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Aliases for ADM Gene

Aliases for ADM Gene

  • Adrenomedullin 2 3
  • AM 3 4
  • Proadrenomedullin N-20 Terminal Peptide 3
  • Preproadrenomedullin 3
  • PAMP 3

External Ids for ADM Gene

Summaries for ADM Gene

Entrez Gene Summary for ADM Gene

  • The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]

GeneCards Summary for ADM Gene

ADM (Adrenomedullin) is a Protein Coding gene. Diseases associated with ADM include nephrosclerosis and malignant hypertension. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include receptor binding and adrenomedullin receptor binding.

UniProtKB/Swiss-Prot for ADM Gene

  • AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels

Gene Wiki entry for ADM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADM Gene

Genomics for ADM Gene

Genomic Location for ADM Gene

Start:
10,304,680 bp from pter
End:
10,307,397 bp from pter
Size:
2,718 bases
Orientation:
Plus strand

Genomic View for ADM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADM Gene

Proteins for ADM Gene

  • Protein details for ADM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35318-ADML_HUMAN
    Recommended name:
    ADM
    Protein Accession:
    P35318
    Secondary Accessions:
    • B2R793
    • D3DQV3
    • Q6FGW2

    Protein attributes for ADM Gene

    Size:
    185 amino acids
    Molecular mass:
    20420 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADM Gene

neXtProt entry for ADM Gene

Proteomics data for ADM Gene at MOPED

Post-translational modifications for ADM Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Ser49, Ser50, Ser51, Thr54, Thr66, Tyr125, Thr128, Thr162, Ser165, Ser178, and Ser180

Other Protein References for ADM Gene

No data available for DME Specific Peptides for ADM Gene

Domains for ADM Gene

Gene Families for ADM Gene

HGNC:

Protein Domains for ADM Gene

UniProtKB/Swiss-Prot:

ADML_HUMAN
Family:
  • Belongs to the adrenomedullin family.:
    • P35318
genes like me logo Genes that share domains with ADM: view

Function for ADM Gene

Molecular function for ADM Gene

GENATLAS Biochemistry: adrenomedullin downregulated by cMyc
UniProtKB/Swiss-Prot Function: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels

Gene Ontology (GO) - Molecular Function for ADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8074714
GO:0005179 hormone activity IEA --
GO:0005515 protein binding IPI 20074556
GO:0031700 adrenomedullin receptor binding IEA --
genes like me logo Genes that share ontologies with ADM: view
genes like me logo Genes that share phenotypes with ADM: view

Animal Models for ADM Gene

MGI Knock Outs for ADM:

miRNA for ADM Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ADM Gene

Localization for ADM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADM Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADM Gene COMPARTMENTS Subcellular localization image for ADM gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 12379507
GO:0005737 cytoplasm IDA 12379507
genes like me logo Genes that share ontologies with ADM: view

Pathways for ADM Gene

genes like me logo Genes that share pathways with ADM: view

Gene Ontology (GO) - Biological Process for ADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IDA 16964401
GO:0001666 response to hypoxia IEA --
GO:0001843 neural tube closure IEA --
GO:0002026 regulation of the force of heart contraction IEA --
GO:0002031 G-protein coupled receptor internalization IDA 10882736
genes like me logo Genes that share ontologies with ADM: view

Compounds for ADM Gene

(1) HMDB Compounds for ADM Gene

Compound Synonyms Cas Number PubMed IDs
Aldosterone
  • (+)-Aldosterone
52-39-1

(110) Novoseek inferred chemical compound relationships for ADM Gene

Compound -log(P) Hits PubMed IDs
bibn 4096 bs 74.5 5
peptidylglycine 68.3 6
omapatrilat 61.5 11
nitric oxide 58.2 214
ac 187 57.9 3

(1) PharmGKB related drug/compound annotations for ADM Gene

Drug/compound Annotation
paroxetine CA
genes like me logo Genes that share compounds with ADM: view

Transcripts for ADM Gene

Unigene Clusters for ADM Gene

Adrenomedullin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADM Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5:
SP6:

Relevant External Links for ADM Gene

GeneLoc Exon Structure for
ADM
ECgene alternative splicing isoforms for
ADM

Expression for ADM Gene

mRNA expression in normal human tissues for ADM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADM Gene

This gene is overexpressed in Whole Blood (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADM Gene

SOURCE GeneReport for Unigene cluster for ADM Gene Hs.441047

mRNA Expression by UniProt/SwissProt for ADM Gene

P35318-ADML_HUMAN
Tissue specificity: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues
genes like me logo Genes that share expressions with ADM: view

Orthologs for ADM Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADM 36
  • 100 (n)
  • 100 (a)
ADM 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADM 36
  • 84.29 (n)
  • 87.93 (a)
bta-mir-6518 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADM 36
  • 86.74 (n)
  • 86.36 (a)
ADM 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adm 36
  • 75.29 (n)
  • 69.54 (a)
Adm 16
Adm 37
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADM 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADM 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adm 36
  • 78.48 (n)
  • 73.71 (a)
chicken
(Gallus gallus)
Aves ADM 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adm 36
  • 56.55 (n)
  • 46.21 (a)
Str.12882 36
zebrafish
(Danio rerio)
Actinopterygii adma 37
  • 28 (a)
OneToOne
Species with no ortholog for ADM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADM Gene

ENSEMBL:
Gene Tree for ADM (if available)
TreeFam:
Gene Tree for ADM (if available)

Paralogs for ADM Gene

No data available for Paralogs for ADM Gene

Variants for ADM Gene

Sequence variations from dbSNP and Humsavar for ADM Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs5000 -- 10,304,144(+) TCCTT(G/T)CCTGA upstream-variant-2KB
rs5001 -- 10,304,714(+) CTGTT(C/T)TTCGC upstream-variant-2KB
rs5002 -- 10,304,974(+) CGCGC(A/G)TGGCT upstream-variant-2KB
rs5003 -- 10,305,190(+) TGAGA(C/T)TTTCT utr-variant-5-prime
rs5004 -- 10,305,751(+) TTCCT(A/C/G)GGCGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ADM Gene

Variant ID Type Subtype PubMed ID
nsv483076 CNV Complex 15286789

Relevant External Links for ADM Gene

HapMap Linkage Disequilibrium report
ADM
Human Gene Mutation Database (HGMD)
ADM

Disorders for ADM Gene

(4) University of Copenhagen DISEASES for ADM Gene

(95) Novoseek inferred disease relationships for ADM Gene

Disease -log(P) Hits PubMed IDs
pheochromocytoma 83.8 139
heart failure 55.5 141
essential hypertension 50.8 34
hypertension pulmonary 49.4 56
heart failure congestive 49.1 39

Relevant External Links for ADM

Genetic Association Database (GAD)
ADM
Human Genome Epidemiology (HuGE) Navigator
ADM
genes like me logo Genes that share disorders with ADM: view

No data available for UniProtKB/Swiss-Prot for ADM Gene

Publications for ADM Gene

  1. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. (PMID: 7688224) Kitamura K. … Eto T. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 23
  2. Proadrenomedullin-derived peptides. (PMID: 9578982) Samson W.K. (Front. Neuroendocrinol. 1998) 3 4 23
  3. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. (PMID: 8387282) Kitamura K. … Eto T. (Biochem. Biophys. Res. Commun. 1993) 3 4 23
  4. Microsatellite DNA polymorphism of human adrenomedullin gene in type 2 diabetic patients with renal failure. (PMID: 12753312) Ishimitsu T. … Matsuoka H. (Kidney Int. 2003) 3 23 49
  5. Haplotype-based case-control study revealing an association between the adrenomedullin gene and proteinuria in subjects with essential hypertension. (PMID: 16097366) Kobayashi Y. … Soma M. (Hypertens. Res. 2005) 3 23 49

Products for ADM Gene

  • Addgene plasmids for ADM

Sources for ADM Gene

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