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Aliases for TRAF3IP2 Gene

Aliases for TRAF3IP2 Gene

  • TRAF3 Interacting Protein 2 2 3 5
  • Nuclear Factor NF-Kappa-B Activator 1 3 4
  • Connection To IKK And SAPK/JNK 3 4
  • C6orf2 3 4
  • C6orf4 3 4
  • C6orf5 3 4
  • C6orf6 3 4
  • ACT1 3 4
  • Chromosome 6 Open Reading Frame 5 2
  • Chromosome 6 Open Reading Frame 2 2
  • NFkB-Activating Protein ACT1 3
  • TRAF3-Interacting Protein 2 4
  • Adapter Protein CIKS 3
  • PSORS13 3
  • CANDF8 3
  • CIKS 3

External Ids for TRAF3IP2 Gene

Previous HGNC Symbols for TRAF3IP2 Gene

  • C6orf4
  • C6orf5
  • C6orf6
  • C6orf2

Previous GeneCards Identifiers for TRAF3IP2 Gene

  • GC06M111985
  • GC06M111986
  • GC06M111877
  • GC06M109452

Summaries for TRAF3IP2 Gene

Entrez Gene Summary for TRAF3IP2 Gene

  • This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for TRAF3IP2 Gene

TRAF3IP2 (TRAF3 Interacting Protein 2) is a Protein Coding gene. Diseases associated with TRAF3IP2 include Candidiasis, Familial, 8 and Psoriasis Susceptibility 13. Among its related pathways are IL-17 Family Signaling Pathways and Cytokine production by Th17 cells in CF (Mouse model).

UniProtKB/Swiss-Prot for TRAF3IP2 Gene

  • Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.

Gene Wiki entry for TRAF3IP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF3IP2 Gene

Genomics for TRAF3IP2 Gene

Regulatory Elements for TRAF3IP2 Gene

Enhancers for TRAF3IP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G111550 2.4 VISTA FANTOM5 Ensembl ENCODE dbSUPER 17.3 +53.4 53416 5.9 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 ZNF143 ENSG00000255389 REV3L TRAF3IP2 TRAF3IP2-AS1 MFSD4B GC06M111521 GC06M111495
GH06G111563 1.8 FANTOM5 Ensembl ENCODE dbSUPER 22.8 +40.5 40490 6.3 PKNOX1 SIN3A FEZF1 ZNF2 ZNF416 FOS REST ZNF662 ZNF610 SMARCA4 MFSD4B ENSG00000220506 ENSG00000255389 TRAF3IP2 REV3L BRD7P4 FCF1P5 TRAF3IP2-AS1 CNN2P9 GC06M111521
GH06G111572 1.5 Ensembl ENCODE dbSUPER 23.6 +32.5 32454 4.8 MLX ARID4B FEZF1 DMAP1 ZNF48 GATA2 ZNF143 FOS ZHX2 NFYC ENSG00000255389 TRAF3IP2 REV3L TRAF3IP2-AS1 TUBE1 MFSD4B GC06P111586 GC06M111521
GH06G111599 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.3 +3.5 3540 7.9 HDGF PKNOX1 FOXA2 CREB3L1 ARNT SIN3A YBX1 DMAP1 FEZF1 ZNF2 ENSG00000255389 TRAF3IP2 ENSG00000220506 BRD7P4 MFSD4B FCF1P5 CNN2P9 REV3L
GH06G111584 1.2 Ensembl ENCODE dbSUPER 23.5 +21.5 21460 2.8 ZNF680 MTA2 CEBPB MAX CEBPG RAD21 YY1 ZNF664 ZFHX2 GATA3 TRAF3IP2 REV3L TRAF3IP2-AS1 ENSG00000255389 GC06P111586 GC06M111521
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAF3IP2 on UCSC Golden Path with GeneCards custom track

Promoters for TRAF3IP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000201175 1174 1801 HDGF CREB3L1 ARNT SIN3A DMAP1 ZNF2 YY1 FOS SP3 ZNF592

Genomic Location for TRAF3IP2 Gene

111,555,378 bp from pter
111,606,874 bp from pter
51,497 bases
Minus strand

Genomic View for TRAF3IP2 Gene

Genes around TRAF3IP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAF3IP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAF3IP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF3IP2 Gene

Proteins for TRAF3IP2 Gene

  • Protein details for TRAF3IP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adapter protein CIKS
    Protein Accession:
    Secondary Accessions:
    • B2RAY9
    • E1P555
    • Q5R3A3
    • Q7Z6Q1
    • Q7Z6Q2
    • Q7Z6Q3
    • Q9H5W2
    • Q9H6Y3
    • Q9NS14
    • Q9UG72

    Protein attributes for TRAF3IP2 Gene

    574 amino acids
    Molecular mass:
    64666 Da
    Quaternary structure:
    • Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta. Interacts with TRAF6.
    • Sequence=BAB15507.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAF3IP2 Gene


neXtProt entry for TRAF3IP2 Gene

Post-translational modifications for TRAF3IP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for TRAF3IP2 Gene

Domains & Families for TRAF3IP2 Gene

Protein Domains for TRAF3IP2 Gene


Suggested Antigen Peptide Sequences for TRAF3IP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAF3IP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TRAF3IP2 Gene

Function for TRAF3IP2 Gene

Molecular function for TRAF3IP2 Gene

UniProtKB/Swiss-Prot Function:
Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.

Gene Ontology (GO) - Molecular Function for TRAF3IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 12459498
genes like me logo Genes that share ontologies with TRAF3IP2: view
genes like me logo Genes that share phenotypes with TRAF3IP2: view

Human Phenotype Ontology for TRAF3IP2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TRAF3IP2 Gene

MGI Knock Outs for TRAF3IP2:

Animal Model Products

CRISPR Products

miRNA for TRAF3IP2 Gene

miRTarBase miRNAs that target TRAF3IP2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TRAF3IP2 Gene

Localization for TRAF3IP2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAF3IP2 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TRAF3IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRAF3IP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRAF3IP2 Gene

Pathways & Interactions for TRAF3IP2 Gene

genes like me logo Genes that share pathways with TRAF3IP2: view

Pathways by source for TRAF3IP2 Gene

1 BioSystems pathway for TRAF3IP2 Gene
1 KEGG pathway for TRAF3IP2 Gene
1 R&D Systems pathway for TRAF3IP2 Gene
1 Qiagen pathway for TRAF3IP2 Gene

Gene Ontology (GO) - Biological Process for TRAF3IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001783 B cell apoptotic process IEA --
GO:0002230 positive regulation of defense response to virus by host IDA 23066157
GO:0006959 humoral immune response IEA --
GO:0035556 intracellular signal transduction NAS 10962033
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP 12761501
genes like me logo Genes that share ontologies with TRAF3IP2: view

No data available for SIGNOR curated interactions for TRAF3IP2 Gene

Drugs & Compounds for TRAF3IP2 Gene

(2) Drugs for TRAF3IP2 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nevirapine Approved Pharma 223

(2) Additional Compounds for TRAF3IP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRAF3IP2: view

Transcripts for TRAF3IP2 Gene

Unigene Clusters for TRAF3IP2 Gene

TRAF3 interacting protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF3IP2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - -
SP7: - - - - -
SP8: - -
SP10: -
SP11: - - - - - -

ExUns: 15b · 15c · 15d

Relevant External Links for TRAF3IP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAF3IP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAF3IP2 Gene

Protein differential expression in normal tissues from HIPED for TRAF3IP2 Gene

This gene is overexpressed in Pancreatic juice (36.4), Bone marrow stromal cell (23.1), and Platelet (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAF3IP2 Gene

Protein tissue co-expression partners for TRAF3IP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAF3IP2 Gene:


SOURCE GeneReport for Unigene cluster for TRAF3IP2 Gene:


mRNA Expression by UniProt/SwissProt for TRAF3IP2 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for TRAF3IP2 Gene

  • Intestine(4.2)
  • Kidney(4.2)
  • Liver(4.1)
  • Nervous system(3.6)
  • Lung(2.5)
  • Skin(2.3)
  • Lymph node(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAF3IP2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • reproductive
  • respiratory
  • skeleton
Head and neck:
  • eye
  • eyelid
  • face
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • pharynx
  • skull
  • tongue
  • tooth
  • esophagus
  • thymus
  • liver
  • spleen
  • vagina
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with TRAF3IP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRAF3IP2 Gene

Orthologs for TRAF3IP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRAF3IP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRAF3IP2 34 35
  • 99.47 (n)
(Bos Taurus)
Mammalia TRAF3IP2 34 35
  • 87.27 (n)
(Mus musculus)
Mammalia Traf3ip2 34 16 35
  • 85.64 (n)
(Canis familiaris)
Mammalia TRAF3IP2 34 35
  • 84.88 (n)
(Rattus norvegicus)
Mammalia Traf3ip2 34
  • 84.37 (n)
(Monodelphis domestica)
Mammalia TRAF3IP2 35
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia TRAF3IP2 35
  • 47 (a)
(Gallus gallus)
Aves TRAF3IP2 34 35
  • 67.19 (n)
(Anolis carolinensis)
Reptilia TRAF3IP2 35
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3945 34
(Danio rerio)
Actinopterygii traf3ip2 35
  • 36 (a)
traf3ip2l 35
  • 30 (a)
TRAF3IP2 (1 of 3) 35
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10695 35
  • 19 (a)
Species where no ortholog for TRAF3IP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRAF3IP2 Gene

Gene Tree for TRAF3IP2 (if available)
Gene Tree for TRAF3IP2 (if available)

Paralogs for TRAF3IP2 Gene

No data available for Paralogs for TRAF3IP2 Gene

Variants for TRAF3IP2 Gene

Sequence variations from dbSNP and Humsavar for TRAF3IP2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs33980500 other, Psoriasis 13 (PSORS13) [MIM:614070] 111,592,059(+) TTCAT(C/T)AACCT intron-variant, reference, missense
rs397518485 Pathogenic, Candidiasis, familial, 8 (CANDF8) [MIM:615527] 111,559,523(-) GAACA(C/T)TCATG intron-variant, reference, missense
rs1000031289 -- 111,608,331(+) TCTAC(A/G)AAAAT upstream-variant-2KB
rs1000062542 -- 111,582,748(+) GTAGC(C/T)AGAAC intron-variant
rs1000141927 -- 111,576,136(+) CAAAG(C/T)AGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAF3IP2 Gene

Variant ID Type Subtype PubMed ID
esv2732577 CNV deletion 23290073
esv2732578 CNV deletion 23290073

Variation tolerance for TRAF3IP2 Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.72; 73.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAF3IP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF3IP2 Gene

Disorders for TRAF3IP2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for TRAF3IP2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
candidiasis, familial, 8
  • candidiasis, familial chronic mucocutaneous
psoriasis susceptibility 13
  • psoriasis 13
chronic mucocutaneous candidiasis
  • cmc
combat disorder
  • combat neurosis
acute stress disorder
  • traumatic stress disorder
- elite association - COSMIC cancer census association via MalaCards


  • Candidiasis, familial, 8 (CANDF8) [MIM:615527]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269 PubMed:24120361}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Psoriasis 13 (PSORS13) [MIM:614070]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. {ECO:0000269 PubMed:20953186, ECO:0000269 PubMed:20953188}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for TRAF3IP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRAF3IP2: view

No data available for Genatlas for TRAF3IP2 Gene

Publications for TRAF3IP2 Gene

  1. Act1, an NF-kappa B-activating protein. (PMID: 10962024) Li X. … Stark G.R. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 22 64
  2. CIKS, a connection to Ikappa B kinase and stress-activated protein kinase. (PMID: 10962033) Leonardi A. … Siebenlist U. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 22 64
  3. Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. (PMID: 20953186) Huffmeier U. … Reis A. (Nat. Genet. 2010) 3 4 46 64
  4. Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. (PMID: 20953188) Ellinghaus E. … Franke A. (Nat. Genet. 2010) 3 4 46 64
  5. NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6. (PMID: 12459498) Kanamori M. … Suzuki H. (FEBS Lett. 2002) 3 4 22 64

Products for TRAF3IP2 Gene

Sources for TRAF3IP2 Gene

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