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Aliases for KCNN1 Gene

Aliases for KCNN1 Gene

  • Potassium Calcium-Activated Channel Subfamily N Member 1 2 3 5
  • Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 1 2 3
  • Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 1 2 3
  • Small Conductance Calcium-Activated Potassium Channel 1 2 3
  • KCa2.1 3 4
  • SKCA1 3 4
  • SK1 3 4
  • Small Conductance Calcium-Activated Potassium Channel Protein 1 3
  • SKCa 1 4
  • Hsk1 3
  • SK 4

External Ids for KCNN1 Gene

Previous GeneCards Identifiers for KCNN1 Gene

  • GC19P018555
  • GC19P018454
  • GC19P017907
  • GC19P017924
  • GC19P017925
  • GC19P017926
  • GC19P018062
  • GC19P017627
  • GC19P017978
  • GC19P018179
  • GC19P018299
  • GC19P018331
  • GC19P018705
  • GC19P019014
  • GC19P019332

Summaries for KCNN1 Gene

Entrez Gene Summary for KCNN1 Gene

  • Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNN1 Gene

KCNN1 (Potassium Calcium-Activated Channel Subfamily N Member 1) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNN2.

UniProtKB/Swiss-Prot for KCNN1 Gene

  • Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).

Tocris Summary for KCNN1 Gene

  • Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).

Gene Wiki entry for KCNN1 Gene

Additional gene information for KCNN1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNN1 Gene

Genomics for KCNN1 Gene

GeneHancer (GH) Regulatory Elements for KCNN1 Gene

Promoters and enhancers for KCNN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I017949 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 +0.4 366 4 HDGF SIN3A ZBTB7B GLIS2 ZNF143 ATF7 RUNX3 ZNF263 SP3 ZNF623 KCNN1 CCDC124 RNA5SP468
GH19I017966 Promoter/Enhancer 1.1 EPDnew Ensembl 550.4 +16.3 16286 2.5 ZBTB10 SP2 ZNF398 ZBTB8A ZIC2 ZBTB7A POLR2A GLIS1 PATZ1 VEZF1 KCNN1 RNA5SP468
GH19I018372 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5 +429.8 429807 18 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 GDF15 NR2C2AP ENSG00000268030 UPF1 ENSG00000268938 MEF2B COLGALT1 SUGP2 MVB12A IQCN
GH19I018392 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 5.3 +444.7 444653 7.9 FOXA2 ARNT ARID4B SIN3A ZNF48 YY1 ZNF143 FOS ATF7 RUNX3 LRRC25 IFI30 IQCN LSM4 PGPEP1 GDF15 ELL SSBP4 KCNN1 ARRDC2
GH19I017946 Enhancer 1.3 FANTOM5 Ensembl ENCODE 5.1 -3.0 -2992 2.7 HDGF PKNOX1 ARID4B SIN3A GLIS2 ELK1 ZNF143 RUNX3 ZHX2 REST CCDC124 KCNN1 UNC13A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KCNN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCNN1 gene promoter:

Genomic Locations for KCNN1 Gene

Genomic Locations for KCNN1 Gene
chr19:17,951,293-18,000,080
(GRCh38/hg38)
Size:
48,788 bases
Orientation:
Plus strand
chr19:18,062,102-18,110,889
(GRCh37/hg19)

Genomic View for KCNN1 Gene

Genes around KCNN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNN1 Gene

Proteins for KCNN1 Gene

  • Protein details for KCNN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92952-KCNN1_HUMAN
    Recommended name:
    Small conductance calcium-activated potassium channel protein 1
    Protein Accession:
    Q92952
    Secondary Accessions:
    • Q5KR10
    • Q6DJU4

    Protein attributes for KCNN1 Gene

    Size:
    543 amino acids
    Molecular mass:
    59987 Da
    Quaternary structure:
    • Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

    Alternative splice isoforms for KCNN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNN1 Gene

Post-translational modifications for KCNN1 Gene

No Post-translational modifications

Other Protein References for KCNN1 Gene

No data available for DME Specific Peptides for KCNN1 Gene

Domains & Families for KCNN1 Gene

Gene Families for KCNN1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Voltage-gated ion channels

Suggested Antigen Peptide Sequences for KCNN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92952

UniProtKB/Swiss-Prot:

KCNN1_HUMAN :
  • Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.
Family:
  • Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.
genes like me logo Genes that share domains with KCNN1: view

Function for KCNN1 Gene

Molecular function for KCNN1 Gene

GENATLAS Biochemistry:
potassium intermediate/small conductance calcium-activated channel,subfamily N member 1,regulating neuronal excitabability
UniProtKB/Swiss-Prot Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).

Phenotypes From GWAS Catalog for KCNN1 Gene

Gene Ontology (GO) - Molecular Function for KCNN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IBA --
GO:0015269 calcium-activated potassium channel activity IEA,TAS 8781233
GO:0016286 small conductance calcium-activated potassium channel activity IEA,IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with KCNN1: view
genes like me logo Genes that share phenotypes with KCNN1: view

Animal Models for KCNN1 Gene

MGI Knock Outs for KCNN1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNN1 Gene

Localization for KCNN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNN1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCNN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex TAS 8781233
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043025 neuronal cell body IEA,IBA --
genes like me logo Genes that share ontologies with KCNN1: view

No data available for Subcellular locations from COMPARTMENTS for KCNN1 Gene

Pathways & Interactions for KCNN1 Gene

genes like me logo Genes that share pathways with KCNN1: view

Pathways by source for KCNN1 Gene

1 KEGG pathway for KCNN1 Gene

Interacting Proteins for KCNN1 Gene

Gene Ontology (GO) - Biological Process for KCNN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA,TAS 8781233
GO:0007268 chemical synaptic transmission TAS 8781233
GO:0071805 potassium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNN1: view

No data available for SIGNOR curated interactions for KCNN1 Gene

Drugs & Compounds for KCNN1 Gene

(32) Drugs for KCNN1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Miconazole Approved, Investigational, Vet_approved Pharma Antagonist, Pore Blocker, Target, inhibitor 3838
calcium Approved Nutra 0
Procaine Approved, Investigational, Vet_approved Pharma Channel blocker, Target, binder 60
Trimebutine Approved Pharma Target, inhibitor Antimuscarinic 7
Dequalinium Approved, Investigational Pharma 2

(4) Additional Compounds for KCNN1 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-tubocurarine
Antagonist, Pore Blocker

(4) Tocris Compounds for KCNN1 Gene

Compound Action Cas Number
1-EBIO Activator of epithelial KCa channels 10045-45-1
BMS 191011 Potent BKCa (KCa1.1) channel opener 202821-81-6
CyPPA Activator of KCa2.2 and KCa2.3 channels 73029-73-9
SKA 31 Activator of KCa3.1 and KCa2 channels 40172-65-4

(1) ApexBio Compounds for KCNN1 Gene

Compound Action Cas Number
LOE 908 hydrochloride 143482-60-4
genes like me logo Genes that share compounds with KCNN1: view

Drug Products

Transcripts for KCNN1 Gene

Unigene Clusters for KCNN1 Gene

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNN1 Gene

No ASD Table

Relevant External Links for KCNN1 Gene

GeneLoc Exon Structure for
KCNN1
ECgene alternative splicing isoforms for
KCNN1

Expression for KCNN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNN1 Gene

Protein differential expression in normal tissues from HIPED for KCNN1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNN1 Gene



Protein tissue co-expression partners for KCNN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCNN1 Gene:

KCNN1

SOURCE GeneReport for Unigene cluster for KCNN1 Gene:

Hs.158173
genes like me logo Genes that share expression patterns with KCNN1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNN1 Gene

Orthologs for KCNN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNN1 33 34
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia KCNN1 33 34
  • 89.87 (n)
cow
(Bos Taurus)
Mammalia KCNN1 33 34
  • 89.44 (n)
rat
(Rattus norvegicus)
Mammalia Kcnn1 33
  • 82.21 (n)
mouse
(Mus musculus)
Mammalia Kcnn1 33 16 34
  • 81.91 (n)
oppossum
(Monodelphis domestica)
Mammalia KCNN1 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNN1 34
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kcnn1b 34
  • 48 (a)
OneToMany
kcnn1a 34
  • 44 (a)
OneToMany
Dr.14710 33
fruit fly
(Drosophila melanogaster)
Insecta SK 35 34
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea C03F11.1 35
  • 35 (a)
kcnl-2 34
  • 30 (a)
ManyToMany
C53A5.5 35
  • 29 (a)
kcnl-4 34
  • 26 (a)
ManyToMany
kcnl-1 34
  • 23 (a)
ManyToMany
kcnl-3 34
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 59 (a)
OneToMany
Species where no ortholog for KCNN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCNN1 Gene

ENSEMBL:
Gene Tree for KCNN1 (if available)
TreeFam:
Gene Tree for KCNN1 (if available)

Paralogs for KCNN1 Gene

Paralogs for KCNN1 Gene

(4) SIMAP similar genes for KCNN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNN1: view

Variants for KCNN1 Gene

Sequence variations from dbSNP and Humsavar for KCNN1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000006098 -- 17,958,447(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000174189 -- 17,998,645(+) G/A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000205292 -- 17,961,334(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000243075 -- 17,950,747(+) G/T upstream_transcript_variant
rs1000248418 -- 17,973,408(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KCNN1 Gene

Variant ID Type Subtype PubMed ID
esv3367177 CNV insertion 20981092
esv3556127 CNV deletion 23714750
esv3643828 CNV gain 21293372
esv3643829 CNV gain 21293372
esv991938 CNV gain 20482838
nsv1071515 CNV deletion 25765185
nsv2428 CNV insertion 18451855
nsv470130 CNV loss 18288195
nsv833772 CNV gain+loss 17160897

Variation tolerance for KCNN1 Gene

Gene Damage Index Score: 1.20; 24.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNN1 Gene

Disorders for KCNN1 Gene

Additional Disease Information for KCNN1

No disorders were found for KCNN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNN1 Gene

Publications for KCNN1 Gene

  1. Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1). (PMID: 10516439) Litt M … Adelman JP (Cytogenetics and cell genetics 1999) 2 3 4 22 58
  2. Small-conductance, calcium-activated potassium channels from mammalian brain. (PMID: 8781233) Köhler M … Adelman JP (Science (New York, N.Y.) 1996) 2 3 4 58
  3. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PMID: 16382103) Wei AD … Wulff H (Pharmacological reviews 2005) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Calmodulin binding to the C-terminus of the small-conductance Ca2+-activated K+ channel hSK1 is affected by alternative splicing. (PMID: 11258935) Zhang BM … Sullivan R (Biochemistry 2001) 3 22 58

Products for KCNN1 Gene

Sources for KCNN1 Gene

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