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Aliases for ZFP57 Gene

Aliases for ZFP57 Gene

  • ZFP57 Zinc Finger Protein 2 3
  • Zinc Finger Protein 698 3 4
  • C6orf40 3 4
  • Zfp-57 3 4
  • ZNF698 3 4
  • TNDM1 3 6
  • Zinc Finger Protein 57 Homolog (Mouse) 2
  • Chromosome 6 Open Reading Frame 40 2
  • Zinc Finger Protein 57 Homolog 3
  • BA145L22.2 3
  • BA145L22 3

External Ids for ZFP57 Gene

Previous HGNC Symbols for ZFP57 Gene

  • C6orf40

Previous GeneCards Identifiers for ZFP57 Gene

  • GC06M029751
  • GC06M029447

Summaries for ZFP57 Gene

Entrez Gene Summary for ZFP57 Gene

  • The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009]

GeneCards Summary for ZFP57 Gene

ZFP57 (ZFP57 Zinc Finger Protein) is a Protein Coding gene. Diseases associated with ZFP57 include diabetes mellitus, transient neonatal, 1 and diabetes mellitus, 6q24-related transient neonatal.

UniProtKB/Swiss-Prot for ZFP57 Gene

  • Binds to a 5-TGCCGC-3 consensus sequence and recognizes the methylated CpG within this element (By similarity). Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells.

Gene Wiki entry for ZFP57 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP57 Gene

Genomics for ZFP57 Gene

Regulatory Elements for ZFP57 Gene

Genomic Location for ZFP57 Gene

Start:
29,672,392 bp from pter
End:
29,681,136 bp from pter
Size:
8,745 bases
Orientation:
Minus strand

Genomic View for ZFP57 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFP57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for ZFP57 Gene

  • Protein details for ZFP57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NU63-ZFP57_HUMAN
    Recommended name:
    Zinc finger protein 57 homolog
    Protein Accession:
    Q9NU63
    Secondary Accessions:
    • B0S894
    • B0V254
    • B2RXJ7
    • Q5SSB1

    Protein attributes for ZFP57 Gene

    Size:
    452 amino acids
    Molecular mass:
    51919 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAQ10094.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFP57 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP57 Gene

Proteomics data for ZFP57 Gene at MOPED

Post-translational modifications for ZFP57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP57 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFP57 Gene

Domains for ZFP57 Gene

Gene Families for ZFP57 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZFP57 Gene

Suggested Antigen Peptide Sequences for ZFP57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NU63

UniProtKB/Swiss-Prot:

ZFP57_HUMAN :
  • Q9NU63
Domain:
  • The KRAB domain is required for function as transcriptional repressor.
  • Zinc fingers 3 and 4 mediate recognition of the target element, ZF3 interacting with the 5 half (TGC) and ZF4 interacting with the 3 half (CGC).
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFP57 subfamily.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFP57: view

Function for ZFP57 Gene

Molecular function for ZFP57 Gene

UniProtKB/Swiss-Prot Function: Binds to a 5-TGCCGC-3 consensus sequence and recognizes the methylated CpG within this element (By similarity). Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells.

Gene Ontology (GO) - Molecular Function for ZFP57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP57: view

Phenotypes for ZFP57 Gene

genes like me logo Genes that share phenotypes with ZFP57: view

Animal Models for ZFP57 Gene

MGI Knock Outs for ZFP57:

Animal Model Products

CRISPR Products

miRNA for ZFP57 Gene

miRTarBase miRNAs that target ZFP57

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZFP57 Gene

Localization for ZFP57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP57 Gene

Nucleus. Note=Binds various differentially methylated regions (DMR), including the SNRPN DMR. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP57 Gene COMPARTMENTS Subcellular localization image for ZFP57 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZFP57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005720 nuclear heterochromatin IEA --
genes like me logo Genes that share ontologies with ZFP57: view

Pathways for ZFP57 Gene

SuperPathways for ZFP57 Gene

No Data Available

Interacting Proteins for ZFP57 Gene

Gene Ontology (GO) - Biological Process for ZFP57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006349 regulation of gene expression by genetic imprinting IMP 18622393
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007422 peripheral nervous system development IEA --
genes like me logo Genes that share ontologies with ZFP57: view

No data available for Pathways by source for ZFP57 Gene

Transcripts for ZFP57 Gene

mRNA/cDNA for ZFP57 Gene

Unigene Clusters for ZFP57 Gene

ZFP57 zinc finger protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFP57

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZFP57

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP57 Gene

No ASD Table

Relevant External Links for ZFP57 Gene

GeneLoc Exon Structure for
ZFP57
ECgene alternative splicing isoforms for
ZFP57

Expression for ZFP57 Gene

mRNA expression in normal human tissues for ZFP57 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZFP57 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (9.3) and Brain - Substantia nigra (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZFP57 Gene

SOURCE GeneReport for Unigene cluster for ZFP57 Gene Hs.156326

genes like me logo Genes that share expressions with ZFP57: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZFP57 Gene

Orthologs for ZFP57 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP57 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP57 35
  • 99.5 (n)
  • 98.69 (a)
ZFP57 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFP57 35
  • 76.06 (n)
  • 63.14 (a)
ZFP57 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP57 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp57 35
  • 63.59 (n)
  • 48.55 (a)
Zfp57 16
Zfp57 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp57 35
  • 66.07 (n)
  • 50.74 (a)
Species with no ortholog for ZFP57:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP57 Gene

ENSEMBL:
Gene Tree for ZFP57 (if available)
TreeFam:
Gene Tree for ZFP57 (if available)

Paralogs for ZFP57 Gene

genes like me logo Genes that share paralogs with ZFP57: view

No data available for Paralogs for ZFP57 Gene

Variants for ZFP57 Gene

Sequence variations from dbSNP and Humsavar for ZFP57 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs365052 -- 29,680,621(+) CATTG(C/G)GCGCC intron-variant
rs374317 -- 29,676,263(+) CCGGA(C/T)GCGGT intron-variant
rs375248 -- 29,676,498(+) GCCAC(C/T)GCACT intron-variant
rs375984 -- 29,676,725(+) TGGTG(C/T)GGGAG intron-variant
rs376319 -- 29,676,856(+) CCCCA(C/T)CTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP57 Gene

Variant ID Type Subtype PubMed ID
dgv1908e1 CNV Complex 17122850

Relevant External Links for ZFP57 Gene

HapMap Linkage Disequilibrium report
ZFP57
Human Gene Mutation Database (HGMD)
ZFP57

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP57 Gene

Disorders for ZFP57 Gene

(1) OMIM Diseases for ZFP57 Gene (612192)

UniProtKB/Swiss-Prot

ZFP57_HUMAN
  • Transient neonatal diabetes mellitus 1 (TNDM1) [MIM:601410]: Neonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first months of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. {ECO:0000269 PubMed:18622393}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for ZFP57 Gene

Relevant External Links for ZFP57

Genetic Association Database (GAD)
ZFP57
Human Genome Epidemiology (HuGE) Navigator
ZFP57
genes like me logo Genes that share disorders with ZFP57: view

Publications for ZFP57 Gene

  1. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48
  2. Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57. (PMID: 18622393) Mackay D.J.G. … Temple I.K. (Nat. Genet. 2008) 3 4
  3. A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. (PMID: 18854139) Li X. … Ferguson-Smith A.C. (Dev. Cell 2008) 3
  4. Screening for genomic variants in ZFP57 in Silver-Russell syndrome patients with 11p15 epimutations. (PMID: 19632365) Spengler S. … Eggermann T. (Eur J Med Genet 2009) 3
  5. A novel nuclear protein with zinc fingers down-regulated during early mammalian cell differentiation. (PMID: 8120052) Okazaki S. … Setoyama C. (J. Biol. Chem. 1994) 3

Products for ZFP57 Gene

Sources for ZFP57 Gene

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