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Aliases for MIR31 Gene

Subcategory (RNA class) for MIR31 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR31 Gene

  • MicroRNA 31 2 3 5
  • Hsa-Mir-31 3
  • MiR-31 3
  • MIRN31 3

External Ids for MIR31 Gene

Previous HGNC Symbols for MIR31 Gene

  • MIRN31

Summaries for MIR31 Gene

Entrez Gene Summary for MIR31 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR31 Gene

MIR31 (MicroRNA 31) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miR-148a/miR-31/FIH1/HIF1andalpha;-Notch signaling in glioblastoma and MicroRNAs in cancer.

Additional gene information for MIR31 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR31 Gene

Genomics for MIR31 Gene

Regulatory Elements for MIR31 Gene

Enhancers for MIR31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H021573 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -71.7 -71731 20 PKNOX1 SIN3A FEZF1 GTF3C2 ZNF121 FOS RUNX3 DEK TSHZ1 MAFF FOCAD MIR31 IFNW1 IFNA1 IFNA6 MIR31HG ENSG00000227443
GH09H021674 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10 -170.4 -170411 16 ELF3 TBP FOXA2 SIN3A FEZF1 RAD21 ZNF366 ZSCAN5C SCRT2 FOS MIR31 MTAP CDKN2A KHSRPP1 ENSG00000227443
GH09H021547 1.4 Ensembl ENCODE dbSUPER 11 -42.8 -42799 14 SIN3A FEZF1 ZNF2 ZNF121 GLIS2 ZNF302 FOS MAFF GLIS1 SP7 MIR31 IFNE MIR31HG GC09M021524
GH09H021605 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -93.7 -93659 0 STAT3 CEBPB ZNF398 EP300 PRDM4 ZNF518A MIR31 ENSG00000227443 MIR31HG
GH09H021787 1.3 Ensembl ENCODE dbSUPER 10.1 -276.8 -276843 2 ELF3 CTCF MXI1 FOXA2 RB1 ARID4B SIN3A MAX ZNF384 RAD21 MTAP MIR31 RN7SL151P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR31 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR31 Gene

Chromosome:
9
Start:
21,512,115 bp from pter
End:
21,512,185 bp from pter
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR31 Gene

Genes around MIR31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR31 Gene

ORGUL Member Location for MIR31 Gene

ORGUL Member Location for MIR31 gene

Proteins for MIR31 Gene

Post-translational modifications for MIR31 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR31 Gene

Domains & Families for MIR31 Gene

Gene Families for MIR31 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR31: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR31 Gene

Function for MIR31 Gene

Phenotypes From GWAS Catalog for MIR31 Gene

Gene Ontology (GO) - Molecular Function for MIR31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 19949084
genes like me logo Genes that share ontologies with MIR31: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Addgene plasmids for MIR31
  • Applied Biological Materials Clones for MIR31
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR31 Gene

Localization for MIR31 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR31 Gene

Pathways & Interactions for MIR31 Gene

genes like me logo Genes that share pathways with MIR31: view

Pathways by source for MIR31 Gene

1 KEGG pathway for MIR31 Gene

Interacting Proteins for MIR31 Gene

Gene Ontology (GO) - Biological Process for MIR31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 19949084
GO:0035278 miRNA mediated inhibition of translation IDA 20826792
GO:0050728 negative regulation of inflammatory response IC 19949084
GO:0071356 cellular response to tumor necrosis factor IDA 19949084
GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell IDA 19949084
genes like me logo Genes that share ontologies with MIR31: view

No data available for SIGNOR curated interactions for MIR31 Gene

Drugs & Compounds for MIR31 Gene

No Compound Related Data Available

Transcripts for MIR31 Gene

mRNA/cDNA for MIR31 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Addgene plasmids for MIR31
  • Applied Biological Materials Clones for MIR31
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR31 Gene

No ASD Table

Relevant External Links for MIR31 Gene

GeneLoc Exon Structure for
MIR31
ECgene alternative splicing isoforms for
MIR31

Expression for MIR31 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR31 Gene:

MIR31
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR31 Gene

Orthologs for MIR31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-31 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-31 34
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-31 34
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-31 34
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir31 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-31 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-31 34
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-31 34
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-31 34
  • 75 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-31 34
  • 49 (a)
OneToOne
Species where no ortholog for MIR31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR31 Gene

ENSEMBL:
Gene Tree for MIR31 (if available)
TreeFam:
Gene Tree for MIR31 (if available)

Paralogs for MIR31 Gene

No data available for Paralogs for MIR31 Gene

Variants for MIR31 Gene

Sequence variations from dbSNP and Humsavar for MIR31 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000089385 -- 21,512,910(+) CTGGT(A/C)TCAAA intron-variant, upstream-variant-2KB
rs1000272794 -- 21,512,701(+) TTGGA(-/T)TTTTT intron-variant, upstream-variant-2KB
rs1001342027 -- 21,513,782(+) TGTAA(C/G)GGTAT intron-variant, upstream-variant-2KB
rs1003730730 -- 21,512,389(+) TTAAT(A/G)GTCTT intron-variant, upstream-variant-2KB
rs1004893229 -- 21,512,563(+) CAGTA(C/T)AATTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR31 Gene

Variant ID Type Subtype PubMed ID
dgv7475n100 CNV loss 25217958
esv2759680 CNV loss 17122850
esv2764150 CNV gain+loss 21179565

Relevant External Links for MIR31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR31 Gene

Disorders for MIR31 Gene

Relevant External Links for MIR31

Human Genome Epidemiology (HuGE) Navigator
MIR31
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR31

No disorders were found for MIR31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR31 Gene

Publications for MIR31 Gene

  1. Increased expression of microRNA-31-5p inhibits cell proliferation, migration, and invasion via regulating Sp1 transcription factor in HepG2 hepatocellular carcinoma cell line. (PMID: 28623129) Zhao G … Xu J (Biochemical and biophysical research communications 2017) 3 60
  2. Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact. (PMID: 28122331) Kuasne H … Rogatto SR (Oncotarget 2017) 3 60
  3. Klf4 inhibits tumor growth and metastasis by targeting microRNA-31 in human hepatocellular carcinoma. (PMID: 27909734) Tian C … Li Q (International journal of molecular medicine 2017) 3 60
  4. MiR-31 Functions as a Tumor Suppressor in Lung Adenocarcinoma Mainly by Targeting HuR. (PMID: 27215092) Xu H … Xu S (Clinical laboratory 2016) 3 60
  5. MicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers. (PMID: 27082577) Choi YW … Lee D (Medicine 2016) 3 60

Products for MIR31 Gene

Sources for MIR31 Gene

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