Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TLNRD1 Gene

Aliases for TLNRD1 Gene

  • Talin Rod Domain Containing 1 2 3
  • Mesoderm Development Candidate 1 2 3 5
  • MESDC1 3 4 5

External Ids for TLNRD1 Gene

Previous HGNC Symbols for TLNRD1 Gene

  • MESDC1

Summaries for TLNRD1 Gene

Entrez Gene Summary for TLNRD1 Gene

  • This gene encodes a protein that is regulated by micro RNA MiR-574-3, and is thought to have an oncogenic function in human bladder cancer. A similar gene in mouse is located in a chromosomal region critical for differentiation of mesoderm, which affects embryo patterning and the formation of heart, muscle, blood, skeleton and the urogenital system. The mouse gene is expressed in early development, and in the adult. [provided by RefSeq, Nov 2016]

GeneCards Summary for TLNRD1 Gene

TLNRD1 (Talin Rod Domain Containing 1) is a Protein Coding gene. Diseases associated with TLNRD1 include Autosomal Dominant Nocturnal Frontal Lobe Epilepsy 2. An important paralog of this gene is TLN1.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLNRD1 Gene

Genomics for TLNRD1 Gene

Regulatory Elements for TLNRD1 Gene

Enhancers for TLNRD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G081022 1.9 FANTOM5 Ensembl ENCODE dbSUPER 46.1 +23.1 23057 2.8 HDGF PKNOX1 WRNIP1 GATA2 FOS KLF13 ZNF263 CAVIN1 JUNB TBX21 TLNRD1 MESD STARD5 GC15P081022 GC15M081029
GH15G081029 1.1 FANTOM5 Ensembl 36.3 +29.1 29057 1.2 CBX3 JUN BACH1 MAX ZIC2 ZNF316 STAT2 FOS TRIM24 NFE2 TLNRD1 MESD STARD5 GC15M081029 GC15P081022
GH15G081291 1.6 FANTOM5 ENCODE dbSUPER 22.1 +297.4 297438 14.7 HDGF PKNOX1 WRNIP1 SIN3A YY1 GATA2 ELK1 ZNF143 ZNF207 FOS TLNRD1 STARD5 IL16 TMC3 ENSG00000271725 PIR53519 PIR47037
GH15G080984 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.9 -15.8 -15799 1.9 CBX3 ZFP64 IKZF2 ZNF202 ZNF280D ZBTB11 ZNF426 ZNF623 ZNF518A ZNF781 TLNRD1 MESD STARD5 GC15M080956
GH15G081284 1.4 FANTOM5 Ensembl ENCODE dbSUPER 20.3 +285.9 285913 5.1 HDGF ARID3A POLR2A WRNIP1 NR2F2 TLNRD1 STARD5 TMC3 ENSG00000271725 IL16 PIR39910 GC15P081268
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TLNRD1 on UCSC Golden Path with GeneCards custom track

Promoters for TLNRD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000080043 356 2601 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Location for TLNRD1 Gene

Chromosome:
15
Start:
81,000,944 bp from pter
End:
81,005,788 bp from pter
Size:
4,845 bases
Orientation:
Plus strand

Genomic View for TLNRD1 Gene

Genes around TLNRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLNRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLNRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLNRD1 Gene

Proteins for TLNRD1 Gene

  • Protein details for TLNRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1K6-MESD1_HUMAN
    Recommended name:
    Mesoderm development candidate 1
    Protein Accession:
    Q9H1K6

    Protein attributes for TLNRD1 Gene

    Size:
    362 amino acids
    Molecular mass:
    37758 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TLNRD1 Gene

Post-translational modifications for TLNRD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLNRD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TLNRD1 Gene

Domains & Families for TLNRD1 Gene

Protein Domains for TLNRD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TLNRD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TLNRD1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TLNRD1 Gene

Function for TLNRD1 Gene

Gene Ontology (GO) - Molecular Function for TLNRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS --
genes like me logo Genes that share ontologies with TLNRD1: view
genes like me logo Genes that share phenotypes with TLNRD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLNRD1 Gene

Localization for TLNRD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLNRD1 gene
Compartment Confidence
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TLNRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 colocalizes_with stress fiber ISS --
genes like me logo Genes that share ontologies with TLNRD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TLNRD1 Gene

Pathways & Interactions for TLNRD1 Gene

SuperPathways for TLNRD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TLNRD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TLNRD1 Gene

Drugs & Compounds for TLNRD1 Gene

No Compound Related Data Available

Transcripts for TLNRD1 Gene

mRNA/cDNA for TLNRD1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLNRD1 Gene

Mesoderm development candidate 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLNRD1 Gene

No ASD Table

Relevant External Links for TLNRD1 Gene

GeneLoc Exon Structure for
TLNRD1
ECgene alternative splicing isoforms for
TLNRD1

Expression for TLNRD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TLNRD1 Gene:

TLNRD1

SOURCE GeneReport for Unigene cluster for TLNRD1 Gene:

Hs.513071

Evidence on tissue expression from TISSUES for TLNRD1 Gene

  • Skin(4.5)
  • Eye(4)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLNRD1 Gene

Orthologs for TLNRD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TLNRD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MESDC1 35 34
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MESDC1 35 34
  • 96.04 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MESDC1 35 34
  • 95.03 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mesdc1 34
  • 91.16 (n)
mouse
(Mus musculus)
Mammalia Mesdc1 16 35 34
  • 90.88 (n)
oppossum
(Monodelphis domestica)
Mammalia MESDC1 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MESDC1 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves MESDC1 35 34
  • 75.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MESDC1 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mesdc1 34
  • 77.68 (n)
MGC75847 34
zebrafish
(Danio rerio)
Actinopterygii MESDC1 35
  • 72 (a)
OneToOne
LOC100003148 34
  • 70.35 (n)
worm
(Caenorhabditis elegans)
Secernentea Y18D10A.22 35
  • 5 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLA2 35
  • 7 (a)
OneToMany
Species where no ortholog for TLNRD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLNRD1 Gene

ENSEMBL:
Gene Tree for TLNRD1 (if available)
TreeFam:
Gene Tree for TLNRD1 (if available)

Paralogs for TLNRD1 Gene

Paralogs for TLNRD1 Gene

genes like me logo Genes that share paralogs with TLNRD1: view

Variants for TLNRD1 Gene

Sequence variations from dbSNP and Humsavar for TLNRD1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs758561889 Likely benign 81,003,116(+) GGGCA(A/G)GGCGG reference, missense
rs1001066427 -- 81,003,631(+) TACCC(C/T)AGCCC utr-variant-3-prime
rs1002230626 -- 81,003,992(+) AATGT(A/T)ATGTT utr-variant-3-prime
rs1002361611 -- 80,999,372(+) ACTAA(A/G)GTGCA upstream-variant-2KB
rs1002412511 -- 80,999,137(+) GTTCA(C/T)GCCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TLNRD1 Gene

Variant ID Type Subtype PubMed ID
esv28677 CNV loss 19812545
nsv1143787 CNV deletion 24896259
nsv1637 CNV deletion 18451855

Variation tolerance for TLNRD1 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLNRD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLNRD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLNRD1 Gene

Disorders for TLNRD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TLNRD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
autosomal dominant nocturnal frontal lobe epilepsy 2
  • enfl2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TLNRD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLNRD1
genes like me logo Genes that share disorders with TLNRD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLNRD1 Gene

Publications for TLNRD1 Gene

  1. Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. (PMID: 11247670) Wines M.E. … Holdener B.C. (Genomics 2001) 2 3 4 64
  2. Central region of talin has a unique fold that binds vinculin and actin. (PMID: 20610383) Gingras A.R. … Critchley D.R. (J. Biol. Chem. 2010) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Novel oncogenic function of mesoderm development candidate 1 and its regulation by MiR-574-3p in bladder cancer cell lines. (PMID: 22179486) Tatarano S. … Nakagawa M. (Int. J. Oncol. 2012) 3 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for TLNRD1 Gene

Sources for TLNRD1 Gene

Content
Loading form....