ADORA3 Gene
protein-coding GIFtS: 66
GCID: GC01M112025
|
|
adenosine A3 receptor
| |
Aliases
for ADORA3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adenosine A3 Receptor1 2 | | AD0261 2 | | A3AR2 | | Adenosine Receptor A32 | | BA552M11.51 |
Export aliases for ADORA3 gene to outside databasesPrevious GC identifers: GC01M112458 GC01M110913 GC01M111144 GC01M111340 GC01M111326 GC01M111739 GC01M111827 GC01M109897 |
Summaries
for ADORA3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADORA3:
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptorsthat are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encodedby this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibitionof neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective andneurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcriptvariants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/ace: AA3RB_HUMAN, Q6P2N6 (see all)Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylylcyclase. Possible role in reproduction
 summary
for ADORA3: The adenosine A3 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that
also includes A1, A2A and A2B. They display high expression levels in the testes and mast cells of rats,
with low expression levels in the thyroid, liver, kidney, heart, intestine and most brain areas. Adenosine
A3 receptors play a role in mast cell degranulation, coronary vasodilation and protection from reperfusion.
The human A3 receptor gene is localized on chromosome 1 (1p21-p13).
Gene Wiki entry for ADORA3 (Adenosine A3 receptor)
|
Genomic Views
for ADORA3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADORA3 gene promoter:
CREB Elk-1 FOXF2 FOXO4 deltaCREB PPAR-gamma2 Evi-1 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADORA3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADORA3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.2 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.2ADORA3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M112025: view genomic region
(about GC identifiers)
Start:
|
112,025,970 bp from pter |
End:
|
112,106,597 bp from pter |
Size:
|
80,628 bases |
Orientation:
|
minus strand |
|
Proteins
for ADORA3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AA3RB_HUMAN, Q6P2N6 (See
protein sequence)Recommended Name: Protein ADORA3, isoform 3 Size: 266 amino acids; 30327 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAH41707.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAH64411.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW56500.1;Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5QNY7Alternative splicing: 3 isoforms: Q6P2N6-1 P33765-1 P33765-2 UniProtKB/Swiss-Prot: AA3R_HUMAN, P33765 (See
protein sequence) Recommended Name: Adenosine receptor A3 Size: 318 amino acids; 36185 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
2 PDB 3D structures from  and Proteopedia  for ADORA3:1OEA (3D)
1R7N (3D)
Secondary accessions: A2A3P4 Q6UWU0 Q9BYZ1Alternative splicing: 3 isoforms: P33765-1 P33765-2 Q6P2N6-1 Explore the universe of human proteins at neXtProt for ADORA3: NX_P33765
Post-translational modifications:
Phosphorylation on Ser-317 may be crucial for rapid desensitization (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P33765
ADORA3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_000668.1 NP_001075445.1 NP_065734.5
ENSEMBL proteins: ENSP00000358731 ENSP00000415646 ENSP00000358730 ENSP00000398770 ENSP00000406102 ENSP00000241356 Reactome Protein details: P33765
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0005887 | integral to plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
ADORA3 for ontologies About GeneDecksing
ADORA3 Antibody Products:
Assay Products for ADORA3: |
Protein
Domains /
Families
for ADORA3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADORA3 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6P2N6Graphical View of Domain Structure for InterPro Entry P33765ProtoNet protein and cluster: Q6P2N6 UniProtKB/Swiss-Prot: AA3RB_HUMAN, Q6P2N6Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: AA3R_HUMAN, P33765Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for ADORA3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/ace: AA3RB_HUMAN, Q6P2N6 (see all)Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylylcyclase. Possible role in reproduction Genatlas biochemistry entry for ADORA3:adenosine receptor A3,widely expressed,most abundant in brain and some endocrine tissues,G protein coupled receptorsuperfamily,activating adenylate cyclase
Clone
Products: |  | EMD Millipore Clones for the Expression of ADORA3 | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADORA3 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADORA3 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ADORA3 (NM_001081976) | |  | Sino Biological Human cDNA Clone for ADORA3 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADORA3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADORA3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADORA3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001609 | G-protein coupled adenosine receptor activity |
IEA | -- | | GO:0004872 | receptor activity |
-- | -- |
ADORA3 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for ADORA3:
Animal Models:
Mouse knock-out Adora3tm1Jbsn for ADORA3
9 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Adora3):
ADORA3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ADORA3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Nucleotide-like (purinergic) receptors | | | 3 | Signaling by GPCR | | | 4 | Signal transduction_IP3 signaling | | | 5 | Development_A3 receptor signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for ADORA3
2  GeneGo (Thomson Reuters) Pathways for ADORA3
3  BioSystems Pathways for ADORA3
5/8 
Reactome Pathways for ADORA3 (see all 8)
1  PharmGKB Pathway for ADORA3
1 
Kegg Pathway (Kegg details for ADORA3):
ADORA3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADORA3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/149 Interacting proteins for ADORA3 (P337653 ENSP000003587304) via UniProtKB, MINT, STRING, and/or I2D (see all 149)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
ADORA3 for ontologies About GeneDecksing
|
Drugs & Compounds
for ADORA3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ADORA3 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for ADORA3 |
Compounds for ADORA3 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| MRS 1220 | Highly potent, selective hA3 antagonist | [183721-15-5] | | 2-Cl-IB-MECA | Highly selective A3 agonist | [163042-96-4] | | IB-MECA | A3 selective agonist | [152918-18-8] | | Staurosporine | Non-selective protein kinase inhibitor | [62996-74-1] |
1 HMDB Compound for ADORA3 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Adenosine | 1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32) | 58-61-7 | -- |
2 DrugBank Compounds for ADORA3 About this table
10/50 Novoseek chemical compound relationships for ADORA3 gene (see all 50) About this table
Search CenterWatch for drugs/clinical trials and news about ADORA3 / AA3R
|
Transcripts
for ADORA3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADORA3 gene (3 alternative transcripts): NM_000677.3 NM_001081976.1 NM_020683.6 Unigene Cluster for ADORA3: Adenosine A3 receptor Hs.281342 [show with all ESTs]Unigene Representative Sequence: NM_00067710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369717(uc001ebg.4) ENST00000414219 ENST00000369716(uc001ebf.3)
ENST00000443498 ENST00000472933 ENST00000442484 ENST00000463993 ENST00000241356(uc001ebh.4)
ENST00000495493 ENST00000486342
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADORA3 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADORA3 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ADORA3 (NM_001081976) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADORA3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADORA3 |
Additional cDNA sequence: AK313095.1 AY136749.1 AY358644.1 BC029831.1 BC041707.1 BC064411.1 JN855714.1 L20463.1 L22607.1 X76981.1 10 DOTS entries: DT.309636 DT.95167280 DT.410375 DT.95167281 DT.92471263 DT.95167272 DT.91680433 DT.97773741 DT.121382674 DT.121382732 24/87 AceView cDNA sequences (see all 87): CA843261 BX093971 BG205723 BQ575272 BI828255 CK903038 AY358644 AA974687 BC041707 AI129184 CD013875 BC064411 BI822569 AI198874 CF456186 NM_020683 BF432324 BX283401 AI338828 AI139115 CD104512 CF147805 AU100171 AI768345
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ADORA3 (see all 12) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | - | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | - | | |
| SP3: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | |
| ExUns: | 10c | ^ | 11a | · | 11b |
|---|
|
| SP1: | - | | | | | | |
| SP2: | - | | | | | | |
| SP3: | - | | | | | | |
| SP4: | - | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for ADORA3
|
Expression
for ADORA3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADORA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCATTGTGGA
About this image
See ADORA3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADORA3
SOURCE GeneReport for Unigene cluster: Hs.281342
SABiosciences Expression via Pathway-Focused PCR Array including ADORA3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADORA3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADORA3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADORA3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADORA3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADORA3 |
Orthologs
for ADORA3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ADORA3 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ADORA31 |
adenosine A3 receptor |
64.97(n)
60.34(a) |
|
373956 NM_204151.1 NP_989482.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ADORA36 |
-- |
27(a) |
1 ↔ 1 |
4(126369526-126371261) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5714101 |
adenosine receptor A3-like |
57.7(n)
51.72(a) |
|
571410 XM_694994.1 XP_700086.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG97533 |
G-protein coupled receptor protein signaling
pathway G-protein coupled receptor less |
32(a) |
|
99D8 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
ador-11 |
Protein ADOR-1 |
42.4(n)
31.62(a) |
|
174890 NM_001047344.1 NP_001040809.1 |
ENSEMBL Gene Tree for ADORA3 (if available)
TreeFam Gene Tree for ADORA3 (if available) |
Paralogs
for ADORA3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADORA3 gene
- ADORA12 GPR1192 ADORA2B2 ADORA2A2
4 SIMAP similar genes for ADORA3 using alignment to 5 protein entries: AA3RB_HUMAN (see all proteins):ADORA1 ADORA2A ADORA2B CD300E
ADORA3 for paralogs About GeneDecksing
|
Genomic Variants
for ADORA3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADORA3 (112025970 - 112106597 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ADORA3
2 Indels: 23947 39647
Human Gene Mutation Database (HGMD): ADORA3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADORA3 |
|
Disorders
/ Diseases
for ADORA3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADORA3 for disorders About GeneDecksing
OMIM gene information: 600445
OMIM disorders: --
20/32  diseases for ADORA3 (see all 32): About MalaCardsischemia thyroiditis brain ischemia coronary heart disease
rheumatoid arthritis glaucoma colon carcinoma urticaria
arthritis crohn's disease astrocytoma hepatitis b
parkinson's disease breast cancer asthma hepatocellular carcinoma
cerebritis thyroid cancer carcinoma psoriasis
10/22 Novoseek disease relationships for ADORA3 gene (see all 22) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pseudoexfoliation syndrome |
47.2 |
1 |
15914619 (1) |
| cerebral ischemia |
43.7 |
3 |
10078988 (1), 10668416 (1), 7821362 (1) |
| ischemia |
41.4 |
5 |
9988118 (1), 12970092 (1), 10355598 (1), 15922260 (1) (see all 5) |
| brain ischemia |
25.5 |
1 |
11462807 (1) |
| glaucoma |
24.9 |
3 |
15203160 (1), 15914619 (1), 15830199 (1) |
| aqueous humor |
21.2 |
3 |
15914619 (1), 15830199 (1) |
| effects cardiovascular |
14.8 |
2 |
9380026 (1) |
| rheumatoid arthritis |
13.3 |
11 |
17216675 (2), 18050382 (2), 16305531 (1), 17922624 (1) (see all 8) |
| arthritis |
12.4 |
7 |
17101059 (1), 17216675 (1), 19639281 (1), 17922624 (1) (see all 5) |
| asthma |
11.8 |
4 |
16300745 (1), 20190146 (1) |
Human Genome Epidemiology (HuGE) Navigator: ADORA3 (11 documents)
Export disorders for ADORA3 gene to outside databases
|
Publications
for ADORA3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADORA3 gene, integrated from 9 sources (see all 212):
(articles sorted by number of sources associating them with ADORA3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of the human A3 adenosine receptor. (PubMed id 8234299)1, 2, 9 Salvatore C.A.... Johnson R.G. (1993)
- cDNA cloning and sequence analysis of the human A3 adenosine receptor. (PubMed id 8399349)1, 2, 9 Sajjadi F.G. and Firestein G.S. (1993)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Molecular phylogenetics and the origins of placental mammals. (PubMed id 11214319)1, 2 Murphy W.J....O'Brien S.J. (2001)
- Localization of the A3 adenosine receptor gene (ADORA3) to human chromosome 1p. (PubMed id 7607699)1, 3 Monitto C.L....Holroyd K.J. (1995)
- Overexpression of A3 adenosine receptor in peripheral blood mononuclear cells in rheumatoid arthritis: involvement of nuclear factor-kappaB in mediating receptor level. (PubMed id 17216675)1, 9 Madi L....Fishman P. (2007)
- Induction of multiple effects on adenylyl cyclase regulation by chronic activation of the human A3 adenosine receptor. (PubMed id 9380026)1, 9 Palmer T.M....Stiles G.L. (1997)
- Cloning, characterisation and chromosomal assignment of the human adenosine A3 receptor (ADORA3) gene. (PubMed id 9293494)1, 9 Atkinson M.R....Schofield P.R. (1997)
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External Searches for ADORA3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing ADORA3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing ADORA3 gene
(According to HUGE)
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Specialized Databases showing ADORA3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for ADORA3 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for ADORA3 gene:
Search GeneIP for patents involving ADORA3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ADORA3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ADORA3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADORA3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADORA3 | | | OriGene Protein Over-expression Lysate for ADORA3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADORA3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADORA3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADORA3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ADORA3 | | OriGene Custom Protein Services for ADORA3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADORA3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADORA3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADORA3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADORA3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADORA3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADORA3 |
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 | | | ADORA3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADORA3 |
|  |  |  | | | | Search ThermoFisher Antibodies for ADORA3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADORA3 |
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