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Aliases for TRA Gene

Aliases for TRA Gene

  • T Cell Receptor Alpha Locus 2 3
  • TCRA, TRA@ 2 3
  • T-Cell Antigen Receptor, Alpha Polypeptide 3
  • T-Cell Receptor, Alpha (V,D,J,C) 3
  • TRAC 3
  • IMD7 3
  • TCRD 3
  • TCRA 3
  • TRA@ 3

External Ids for TRA Gene

Previous HGNC Symbols for TRA Gene

  • TCRA
  • TRA@

Previous GeneCards Identifiers for TRA Gene

  • GC14P022093

Summaries for TRA Gene

GeneCards Summary for TRA Gene

TRA (T Cell Receptor Alpha Locus) is a Protein Coding gene. Diseases associated with TRA include Precursor T-Cell Acute Lymphoblastic Leukemia and Hypersomnia. Among its related pathways are G-protein signaling N-RAS regulation pathway and T-Cell Receptor and Co-stimulatory Signaling.

Gene Wiki entry for TRA Gene

Additional gene information for TRA Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRA Gene

Genomics for TRA Gene

GeneHancer (GH) Regulatory Elements for TRA Gene

Promoters and enhancers for TRA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I021703 Enhancer 0.8 VISTA 0.2 +82.2 82159 2 PKNOX1 FOXA2 EBF1 FEZF1 ZNF217 GATA3 MYNN WT1 OR10G3 ENSG00000256350 TRAV2 TRA
GH14I021647 Enhancer 0.5 FANTOM5 0.3 +25.5 25548 0.5 GATA3 ZSCAN16 HLF ZNF580 ZNF398 SALL2 RPGRIP1 GC14M021649 TRAV1-2 ARL6IP1P1 TRA
GH14I021711 Enhancer 0.6 ENCODE 0.2 +89.7 89669 0.2 CTCF FOXA2 FOXA3 HLF TRIM22 CEBPB CEBPG RAD21 NFIL3 CEBPA TRAV2 ENSG00000256350 TRA
GH14I021668 Enhancer 0.5 ENCODE 0.2 +46.7 46699 0.2 FOXA2 JUN ZNF629 ZEB2 ZBTB17 OR10G2 METTL17 GC14M021667 GC14M021665 OR4E1 TRA
GH14I021712 Enhancer 0.5 ENCODE 0.2 +90.3 90309 0.2 CTCF ATF1 ZNF629 CREB1 ATF7 ATF2 TRAV2 ENSG00000256350 TRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRA on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRA Gene

Genomic Locations for TRA Gene
chr14:21,621,904-22,552,132
(GRCh38/hg38)
Size:
930,229 bases
Orientation:
Plus strand
chr14:22,090,057-23,021,075
(GRCh37/hg19)

Genomic View for TRA Gene

Genes around TRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRA Gene

Proteins for TRA Gene

  • Protein details for TRA Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0C4ZLG8
    Recommended name:
    TRA protein
    Protein Accession:
    A0A0C4ZLG8

    Protein attributes for TRA Gene

    Size:
    187 amino acids
    Molecular mass:
    20713 Da
    Quaternary structure:
    No Data Available
  • Protein details for TRA Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0C4ZNA2
    Recommended name:
    TRA protein
    Protein Accession:
    A0A0C4ZNA2

    Protein attributes for TRA Gene

    Size:
    132 amino acids
    Molecular mass:
    14614 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRA Gene

Post-translational modifications for TRA Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRA Gene

Domains & Families for TRA Gene

Gene Families for TRA Gene

Suggested Antigen Peptide Sequences for TRA Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRA: view

No data available for UniProtKB/Swiss-Prot for TRA Gene

Function for TRA Gene

Phenotypes From GWAS Catalog for TRA Gene

Phenotypes for TRA Gene

GenomeRNAi human phenotypes for TRA:
genes like me logo Genes that share phenotypes with TRA: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRA Gene

Localization for TRA Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TRA Gene

Drugs & Compounds for TRA Gene

(2) Drugs for TRA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TRA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRA: view

Transcripts for TRA Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRA Gene

No ASD Table

Relevant External Links for TRA Gene

GeneLoc Exon Structure for
TRA
ECgene alternative splicing isoforms for
TRA

No data available for mRNA/cDNA for TRA Gene

Expression for TRA Gene

NURSA nuclear receptor signaling pathways regulating expression of TRA Gene:

TRA
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRA Gene

Orthologs for TRA Gene

No data available for Orthologs and Evolution for TRA Gene

Paralogs for TRA Gene

No data available for Paralogs for TRA Gene

Variants for TRA Gene

Additional Variant Information for TRA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRA Gene

Disorders for TRA Gene

MalaCards: The human disease database

(3) MalaCards diseases for TRA Gene - From: Orphanet, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
hypersomnia
narcolepsy
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards
Search TRA in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with TRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRA Gene

Publications for TRA Gene

  1. Pre T-cell receptor alpha (pTalpha) expression patterns and functional analysis in human T-cell lymphoblastic leukemia. (PMID: 20208138) Ivanyi P … Franzke A (Cellular oncology : the official journal of the International Society for Cellular Oncology 2010) 3 22 58
  2. Gene-specific signal joint modifications during V(D)J recombination of TCRAD locus genes in murine and human thymocytes. (PMID: 17015149) Touvrey C … Candéias SM (Immunobiology 2006) 3 22 58
  3. Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias. (PMID: 3875152) Erikson J … Croce CM (Science (New York, N.Y.) 1985) 2 3 58
  4. The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia. (PMID: 3875483) Rabbitts TH … Goodfellow PN (The EMBO journal 1985) 2 3 58
  5. Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope. (PMID: 28931605) Yang X … Mariuzza RA (The Journal of biological chemistry 2017) 3 58

Products for TRA Gene

Sources for TRA Gene

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