Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL13 Gene

Aliases for IL13 Gene

  • Interleukin 13 2 3
  • IL-13 3 4
  • Bronchial Hyperresponsiveness-1 (Bronchial Asthma) 2
  • Allergic Rhinitis 2
  • Interleukin-13 3
  • P600 3
  • ALRH 6
  • BHR1 6
  • NC30 4

External Ids for IL13 Gene

Summaries for IL13 Gene

Entrez Gene Summary for IL13 Gene

  • This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL13 Gene

IL13 (Interleukin 13) is a Protein Coding gene. Diseases associated with IL13 include actinic prurigo and lipoid nephrosis. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and interleukin-13 receptor binding.

UniProtKB/Swiss-Prot for IL13 Gene

  • Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses

Tocris Summary for IL13 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL13 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL13 Gene

Genomics for IL13 Gene

Genomic Location for IL13 Gene

Start:
132,656,263 bp from pter
End:
132,661,110 bp from pter
Size:
4,848 bases
Orientation:
Plus strand

Genomic View for IL13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL13 Gene

Regulatory Elements for IL13 Gene

Transcription factor binding sites by QIAGEN in the IL13 gene promoter:

Proteins for IL13 Gene

  • Protein details for IL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35225-IL13_HUMAN
    Recommended name:
    Interleukin-13
    Protein Accession:
    P35225
    Secondary Accessions:
    • O43644
    • Q4VB52
    • Q9UDC7

    Protein attributes for IL13 Gene

    Size:
    146 amino acids
    Molecular mass:
    15816 Da
    Quaternary structure:
    • Interacts with IL13RA2.
    SequenceCaution:
    • Sequence=AAA36107.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA83738.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB01681.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC03535.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK53823.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA48824.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL13 Gene

neXtProt entry for IL13 Gene

Proteomics data for IL13 Gene at MOPED

Post-translational modifications for IL13 Gene

  • Glycosylation at Asn52, Asn63, Asn71, and Asn86

Other Protein References for IL13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL13 Gene

Domains for IL13 Gene

Gene Families for IL13 Gene

HGNC:
  • IL :Interleukins and interleukin receptors

UniProtKB/Swiss-Prot:

IL13_HUMAN
Family:
  • Belongs to the IL-4/IL-13 family.:
    • P35225
genes like me logo Genes that share domains with IL13: view

Function for IL13 Gene

Molecular function for IL13 Gene

GENATLAS Biochemistry: interleukin 13,expressed in activated T cell,important switch factor directing Ig-E synthesis
UniProtKB/Swiss-Prot Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses

Gene Ontology (GO) - Molecular Function for IL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005126 cytokine receptor binding --
GO:0005144 interleukin-13 receptor binding IBA --
GO:0005515 protein binding IPI 18243101
genes like me logo Genes that share ontologies with IL13: view
genes like me logo Genes that share phenotypes with IL13: view

Animal Models for IL13 Gene

MGI Knock Outs for IL13:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL13 Gene

Localization for IL13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL13 Gene COMPARTMENTS Subcellular localization image for IL13 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
cytoskeleton 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 20041150
GO:0005615 extracellular space ISS 16275384
GO:0005737 cytoplasm IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with IL13: view

Pathways for IL13 Gene

genes like me logo Genes that share pathways with IL13: view

Gene Ontology (GO) - Biological Process for IL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEA --
GO:0002639 positive regulation of immunoglobulin production IBA --
GO:0006928 movement of cell or subcellular component TAS 10725748
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with IL13: view

Compounds for IL13 Gene

(5) Tocris Compounds for IL13 Gene

Compound Action Cas Number
4-IPP Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate [41270-96-6]
AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
GIT 27 Immunomodulator; reduces production of pro-inflammatory cytokines [6501-72-0]
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo [53179-13-8]
Thalidomide TNF-alpha synthesis inhibitor [50-35-1]

(124) Novoseek inferred chemical compound relationships for IL13 Gene

Compound -log(P) Hits PubMed IDs
rantes 78.4 101
tarc 74.8 42
allergens 72.6 49
scca1 65.9 5
il 10 65.1 24
genes like me logo Genes that share compounds with IL13: view

Transcripts for IL13 Gene

mRNA/cDNA for IL13 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL13 Gene

Interleukin 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL13 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - -
SP3: - -
SP4:
SP5:

Relevant External Links for IL13 Gene

GeneLoc Exon Structure for
IL13
ECgene alternative splicing isoforms for
IL13

Expression for IL13 Gene

mRNA expression in normal human tissues for IL13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL13 Gene

This gene is overexpressed in Testis (46.3).

SOURCE GeneReport for Unigene cluster for IL13 Gene Hs.845

genes like me logo Genes that share expressions with IL13: view

Orthologs for IL13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL13 36
  • 99.24 (n)
  • 98.48 (a)
IL13 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL13 36
  • 80.56 (n)
  • 69.7 (a)
IL13 37
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL13 36
  • 79.23 (n)
  • 72.31 (a)
IL13 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il13 36
  • 71.04 (n)
  • 62.3 (a)
Il13 16
Il13 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il13 36
  • 74.32 (n)
  • 64.75 (a)
Species with no ortholog for IL13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL13 Gene

ENSEMBL:
Gene Tree for IL13 (if available)
TreeFam:
Gene Tree for IL13 (if available)

Paralogs for IL13 Gene

No data available for Paralogs for IL13 Gene

Variants for IL13 Gene

Sequence variations from dbSNP and Humsavar for IL13 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs847 -- 132,660,977(-) AATAC(A/G)AGGAA utr-variant-3-prime
rs848 -- 132,660,808(-) CCTGG(G/T)GTCCA utr-variant-3-prime
rs20541 other, - 132,660,272(-) TGAAC(C/T)GTCCC reference, missense
rs1295685 -- 132,660,753(-) AGTGC(C/T)AGCAG utr-variant-3-prime
rs1295686 -- 132,660,151(-) AGCAC(A/G)TGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL13 Gene

Variant ID Type Subtype PubMed ID
nsv528281 CNV Gain 19592680
dgv6332n71 CNV Gain 21882294

Relevant External Links for IL13 Gene

HapMap Linkage Disequilibrium report
IL13
Human Gene Mutation Database (HGMD)
IL13

Disorders for IL13 Gene

(2) OMIM Diseases for IL13 Gene (147683)

UniProtKB/Swiss-Prot

IL13_HUMAN
  • Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(96) Novoseek inferred disease relationships for IL13 Gene

Disease -log(P) Hits PubMed IDs
asthma allergic 84.1 88
asthma 83.9 262
inflammation 78 124
dermatitis atopic 77.9 59
atopy 75.8 60

Relevant External Links for IL13

Genetic Association Database (GAD)
IL13
Human Genome Epidemiology (HuGE) Navigator
IL13
genes like me logo Genes that share disorders with IL13: view

Publications for IL13 Gene

  1. Genetic variants of IL-13 signalling and human asthma and atopy. (PMID: 10699178) Heinzmann A. … Deichmann K.A. (Hum. Mol. Genet. 2000) 3 4 23 49
  2. Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population. (PMID: 11588017) Howard T.D. … Bleecker E.R. (Am. J. Respir. Cell Mol. Biol. 2001) 3 4 23 49
  3. A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis. (PMID: 12928861) Wang M. … Yu L.-S. (Hum. Genet. 2003) 3 4 23 49
  4. Interleukin-13 gene polymorphisms in patients with Graves' disease. (PMID: 14510917) Bednarczuk T. … Nauman J. (Clin. Endocrinol. (Oxf) 2003) 3 23 49
  5. Genomic analysis of Th1-Th2 cytokine genes in an AIDS cohort: identification of IL4 and IL10 haplotypes associated with the disease progression. (PMID: 12944981) Vasilescu A. … Zagury J.F. (Genes Immun. 2003) 3 23 49

Products for IL13 Gene

  • Addgene plasmids for IL13

Sources for IL13 Gene

Back to Top

Content