalia Cyp2a3 34
  • 85.63 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 60 (a)
-- 35
  • 60 (a)
-- 35
  • 60 (a)
-- 35
  • 55 (a)
-- 35
  • 54 (a)
-- 35
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC548374 34
  • 58.87 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.43 34
(Danio rerio)
Actinopterygii zgc55856 34
fruit fly
(Drosophila melanogaster)
Insecta Cyp303a1 36
  • 28 (a)
Cyp304a1 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea cyp-36A1 34
  • 43.1 (n)
C50H11.15 36
  • 34 (a)
K09A11.3 36
  • 34 (a)
C34B7.3 36
  • 33 (a)
C49C8.4 36
  • 32 (a)
F41B5.3 36
  • 32 (a)
F42A9.5 36
  • 32 (a)
K05D4.4 36
  • 32 (a)
K09A11.2 36
  • 32 (a)
K09A11.4 36
  • 32 (a)
C45H4.17 36
  • 31 (a)
R08F11.3 36
  • 31 (a)
Y49C4A.9 36
  • 31 (a)
B0213.11 36
  • 30 (a)
B0213.15 36
  • 30 (a)
B0304.3 36
  • 30 (a)
C03G6.15 36
  • 30 (a)
F14H3.10 36
  • 30 (a)
F41B5.2 36
  • 30 (a)
F41B5.4 36
  • 30 (a)
F44C8.1 36
  • 30 (a)
K07C6.2 36
  • 30 (a)
K07C6.3 36
  • 30 (a)
T10H4.10 36
  • 30 (a)
T10H4.11 36
  • 30 (a)
B0213.14 36
  • 29 (a)
C49G7.8 36
  • 29 (a)
F41B5.7 36
  • 29 (a)
K07C6.5 36
  • 29 (a)
K09D9.2 36
  • 29 (a)
Y5H2B.6 36
  • 29 (a)
B0213.10 36
  • 28 (a)
C03G6.14 36
  • 28 (a)
C12D5.7 36
  • 27 (a)
C25E10.2 36
  • 27 (a)
C41G6.1 36
  • 26 (a)
Species where no ortholog for CYP2A13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP2A13 Gene

Gene Tree for CYP2A13 (if available)
Gene Tree for CYP2A13 (if available)

Paralogs for CYP2A13 Gene Pseudogenes for CYP2A13 Gene

genes like me logo Genes that share paralogs with CYP2A13: view

Variants for CYP2A13 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2A13 Gene

The frequencies of the Cys-257 allele in white, black, Hispanic, and Asian individuals are 1.9%, 14.4%, 5.8%, and 7.7%, respectively. The Cys-257 variant is 37 to 56% less active than the wild-type Arg-257 protein toward all substrates tested.

Sequence variations from dbSNP and Humsavar for CYP2A13 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10425590 -- 41,094,875(+) GGGCA(C/G)CCTAG intron-variant
rs111321734 -- 41,093,003(+) CTATC(A/G)TTAAA intron-variant
rs111464580 -- 41,088,589(+) CCCCA(C/T)TGCCC reference, synonymous-codon
rs111469896 -- 41,092,012(+) CCCTC(A/G)TCATA intron-variant
rs111472610 -- 41,096,375(+) TTGAA(C/T)ACAGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CYP2A13 Gene

Variant ID Type Subtype PubMed ID
nsv1065684 CNV gain 25217958
nsv1066637 CNV gain 25217958
nsv1125310 OTHER inversion 24896259
nsv2491 CNV deletion 18451855
nsv978819 CNV duplication 23825009

Variation tolerance for CYP2A13 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.93; 79.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP2A13 Gene

Human Gene Mutation Database (HGMD)
The Human Cytochrome P450 Allele Nomenclature Database
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for CYP2A13 Gene

Relevant External Links for CYP2A13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CYP2A13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP2A13 Gene

Publications for CYP2A13 Gene

  1. Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility. (PMID: 15063809) Cauffiez C. … Broly F. (Biochem. Biophys. Res. Commun. 2004) 3 4 22 46 64
  2. A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. (PMID: 7668294) Fernandez-Salguero P. … Idle J.R. (Am. J. Hum. Genet. 1995) 2 3 4 22 64
  3. CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk. (PMID: 19812523) Mohelnikova-Duchonova B. … Soucek P. (Pancreas 2010) 3 22 46 64
  4. CYP450 polymorphisms as risk factors for early-onset lung cancer: gender-specific differences. (PMID: 19414505) Timofeeva M.N. … Wichmann H.E. (Carcinogenesis 2009) 3 22 46 64
  5. Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China. (PMID: 19303722) Song D.K. … Qiao B.P. (Cancer Detect. Prev. 2009) 3 22 46 64

Products for CYP2A13 Gene

Sources for CYP2A13 Gene

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