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Aliases for IL13 Gene

Aliases for IL13 Gene

  • Interleukin 13 2 3 5
  • IL-13 3 4
  • Bronchial Hyperresponsiveness-1 (Bronchial Asthma) 2
  • Allergic Rhinitis 2
  • Interleukin-13 3
  • P600 3
  • NC30 4

External Ids for IL13 Gene

Previous GeneCards Identifiers for IL13 Gene

  • GC05P131516
  • GC05P132441
  • GC05P132023
  • GC05P132070
  • GC05P132021
  • GC05P131991
  • GC05P127186

Summaries for IL13 Gene

Entrez Gene Summary for IL13 Gene

  • This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL13 Gene

IL13 (Interleukin 13) is a Protein Coding gene. Diseases associated with IL13 include Asthma and Allergic Rhinitis. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-13 receptor binding.

UniProtKB/Swiss-Prot for IL13 Gene

  • Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).

Tocris Summary for IL13 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL13 Gene

Additional gene information for IL13 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL13 Gene

Genomics for IL13 Gene

GeneHancer (GH) Regulatory Elements for IL13 Gene

Promoters and enhancers for IL13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I132655 Enhancer 0.7 Ensembl 550.8 +0.4 379 1.7 HDGF CTCF MAX BACH1 GATA3 POLR2A ZNF143 IKZF2 EZH2 ZNF687 IL13 TH2LCRR LOC105379175
GH05I132658 Promoter 0.6 EPDnew 550.8 +1.9 1891 0.1 ZBTB33 IL13 TH2LCRR
GH05I132770 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.7 +118.2 118240 7.9 HDGF PKNOX1 ARID4B SIN3A ZBTB7B YY1 ZNF766 ZNF143 ZNF263 SP3 SEPT8 GC05M132776 GC05M132777 IL4 ENSG00000202533 LOC105379175 CCNI2 KIF3A SOWAHA AFF4
GH05I132736 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.1 +81.5 81516 2.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 BRCA1 ZNF48 YY1 POLR2B KIF3A SEPT8 ENSG00000230612 IL4 TH2LCRR IL13 SHROOM1 IL5 RAD50 RNU7-15P
GH05I132812 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 10.7 +159.3 159340 5.4 BMI1 YY1 ZNF335 GLIS2 KLF13 EGR2 ZNF202 ZNF362 CEBPB ZEB2 SOWAHA IL4 GDF9 RAD50 AFF4 RNU7-15P RNA5SP192 CCNI2 UQCRQ KIF3A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IL13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL13 gene promoter:

Genomic Locations for IL13 Gene

Genomic Locations for IL13 Gene
chr5:132,656,263-132,661,110
(GRCh38/hg38)
Size:
4,848 bases
Orientation:
Plus strand
chr5:131,991,955-131,996,802
(GRCh37/hg19)

Genomic View for IL13 Gene

Genes around IL13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL13 Gene

Proteins for IL13 Gene

  • Protein details for IL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35225-IL13_HUMAN
    Recommended name:
    Interleukin-13
    Protein Accession:
    P35225
    Secondary Accessions:
    • O43644
    • Q4VB52
    • Q9UDC7

    Protein attributes for IL13 Gene

    Size:
    146 amino acids
    Molecular mass:
    15816 Da
    Quaternary structure:
    • Interacts with IL13RA2.
    SequenceCaution:
    • Sequence=AAA36107.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA83738.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB01681.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC03535.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK53823.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA48824.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL13 Gene

neXtProt entry for IL13 Gene

Post-translational modifications for IL13 Gene

  • Glycosylation at isoforms=52, isoforms=63, isoforms=71, and posLast=8686

Other Protein References for IL13 Gene

No data available for DME Specific Peptides for IL13 Gene

Domains & Families for IL13 Gene

Gene Families for IL13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

P35225

UniProtKB/Swiss-Prot:

IL13_HUMAN :
  • Belongs to the IL-4/IL-13 family.
Family:
  • Belongs to the IL-4/IL-13 family.
genes like me logo Genes that share domains with IL13: view

Function for IL13 Gene

Molecular function for IL13 Gene

GENATLAS Biochemistry:
interleukin 13,expressed in activated T cell,important switch factor directing Ig-E synthesis
UniProtKB/Swiss-Prot Function:
Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).

Phenotypes From GWAS Catalog for IL13 Gene

Gene Ontology (GO) - Molecular Function for IL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,TAS --
GO:0005126 cytokine receptor binding IEA --
GO:0005144 interleukin-13 receptor binding IEA --
GO:0005515 protein binding IPI 18243101
genes like me logo Genes that share ontologies with IL13: view
genes like me logo Genes that share phenotypes with IL13: view

Animal Models for IL13 Gene

MGI Knock Outs for IL13:

Clone Products

  • Addgene plasmids for IL13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL13 Gene

Localization for IL13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL13 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space ISS 16275384
GO:0005737 cytoplasm IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with IL13: view

Pathways & Interactions for IL13 Gene

genes like me logo Genes that share pathways with IL13: view

SIGNOR curated interactions for IL13 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEA --
GO:0002639 positive regulation of immunoglobulin production IEA --
GO:0006928 movement of cell or subcellular component TAS --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with IL13: view

Drugs & Compounds for IL13 Gene

(99) Drugs for IL13 Gene - From: DrugBank, PharmGKB, ClinicalTrials, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Histamine Approved, Investigational Pharma Full agonist, Agonist 1105
Montelukast Approved Pharma Antagonist 280
Omalizumab Approved, Investigational Pharma 151
Sunitinib Approved, Investigational Pharma VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 518
Coal tar Approved Pharma 218

(48) Additional Compounds for IL13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for IL13 Gene

Compound Action Cas Number
AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release 106566-58-9
GIT 27 Immunomodulator; reduces production of pro-inflammatory cytokines 6501-72-0
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo 53179-13-8
Thalidomide TNF-alpha synthesis inhibitor 50-35-1
genes like me logo Genes that share compounds with IL13: view

Transcripts for IL13 Gene

mRNA/cDNA for IL13 Gene

Unigene Clusters for IL13 Gene

Interleukin 13:
Representative Sequences:

Clone Products

  • Addgene plasmids for IL13

Alternative Splicing Database (ASD) splice patterns (SP) for IL13 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - -
SP3: - -
SP4:
SP5:

Relevant External Links for IL13 Gene

GeneLoc Exon Structure for
IL13
ECgene alternative splicing isoforms for
IL13

Expression for IL13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL13 Gene

This gene is overexpressed in Testis (x46.3).

NURSA nuclear receptor signaling pathways regulating expression of IL13 Gene:

IL13

SOURCE GeneReport for Unigene cluster for IL13 Gene:

Hs.845

Evidence on tissue expression from TISSUES for IL13 Gene

  • Blood(4.7)
  • Lung(3.6)
  • Lymph node(2.9)
  • Spleen(2.9)
  • Intestine(2.7)
  • Skin(2.7)
  • Bone marrow(2.3)
  • Muscle(2.3)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with IL13: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL13 Gene

Orthologs for IL13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL13 33 34
  • 99.24 (n)
cow
(Bos Taurus)
Mammalia IL13 33 34
  • 80.56 (n)
dog
(Canis familiaris)
Mammalia IL13 33 34
  • 79.23 (n)
rat
(Rattus norvegicus)
Mammalia Il13 33
  • 74.32 (n)
mouse
(Mus musculus)
Mammalia Il13 33 16 34
  • 71.04 (n)
Species where no ortholog for IL13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL13 Gene

ENSEMBL:
Gene Tree for IL13 (if available)
TreeFam:
Gene Tree for IL13 (if available)

Paralogs for IL13 Gene

No data available for Paralogs for IL13 Gene

Variants for IL13 Gene

Sequence variations from dbSNP and Humsavar for IL13 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs20541 risk-factor, Asthma, susceptibility to, Allergic rhinitis, susceptibility to 132,660,272(+) A/G coding_sequence_variant, missense_variant
rs1000169601 -- 132,659,612(+) C/T intron_variant
rs1000978586 -- 132,660,576(+) C/T 3_prime_UTR_variant
rs1001232679 -- 132,661,251(+) T/C downstream_transcript_variant
rs1001579345 -- 132,660,901(+) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for IL13 Gene

Variant ID Type Subtype PubMed ID
nsv528281 CNV gain 19592680
nsv950392 CNV deletion 24416366

Variation tolerance for IL13 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL13 Gene

Human Gene Mutation Database (HGMD)
IL13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL13 Gene

Disorders for IL13 Gene

MalaCards: The human disease database

(86) MalaCards diseases for IL13 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, susceptibility to
allergic rhinitis
  • alrh
rhinitis
  • runny nose
allergic asthma
  • atopic asthma
lipoid nephrosis
  • minimal change disease
- elite association - COSMIC cancer census association via MalaCards
Search IL13 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IL13_HUMAN
  • Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for IL13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL13: view

No data available for Genatlas for IL13 Gene

Publications for IL13 Gene

  1. Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. (PMID: 20223216) Lupardus PJ … Garcia KC (Structure (London, England : 1993) 2010) 3 4 22 58
  2. IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis. (PMID: 19220774) Zitnik SE … Nickel R (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2009) 3 22 44 58
  3. Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children. (PMID: 18691306) Chan IH … Lam CW (Allergy 2008) 3 22 44 58
  4. Association of IL-13 polymorphisms with leukotriene receptor antagonist drug responsiveness in Korean children with exercise-induced bronchoconstriction. (PMID: 18551035) Kang MJ … Hong SJ (Pharmacogenetics and genomics 2008) 3 22 44 58
  5. Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population. (PMID: 17355643) Huang HY … Helzlsouer KJ (BMC genetics 2007) 3 22 44 58

Products for IL13 Gene

  • Addgene plasmids for IL13

Sources for IL13 Gene

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