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Aliases for CLU Gene

Aliases for CLU Gene

  • Clusterin 2 3 3 5
  • Testosterone-Repressed Prostate Message 2 2 3 4
  • Apolipoprotein J 2 3 4
  • Complement-Associated Protein SP-40,40 3 4
  • Complement Cytolysis Inhibitor 3 4
  • Complement Lysis Inhibitor 2 3
  • Sulfated Glycoprotein 2 2 3
  • Ku70-Binding Protein 1 3 4
  • NA1/NA2 3 4
  • TRPM-2 3 4
  • APO-J 3 4
  • APOJ 3 4
  • KUB1 3 4
  • CLI 3 4
  • Clusterin (Complement Lysis Inhibitor, SP-40,40, Sulfated Glycoprotein 2, Testosterone-Repressed Prostate Message 2, Apolipoprotein J) 2
  • Aging-Associated Gene 4 Protein 4
  • Aging-Associated Protein 4 3
  • SGP-2 3
  • SP-40 3
  • TRPM2 3
  • AAG4 3
  • CLU1 3
  • CLU2 3
  • SGP2 3

External Ids for CLU Gene

Previous HGNC Symbols for CLU Gene

  • CLI
  • APOJ

Previous GeneCards Identifiers for CLU Gene

  • GC08M027237
  • GC08M027960
  • GC08M027477
  • GC08M027462
  • GC08M027510
  • GC08M025999
  • GC08M027454

Summaries for CLU Gene

Entrez Gene Summary for CLU Gene

  • The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]

GeneCards Summary for CLU Gene

CLU (Clusterin) is a Protein Coding gene. Diseases associated with CLU include Follicular Dendritic Cell Sarcoma and Transient Neonatal Neutropenia. Among its related pathways are Creation of C4 and C2 activators and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and chaperone binding. An important paralog of this gene is CLUL1.

UniProtKB/Swiss-Prot for CLU Gene

  • Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

Gene Wiki entry for CLU Gene

Additional gene information for CLU Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLU Gene

Genomics for CLU Gene

GeneHancer (GH) Regulatory Elements for CLU Gene

Promoters and enhancers for CLU Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I027610 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 556 +1.0 956 8.1 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 CLU FZD3 SCARA3 GULOP MIR6843
GH08I027771 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10 -158.5 -158518 4 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CCDC25 ESCO2 RNU6-1276P GC08P027774 CLU ELP3 SCARA3
GH08I027324 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 10.4 +288.2 288212 4.3 HDGF HDAC1 PKNOX1 ZSCAN4 SIN3A ETV6 IKZF2 RUNX3 SMAD5 CBFB PTK2B CLU TRIM35 MIR6842
GH08I027359 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +248.9 248888 13.4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A IRF4 YY1 ZNF766 PTK2B CLU ADRA1A EPHX2 MIR6842
GH08I027330 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +281.3 281332 6.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 YY1 FOS PTK2B TRIM35 EPHX2 CLU CHRNA2 MIR6842
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CLU on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLU gene promoter:

Genomic Locations for CLU Gene

Genomic Locations for CLU Gene
chr8:27,596,917-27,615,031
(GRCh38/hg38)
Size:
18,115 bases
Orientation:
Minus strand
chr8:27,454,434-27,472,548
(GRCh37/hg19)

Genomic View for CLU Gene

Genes around CLU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLU Gene

Proteins for CLU Gene

  • Protein details for CLU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10909-CLUS_HUMAN
    Recommended name:
    Clusterin
    Protein Accession:
    P10909
    Secondary Accessions:
    • B2R9Q1
    • B3KSE6
    • P11380
    • P11381
    • Q2TU75
    • Q5HYC1
    • Q7Z5B9

    Protein attributes for CLU Gene

    Size:
    449 amino acids
    Molecular mass:
    52495 Da
    Quaternary structure:
    • Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers. Interacts with a broad range of misfolded proteins, including APP, APOC2 and LYZ. Slightly acidic pH promotes interaction with misfolded proteins. Forms high-molecular weight oligomers upon interaction with misfolded proteins. Interacts with APOA1, LRP2, CLUAP1 AND PON1. Interacts with the complement complex. Interacts (via alpha chain) with XRCC6. Interacts with SYVN1, COMMD1, BTRC, CUL1 and with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Interacts (via alpha chain) with BAX in stressed cells, where BAX undergoes a conformation change leading to association with the mitochondrial membrane. Does not interact with BAX in unstressed cells. Found in a complex with LTF, CLU, EPPIN and SEMG1.
    SequenceCaution:
    • Sequence=AAA35692.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB06508.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB06508.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=AAH10514.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH19588.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAP88927.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAP88927.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAT08041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36598.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA32847.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CLU Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLU Gene

Post-translational modifications for CLU Gene

  • Heavily N-glycosylated. About 30% of the protein mass is comprised of complex N-linked carbohydrate.
  • Isoform 1 is proteolytically cleaved on its way through the secretory system, probably within the Golgi lumen.
  • Polyubiquitinated, leading to proteasomal degradation.
  • Glycosylation at posLast=8686, Asn103, posLast=145145, Ser210, posLast=291291, posLast=354354, and Asn374

No data available for DME Specific Peptides for CLU Gene

Domains & Families for CLU Gene

Gene Families for CLU Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CLU Gene

Suggested Antigen Peptide Sequences for CLU Gene

Graphical View of Domain Structure for InterPro Entry

P10909

UniProtKB/Swiss-Prot:

CLUS_HUMAN :
  • Belongs to the clusterin family.
Family:
  • Belongs to the clusterin family.
genes like me logo Genes that share domains with CLU: view

Function for CLU Gene

Molecular function for CLU Gene

GENATLAS Biochemistry:
clusterin,sulfated multifunctional glycoprotein 2,cell cycle dependent expressed in normal dermal fibroblasts,major secreted product of Sertoli cells,potentially involved in spermatogenesis,increased in hippocampus and in frontal cortex in Alzheimers disease. Recently recognized as an autoantigen (70kDa) identified in the serum of patients with scleroderma-polymyositis syndrome,dimerizing with KUP80 to form an ATP dependent DNA unwinding enzyme (helicase II) and the regulatory component of a DNA dependent protein kinase (PRKDC),involved in DNA double-strand break repair by end joining (non homologous recombination) and V(D)J recombination
UniProtKB/Swiss-Prot Function:
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to enterovirus 71 (EV71) infection (at protein level). Up-regulated by agents that induce apoptosis, both at mRNA and protein level. Isoform 1 is up-regulated by androgen. Isoform 2 is down-regulated by androgen.

Phenotypes From GWAS Catalog for CLU Gene

Gene Ontology (GO) - Molecular Function for CLU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding IPI 9228033
GO:0005515 protein binding IPI 16113678
GO:0016887 NOT ATPase activity IDA 11123922
GO:0031625 ubiquitin protein ligase binding IDA 20068069
GO:0032403 protein complex binding IPI 22179788
genes like me logo Genes that share ontologies with CLU: view
genes like me logo Genes that share phenotypes with CLU: view

Animal Models for CLU Gene

MGI Knock Outs for CLU:
  • Clu tm1Jakh
  • Clu tm1b(EUCOMM)Hmgu

miRNA for CLU Gene

miRTarBase miRNAs that target CLU

Clone Products

  • Addgene plasmids for CLU

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLU Gene

Localization for CLU Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLU Gene

Isoform 1: Secreted. Note=Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress.
Nucleus. Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Note=Isoforms lacking the N-terminal signal sequence have been shown to be cytoplasmic and/or nuclear. Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Detected at the mitochondrion membrane upon induction of apoptosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLU gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 4
endoplasmic reticulum 4
cytosol 4
golgi apparatus 4
plasma membrane 3
cytoskeleton 2
lysosome 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IDA 23164821
GO:0005615 extracellular space IDA 11123922
GO:0005622 intracellular TAS 23164821
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 9560017
genes like me logo Genes that share ontologies with CLU: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLU Gene

Pathways & Interactions for CLU Gene

genes like me logo Genes that share pathways with CLU: view

Pathways by source for CLU Gene

Gene Ontology (GO) - Biological Process for CLU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IDA 15857407
GO:0001774 microglial cell activation IDA 15857407
GO:0001836 release of cytochrome c from mitochondria IC 16113678
GO:0002376 immune system process IEA --
GO:0002576 platelet degranulation TAS --
genes like me logo Genes that share ontologies with CLU: view

No data available for SIGNOR curated interactions for CLU Gene

Drugs & Compounds for CLU Gene

(44) Drugs for CLU Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma Target 2430
Copper Approved, Investigational Pharma Target 202
Custirsen Investigational Pharma Antisense oligonucleotide Others 0
OGX-011 Pharma Inhibition, antisense 0

(40) Additional Compounds for CLU Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLU: view

Transcripts for CLU Gene

Unigene Clusters for CLU Gene

Clusterin:
Representative Sequences:

Clone Products

  • Addgene plasmids for CLU

Alternative Splicing Database (ASD) splice patterns (SP) for CLU Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ·
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: -
SP5: - - - - - -
SP6: -
SP7: - -
SP8: - - - - - -
SP9:
SP10:
SP11: -
SP12: - - - -

ExUns: 12c ^ 13a · 13b · 13c · 13d · 13e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CLU Gene

GeneLoc Exon Structure for
CLU
ECgene alternative splicing isoforms for
CLU

Expression for CLU Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLU Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLU Gene

This gene is overexpressed in Vitreous humor (18.1), Serum (10.4), Synovial fluid (9.5), and Cerebrospinal fluid (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CLU Gene



Protein tissue co-expression partners for CLU Gene

NURSA nuclear receptor signaling pathways regulating expression of CLU Gene:

CLU

SOURCE GeneReport for Unigene cluster for CLU Gene:

Hs.436657

mRNA Expression by UniProt/SwissProt for CLU Gene:

P10909-CLUS_HUMAN
Tissue specificity: Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung.

Evidence on tissue expression from TISSUES for CLU Gene

  • Liver(5)
  • Nervous system(5)
  • Eye(4.9)
  • Blood(4.7)
  • Intestine(4.7)
  • Stomach(4.6)
  • Pancreas(4.5)
  • Bone marrow(4.4)
  • Kidney(4.4)
  • Lung(4.3)
  • Saliva(4.1)
  • Bone(4)
  • Lymph node(3.5)
  • Adrenal gland(3.4)
  • Gall bladder(3.2)
  • Thyroid gland(3.2)
  • Heart(3.1)
  • Muscle(3.1)
  • Skin(2.8)
  • Spleen(2.7)
  • Urine(2.1)
genes like me logo Genes that share expression patterns with CLU: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLU Gene

Orthologs for CLU Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLU 33 34
  • 98.96 (n)
dog
(Canis familiaris)
Mammalia CLU 33 34
  • 82.85 (n)
rat
(Rattus norvegicus)
Mammalia Clu 33
  • 81.66 (n)
mouse
(Mus musculus)
Mammalia Clu 33 16 34
  • 80.92 (n)
cow
(Bos Taurus)
Mammalia CLU 33 34
  • 79.57 (n)
-- 34
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CLU 34
  • 45 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLU 34
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLU 33
  • 61.23 (n)
lizard
(Anolis carolinensis)
Reptilia CLU 34
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clu 33
  • 58.29 (n)
African clawed frog
(Xenopus laevis)
Amphibia clu-prov 33
zebrafish
(Danio rerio)
Actinopterygii clu 33 34
  • 55.12 (n)
zgc73352 33
Species where no ortholog for CLU was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLU Gene

ENSEMBL:
Gene Tree for CLU (if available)
TreeFam:
Gene Tree for CLU (if available)

Paralogs for CLU Gene

Paralogs for CLU Gene

genes like me logo Genes that share paralogs with CLU: view

Variants for CLU Gene

Sequence variations from dbSNP and Humsavar for CLU Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000031306 -- 27,604,862(-) C/T intron_variant
rs1000090414 -- 27,611,289(-) C/T intron_variant, non_coding_transcript_variant
rs1000312240 -- 27,608,099(-) G/A intron_variant
rs1000320853 -- 27,613,817(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000373120 -- 27,614,124(-) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CLU Gene

Variant ID Type Subtype PubMed ID
esv3572652 CNV loss 25503493
esv3572654 CNV loss 25503493
nsv610867 CNV gain 21841781
nsv831275 CNV loss 17160897

Variation tolerance for CLU Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLU Gene

Human Gene Mutation Database (HGMD)
CLU
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLU Gene

Disorders for CLU Gene

MalaCards: The human disease database

(28) MalaCards diseases for CLU Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
follicular dendritic cell sarcoma
  • follicular dendritic cell tumour
transient neonatal neutropenia
  • transient neonatal neutropenia nos
testicular seminoma
  • seminoma of testis
pediatric multiple sclerosis
  • ms pediatric
ovarian cystadenoma
  • cystoma serosum simplex
- elite association - COSMIC cancer census association via MalaCards
Search CLU in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CLU

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CLU: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLU Gene

Publications for CLU Gene

  1. Identification of human plasma proteins as major clients for the extracellular chaperone clusterin. (PMID: 19996109) Wyatt AR … Wilson MR (The Journal of biological chemistry 2010) 3 4 22 58
  2. Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells. (PMID: 19137541) Rizzi F … Bettuzzi S (Journal of cellular physiology 2009) 3 4 22 58
  3. Clusterin expression in normal mucosa and colorectal cancer. (PMID: 17322305) Andersen CL … Ørntoft TF (Molecular & cellular proteomics : MCP 2007) 3 4 22 58
  4. Multiple pathways regulating the anti-apoptotic protein clusterin in breast cancer. (PMID: 17689225) Ranney MK … Craven RJ (Biochimica et biophysica acta 2007) 3 4 22 58
  5. Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol. (PMID: 17451556) Nizard P … Michel D (Traffic (Copenhagen, Denmark) 2007) 3 4 22 58

Products for CLU Gene

  • Addgene plasmids for CLU

Sources for CLU Gene

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