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Aliases for RCE1 Gene

Aliases for RCE1 Gene

  • Ras Converting CAAX Endopeptidase 1 2 3
  • Prenyl Protein-Specific Endoprotease 2 2 3 4
  • Farnesylated Proteins-Converting Enzyme 2 3 4
  • Farnesylated Protein-Converting Enzyme 2 2 3
  • CAAX Prenyl Protease 2 2 3
  • RCE1 Homolog 2 4
  • RCE1A 3 4
  • RCE1B 3 4
  • FACE2 3 4
  • RCE1 Homolog, Prenyl Protein Peptidase (S. Cerevisiae) 2
  • RCE1 (S. Cerevisiae) Homolog, Prenyl Protein Protease 2
  • RCE1 Homolog, Prenyl Protein Protease (S. Cerevisiae) 2
  • RCE1 Homolog, Prenyl Protein Peptidase 3
  • Prenyl Protein Protease 2
  • EC 3.4.22.- 4
  • FACE-2 4
  • HRCE1 4

External Ids for RCE1 Gene

Previous HGNC Symbols for RCE1 Gene

  • RCE1A
  • RCE1B

Previous GeneCards Identifiers for RCE1 Gene

  • GC11P069144
  • GC11P068292
  • GC11P066860
  • GC11P066386
  • GC11P066367
  • GC11P066611
  • GC11P062938

Summaries for RCE1 Gene

Entrez Gene Summary for RCE1 Gene

  • This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for RCE1 Gene

RCE1 (Ras Converting CAAX Endopeptidase 1) is a Protein Coding gene. Diseases associated with RCE1 include phaeohyphomycosis and follicular mucinosis. Among its related pathways are superpathway of cholesterol biosynthesis and G-protein signaling_Rap1B regulation pathway. GO annotations related to this gene include metalloendopeptidase activity and cysteine-type endopeptidase activity.

UniProtKB/Swiss-Prot for RCE1 Gene

  • Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1

Gene Wiki entry for RCE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCE1 Gene

Genomics for RCE1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RCE1 Gene

Start:
66,842,835 bp from pter
End:
66,846,546 bp from pter
Size:
3,712 bases
Orientation:
Plus strand

Genomic View for RCE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RCE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCE1 Gene

Proteins for RCE1 Gene

  • Protein details for RCE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y256-FACE2_HUMAN
    Recommended name:
    CAAX prenyl protease 2
    Protein Accession:
    Q9Y256
    Secondary Accessions:
    • Q52LZ9

    Protein attributes for RCE1 Gene

    Size:
    329 amino acids
    Molecular mass:
    35833 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RCE1 Gene

Proteomics data for RCE1 Gene at MOPED

Post-translational modifications for RCE1 Gene

  • Ubiquitinated. Undergoes Lys-48-and Lys-63-linked ubiquitination. Lys-48 ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves Lys-63-linked ubiquitin chains.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RCE1 Gene

No data available for DME Specific Peptides for RCE1 Gene

Domains for RCE1 Gene

Protein Domains for RCE1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RCE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y256

UniProtKB/Swiss-Prot:

FACE2_HUMAN :
  • Q9Y256
Family:
  • Belongs to the peptidase U48 family.
genes like me logo Genes that share domains with RCE1: view

No data available for Gene Families for RCE1 Gene

Function for RCE1 Gene

Molecular function for RCE1 Gene

GENATLAS Biochemistry:
CAAX-prenyl protein protease S cerevisiae Rce1p homolog,,ubiquitously expressed,catalyzing the the first step of the proteolytic processing of farnesylated proteins,including Ras
UniProtKB/Swiss-Prot EnzymeRegulation:
Deubiquitination by USP17L2/USP17 negatively regulates the proteolytic activity toward Ras GTPases.
UniProtKB/Swiss-Prot Function:
Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1

Enzyme Numbers (IUBMB) for RCE1 Gene

Gene Ontology (GO) - Molecular Function for RCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IDA 19188362
GO:0004222 metalloendopeptidase activity TAS 10085068
genes like me logo Genes that share ontologies with RCE1: view
genes like me logo Genes that share phenotypes with RCE1: view

Animal Models for RCE1 Gene

MGI Knock Outs for RCE1:

Animal Model Products

miRNA for RCE1 Gene

miRTarBase miRNAs that target RCE1

No data available for Transcription Factor Targeting and HOMER Transcription for RCE1 Gene

Localization for RCE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCE1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RCE1 Gene COMPARTMENTS Subcellular localization image for RCE1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
nucleus 1

Gene Ontology (GO) - Cellular Components for RCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IDA 19188362
GO:0005887 integral component of plasma membrane TAS 10085068
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RCE1: view

Pathways for RCE1 Gene

genes like me logo Genes that share pathways with RCE1: view

Pathways by source for RCE1 Gene

1 KEGG pathway for RCE1 Gene
1 GeneGo (Thomson Reuters) pathway for RCE1 Gene

Gene Ontology (GO) - Biological Process for RCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS 10085068
GO:0071586 CAAX-box protein processing IMP 19188362
genes like me logo Genes that share ontologies with RCE1: view

Compounds for RCE1 Gene

(2) Novoseek inferred chemical compound relationships for RCE1 Gene

Compound -log(P) Hits PubMed IDs
tripeptide 57.8 1
cysteine 48.5 1
genes like me logo Genes that share compounds with RCE1: view

Transcripts for RCE1 Gene

Unigene Clusters for RCE1 Gene

RCE1 homolog, prenyl protein protease (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RCE1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCE1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6: - -

Relevant External Links for RCE1 Gene

GeneLoc Exon Structure for
RCE1
ECgene alternative splicing isoforms for
RCE1

Expression for RCE1 Gene

mRNA expression in normal human tissues for RCE1 Gene

Protein differential expression in normal tissues for RCE1 Gene

This gene is overexpressed in Breast (37.5), Retina (9.2), and Testis (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RCE1 Gene

SOURCE GeneReport for Unigene cluster for RCE1 Gene Hs.654972

mRNA Expression by UniProt/SwissProt for RCE1 Gene

Q9Y256-FACE2_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with RCE1: view

Expression partners for RCE1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RCE1 Gene

Orthologs for RCE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RCE1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RCE1 35
  • 93.07 (n)
  • 98.05 (a)
RCE1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RCE1 35
  • 93.01 (n)
  • 98.48 (a)
RCE1 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rce1 35
  • 89.46 (n)
  • 94.83 (a)
Rce1 16
Rce1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RCE1 35
  • 99.49 (n)
  • 99.7 (a)
RCE1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rce1 35
  • 88.65 (n)
  • 94.83 (a)
oppossum
(Monodelphis domestica)
Mammalia RCE1 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RCE1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rce1 35
  • 65.56 (n)
  • 72.85 (a)
zebrafish
(Danio rerio)
Actinopterygii rce1a 35
  • 66.89 (n)
  • 72.26 (a)
rce1a 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sras 37
  • 41 (a)
Sras 35
  • 50.34 (n)
  • 40.41 (a)
Sras 36
  • 37 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004086 35
  • 51.75 (n)
  • 45.53 (a)
worm
(Caenorhabditis elegans)
Secernentea fce-2 35
  • 41.78 (n)
  • 32.58 (a)
fce-2 36
  • 31 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCE1 36
  • 26 (a)
OneToOne
RCE1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU11314 35
  • 47.26 (n)
  • 38.03 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1687.02 35
  • 44.72 (n)
  • 39.6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToOne
Species with no ortholog for RCE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCE1 Gene

ENSEMBL:
Gene Tree for RCE1 (if available)
TreeFam:
Gene Tree for RCE1 (if available)

Paralogs for RCE1 Gene

No data available for Paralogs for RCE1 Gene

Variants for RCE1 Gene

Sequence variations from dbSNP and Humsavar for RCE1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs11538048 -- 66,845,924(+) GTTTG(C/T)GCGGC reference, synonymous-codon
rs61732910 -- 66,845,528(+) GTCTT(C/T)GGTGC reference, synonymous-codon
rs61737209 -- 66,844,993(+) ATGGG(C/T)CTGGG reference, synonymous-codon
rs75404994 -- 66,844,763(+) CTAAC(C/T)TGAGT intron-variant
rs77218191 -- 66,845,079(+) ATGAG(A/C)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCE1 Gene

Variant ID Type Subtype PubMed ID
nsv897789 CNV Gain 21882294
nsv897790 CNV Loss 21882294
nsv468602 CNV Loss 19166990
nsv508638 CNV Loss 20534489
nsv897794 CNV Loss 21882294
nsv364 CNV Insertion 18451855
nsv897795 CNV Loss 21882294

Relevant External Links for RCE1 Gene

HapMap Linkage Disequilibrium report
RCE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCE1 Gene

Disorders for RCE1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RCE1 Gene in MalaCards »

(3) Diseases for RCE1 Gene including...

(3) University of Copenhagen DISEASES for RCE1 Gene

genes like me logo Genes that share disorders with RCE1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for RCE1 Gene

Publications for RCE1 Gene

  1. Cloning and characterization of a mammalian prenyl protein-specific protease. (PMID: 10085068) Otto J.C. … Casey P.J. (J. Biol. Chem. 1999) 2 3 4 23
  2. Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins. (PMID: 10373325) Freije J.M.P. … Lopez-Otin C. (Genomics 1999) 2 3 4 23
  3. Human ras-converting enzyme (hRCE1) endoproteolytic activity on K- ras-derived peptides. (PMID: 11038283) Hollander I. … Mallon R. (Anal. Biochem. 2000) 3 4 23
  4. USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. (PMID: 19188362) Burrows J.F. … Johnston J.A. (J. Biol. Chem. 2009) 3 4 23
  5. Human Ras converting enzyme endoproteolytic specificity at the P2' and P3' positions of K-Ras-derived peptides. (PMID: 12818187) Hollander I.J. … Mallon R. (Biochim. Biophys. Acta 2003) 3 23

Products for RCE1 Gene

Sources for RCE1 Gene

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