Aliases for SORD Gene
External Ids for SORD Gene
Previous GeneCards Identifiers for SORD Gene
Sorbitol dehydrogenase (SORD; EC 18.104.22.168) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]
GeneCards Summary for SORD Gene
SORD (Sorbitol Dehydrogenase) is a Protein Coding gene. Diseases associated with SORD include acute diffuse nephritis and mature cataract. Among its related pathways are Metabolism and Fructose and mannose metabolism. GO annotations related to this gene include carbohydrate binding and L-iditol 2-dehydrogenase activity.
UniProtKB/Swiss-Prot for SORD Gene
Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.