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Aliases for TLNRD1 Gene

Aliases for TLNRD1 Gene

  • Talin Rod Domain Containing 1 2 3 5
  • Mesoderm Development Candidate 1 2 3
  • MESDC1 3 4

External Ids for TLNRD1 Gene

Previous HGNC Symbols for TLNRD1 Gene

  • MESDC1

Summaries for TLNRD1 Gene

Entrez Gene Summary for TLNRD1 Gene

  • This gene encodes a protein that is regulated by micro RNA MiR-574-3, and is thought to have an oncogenic function in human bladder cancer. A similar gene in mouse is located in a chromosomal region critical for differentiation of mesoderm, which affects embryo patterning and the formation of heart, muscle, blood, skeleton and the urogenital system. The mouse gene is expressed in early development, and in the adult. [provided by RefSeq, Nov 2016]

GeneCards Summary for TLNRD1 Gene

TLNRD1 (Talin Rod Domain Containing 1) is a Protein Coding gene. Diseases associated with TLNRD1 include Autosomal Dominant Nocturnal Frontal Lobe Epilepsy 2. An important paralog of this gene is TLN1.

Additional gene information for TLNRD1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLNRD1 Gene

Genomics for TLNRD1 Gene

Regulatory Elements for TLNRD1 Gene

Enhancers for TLNRD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H081022 1.8 FANTOM5 Ensembl ENCODE dbSUPER 46.1 +23.1 23057 2.8 HDGF PKNOX1 TBL1XR1 BMI1 BATF ATF7 ETV6 RUNX3 CREM IKZF2 TLNRD1 MESD STARD5 GC15P081022 GC15M081029
GH15H081029 1 FANTOM5 Ensembl 36.3 +29.1 29057 1.2 JUN BACH1 MAX ZNF316 FOS NFE2 TRIM24 MAFK NFE2L2 SMARCE1 TLNRD1 MESD STARD5 GC15M081029 GC15P081022
GH15H081291 1.6 FANTOM5 ENCODE dbSUPER 22.1 +297.4 297438 14.7 HDGF FOXA2 PKNOX1 SIN3A YY1 ZNF143 ZNF207 FOS ATF7 RUNX3 TLNRD1 STARD5 IL16 TMC3 ENSG00000271725 PIR53519 PIR47037
GH15H081284 1.5 FANTOM5 Ensembl ENCODE dbSUPER 20.3 +285.9 285913 5.1 HDGF ZNF687 POLR2A REST RUNX3 NR2F2 TLNRD1 STARD5 TMC3 ENSG00000271725 IL16 PIR39910 GC15P081268
GH15H080984 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18.9 -15.8 -15799 1.9 ZNF687 PRDM6 NCOR1 IKZF1 EED CREB1 ZSCAN29 ZNF600 IKZF2 PRDM1 TLNRD1 MESD STARD5 GC15M080956
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TLNRD1 on UCSC Golden Path with GeneCards custom track

Promoters for TLNRD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000080043 356 2601 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF766 ZNF143 ZNF207

Genomic Locations for TLNRD1 Gene

Genomic Locations for TLNRD1 Gene
4,845 bases
Plus strand

Genomic View for TLNRD1 Gene

Genes around TLNRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLNRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLNRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLNRD1 Gene

Proteins for TLNRD1 Gene

  • Protein details for TLNRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mesoderm development candidate 1
    Protein Accession:

    Protein attributes for TLNRD1 Gene

    362 amino acids
    Molecular mass:
    37758 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TLNRD1 Gene

Post-translational modifications for TLNRD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLNRD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TLNRD1 Gene

Domains & Families for TLNRD1 Gene

Gene Families for TLNRD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TLNRD1 Gene


Suggested Antigen Peptide Sequences for TLNRD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TLNRD1: view

No data available for UniProtKB/Swiss-Prot for TLNRD1 Gene

Function for TLNRD1 Gene

Phenotypes From GWAS Catalog for TLNRD1 Gene

Gene Ontology (GO) - Molecular Function for TLNRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS,IEA --
genes like me logo Genes that share ontologies with TLNRD1: view
genes like me logo Genes that share phenotypes with TLNRD1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLNRD1 Gene

Localization for TLNRD1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLNRD1 gene
Compartment Confidence
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TLNRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 colocalizes_with stress fiber ISS --
genes like me logo Genes that share ontologies with TLNRD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TLNRD1 Gene

Pathways & Interactions for TLNRD1 Gene

SuperPathways for TLNRD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TLNRD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TLNRD1 Gene

Drugs & Compounds for TLNRD1 Gene

No Compound Related Data Available

Transcripts for TLNRD1 Gene

mRNA/cDNA for TLNRD1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLNRD1 Gene

No ASD Table

Relevant External Links for TLNRD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLNRD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TLNRD1 Gene:


Evidence on tissue expression from TISSUES for TLNRD1 Gene

  • Skin(4.5)
  • Eye(4)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLNRD1 Gene

Orthologs for TLNRD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TLNRD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MESDC1 33 34
  • 99.54 (n)
(Canis familiaris)
Mammalia MESDC1 33 34
  • 96.04 (n)
(Bos Taurus)
Mammalia MESDC1 33 34
  • 95.03 (n)
(Rattus norvegicus)
Mammalia Mesdc1 33
  • 91.16 (n)
(Mus musculus)
Mammalia Mesdc1 33 34
  • 90.88 (n)
Tlnrd1 16
(Monodelphis domestica)
Mammalia MESDC1 34
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia MESDC1 34
  • 87 (a)
(Gallus gallus)
Aves MESDC1 33 34
  • 75.31 (n)
(Anolis carolinensis)
Reptilia MESDC1 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mesdc1 33
  • 77.68 (n)
MGC75847 33
(Danio rerio)
Actinopterygii MESDC1 34
  • 72 (a)
LOC100003148 33
  • 70.35 (n)
(Caenorhabditis elegans)
Secernentea Y18D10A.22 34
  • 5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLA2 34
  • 7 (a)
Species where no ortholog for TLNRD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLNRD1 Gene

Gene Tree for TLNRD1 (if available)
Gene Tree for TLNRD1 (if available)

Paralogs for TLNRD1 Gene

Paralogs for TLNRD1 Gene

genes like me logo Genes that share paralogs with TLNRD1: view

Variants for TLNRD1 Gene

Sequence variations from dbSNP and Humsavar for TLNRD1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs758561889 Likely benign 81,003,116(+) GGGCA(A/G)GGCGG reference, missense
rs1001066427 -- 81,003,631(+) TACCC(C/T)AGCCC utr-variant-3-prime
rs1002230626 -- 81,003,992(+) AATGT(A/T)ATGTT utr-variant-3-prime
rs1002361611 -- 80,999,372(+) ACTAA(A/G)GTGCA upstream-variant-2KB
rs1002412511 -- 80,999,137(+) GTTCA(C/T)GCCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TLNRD1 Gene

Variant ID Type Subtype PubMed ID
nsv1637 CNV deletion 18451855
nsv1143787 CNV deletion 24896259
esv28677 CNV loss 19812545

Variation tolerance for TLNRD1 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLNRD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLNRD1 Gene

Disorders for TLNRD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TLNRD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
autosomal dominant nocturnal frontal lobe epilepsy 2
  • enfl2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TLNRD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TLNRD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLNRD1 Gene

Publications for TLNRD1 Gene

  1. Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. (PMID: 11247670) Wines ME … Holdener BC (Genomics 2001) 2 3 4 60
  2. Central region of talin has a unique fold that binds vinculin and actin. (PMID: 20610383) Gingras AR … Critchley DR (The Journal of biological chemistry 2010) 2 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Novel oncogenic function of mesoderm development candidate 1 and its regulation by MiR-574-3p in bladder cancer cell lines. (PMID: 22179486) Tatarano S … Nakagawa M (International journal of oncology 2012) 3 60
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 60

Products for TLNRD1 Gene

Sources for TLNRD1 Gene

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