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SHPK Gene

protein-coding   GIFtS: 52
GCID: GC17M003514

Sedoheptulokinase

(Previous name: carbohydrate kinase-like)
(Previous symbol: CARKL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
sedoheptulokinase1 2
CARKL1 2 3 5
Carbohydrate Kinase-Like Protein2 3
SHK2 3
Carbohydrate Kinase-Like1
EC 2.7.1.143

External Ids:    HGNC: 14921   Entrez Gene: 237292   Ensembl: ENSG000001974177   OMIM: 6050605   UniProtKB: Q9UHJ63   

Export aliases for SHPK gene to outside databases

Previous GC identifers: GC17M003459 GC17M003403


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SHPK Gene:
The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved
in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence
variation between this novel gene and known carbohydrate kinases suggests the possibility of a different
substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene
resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis
phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal
rearrangements. (provided by RefSeq, Jul 2008)

GeneCards Summary for SHPK Gene:
SHPK (sedoheptulokinase) is a protein-coding gene. Diseases associated with SHPK include nephropathic cystinosis, and cystinosis. GO annotations related to this gene include sedoheptulokinase activity.

UniProtKB/Swiss-Prot: SHPK_HUMAN, Q9UHJ6
Function: Acts as a modulator of macrophage activation through control of glucose metabolism (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SHPK gene promoter:
         USF1   AML1a   Tal-1   E47   FAC1   FOXJ2 (long isoform)   USF-1   FOXJ2   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSHPK promoter sequence
   Search Chromatin IP Primers for SHPK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHPK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13

SHPK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHPK gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M003514:  view genomic region     (about GC identifiers)

Start:
3,511,556 bp from pter      End:
3,539,616 bp from pter
Size:
28,061 bases      Orientation:
minus strand

1 alternative location:
Chr17- 3,468,738-3,539,543     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SHPK_HUMAN, Q9UHJ6 (See protein sequence)
Recommended Name: Sedoheptulokinase  
Size: 478 amino acids; 51491 Da
Secondary accessions: B2R640 Q8WUH3

Explore the universe of human proteins at neXtProt for SHPK: NX_Q9UHJ6

Explore proteomics data for SHPK at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys18, Lys441
  • Modification sites at PhosphoSitePlus

  • See SHPK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037408.2  
    ENSEMBL proteins: 
     ENSP00000225519  

    SHPK Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR028491 Sedoheptulokinase
     IPR018484 Carb_kinase_FGGY_N

    Graphical View of Domain Structure for InterPro Entry Q9UHJ6

    ProtoNet protein and cluster: Q9UHJ6

    UniProtKB/Swiss-Prot: SHPK_HUMAN, Q9UHJ6
    Similarity: Belongs to the FGGY kinase family


    SHPK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHPK_HUMAN, Q9UHJ6
    Function: Acts as a modulator of macrophage activation through control of glucose metabolism (By similarity)
    Catalytic activity: ATP + sedoheptulose = ADP + sedoheptulose 7-phosphate
    Biophysicochemical properties: Kinetic parameters: KM=0.06 mM for sedoheptulose; pH dependence: Optimum pH is 8.5;
    Induction: Down-regulated by LPS

         Enzyme Number (IUBMB): EC 2.7.1.141

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0016773phosphotransferase activity, alcohol group as acceptor ----
    GO:0050277sedoheptulokinase activity IDA19413330
         
    SHPK for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SHPK:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHPK
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    miRNA
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    miRTarBase miRNAs that target SHPK:
    hsa-mir-615-3p (MIRT039817), hsa-mir-124-3p (MIRT022509)

    Block miRNA regulation of human, mouse, rat SHPK using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate SHPK:
    hsa-miR-3618 hsa-miR-124 hsa-miR-3662 hsa-miR-506 hsa-miR-450b-3p hsa-miR-324-5p hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmidSHPK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SHPK

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SHPK_HUMAN, Q9UHJ6: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--

    SHPK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SHPK
    Interactions:

        Search GeneGlobe Interaction Network for SHPK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SHPK (ENSP000002255194) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IST1ENSP000003304084STRING: ENSP00000330408
    ALDH18A1ENSP000003602684STRING: ENSP00000360268
    CADENSP000002647054STRING: ENSP00000264705
    CPS1ENSP000004026084STRING: ENSP00000402608
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IDA19413330
    GO:0009052pentose-phosphate shunt, non-oxidative branch ISS--
    GO:0016310phosphorylation IDA19413330
    GO:0035963cellular response to interleukin-13 ISS--
    GO:0043030regulation of macrophage activation ISS--

    SHPK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHPK

    6 HMDB Compounds for SHPK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    D-Sedoheptulose 7-phosphate7-(dihydrogen phosphate) sedoheptulose (see all 9)2646-35-7--
    Inositol 1,3,4,5,6-pentakisphosphate1D-myo-Inositol 1,3,4,5,6-pentakisphosphate (see all 5)20298-95-7--
    Myo-inositol hexakisphosphate1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate (see all 9)83-86-3--
    SedoheptuloseD-Altro-2-heptulose (see all 4)3019-74-7--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SHPK gene: 
    NM_013276.2  

    Unigene Cluster for SHPK:

    Sedoheptulokinase
    Hs.579217  [show with all ESTs]
    Unigene Representative Sequence: AF163573
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000225519(uc002fvz.1)
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate SHPK:
    hsa-miR-3618 hsa-miR-124 hsa-miR-3662 hsa-miR-506 hsa-miR-450b-3p hsa-miR-324-5p hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmidSHPK 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SHPK
      QuantiTect SYBR Green Assays in human, mouse, rat SHPK
      QuantiFast Probe-based Assays in human, mouse, rat SHPK

    Additional mRNA sequence: 

    AF163573.1 AK055609.1 AK057020.1 AK057040.1 AK298360.1 AK312428.1 AL832420.1 BC020543.1 
    BC111366.1 

    4 DOTS entries:

    DT.428676  DT.97819296  DT.97806108  DT.102826144 

    Selected AceView cDNA sequences (see all 121):

    BQ187326 BQ676342 BM704676 BQ959791 BM014650 AJ277028 AA700014 BX096339 
    AA410918 AA325795 AI245655 CB044884 BP346171 BM676314 AF163573 CA307823 
    AA331298 AA411042 CK300648 NM_013276 AF235160 BC020543 BM051908 BU859441 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHPK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTCAGTTA
    SHPK Expression
    About this image

    SHPK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHPK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.579217

    UniProtKB/Swiss-Prot: SHPK_HUMAN, Q9UHJ6
    Tissue specificity: Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and
    heart. Very weakly expressed in lung and brain

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SHPK gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shpk1 , 5 sedoheptulokinase1, 5 85.19(n)1
    86.95(a)1
      11 (45.25 cM)5
    746371  NM_029031.31  NP_083307.11 
     731994605 
    chicken
    (Gallus gallus)
    Aves SHPK1 sedoheptulokinase 67.47(n)
    65.36(a)
      417607  XM_415852.4  XP_415852.4 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.39962 Xenopus laevis transcribed sequence with weak similarity to protein spQ9UHJ6 (H.sapiens) CARL_HUMAN Carbohydrate kinase-like protein less 72.64(n)    BX851895.1 
    zebrafish
    (Danio rerio)
    Actinopterygii shpk1 sedoheptulokinase 60.99(n)
    57.74(a)
      100001676  XM_001341591.4  XP_001341627.4 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_T25C8.11 CELE_T25C8.1 42.36(n)
    34.64(a)
      188886  NM_067409.2  NP_499810.2 


    ENSEMBL Gene Tree for SHPK (if available)
    TreeFam Gene Tree for SHPK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHPK (see all 563)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400886331,2
    --3406472(+) TTAACC/TGGGCG 1 -- int10--------
    rs1436570851,2
    --3406529(+) GAGAAG/TCACTT 1 -- int10--------
    rs1462522321,2
    --3406579(+) CCACTA/GCACTC 1 -- int10--------
    rs27371411,2
    C,F,O,H--3406655(+) TGTCAT/CTGGGG 1 -- int125Minor allele frequency- C:0.13NS EA NA WA 2906
    rs760563011,2
    C,F--3406707(+) CTGAAT/CGGGCC 1 -- int11Minor allele frequency- C:0.06NA 120
    rs620699291,2
    C,F--3406974(+) GTATTT/CTTAGT 1 -- int13Minor allele frequency- C:0.20NA WA 124
    rs1874102861,2
    --3407000(+) CTACAG/TTGGAC 1 -- int10--------
    rs1392811261,2
    --3407009(+) ACAGGC/GTGGTC 1 -- int10--------
    rs80779731,2
    C,F--3407131(+) AAAAAT/AAAAAA 1 -- int1 trp34Minor allele frequency- A:0.33NA WA 124
    rs1510130631,2
    C--3407193(+) CAGGCA/GGATCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SHPK (3511556 - 3539616 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SHPK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662762CNV Deletion23128226
    esv997341CNV Deletion20482838
    nsv833342CNV Loss17160897
    nsv907568CNV Loss21882294
    dgv358n27CNV Loss19166990
    nsv907565CNV Loss21882294
    nsv526175CNV Gain19592680
    nsv516676CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SHPK
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605060    OMIM disorders: --

    2 diseases for SHPK:    
    About MalaCards
    nephropathic cystinosis    cystinosis

    1 disease from the University of Copenhagen DISEASES database for SHPK:
    Cystinosis

    SHPK for disorders           About GeneDecksing

    Genetic Association Database (GAD): SHPK
    Human Genome Epidemiology (HuGE) Navigator: SHPK (4 documents)

    Export disorders for SHPK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHPK gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with SHPK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sedoheptulokinase deficiency due to a 57-kb deletion in cystinosis patients causes urinary accumulation of sedoheptulose: elucidation of the CARKL gene. (PubMed id 18186520)1, 2, 3, 9 Wamelink M.M.... Wevers R.A. (Hum. Mutat. 2008)
    2. The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion. (PubMed id 10673275)1, 2, 3, 9 Touchman J.W....Green E.D. (Genome Res. 2000)
    3. The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. (PubMed id 22682222)1, 2 Haschemi A.... Wagner O. (Cell Metab. 2012)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray. (PubMed id 19679847)1, 4 Lanktree M.B....Anand S.S. ( a journal of cerebral circulation 2009)
    6. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)1, 2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23729 HGNC: 1492 AceView: CARKL Ensembl:ENSG00000197417 euGenes: HUgn23729
    ECgene: SHPK H-InvDB: SHPK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SHPK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SHPK gene:
    Search GeneIP for patents involving SHPK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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