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Aliases for KCNN1 Gene

Aliases for KCNN1 Gene

  • Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 1 2 3
  • Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 1 2 3
  • Small Conductance Calcium-Activated Potassium Channel 1 2 3
  • KCa2.1 3 4
  • SKCA1 3 4
  • SK1 3 4
  • Small Conductance Calcium-Activated Potassium Channel Protein 1 3
  • SKCa 1 4
  • Hsk1 3
  • SK 4

External Ids for KCNN1 Gene

Previous GeneCards Identifiers for KCNN1 Gene

  • GC19P018555
  • GC19P018454
  • GC19P017907
  • GC19P017924
  • GC19P017925
  • GC19P017926
  • GC19P018062
  • GC19P017627

Summaries for KCNN1 Gene

Entrez Gene Summary for KCNN1 Gene

  • Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNN1 Gene

KCNN1 (Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 1) is a Protein Coding gene. Diseases associated with KCNN1 include schizophrenia. Among its related pathways are Transmission across Chemical Synapses and Insulin secretion. GO annotations related to this gene include calmodulin binding and small conductance calcium-activated potassium channel activity. An important paralog of this gene is KCNN4.

UniProtKB/Swiss-Prot for KCNN1 Gene

  • Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).

Tocris Summary for KCNN1 Gene

  • Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels, based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These channels do not require calmodulin for activation as they contain three direct bivalent cation binding sites.

Gene Wiki entry for KCNN1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNN1 Gene

Genomics for KCNN1 Gene

Regulatory Elements for KCNN1 Gene

Genomic Location for KCNN1 Gene

Start:
17,951,293 bp from pter
End:
18,000,080 bp from pter
Size:
48,788 bases
Orientation:
Plus strand

Genomic View for KCNN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNN1 Gene

Proteins for KCNN1 Gene

  • Protein details for KCNN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92952-KCNN1_HUMAN
    Recommended name:
    Small conductance calcium-activated potassium channel protein 1
    Protein Accession:
    Q92952
    Secondary Accessions:
    • Q5KR10
    • Q6DJU4

    Protein attributes for KCNN1 Gene

    Size:
    543 amino acids
    Molecular mass:
    59987 Da
    Quaternary structure:
    • Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

    Alternative splice isoforms for KCNN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNN1 Gene

Proteomics data for KCNN1 Gene at MOPED

Post-translational modifications for KCNN1 Gene

  • Ubiquitination at Lys373
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNN1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNN1 Gene

Domains for KCNN1 Gene

Gene Families for KCNN1 Gene

HGNC:
  • KCN :Potassium channels
  • KCa :Voltage-gated ion channels / Potassium channels, calcium-activated
IUPHAR :

Suggested Antigen Peptide Sequences for KCNN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92952

UniProtKB/Swiss-Prot:

KCNN1_HUMAN :
  • Q92952
Family:
  • Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.
genes like me logo Genes that share domains with KCNN1: view

Function for KCNN1 Gene

Molecular function for KCNN1 Gene

GENATLAS Biochemistry: potassium intermediate/small conductance calcium-activated channel,subfamily N member 1,regulating neuronal excitabability
UniProtKB/Swiss-Prot Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).

Gene Ontology (GO) - Molecular Function for KCNN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IBA --
GO:0015269 calcium-activated potassium channel activity TAS 8781233
GO:0016286 small conductance calcium-activated potassium channel activity IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with KCNN1: view

Phenotypes for KCNN1 Gene

genes like me logo Genes that share phenotypes with KCNN1: view

Animal Models for KCNN1 Gene

MGI Knock Outs for KCNN1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNN1 Gene

Localization for KCNN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNN1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNN1 Gene COMPARTMENTS Subcellular localization image for KCNN1 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex TAS 8781233
GO:0016021 integral component of membrane --
GO:0043025 neuronal cell body IBA --
genes like me logo Genes that share ontologies with KCNN1: view

Pathways for KCNN1 Gene

genes like me logo Genes that share pathways with KCNN1: view

Pathways by source for KCNN1 Gene

1 KEGG pathway for KCNN1 Gene

Interacting Proteins for KCNN1 Gene

Selected Interacting proteins: Q92952-KCNN1_HUMAN for KCNN1 Gene via I2D

Gene Ontology (GO) - Biological Process for KCNN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport TAS 8781233
GO:0007268 synaptic transmission TAS --
GO:0071805 potassium ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with KCNN1: view

Compounds for KCNN1 Gene

(5) Tocris Compounds for KCNN1 Gene

Compound Action Cas Number
Apamin KCa2 channel blocker (small conductance) [24345-16-2]
Iberiotoxin KCa channel blocker (big conductance) [129203-60-7]
Paxilline SERCA ATPase blocker. Also potent BKCa channel blocker [57186-25-1]
TRAM 34 Potent and highly selective KCa3.1 channel blocker [289905-88-0]
UCL 1684 Highly potent blocker of KCa2 [199934-16-2]

(1) HMDB Compounds for KCNN1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for KCNN1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Miconazole
22916-47-8 target inhibitor

(13) IUPHAR Ligand for KCNN1 Gene

Ligand Type Action Affinity Pubmed IDs
UCL1684 Pore Blocker None 9.1
UCL1848 Pore Blocker Antagonist 9
apamin Pore Blocker Antagonist 8.1
tamapin Pore Blocker Antagonist 7.4
leiurotoxin I Pore Blocker Antagonist 7.1
NS8593 Gating inhibitor Antagonist 6.4
dequalinium chloride Pore Blocker Antagonist 6.4
Lei-Dab7 Pore Blocker Antagonist 5.2
(+)-tubocurarine Antagonist Antagonist 5.2
Ca2+ Antagonist Antagonist
bicuculline Antagonist Antagonist
EBIO Activator Agonist
NS309 Activator Agonist

(17) Novoseek inferred chemical compound relationships for KCNN1 Gene

Compound -log(P) Hits PubMed IDs
apamin 88.9 16
dequalinium chloride 81.1 1
scyllatoxin 77.4 1
potassium 76.6 55
sphingosine 74.4 14
genes like me logo Genes that share compounds with KCNN1: view

Transcripts for KCNN1 Gene

Unigene Clusters for KCNN1 Gene

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNN1 Gene

No ASD Table

Relevant External Links for KCNN1 Gene

GeneLoc Exon Structure for
KCNN1
ECgene alternative splicing isoforms for
KCNN1

Expression for KCNN1 Gene

mRNA expression in normal human tissues for KCNN1 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KCNN1 Gene

SOURCE GeneReport for Unigene cluster for KCNN1 Gene Hs.158173

genes like me logo Genes that share expressions with KCNN1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KCNN1 Gene

Orthologs for KCNN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNN1 35
  • 99.69 (n)
  • 100 (a)
KCNN1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNN1 35
  • 89.44 (n)
  • 92.45 (a)
KCNN1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNN1 35
  • 89.87 (n)
  • 93.92 (a)
KCNN1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnn1 35
  • 81.91 (n)
  • 83.64 (a)
Kcnn1 16
Kcnn1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNN1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNN1 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnn1 35
  • 82.21 (n)
  • 83.77 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14710 35
kcnn1a 36
  • 44 (a)
OneToMany
kcnn1b 36
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta SK 36
  • 30 (a)
OneToMany
SK 37
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea kcnl-1 36
  • 23 (a)
ManyToMany
kcnl-2 36
  • 30 (a)
ManyToMany
kcnl-3 36
  • 22 (a)
ManyToMany
kcnl-4 36
  • 26 (a)
ManyToMany
C03F11.1 37
  • 35 (a)
C53A5.5 37
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
OneToMany
Species with no ortholog for KCNN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCNN1 Gene

ENSEMBL:
Gene Tree for KCNN1 (if available)
TreeFam:
Gene Tree for KCNN1 (if available)

Paralogs for KCNN1 Gene

Paralogs for KCNN1 Gene

Selected SIMAP similar genes for KCNN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNN1: view

Variants for KCNN1 Gene

Sequence variations from dbSNP and Humsavar for KCNN1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1057261 -- 17,998,505(+) AAGCC(A/G)ACGCT utr-variant-3-prime, downstream-variant-500B
rs1057262 -- 17,998,790(+) AATGT(A/G)GGAAT utr-variant-3-prime, downstream-variant-500B
rs1076356 -- 17,952,572(-) TGCGC(A/T)TCCCC intron-variant
rs1076357 -- 17,952,773(-) GGGGG(C/T)TCCCT intron-variant
rs1236847 -- 17,956,620(+) gcatg(C/T)gtgtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNN1 Gene

Variant ID Type Subtype PubMed ID
nsv911214 CNV Loss 21882294
nsv833772 CNV Gain+Loss 17160897
nsv911226 CNV Loss 21882294
nsv911227 CNV Loss 21882294
dgv3767n71 CNV Loss 21882294
nsv470130 CNV Loss 18288195
dgv3768n71 CNV Loss 21882294
dgv3769n71 CNV Loss 21882294
nsv911233 CNV Loss 21882294
esv274435 CNV Insertion 20981092
esv991938 CNV Gain 20482838
nsv2428 CNV Insertion 18451855

Relevant External Links for KCNN1 Gene

HapMap Linkage Disequilibrium report
KCNN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNN1 Gene

Disorders for KCNN1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KCNN1 Gene including...

Search for KCNN1 Gene in MalaCards »

(2) Novoseek inferred disease relationships for KCNN1 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 29.9 3
glioma 0 1
genes like me logo Genes that share disorders with KCNN1: view

No data available for UniProtKB/Swiss-Prot for KCNN1 Gene

Publications for KCNN1 Gene

  1. Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1). (PMID: 10516439) Litt M. … Adelman J.P. (Cytogenet. Cell Genet. 1999) 2 3 4 23
  2. Small-conductance, calcium-activated potassium channels from mammalian brain. (PMID: 8781233) Koehler M. … Adelman J.P. (Science 1996) 2 3 4
  3. Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain. (PMID: 11146124) Rimini R. … Terstappen G.C. (Brain Res. Mol. Brain Res. 2000) 3 23
  4. The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. (PMID: 10683185) Shah M. … Haylett D.G. (Br. J. Pharmacol. 2000) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for KCNN1 Gene

Sources for KCNN1 Gene

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