Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EIF1 Gene

Aliases for EIF1 Gene

  • Eukaryotic Translation Initiation Factor 1 2 3 5
  • Protein Translation Factor SUI1 Homolog 3 4
  • Sui1iso1 3 4
  • A121 3 4
  • SUI1 3 4
  • EIF-1 3
  • EIF1A 3
  • ISO1 3
  • EIF1 4

External Ids for EIF1 Gene

Previous GeneCards Identifiers for EIF1 Gene

  • GC00U990093
  • GC17P037099
  • GC17P039845
  • GC17P035607

Summaries for EIF1 Gene

GeneCards Summary for EIF1 Gene

EIF1 (Eukaryotic Translation Initiation Factor 1) is a Protein Coding gene. Among its related pathways are RNA transport and Translational Control. GO annotations related to this gene include poly(A) RNA binding and translation factor activity, RNA binding. An important paralog of this gene is EIF1B.

UniProtKB/Swiss-Prot for EIF1 Gene

  • Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.

Gene Wiki entry for EIF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF1 Gene

Genomics for EIF1 Gene

Regulatory Elements for EIF1 Gene

Enhancers for EIF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G041645 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7.5 -43.0 -42990 1.3 HDAC1 HDGF ATF1 NFRKB ZNF2 ZNF366 CREM SMARCC1 ZNF592 MAFF EIF1 C17orf113 DHX58 NKIRAS2 KRT42P ENSG00000278954
GH17G041674 2 FANTOM5 Ensembl ENCODE dbSUPER 6.3 -11.2 -11167 5.6 HNRNPUL1 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 SIN3A YBX1 ZNF2 ENSG00000267758 TTC25 DHX58 EIF1 HAP1 RAB5C KRT13 NKIRAS2 DNAJC7 GC17M041665
GH17G041673 1.1 FANTOM5 ENCODE 4.8 -15.5 -15456 1.0 PKNOX1 DDX20 BACH1 ZNF175 CEBPG RELA ELK1 NCOR1 ZSCAN29 ZNF639 HAP1 EIF1 RAB5C NKIRAS2 DHX58 GC17M041665
GH17G041672 0.8 FANTOM5 6.6 -16.5 -16452 0.2 HLF CEBPB YY1 ZNF7 RARA NFIL3 HNF1A JUND ATF3 CEBPA EIF1 RAB5C NKIRAS2 DHX58 DNAJC7 GC17M041665
GH17G041512 1 Ensembl dbSUPER 4.5 -176.0 -175975 0.2 HDGF NFRKB ZBTB40 ZNF335 ZNF366 EGR1 POLR2A ZNF600 EZH2 NRF1 EIF1 MIR6510 KRT13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF1 on UCSC Golden Path with GeneCards custom track

Promoters for EIF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094274 325 2001 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3

Genomic Location for EIF1 Gene

41,688,875 bp from pter
41,692,668 bp from pter
3,794 bases
Plus strand

Genomic View for EIF1 Gene

Genes around EIF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF1 Gene

Proteins for EIF1 Gene

  • Protein details for EIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Eukaryotic translation initiation factor 1
    Protein Accession:
    Secondary Accessions:
    • Q9UNQ9

    Protein attributes for EIF1 Gene

    113 amino acids
    Molecular mass:
    12732 Da
    Quaternary structure:
    • Interacts with RENT2.

    Three dimensional structures from OCA and Proteopedia for EIF1 Gene

neXtProt entry for EIF1 Gene

Post-translational modifications for EIF1 Gene

  • Ubiquitination at Lys91
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF1 Gene

Domains & Families for EIF1 Gene

Protein Domains for EIF1 Gene

Suggested Antigen Peptide Sequences for EIF1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SUI1 family.
  • Belongs to the SUI1 family.
genes like me logo Genes that share domains with EIF1: view

No data available for Gene Families for EIF1 Gene

Function for EIF1 Gene

Molecular function for EIF1 Gene

UniProtKB/Swiss-Prot Function:
Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.

Gene Ontology (GO) - Molecular Function for EIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0003743 translation initiation factor activity NAS,IEA 10347211
GO:0008135 translation factor activity, RNA binding TAS 10347211
genes like me logo Genes that share ontologies with EIF1: view
genes like me logo Genes that share phenotypes with EIF1: view

Animal Model Products

CRISPR Products

miRNA for EIF1 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF1 Gene

Localization for EIF1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF1 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for EIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12426392
GO:0005737 cytoplasm IDA 12426392
genes like me logo Genes that share ontologies with EIF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF1 Gene

Pathways & Interactions for EIF1 Gene

genes like me logo Genes that share pathways with EIF1: view

Pathways by source for EIF1 Gene

1 Cell Signaling Technology pathway for EIF1 Gene
1 BioSystems pathway for EIF1 Gene
1 KEGG pathway for EIF1 Gene

Gene Ontology (GO) - Biological Process for EIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0006446 regulation of translational initiation IDA 22156057
GO:0006950 response to stress NAS 10347211
GO:0009048 dosage compensation by inactivation of X chromosome IEA --
genes like me logo Genes that share ontologies with EIF1: view

No data available for SIGNOR curated interactions for EIF1 Gene

Drugs & Compounds for EIF1 Gene

(2) Additional Compounds for EIF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EIF1: view

Transcripts for EIF1 Gene

Unigene Clusters for EIF1 Gene

Eukaryotic translation initiation factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: - -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for EIF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EIF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF1 Gene

Protein differential expression in normal tissues from HIPED for EIF1 Gene

This gene is overexpressed in Fetal ovary (8.7), NK cells (7.6), and Spinal cord (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF1 Gene

Protein tissue co-expression partners for EIF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of EIF1 Gene:


SOURCE GeneReport for Unigene cluster for EIF1 Gene:


Evidence on tissue expression from TISSUES for EIF1 Gene

  • Nervous system(5)
  • Eye(4.9)
  • Lung(4.9)
  • Pancreas(4.7)
  • Skin(4.3)
  • Muscle(4.2)
  • Intestine(4)
  • Liver(4)
  • Heart(3.9)
  • Blood(3.8)
  • Kidney(3.7)
  • Stomach(3)
  • Bone marrow(2.9)
  • Adrenal gland(2.5)
  • Gall bladder(2.5)
  • Lymph node(2.4)
  • Spleen(2.4)
  • Thyroid gland(2.4)
  • Bone(2.2)
genes like me logo Genes that share expression patterns with EIF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF1 Gene

Orthologs for EIF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EIF1 34 35
  • 100 (n)
(Canis familiaris)
Mammalia SUI1ISO1 35
  • 100 (a)
EIF1 34
  • 97.94 (n)
(Mus musculus)
Mammalia Eif1 35
  • 99 (a)
(Bos Taurus)
Mammalia EIF1 34 35
  • 97.94 (n)
(Rattus norvegicus)
Mammalia Eif1l1 34
  • 97.64 (n)
(Monodelphis domestica)
Mammalia EIF1 35
  • 43 (a)
(Gallus gallus)
Aves EIF1 34 35
  • 89.68 (n)
(Anolis carolinensis)
Reptilia EIF1 35
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia eif1 34
  • 77.88 (n)
(Danio rerio)
Actinopterygii eif1b 34 35
  • 82.01 (n)
wufb54a12 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11829 34
fruit fly
(Drosophila melanogaster)
Insecta CG17737 35
  • 71 (a)
(Caenorhabditis elegans)
Secernentea eif-1 35
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUI1 35
  • 61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6142 35
  • 67 (a)
Species where no ortholog for EIF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF1 Gene

Gene Tree for EIF1 (if available)
Gene Tree for EIF1 (if available)

Paralogs for EIF1 Gene

Paralogs for EIF1 Gene

(3) SIMAP similar genes for EIF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EIF1: view

Variants for EIF1 Gene

Sequence variations from dbSNP and Humsavar for EIF1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000229444 -- 41,690,429(+) AGATG(C/G)ATTGT intron-variant
rs1000261615 -- 41,689,272(+) TAGGT(C/G)AGCCC intron-variant
rs1000558790 -- 41,689,376(+) CCGTT(A/G)CGTCA intron-variant
rs1001668086 -- 41,687,025(+) TACCT(A/C)CTTTT upstream-variant-2KB
rs1002244211 -- 41,687,727(+) AGCCG(-/AC)ACAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EIF1 Gene

Variant ID Type Subtype PubMed ID
esv2758690 CNV gain+loss 17122850
nsv1146669 OTHER inversion 26484159
nsv960105 CNV duplication 23825009

Variation tolerance for EIF1 Gene

Residual Variation Intolerance Score: 50.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF1 Gene

Disorders for EIF1 Gene

Relevant External Links for EIF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EIF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF1 Gene

Publications for EIF1 Gene

  1. Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1 (eIF1(A121/SUI1)). (PMID: 10347211) Sheikh M.S. … Fornace A.J. Jr. (J. Biol. Chem. 1999) 2 3 4 64
  2. Expressed sequence tags identify a human isolog of the suil translation initiation factor. (PMID: 7904817) Fields C.A. … Adams M.D. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. (PMID: 11073994) Mendell J.T. … Dietz H.C. (Mol. Cell. Biol. 2000) 3 4 64
  5. Structure and interactions of the translation initiation factor eIF1. (PMID: 10228174) Fletcher C.M. … Wagner G. (EMBO J. 1999) 3 4 64

Products for EIF1 Gene

Sources for EIF1 Gene

Loading form....