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Aliases for TRAF3IP2 Gene

Aliases for TRAF3IP2 Gene

  • TRAF3 Interacting Protein 2 2 3
  • Nuclear Factor NF-Kappa-B Activator 1 3 4
  • Connection To IKK And SAPK/JNK 3 4
  • C6orf2 3 4
  • C6orf4 3 4
  • C6orf5 3 4
  • C6orf6 3 4
  • ACT1 3 4
  • Chromosome 6 Open Reading Frame 5 2
  • Chromosome 6 Open Reading Frame 2 2
  • NFkB-Activating Protein ACT1 3
  • TRAF3-Interacting Protein 2 4
  • PSORS13 3
  • CANDF8 3
  • CIKS 3

External Ids for TRAF3IP2 Gene

Previous HGNC Symbols for TRAF3IP2 Gene

  • C6orf4
  • C6orf5
  • C6orf6
  • C6orf2

Previous GeneCards Identifiers for TRAF3IP2 Gene

  • GC06M111985
  • GC06M111986
  • GC06M111877
  • GC06M109452

Summaries for TRAF3IP2 Gene

Entrez Gene Summary for TRAF3IP2 Gene

  • This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for TRAF3IP2 Gene

TRAF3IP2 (TRAF3 Interacting Protein 2) is a Protein Coding gene. Diseases associated with TRAF3IP2 include psoriasis susceptibility 13 and candidiasis, familial, 8. Among its related pathways are 4-1BB Pathway and Cytokine production by Th17 cells in CF.

UniProtKB/Swiss-Prot for TRAF3IP2 Gene

  • Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK

Gene Wiki entry for TRAF3IP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF3IP2 Gene

Genomics for TRAF3IP2 Gene

Regulatory Elements for TRAF3IP2 Gene

Genomic Location for TRAF3IP2 Gene

Chromosome:
6
Start:
111,555,378 bp from pter
End:
111,606,874 bp from pter
Size:
51,497 bases
Orientation:
Minus strand

Genomic View for TRAF3IP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAF3IP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF3IP2 Gene

Proteins for TRAF3IP2 Gene

  • Protein details for TRAF3IP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43734-CIKS_HUMAN
    Recommended name:
    Adapter protein CIKS
    Protein Accession:
    O43734
    Secondary Accessions:
    • B2RAY9
    • E1P555
    • Q5R3A3
    • Q7Z6Q1
    • Q7Z6Q2
    • Q7Z6Q3
    • Q9H5W2
    • Q9H6Y3
    • Q9NS14
    • Q9UG72

    Protein attributes for TRAF3IP2 Gene

    Size:
    574 amino acids
    Molecular mass:
    64666 Da
    Quaternary structure:
    • Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta. Interacts with TRAF6.
    SequenceCaution:
    • Sequence=BAB15507.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAF3IP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAF3IP2 Gene

Proteomics data for TRAF3IP2 Gene at MOPED

Post-translational modifications for TRAF3IP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAF3IP2 Gene

Antibody Products

No data available for DME Specific Peptides for TRAF3IP2 Gene

Domains & Families for TRAF3IP2 Gene

Protein Domains for TRAF3IP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TRAF3IP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43734

UniProtKB/Swiss-Prot:

CIKS_HUMAN :
  • Contains 1 SEFIR domain.
Domain:
  • Contains 1 SEFIR domain.
genes like me logo Genes that share domains with TRAF3IP2: view

No data available for Gene Families for TRAF3IP2 Gene

Function for TRAF3IP2 Gene

Molecular function for TRAF3IP2 Gene

UniProtKB/Swiss-Prot Function:
Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK

Gene Ontology (GO) - Molecular Function for TRAF3IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12459498
genes like me logo Genes that share ontologies with TRAF3IP2: view
genes like me logo Genes that share phenotypes with TRAF3IP2: view

Animal Models for TRAF3IP2 Gene

MGI Knock Outs for TRAF3IP2:

Animal Model Products

CRISPR Products

miRNA for TRAF3IP2 Gene

miRTarBase miRNAs that target TRAF3IP2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAF3IP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TRAF3IP2 Gene

Localization for TRAF3IP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAF3IP2 Gene COMPARTMENTS Subcellular localization image for TRAF3IP2 gene
Compartment Confidence
golgi apparatus 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for TRAF3IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular NAS 10962033
GO:0005623 cell --
genes like me logo Genes that share ontologies with TRAF3IP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRAF3IP2 Gene

Pathways & Interactions for TRAF3IP2 Gene

genes like me logo Genes that share pathways with TRAF3IP2: view

Pathways by source for TRAF3IP2 Gene

1 Qiagen pathway for TRAF3IP2 Gene
1 BioSystems pathway for TRAF3IP2 Gene

Gene Ontology (GO) - Biological Process for TRAF3IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001783 B cell apoptotic process IEA --
GO:0002230 positive regulation of defense response to virus by host IDA 23066157
GO:0006959 humoral immune response IEA --
GO:0035556 intracellular signal transduction NAS 10962033
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP 12761501
genes like me logo Genes that share ontologies with TRAF3IP2: view

No data available for SIGNOR curated interactions for TRAF3IP2 Gene

Drugs & Compounds for TRAF3IP2 Gene

(2) Drugs for TRAF3IP2 Gene - From: NovoSeek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nevirapine Approved Pharma 221
salicylic acid Approved Pharma Channel blocker 136

(2) Additional Compounds for TRAF3IP2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glycerol 3-phosphate
  • 1-(Dihydrogen phosphate) Glycerol
  • 1-Glycerophosphate
  • 1-Glycerophosphorate
  • 1-Glycerophosphoric acid
  • 3-Glycerophosphate
57-03-4
xylose
genes like me logo Genes that share compounds with TRAF3IP2: view

Transcripts for TRAF3IP2 Gene

Unigene Clusters for TRAF3IP2 Gene

TRAF3 interacting protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAF3IP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF3IP2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - -
SP6:
SP7: - - - - -
SP8: - -
SP9:
SP10: -
SP11: - - - - - -

ExUns: 15b · 15c · 15d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TRAF3IP2 Gene

GeneLoc Exon Structure for
TRAF3IP2
ECgene alternative splicing isoforms for
TRAF3IP2

Expression for TRAF3IP2 Gene

mRNA expression in normal human tissues for TRAF3IP2 Gene

Protein differential expression in normal tissues from HIPED for TRAF3IP2 Gene

This gene is overexpressed in Pancreatic juice (36.4), Bone marrow stromal cell (23.1), and Platelet (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAF3IP2 Gene



SOURCE GeneReport for Unigene cluster for TRAF3IP2 Gene Hs.561514

mRNA Expression by UniProt/SwissProt for TRAF3IP2 Gene

O43734-CIKS_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expression patterns with TRAF3IP2: view

Protein tissue co-expression partners for TRAF3IP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRAF3IP2 Gene

Orthologs for TRAF3IP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRAF3IP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAF3IP2 35
  • 87.27 (n)
  • 83.13 (a)
TRAF3IP2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAF3IP2 35
  • 84.88 (n)
  • 82.94 (a)
TRAF3IP2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Traf3ip2 35
  • 85.64 (n)
  • 82.3 (a)
Traf3ip2 16
Traf3ip2 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRAF3IP2 35
  • 99.47 (n)
  • 99.12 (a)
TRAF3IP2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Traf3ip2 35
  • 84.37 (n)
  • 80.84 (a)
oppossum
(Monodelphis domestica)
Mammalia TRAF3IP2 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAF3IP2 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRAF3IP2 35
  • 67.19 (n)
  • 64.56 (a)
TRAF3IP2 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAF3IP2 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3945 35
zebrafish
(Danio rerio)
Actinopterygii traf3ip2 36
  • 36 (a)
OneToMany
TRAF3IP2 (1 of 3) 36
  • 28 (a)
OneToMany
traf3ip2l 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10695 36
  • 19 (a)
OneToOne
Species with no ortholog for TRAF3IP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRAF3IP2 Gene

ENSEMBL:
Gene Tree for TRAF3IP2 (if available)
TreeFam:
Gene Tree for TRAF3IP2 (if available)

Paralogs for TRAF3IP2 Gene

No data available for Paralogs for TRAF3IP2 Gene

Variants for TRAF3IP2 Gene

Sequence variations from dbSNP and Humsavar for TRAF3IP2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs187012488 -- 111,608,217(+) GATGC(C/T)GTGCT upstream-variant-2KB
rs186000737 -- 111,604,947(+) CCCCC(C/G)ATCAA intron-variant
rs184115843 -- 111,604,802(+) CAACT(C/G)GTAGT intron-variant
rs183029413 -- 111,608,043(+) CGGAC(C/T)GTGGT upstream-variant-2KB
rs182667227 -- 111,608,799(+) GGACA(C/T)TGTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRAF3IP2 Gene

Variant ID Type Subtype PubMed ID
esv2732577 CNV Deletion 23290073
esv2732578 CNV Deletion 23290073

Variation tolerance for TRAF3IP2 Gene

Residual Variation Intolerance Score: 82.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.72; 73.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAF3IP2 Gene

HapMap Linkage Disequilibrium report
TRAF3IP2
Human Gene Mutation Database (HGMD)
TRAF3IP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF3IP2 Gene

Disorders for TRAF3IP2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for TRAF3IP2 Gene - From: OMIM, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
psoriasis susceptibility 13
  • psoriasis
candidiasis, familial, 8
  • familial chronic mucocutaneous candidiasis
combat disorder
  • combat neurosis
chronic mucocutaneous candidosis
  • chronic mucocutaneous candidiasis
acute stress disorder
  • traumatic stress disorder
- elite association

UniProtKB/Swiss-Prot

CIKS_HUMAN
  • Candidiasis, familial, 8 (CANDF8) [MIM:615527]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269 PubMed:24120361}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Psoriasis 13 (PSORS13) [MIM:614070]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. {ECO:0000269 PubMed:20953186, ECO:0000269 PubMed:20953188}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for TRAF3IP2

Genetic Association Database (GAD)
TRAF3IP2
Human Genome Epidemiology (HuGE) Navigator
TRAF3IP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAF3IP2
genes like me logo Genes that share disorders with TRAF3IP2: view

No data available for Genatlas for TRAF3IP2 Gene

Publications for TRAF3IP2 Gene

  1. CIKS, a connection to Ikappa B kinase and stress-activated protein kinase. (PMID: 10962033) Leonardi A. … Siebenlist U. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 23 67
  2. Act1, an NF-kappa B-activating protein. (PMID: 10962024) Li X. … Stark G.R. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 23 67
  3. Is there an association of regulatory region polymorphism in the alpha-1-antichymotrypsin gene with sporadic Alzheimer's disease in the northern Han-Chinese population? (PMID: 20378355) Yu G. … Jia J. (J Clin Neurosci 2010) 23 67
  4. A new mode of dimerization of allosteric enzymes with ACT domains revealed by the crystal structure of the aspartate kinase from Cyanobacteria. (PMID: 20398676) Robin A.Y. … Dumas R. (J. Mol. Biol. 2010) 23 67
  5. IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling. (PMID: 19543237) Huang H. … Kim H.H. (Cell Death Differ. 2009) 23 67

Products for TRAF3IP2 Gene

Sources for TRAF3IP2 Gene

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