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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UGDH Gene

protein-coding GIFtS: 64
GCID: GC04M039502

UDP-glucose 6-dehydrogenase

(Previous name: UDP-glucose dehydrogenase )

Explore 20 diseases affiliated with
UGDH via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
UDP-Glucose 6-Dehydrogenase¹ ²		EC 1.1.1.22³ ⁸
UDPGDH² ³ ⁵		GDH²
UDP-Glucose Dehydrogenase¹ ²		UGD²
UDP-GlcDH² ³		Uridine Diphospho-Glucose Dehydrogenase²
UDP-Glc Dehydrogenase² ³

External Ids:	HGNC: 12525¹	Entrez Gene: 7358²	Ensembl: ENSG00000109814⁷	OMIM: 603370⁵	UniProtKB: O60701³

Export aliases for UGDH gene to outside databases

Previous GC identifers: GC04M039674 GC04M039335 GC04M039397 GC04M039322 GC04M039176 GC04M038825

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UGDH:

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis

of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are

common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer

growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and

down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.(provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701

Function: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate

Gene Wiki entry for UGDH

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016297.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UGDH gene promoter:
STAT1 Sp1 Egr-1 STAT1beta CUTL1 HNF-1A STAT1alpha HNF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UGDH promoter sequence

Search SABiosciences Chromatin IP Primers for UGDH

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGDH

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.1 Ensembl cytogenetic band: 4p14 HGNC cytogenetic band: 4p14

UGDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGDH gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M039502: view genomic region (about GC identifiers)

Start:	39,500,375 bp from pter	End:	39,529,931 bp from pter
Size:	29,557 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701 (See protein sequence)

Recommended Name: UDP-glucose 6-dehydrogenase

Size: 494 amino acids; 55024 Da

Subunit: Homohexamer

6/9 PDB 3D structures from and Proteopedia for UGDH (see all 9):

2Q3E (3D)

2QG4 (3D)

3ITK (3D)

3KHU (3D)

3PRJ (3D)

3PTZ (3D)

Secondary accessions: B3KUU2 B4DN25 O60589

Alternative splicing: 3 isoforms: O60701-1 O60701-2 O60701-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UGDH: NX_O60701

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60701

4/18 DME Specific Peptides for UGDH (O60701) (see all 18)

EKSTVPV

PIYEPGL

RINAWNS

DRVLIGG

UGDH Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001171629.1 NP_001171630.1 NP_003350.1

ENSEMBL proteins:

ENSP00000319501 ENSP00000422909 ENSP00000421757 ENSP00000426560 ENSP00000421954

ENSP00000425834 ENSP00000424059 ENSP00000424435 ENSP00000422603 ENSP00000422565

ENSP00000427708

Reactome Protein details: O60701
Human Recombinant Protein Products for UGDH:

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	Uscn Proteins for UGDH

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

UGDH for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UGDH for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001732 UDP-Glc/GDP-Man_DH_N

IPR008927 6-PGluconate_DH_C-like

IPR014027 UDP-Glc/GDP-Man_DH_C

IPR016040 NAD(P)-bd_dom

IPR014026 UDP-Glc/GDP-Man_DH_dimer

Graphical View of Domain Structure for InterPro Entry O60701

ProtoNet protein and cluster: O60701

1 Blocks protein family: IPB001732 UDP-glucose/GDP-mannose dehydrogenase

UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: UGDH_HUMAN, O60701

Function: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate

Catalytic activity: UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH

Enzyme regulation: UDP-alpha-D-xylose (UDX) acts as a feedback inhibitor by activating an allosteric switch

Genatlas biochemistry entry for UGDH:

UDP-glucose dehydrogenase,converting UDP-glucose to UDP-glucuronate,involved in normal cell proliferation and

migration,upregulated by androgens,playing a potentially important role in the control of sex steroid inactivation via

glucuronidation in breast cancer cells

Enzyme Number (IUBMB): EC 1.1.1.22¹ ²

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003979	UDP-glucose 6-dehydrogenase activity	TAS	--
GO:0009055	electron carrier activity	TAS	9737970
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	--	--
GO:0051287	NAD binding	IEA	--

UGDH for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for UGDH:

Decreased number of cells in m

8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ugdh):

craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland	growth/size
mortality/aging	normal	vision/eye

UGDH for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for UGDH

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGDH

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glucuronidation

	Glucuronidation	1.00			Starch and sucrose metabolism	0.42
	Glucuronidation	0.67

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Pentose and glucuronate interconversions

Pentose and glucuronate interconversions

1.00

Ascorbate and aldarate metabolism

0.62

Biological oxidations

Biological oxidations

1.00

Phase II conjugation

0.52

Formation of the active cofactor, UDP-glucuronate

Formation of the active cofactor, UDP-glucuronate

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for UGDH

	Glucuronidation
	colanic acid building blocks biosynthesis
	UDP-D-xylose and UDP-D-glucuronate biosynthesis

5 Reactome Pathways for UGDH

	Formation of the active cofactor, UDP-glucuronate
	Metabolism
	Biological oxidations
	Phase II conjugation
	Glucuronidation

5 Kegg Pathways (Kegg details for UGDH):

	Pentose and glucuronate interconversions
	Ascorbate and aldarate metabolism
	Starch and sucrose metabolism
	Amino sugar and nucleotide sugar metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701

Pathway: Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from

UDP-alpha-D-glucose: step 1/1

UGDH for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for UGDH

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/52 Interacting proteins for UGDH (O60701^{2, 3} ENSP00000319501⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 52)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATP6V0D1	P61421³, ENSP00000290949⁴	I2D: score=2 STRING: ENSP00000290949
SIRT3	Q9NTG7³, ENSP00000372191⁴	I2D: score=2 STRING: ENSP00000372191
DHH	O43323³, ENSP00000266991⁴	I2D: score=1 STRING: ENSP00000266991
SIRT1	Q96EB6³, ENSP00000212015⁴	I2D: score=1 STRING: ENSP00000212015
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001702	gastrulation with mouth forming second	IEA	--
GO:0006011	UDP-glucose metabolic process	TAS	9737970
GO:0006024	glycosaminoglycan biosynthetic process	TAS	9737970
GO:0006065	UDP-glucuronate biosynthetic process	TAS	--
GO:0006805	xenobiotic metabolic process	TAS	--

UGDH for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

UGDH for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UGDH

5 HMDB Compounds for UGDH About this table

Compound	Synonyms	CAS #	PubMed Ids
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
NADH	1,4-Dihydronicotinamide adenine dinucleotide (see all 17)	58-68-4	--
Uridine diphosphate glucose	(UPD)-glucose (see all 24)	133-89-1	--
Uridine diphosphate glucuronic acid	UDP glucuronate (see all 41)	2616-64-0	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

1 DrugBank Compound for UGDH About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
NADH	beta-DPNH (see all 18)	606-68-8	target	--	17139284 1472079 17016423 3804697

10/23 Novoseek chemical compound relationships for UGDH gene (see all 23) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
udpglucose	95.7	136	16453102 (5), 1777115 (4), 10336992 (3), 15044486 (3) (see all 63)
udp glucuronic acid	94.8	35	2287590 (1), 7868856 (1), 12682078 (1), 16002992 (1) (see all 22)
udpxylose	82.4	2	16453102 (1)
glycosaminoglycan	63.9	9	18717819 (2), 12910476 (1), 9737970 (1), 16418163 (1) (see all 5)
nad+	54.1	5	15247292 (3), 15044486 (1)
chondroitin	53.9	1	10806213 (1)
chondroitin sulfate	51.9	6	2287590 (1), 8014943 (1)
6-phosphogluconate	51.4	2	12196534 (1), 12604241 (1)
methyl viologen	46.8	2	12526718 (1), 12673771 (1)
hyaluronic acid	45	6	10068780 (2), 2287590 (1), 16023581 (1)

Search CenterWatch for drugs/clinical trials and news about UGDH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UGDH gene (3 alternative transcripts):

NM_001184700.1 NM_001184701.1 NM_003359.3

Unigene Cluster for UGDH:

UDP-glucose 6-dehydrogenase

Hs.572518 [show with all ESTs]

Unigene Representative Sequence: NM_003359

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000316423(uc003guk.2 uc011byp.2 uc003gul.2) ENST00000501493

ENST00000506179 ENST00000507089 ENST00000515021 ENST00000514106 ENST00000510881

ENST00000503779 ENST00000509391 ENST00000515398 ENST00000505698 ENST00000510490

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Additional cDNA sequence:

AF049126.1 AF061016.1 AJ007702.1 AK097930.1 AK297737.1 BC013430.1 BC022781.1

16 DOTS entries:

DT.91770177 DT.95284989 DT.100753327 DT.102827162 DT.91770181 DT.121230260 DT.99934894 DT.100724687

DT.121230198 DT.121230261 DT.121230313 DT.95284980 DT.99967462 DT.121230308 DT.121230324 DT.91924019

24/222 AceView cDNA sequences (see all 222):

T09009 BM454592 BX399667 BU153716 BQ010148 CD677665 AA307893 BQ960028

BU631548 BQ775140 AA992570 BX495002 BQ269780 AF061016 AW961903 BM967111

BG194936 BM905099 BQ716941 BM459904 AI139310 BP376289 AU280160 BX952433

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for UGDH (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7	^	8	^	9
SP1:
SP2:									-		-		-
SP3:
SP4:									-
SP5:									-		-		-

ECgene alternative splicing isoforms for UGDH

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UGDH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGGTCTGG

About this image

UGDH expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Autopod

Mesenchymal Condensate Cells

Selective marker (cell-identifying gene)

Bone, Cartilage

Limb

Autopod Synovial Joint

Central Intermediate Lamina Cells

Cartilage

Limb

Autopod Synovial Joint

Interzone Cells

Cartilage

Limb

Stylopod

Mesenchymal Condensate Cells

Bone, Cartilage

Limb

Stylopod Synovial Joint

Central Intermediate Lamina Cells

Cartilage

Limb

Stylopod Synovial Joint

Interzone Cells

Cartilage

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Limb

Zeugopod Synovial Joint

Central Intermediate Lamina Cells

Cartilage

Limb

Zeugopod Synovial Joint

Interzone Cells

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Sclerotome cells (Primary Cell)

Bone, Cartilage, Somite

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

See UGDH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UGDH

SOURCE GeneReport for Unigene cluster: Hs.572518

UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701

Tissue specificity: Widely expressed

SABiosciences Custom PCR Arrays for UGDH

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for UGDH gene from 9/35 species (see all 35) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ugdh^{1 , 5}	UDP-glucose dehydrogenase^{1, 5}	89.86(n)¹ 97.97(a)¹		5 (33.67 cM)⁵ 22235¹ NM_009466.2¹ NP_033492.1¹ 65413202⁵
chicken (Gallus gallus)	Aves	UGDH¹	UDP-glucose 6-dehydrogenase	82.25(n) 93.72(a)		422792 NM_001012581.1 NP_001012599.1
lizard (Anolis carolinensis)	Reptilia	UGDH⁶	--	90(a)	1 ↔ 1	5(99670123-99675748)
African clawed frog (Xenopus laevis)	Amphibia	MGC52511²	similar to UDP-glucose dehydrogenase	77.36(n)		AY014958.1
zebrafish (Danio rerio)	Actinopterygii	ugdh²	UDP-glucose dehydrogenase	76.97(n)		116991 AF361478.1
fruit fly (Drosophila melanogaster)	Insecta	sgl^{1 , 3}	mesoderm migration UDP-glucose 6-dehydrogenase less³ sugarless¹	68(a)³ 61.28(n)¹ 69.21(a)¹		3 65D5³ 38760¹ NM_057632.3¹ NP_476980.1¹
worm (Caenorhabditis elegans)	Secernentea	sqv-4¹	Protein SQV-4	61.71(n) 66.52(a)		179484 NM_073329.6 NP_505730.1
thale cress (Arabidopsis thaliana)	eudicotyledons	UGD1¹	UDP-glucose dehydrogenase 1	61.23(n) 63.04(a)		839197 NM_102419.3 NP_173979.1
rice (Oryza sativa)	Liliopsida	Os.10473²	Oryza sativa (japonica cultivar-group) cDNA clone001-202-E05, full insert sequence less	72.44(n)		AK105768.1

ENSEMBL Gene Tree for UGDH (if available)
TreeFam Gene Tree for UGDH (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116464200^1,2		--	39500063(+)	`CTGGCC/GTTAAG`	3	--	ds500¹ int¹		1		WA	118
rs149013707^1,2		--	39500114(+)	`TGCATA/GAGCCA`	3	--	ds500¹ int¹		0	--	--	--	--
rs113003977^1,2	C	--	39500151(+)	`ATGACC/TATGTA`	3	--	ds500¹ int¹		2		NA	122
rs11935751^1,2	C,F,A,H	--	39500187(+)	`ACTCAT/CGGCTG`	3	--	int¹ ds500¹		5		NS EA NA	538
rs75711286^1,2		--	39500237(+)	`TTTGCT/CAAATT`	3	--	ds500¹ int¹		1		WA	118
rs13135475^1,2	C,F,A	--	39500244(+)	`AATTCT/CCTCCC`	3	--	int¹ ds500¹		11		NA CSA WA EA	510
rs143808039^1,2		--	39500489(+)	`AGGATA/GAGACC`	3	--	ut3¹		0	--	--	--	--
rs1450^1,2	C,F,A,H	--	39500514(+)	`CAAACT/CGTACA`	3	--	ut3¹		34		MN NA NS EA	3644
rs181729245^1,2		--	39500516(+)	`AACTGA/TACATT`	3	--	ut3¹		0	--	--	--	--
rs11931052^1,2	C,F,H	--	39500614(+)	`CTCAAC/GAAGAG`	3	--	ut3¹ ese³		7		NA EA	386

HapMap Linkage Disequilibrium report for UGDH (39500375 - 39529931 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UGDH: --
Human Gene Mutation Database (HGMD): UGDH

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UGDH

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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UGDH for disorders           About GeneDecksing

OMIM gene information: 603370    OMIM disorders: --

20 diseases for UGDH:    About MalaCards

hypoxia morbid obesity rheumatoid arthritis chordoma

graves' disease synovitis arthritis breast cancer

hyperglycemia obesity pharyngitis peritonitis

prostate cancer neuroblastoma prostatitis tuberculosis

neuronitis carcinoma mycobacterium tuberculosis alcoholism

2 Novoseek disease relationships for UGDH gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rheumatoid arthritis	15.9	2	15059280 (1), 10068780 (1)
breast cancer	0	4	10499502 (2), 16158268 (1)

Human Genome Epidemiology (HuGE) Navigator: UGDH (1 document)

Export disorders for UGDH gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for UGDH gene, integrated from 9 sources (see all 116):
(articles sorted by number of sources associating them with UGDH)

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world of online information

Molecular cloning and characterization of the human and mouse UDP- glucose dehydrogenase genes. (PubMed id 9737970)^{1, 2, 3, 9} Spicer A.P.... Seldin M.F. (1998)
cDNA cloning and expression analysis of the human UDPglucose dehydrogenase. (PubMed id 9850599)^{1, 2, 9} Peng H.L.... Chang H.Y. (1998)
Assignment of the UGDH locus encoding UDP-glucose dehydrogenase to human chromosome band 4p15.1 by radiation hybrid mapping. (PubMed id 10575217)^{1, 3, 9} Marcu O....Marsh J.L. (1999)
Structural and kinetic evidence that catalytic reactio n of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thio ester enzyme intermediates. (PubMed id 22123821)^{1, 2} Egger S....Nidetzky B. (2012)
Structure and mechanism of human UDP-glucose 6-dehydr ogenase. (PubMed id 21502315)^{1, 2} Egger S....Nidetzky B. (2011)
Conformational flexibility in the allosteric regulati on of human UDP-I+-D-glucose 6-dehydrogenase. (PubMed id 21961565)^{1, 2} Sennett N.C....Wood Z.A. (2011)
Structural basis of cooperativity in human UDP-glucos e dehydrogenase. (PubMed id 21984906)^{1, 2} Rajakannan V....Robinson R.C. (2011)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Importance of Gly-13 for the coenzyme binding of human UDP-glucose dehydrogenase. (PubMed id 15247292)^{1, 9} Huh J.W....Cho S.W. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7358	HGNC: 12525	AceView: UGDH	Ensembl:ENSG00000109814	euGenes: HUgn7358
ECgene: UGDH	Kegg: 7358	H-InvDB: UGDH

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for UGDH	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UGDH gene
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Patent Information for UGDH gene:
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