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Aliases for MIR17 Gene

Subcategory (RNA class) for MIR17 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR17 Gene

  • MicroRNA 17 2 3 5
  • Hsa-Mir-17 3
  • MIR17-5p 3
  • MiR17-3p 3
  • MiRNA17 3
  • MiRNA91 3
  • MIRN91 3
  • MiR-17 3
  • MIRN17 3
  • MIR91 3

External Ids for MIR17 Gene

Previous HGNC Symbols for MIR17 Gene

  • MIRN17

Previous GeneCards Identifiers for MIR17 Gene

  • GC13P090870
  • GC13P090878
  • GC13P092002

Summaries for MIR17 Gene

Entrez Gene Summary for MIR17 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR17 Gene

MIR17 (MicroRNA 17) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR17 include Pediatric Systemic Lupus Erythematosus and Polycystic Kidney Disease 2. Among its related pathways are Parkinsons Disease Pathway and DNA Damage Response.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR17 Gene

Genomics for MIR17 Gene

Regulatory Elements for MIR17 Gene

Enhancers for MIR17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G091346 1.3 ENCODE dbSUPER 0.7 -1.6 -1573 4.8 HNRNPUL1 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 CBX5 GPC5 MIR17 MIR17HG GC13P091382
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR17 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR17 Gene

Chromosome:
13
Start:
91,350,605 bp from pter
End:
91,350,688 bp from pter
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR17 Gene

Genes around MIR17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR17 Gene

Proteins for MIR17 Gene

Post-translational modifications for MIR17 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR17 Gene

Domains & Families for MIR17 Gene

Gene Families for MIR17 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR17: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR17 Gene

Function for MIR17 Gene

Animal Model Products

miRNA Products

Clone Products

  • Addgene plasmids for MIR17

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR17 Gene

Localization for MIR17 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR17 Gene

Pathways & Interactions for MIR17 Gene

genes like me logo Genes that share pathways with MIR17: view

Pathways by source for MIR17 Gene

1 KEGG pathway for MIR17 Gene

Interacting Proteins for MIR17 Gene

Gene Ontology (GO) - Biological Process for MIR17 Gene

None

No data available for SIGNOR curated interactions for MIR17 Gene

Drugs & Compounds for MIR17 Gene

No Compound Related Data Available

Transcripts for MIR17 Gene

mRNA/cDNA for MIR17 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

  • Addgene plasmids for MIR17

Alternative Splicing Database (ASD) splice patterns (SP) for MIR17 Gene

No ASD Table

Relevant External Links for MIR17 Gene

GeneLoc Exon Structure for
MIR17
ECgene alternative splicing isoforms for
MIR17

Expression for MIR17 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR17 Gene:

MIR17
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR17 Gene

Orthologs for MIR17 Gene

Evolution for MIR17 Gene

ENSEMBL:
Gene Tree for MIR17 (if available)
TreeFam:
Gene Tree for MIR17 (if available)

No data available for Orthologs for MIR17 Gene

Paralogs for MIR17 Gene

No data available for Paralogs for MIR17 Gene

Variants for MIR17 Gene

Sequence variations from dbSNP and Humsavar for MIR17 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1002349918 -- 91,351,188(+) GTTAC(G/T)GAACA intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs1002944928 -- 91,349,535(+) TATTG(A/G)GCTTT intron-variant, upstream-variant-2KB
rs1003385207 -- 91,349,835(+) GTTGA(A/G)TAAAT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1004372915 -- 91,349,113(+) TCCCC(C/G)TTGTG intron-variant, upstream-variant-2KB
rs1004434983 -- 91,349,440(+) ATCAT(A/T)ATCAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR17 Gene

Variant ID Type Subtype PubMed ID
nsv832679 CNV gain 17160897

Relevant External Links for MIR17 Gene

Human Gene Mutation Database (HGMD)
MIR17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR17 Gene

Disorders for MIR17 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR17 Gene - From: GeneCards

Disorder Aliases PubMed IDs
pediatric systemic lupus erythematosus
  • sle, pediatric onset
polycystic kidney disease 2
  • polycystic kidney disease, adult, type ii
familial breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search MIR17 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MIR17

Genetic Association Database (GAD)
MIR17
Human Genome Epidemiology (HuGE) Navigator
MIR17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR17
genes like me logo Genes that share disorders with MIR17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR17 Gene

Publications for MIR17 Gene

  1. Association between hsa-mir-146a genotype and tumor age-of-onset in BRCA1/BRCA2-negative familial breast and ovarian cancer patients. (PMID: 20810544) Pastrello C. … Maestro R. (Carcinogenesis 2010) 3 46 64
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 46 64
  3. Inhibition of Beclin-1-Mediated Autophagy by MicroRNA-17-5p Enhanced the Radiosensitivity of Glioma Cells. (PMID: 28081732) Hou W. … Zhang S. (Oncol. Res. 2017) 3 64
  4. miR-17 inhibits ovarian cancer cell peritoneal metastasis by targeting ITGA5 and ITGB1. (PMID: 27499367) Gong C. … Gong W. (Oncol. Rep. 2016) 3 64
  5. Upregulated miR-17 Regulates Hypoxia-Mediated Human Pulmonary Artery Smooth Muscle Cell Proliferation and Apoptosis by Targeting Mitofusin 2. (PMID: 27640178) Lu Z. … Fa X. (Med. Sci. Monit. 2016) 3 64

Products for MIR17 Gene

Sources for MIR17 Gene

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