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Aliases for LDHA Gene

Aliases for LDHA Gene

  • Lactate Dehydrogenase A 2 3
  • Cell Proliferation-Inducing Gene 19 Protein 3 4
  • Renal Carcinoma Antigen NY-REN-59 3 4
  • LDH Muscle Subunit 3 4
  • EC 1.1.1.27 4 63
  • LDH-A 3 4
  • LDH-M 3 4
  • Epididymis Secretory Sperm Binding Protein Li 133P 3
  • Proliferation-Inducing Gene 19 3
  • Lactate Dehydrogenase M 3
  • HEL-S-133P 3
  • EC 1.1.1 63
  • GSD11 3
  • PIG19 3
  • LDHM 3

External Ids for LDHA Gene

Previous GeneCards Identifiers for LDHA Gene

  • GC11P019537
  • GC11P019358
  • GC11P018455
  • GC11P018380
  • GC11P018372
  • GC11P018101

Summaries for LDHA Gene

Entrez Gene Summary for LDHA Gene

  • The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for LDHA Gene

LDHA (Lactate Dehydrogenase A) is a Protein Coding gene. Diseases associated with LDHA include glycogen storage disease due to lactate dehydrogenase m-subunit deficiency and fanconi-bickel syndrome. Among its related pathways are Central carbon metabolism in cancer and Metabolism. GO annotations related to this gene include oxidoreductase activity and L-lactate dehydrogenase activity. An important paralog of this gene is LDHC.

Gene Wiki entry for LDHA Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDHA Gene

Genomics for LDHA Gene

Regulatory Elements for LDHA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LDHA Gene

Chromosome:
11
Start:
18,394,388 bp from pter
End:
18,408,425 bp from pter
Size:
14,038 bases
Orientation:
Plus strand

Genomic View for LDHA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LDHA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDHA Gene

Proteins for LDHA Gene

  • Protein details for LDHA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00338-LDHA_HUMAN
    Recommended name:
    L-lactate dehydrogenase A chain
    Protein Accession:
    P00338
    Secondary Accessions:
    • B4DKQ2
    • B7Z5E3
    • D3DQY3
    • F8W819
    • Q53G53
    • Q6IBM7
    • Q6ZNV1
    • Q9UDE8
    • Q9UDE9

    Protein attributes for LDHA Gene

    Size:
    332 amino acids
    Molecular mass:
    36689 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for LDHA Gene

    Alternative splice isoforms for LDHA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LDHA Gene

Proteomics data for LDHA Gene at MOPED

Post-translational modifications for LDHA Gene

  • ISGylated.
  • Ubiquitination at Lys 5, Lys 14, Lys 59, Lys 76, Lys 118, Lys 126, Lys 132, Lys 278, Lys 318, Lys 328, and Lys 27
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for LDHA (Lactate Dehydrogenase A/LDHA)
  • Cell Signaling Technology (CST) Antibodies for LDHA (LDH-A)

Domains & Families for LDHA Gene

Graphical View of Domain Structure for InterPro Entry

P00338

UniProtKB/Swiss-Prot:

LDHA_HUMAN :
  • Belongs to the LDH/MDH superfamily. LDH family.
Family:
  • Belongs to the LDH/MDH superfamily. LDH family.
genes like me logo Genes that share domains with LDHA: view

No data available for Gene Families for LDHA Gene

Function for LDHA Gene

Molecular function for LDHA Gene

GENATLAS Biochemistry:
lactate dehydrogenase A,glycolysis,energy pathway,putative up-regulated c-Myc target gene,
UniProtKB/Swiss-Prot CatalyticActivity:
(S)-lactate + NAD(+) = pyruvate + NADH

Enzyme Numbers (IUBMB) for LDHA Gene

Gene Ontology (GO) - Molecular Function for LDHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004457 lactate dehydrogenase activity --
GO:0004459 L-lactate dehydrogenase activity NAS 1953713
GO:0005515 protein binding IPI 23523103
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with LDHA: view
genes like me logo Genes that share phenotypes with LDHA: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for LDHA Gene

Localization for LDHA Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDHA Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LDHA Gene COMPARTMENTS Subcellular localization image for LDHA gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
mitochondrion 2
cytoskeleton 1
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LDHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with LDHA: view

Pathways & Interactions for LDHA Gene

genes like me logo Genes that share pathways with LDHA: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Adherens Junctions in human,mouse,rat
    • Adipogenesis in human,mouse,rat

UniProtKB/Swiss-Prot P00338-LDHA_HUMAN

  • Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1

SIGNOR curated interactions for LDHA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for LDHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0005975 carbohydrate metabolic process --
GO:0006089 lactate metabolic process IEA --
GO:0006090 pyruvate metabolic process TAS --
GO:0006096 glycolytic process NAS 1953713
genes like me logo Genes that share ontologies with LDHA: view

Drugs & Compounds for LDHA Gene

(13) Drugs for LDHA Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra 0
Nitric Oxide Approved Pharma 540
Nicotinamide Experimental Nutra Target 332,340
Etheno-Nad Experimental Pharma Target 0
Oxamic Acid Experimental Pharma Target 0

(11) Additional Compounds for LDHA Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxybutyric acid
  • (RS)-2-Hydroxybutyrate
  • (RS)-2-Hydroxybutyric acid
  • 2-Hydroxy-Butanoate
  • 2-Hydroxy-Butanoic acid
  • 2-Hydroxy-DL-Butyrate
600-15-7
3-Mercaptolactic acid
  • 3-Mercaptolactate
  • b-Mercaptolactate
  • b-Mercaptolactic acid
  • beta-Mercaptolactate
  • beta-Mercaptolactic acid
2614-83-7
3-Mercaptopyruvic acid
  • 3-Mercapto-pyruvate
  • 3-Mercapto-pyruvic acid
  • 3-Mercaptopyruvate
  • 3-Mercaptopyruvic acid
  • beta-3-Mercapto-2-oxo-propanoate
2464-23-5
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Agarose
genes like me logo Genes that share compounds with LDHA: view

Transcripts for LDHA Gene

Unigene Clusters for LDHA Gene

Lactate dehydrogenase A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LDHA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - - - - - - - - - - - -
SP6: - - -
SP7:

Relevant External Links for LDHA Gene

GeneLoc Exon Structure for
LDHA
ECgene alternative splicing isoforms for
LDHA

Expression for LDHA Gene

mRNA expression in normal human tissues for LDHA Gene

Protein differential expression in normal tissues from HIPED for LDHA Gene

This gene is overexpressed in Tonsil (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LDHA Gene



SOURCE GeneReport for Unigene cluster for LDHA Gene Hs.2795

genes like me logo Genes that share expression patterns with LDHA: view

Protein tissue co-expression partners for LDHA Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LDHA Gene

Orthologs for LDHA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LDHA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LDHA 35
  • 91.97 (n)
  • 93.67 (a)
LDHA 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LDHA 35
  • 93.17 (n)
  • 94.46 (a)
-- 36
  • 87 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ldha 35
  • 84.49 (n)
  • 90.86 (a)
Ldha 16
Ldha 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LDHA 35
  • 99.5 (n)
  • 99.7 (a)
LDHA 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
LDHA 36
  • 91 (a)
OneToMany
LDHA 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia LDHA 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves LDHA 35
  • 79.6 (n)
  • 85.15 (a)
LDHA 36
  • 85 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 86 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ldha 35
  • 74.1 (n)
  • 84.64 (a)
MGC76171 35
African clawed frog
(Xenopus laevis)
Amphibia ldha-prov 35
zebrafish
(Danio rerio)
Actinopterygii ldha 35
  • 69.78 (n)
  • 76.51 (a)
ldha 36
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13334 37
  • 40 (a)
ImpL3 37
  • 59 (a)
ImpL3 35
  • 59.04 (n)
  • 59.94 (a)
CG13334 36
  • 37 (a)
ManyToMany
ImpL3 36
  • 61 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004880 35
  • 58.94 (n)
  • 60.24 (a)
worm
(Caenorhabditis elegans)
Secernentea ldh-1 37
  • 61 (a)
ldh-1 35
  • 59.23 (n)
  • 59.02 (a)
ldh-1 36
  • 58 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G17260 35
  • 54.56 (n)
  • 54.34 (a)
rice
(Oryza sativa)
Liliopsida Os02g0105400 35
  • 52.44 (n)
  • 56.67 (a)
corn
(Zea mays)
Liliopsida Zm.10337 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3533 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11301 36
  • 56 (a)
OneToMany
Species with no ortholog for LDHA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LDHA Gene

ENSEMBL:
Gene Tree for LDHA (if available)
TreeFam:
Gene Tree for LDHA (if available)

Paralogs for LDHA Gene

Paralogs for LDHA Gene

genes like me logo Genes that share paralogs with LDHA: view

Variants for LDHA Gene

Sequence variations from dbSNP and Humsavar for LDHA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4687 -- 18,402,904(+) GGAAG(C/T)GGTTG reference, synonymous-codon, nc-transcript-variant
rs4820 -- 18,402,940(+) TACCT(A/G/T)ATGGG reference, synonymous-codon, nc-transcript-variant
rs6498 -- 18,400,940(+) AACAT(A/C)TTTAA intron-variant, synonymous-codon, reference, nc-transcript-variant
rs14789 -- 18,407,703(+) TTGTG(C/T)ATAAT utr-variant-3-prime, nc-transcript-variant
rs14790 -- 18,407,649(+) TTTTT(A/C)CCAGT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for LDHA Gene

Variant ID Type Subtype PubMed ID
nsv509392 CNV Insertion 20534489
nsv510999 CNV Complex 20534489
esv2744169 CNV Deletion 23290073
nsv39368 CNV Loss 16902084

Variation tolerance for LDHA Gene

Residual Variation Intolerance Score: 55.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LDHA Gene

HapMap Linkage Disequilibrium report
LDHA
Human Gene Mutation Database (HGMD)
LDHA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDHA Gene

Disorders for LDHA Gene

MalaCards: The human disease database

(11) MalaCards diseases for LDHA Gene - From: OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
glycogen storage disease due to lactate dehydrogenase m-subunit deficiency
  • gsd due to lactate dehydrogenase m-subunit deficiency
fanconi-bickel syndrome
  • glycogen storage disease xi
breast abscess
subendocardial myocardial infarction
korean hemorrhagic fever
  • hemorrhagic fever with renal syndrome
- elite association
Search LDHA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LDHA_HUMAN
  • Glycogen storage disease 11 (GSD11) [MIM:612933]: A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue. {ECO:0000269 PubMed:2334430}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for LDHA Gene

myoglobinuria,exertional and/or excessive fatigability

Relevant External Links for LDHA

Genetic Association Database (GAD)
LDHA
Human Genome Epidemiology (HuGE) Navigator
LDHA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LDHA
genes like me logo Genes that share disorders with LDHA: view

Publications for LDHA Gene

  1. Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials. (PMID: 20088761) Granchi C. … Minutolo F. (Curr. Med. Chem. 2010) 23 67
  2. [Mass spectrography analysis of differential proteome in childhood TEL/AML1-positive acute lymphoblastic leukemia]. (PMID: 20137130) Guo Y. … Zhu X.F. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010) 23 67
  3. Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol. (PMID: 20144215) Zhou M. … Tan M. (Mol. Cancer 2010) 23 67
  4. Roles of coactivators in hypoxic induction of the erythropoietin gene. (PMID: 20368990) Wang F. … Hankinson O. (PLoS ONE 2010) 23 67
  5. Glycolytic metabolism and tumour response to fractionated irradiation. (PMID: 20036432) Sattler U.G. … Mueller-Klieser W. (Radiother Oncol 2010) 23 67

Products for LDHA Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Adherens Junctions in human,mouse,rat
    • Adipogenesis in human,mouse,rat
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for LDHA
  • Block miRNA regulation of LDHA using miScript Target Protectors

Sources for LDHA Gene

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