Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LMNB2 Gene

Aliases for LMNB2 Gene

  • Lamin B2 2 3
  • LMN2 3 4 6
  • Lamin B3 3
  • Lamin-B2 3
  • LAMB2 3

External Ids for LMNB2 Gene

Previous HGNC Symbols for LMNB2 Gene

  • LMN2

Previous GeneCards Identifiers for LMNB2 Gene

  • GC19U990060
  • GC19M002498
  • GC19M002368
  • GC19M002379
  • GC19M002200

Summaries for LMNB2 Gene

Entrez Gene Summary for LMNB2 Gene

  • This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012]

GeneCards Summary for LMNB2 Gene

LMNB2 (Lamin B2) is a Protein Coding gene. Diseases associated with LMNB2 include lipodystrophy, partial, acquired and reynolds syndrome. Among its related pathways are PI3K-Akt signaling pathway and Pathways in cancer. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is NEFM.

UniProtKB/Swiss-Prot for LMNB2 Gene

  • Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMNB2 Gene

Genomics for LMNB2 Gene

Regulatory Elements for LMNB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LMNB2 Gene

2,427,638 bp from pter
2,456,996 bp from pter
29,359 bases
Minus strand

Genomic View for LMNB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LMNB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMNB2 Gene

Proteins for LMNB2 Gene

  • Protein details for LMNB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O75292
    • Q14734
    • Q96DF6

    Protein attributes for LMNB2 Gene

    600 amino acids
    Molecular mass:
    67689 Da
    Quaternary structure:
    • Interacts with TMEM43.
    • The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively

    Three dimensional structures from OCA and Proteopedia for LMNB2 Gene

neXtProt entry for LMNB2 Gene

Proteomics data for LMNB2 Gene at MOPED

Post-translational modifications for LMNB2 Gene

  • B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations
  • Ubiquitination at Lys57, Lys61, Lys103, Lys130, Lys150, Lys255, Lys265, Lys278, Lys306, Lys373, Lys383, Lys496, and Lys500
  • Modification sites at PhosphoSitePlus

Other Protein References for LMNB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LMNB2 (Lamin B2)

No data available for DME Specific Peptides for LMNB2 Gene

Domains for LMNB2 Gene

Gene Families for LMNB2 Gene

  • IFF5 :Intermediate filaments type V, lamins

Suggested Antigen Peptide Sequences for LMNB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q03252
  • Contains 1 LTD domain.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with LMNB2: view

Function for LMNB2 Gene

Molecular function for LMNB2 Gene

GENATLAS Biochemistry:
lamin,type B2
UniProtKB/Swiss-Prot Function:
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin

Gene Ontology (GO) - Molecular Function for LMNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with LMNB2: view
genes like me logo Genes that share phenotypes with LMNB2: view

Animal Models for LMNB2 Gene

MGI Knock Outs for LMNB2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LMNB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LMNB2 Gene

Localization for LMNB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMNB2 Gene

Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.

Subcellular locations from

Jensen Localization Image for LMNB2 Gene COMPARTMENTS Subcellular localization image for LMNB2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for LMNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope --
GO:0005637 nuclear inner membrane IEA --
GO:0005638 lamin filament IEA --
GO:0005882 intermediate filament --
genes like me logo Genes that share ontologies with LMNB2: view

Pathways for LMNB2 Gene

genes like me logo Genes that share pathways with LMNB2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for LMNB2 Gene

Selected Interacting proteins: Q03252-LMNB2_HUMAN for LMNB2 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for LMNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LMNB2: view

Compounds for LMNB2 Gene

(2) Novoseek inferred chemical compound relationships for LMNB2 Gene

Compound -log(P) Hits PubMed IDs
dihydrofolate 32.3 1
serine 3 1
genes like me logo Genes that share compounds with LMNB2: view

Transcripts for LMNB2 Gene

Unigene Clusters for LMNB2 Gene

Lamin B2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LMNB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMNB2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: -

Relevant External Links for LMNB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LMNB2 Gene

mRNA expression in normal human tissues for LMNB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for LMNB2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.4) and Retina (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for LMNB2 Gene

SOURCE GeneReport for Unigene cluster for LMNB2 Gene Hs.538286

genes like me logo Genes that share expressions with LMNB2: view

Expression partners for LMNB2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LMNB2 Gene

Orthologs for LMNB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LMNB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LMNB2 35
  • 85.59 (n)
  • 87.1 (a)
LMNB2 36
  • 88 (a)
(Canis familiaris)
Mammalia LMNB2 35
  • 87.78 (n)
  • 89.1 (a)
LMNB2 36
  • 91 (a)
(Mus musculus)
Mammalia Lmnb2 35
  • 82.29 (n)
  • 84.43 (a)
Lmnb2 16
Lmnb2 36
  • 84 (a)
(Pan troglodytes)
Mammalia LMNB2 35
  • 99.44 (n)
  • 99.44 (a)
LMNB2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Lmnb2 35
  • 81.26 (n)
  • 82.03 (a)
(Monodelphis domestica)
Mammalia LMNB2 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia LMNB2 36
  • 77 (a)
(Gallus gallus)
Aves LMNB2 35
  • 74.3 (n)
  • 80.3 (a)
LMNB2 36
  • 80 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lmnb2 35
  • 68.02 (n)
  • 74.87 (a)
(Danio rerio)
Actinopterygii lmnb2 35
  • 71.36 (n)
  • 69.93 (a)
lmnb2 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3871 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011938 35
  • 40.07 (n)
  • 23.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta LamC 35
  • 51.18 (n)
  • 38.62 (a)
Lam 36
  • 36 (a)
LamC 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea ifb-1 35
  • 43.74 (n)
  • 32.86 (a)
lmn-1 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8283 36
  • 38 (a)
Species with no ortholog for LMNB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LMNB2 Gene

Gene Tree for LMNB2 (if available)
Gene Tree for LMNB2 (if available)

Paralogs for LMNB2 Gene

Paralogs for LMNB2 Gene

Selected SIMAP similar genes for LMNB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LMNB2: view

Variants for LMNB2 Gene

Sequence variations from dbSNP and Humsavar for LMNB2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs733820 -- 2,432,075(+) ACCAG(A/G)GTTCA intron-variant
rs733821 -- 2,432,179(+) GGGGA(C/T)GCCTG intron-variant
rs736704 -- 2,432,705(-) GTGAC(A/G)GGGCC intron-variant
rs736705 -- 2,432,557(-) CCTGG(C/T)GGCTG intron-variant
rs743578 -- 2,430,234(+) TGGCC(C/T)TGCAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LMNB2 Gene

Variant ID Type Subtype PubMed ID
nsv910623 CNV Loss 21882294
dgv3636n71 CNV Loss 21882294
dgv3637n71 CNV Loss 21882294
nsv910655 CNV Loss 21882294
dgv3638n71 CNV Loss 21882294
nsv910660 CNV Loss 21882294
dgv3639n71 CNV Loss 21882294
nsv910665 CNV Loss 21882294
nsv910667 CNV Loss 21882294
esv2717892 CNV Deletion 23290073
esv2717893 CNV Deletion 23290073
esv23012 CNV Loss 19812545
esv2717894 CNV Deletion 23290073
esv1372661 CNV Deletion 17803354
esv2717896 CNV Deletion 23290073

Relevant External Links for LMNB2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMNB2 Gene

Disorders for LMNB2 Gene

(1) OMIM Diseases for LMNB2 Gene (150341)


  • Partial acquired lipodystrophy (APLD) [MIM:608709]: A rare childhood disease characterized by loss of subcutaneous fat from the face and trunk. Fat deposition on the pelvic girdle and lower limbs is normal or excessive. Most frequently, onset between 5 and 15 years of age. Most affected subjects are females and some show no other abnormality, but many develop glomerulonephritis, diabetes mellitus, hyperlipidemia, and complement deficiency. Mental retardation in some cases. APLD is a sporadic disorder of unknown etiology. {ECO:0000269 PubMed:16826530}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for LMNB2 Gene

(1) Novoseek inferred disease relationships for LMNB2 Gene

Disease -log(P) Hits PubMed IDs
partial lipodystrophy 83.6 1

Relevant External Links for LMNB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LMNB2: view

No data available for Genatlas for LMNB2 Gene

Publications for LMNB2 Gene

  1. The gene for a novel human lamin maps at a highly transcribed locus of chromosome 19 which replicates at the onset of S-phase. (PMID: 1630457) Biamonti G. … Falaschi A. (Mol. Cell. Biol. 1992) 2 3 4 23
  2. Sequencing of the reannotated LMNB2 gene reveals novel mutations in patients with acquired partial lipodystrophy. (PMID: 16826530) Hegele R.A. … Durrington P.N. (Am. J. Hum. Genet. 2006) 3 4 23
  3. The stability of the nuclear lamina polymer changes with the composition of lamin subtypes according to their individual binding strengths. (PMID: 15284226) Schirmer E.C. … Gerace L. (J. Biol. Chem. 2004) 3 23
  4. Ku80 binds to human replication origins prior to the assembly of the ORC complex. (PMID: 15910003) Sibani S. … Zannis-Hadjopoulos M. (Biochemistry 2005) 3 23
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4

Products for LMNB2 Gene

  • Addgene plasmids for LMNB2

Sources for LMNB2 Gene

Back to Top