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Aliases for NUP153 Gene

Aliases for NUP153 Gene

  • Nucleoporin 153kDa 2 3
  • 153 KDa Nucleoporin 3 4
  • Nucleoporin Nup153 3 4
  • Nucleoporin 153kD 2 3
  • Nuclear Pore Complex Protein Hnup153 3
  • Nuclear Pore Complex Protein Nup153 3
  • HNUP153 3
  • N153 3

External Ids for NUP153 Gene

Previous GeneCards Identifiers for NUP153 Gene

  • GC06M017672
  • GC06M017723
  • GC06M017559

Summaries for NUP153 Gene

Entrez Gene Summary for NUP153 Gene

  • Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for NUP153 Gene

NUP153 (Nucleoporin 153kDa) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include identical protein binding and nucleocytoplasmic transporter activity.

UniProtKB/Swiss-Prot for NUP153 Gene

  • Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC).

Gene Wiki entry for NUP153 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP153 Gene

Genomics for NUP153 Gene

Regulatory Elements for NUP153 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUP153 Gene

Start:
17,615,035 bp from pter
End:
17,706,834 bp from pter
Size:
91,800 bases
Orientation:
Minus strand

Genomic View for NUP153 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUP153 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP153 Gene

Proteins for NUP153 Gene

  • Protein details for NUP153 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49790-NU153_HUMAN
    Recommended name:
    Nuclear pore complex protein Nup153
    Protein Accession:
    P49790
    Secondary Accessions:
    • B4DIK2
    • E7EPX5
    • F6QR24
    • Q4LE47
    • Q5T9I7
    • Q7Z743

    Protein attributes for NUP153 Gene

    Size:
    1475 amino acids
    Molecular mass:
    153938 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds at least 4 zinc ions per subunit.;
    Quaternary structure:
    • Interacts with RAN; the interaction occurs in a GTP- and GDP-independent manner (By similarity). Part of the nuclear pore complex (NPC). Interacts with TPR (via coiled coil region); the interaction is direct and provides a link between the core structure and the TPR-containing nuclear basket of the nuclear pore complex (NPC). Interacts with HIV-1 integrase; this interaction might play a role in nuclear import of HIV pre-integration complex. Interacts with hepatitis B virus capsid protein; this interaction probably plays a role in nuclear import of HBV genome. Interacts with C11orf73/Hikeshi, SENP2 and XPO5.
    SequenceCaution:
    • Sequence=BAE06106.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP153 Gene

    Alternative splice isoforms for NUP153 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP153 Gene

Proteomics data for NUP153 Gene at MOPED

Post-translational modifications for NUP153 Gene

  • O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.
  • Phosphorylated in interphase, hyperphosphorylated during mitosis. May play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity).
  • Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains withstand degradation
  • Ubiquitination at Lys15, Lys48, Lys263, Lys384, Lys960, and Lys1148
  • Glycosylation at Ser534, Ser544, Ser908, Ser909, Ser1113, and Thr1156
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP153 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NUP153 Gene

Domains for NUP153 Gene

Suggested Antigen Peptide Sequences for NUP153 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49790

UniProtKB/Swiss-Prot:

NU153_HUMAN :
  • P49790
Domain:
  • Contains F-X-F-G repeats
Family:
  • Belongs to the NUP153 family.
Similarity:
  • Contains 4 RanBP2-type zinc fingers.
genes like me logo Genes that share domains with NUP153: view

No data available for Gene Families for NUP153 Gene

Function for NUP153 Gene

Molecular function for NUP153 Gene

UniProtKB/Swiss-Prot Function: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC).

Gene Ontology (GO) - Molecular Function for NUP153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005215 transporter activity TAS 8110839
GO:0005487 nucleocytoplasmic transporter activity IDA 22253824
GO:0005515 protein binding IPI 11777942
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with NUP153: view
genes like me logo Genes that share phenotypes with NUP153: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUP153

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUP153 Gene

Localization for NUP153 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP153 Gene

Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Note=Tightly associated with the nuclear membrane and lamina (By similarity). Localized to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Dissociates from the NPC structure early during prophase of mitosis. Integrated in the newly assembled nuclear envelope of postmitotic cells early in G1. Colocalized with NUP98 and TPR to the nuclear basket at the nucleoplasmic side of the NPC. Detected in diffuse and discrete intranuclear foci. Remained localized to the nuclear membrane after poliovirus (PV) infection. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP153 Gene COMPARTMENTS Subcellular localization image for NUP153 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for NUP153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005643 nuclear pore IDA 12802065
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with NUP153: view

Pathways for NUP153 Gene

SuperPathways for NUP153 Gene

genes like me logo Genes that share pathways with NUP153: view

Pathways by source for NUP153 Gene

1 KEGG pathway for NUP153 Gene

Gene Ontology (GO) - Biological Process for NUP153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0008645 hexose transport TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with NUP153: view

Compounds for NUP153 Gene

(3) Novoseek inferred chemical compound relationships for NUP153 Gene

Compound -log(P) Hits PubMed IDs
zinc 27.4 3
actinomycin d 26.4 1
pyruvate 15 1
genes like me logo Genes that share compounds with NUP153: view

Transcripts for NUP153 Gene

Unigene Clusters for NUP153 Gene

Nucleoporin 153kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUP153

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP153 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:

ExUns: 22a · 22b ^ 23a · 23b ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:

Relevant External Links for NUP153 Gene

GeneLoc Exon Structure for
NUP153
ECgene alternative splicing isoforms for
NUP153

Expression for NUP153 Gene

mRNA expression in normal human tissues for NUP153 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP153 Gene

SOURCE GeneReport for Unigene cluster for NUP153 Gene Hs.601591

genes like me logo Genes that share expressions with NUP153: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP153 Gene

Orthologs for NUP153 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP153 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP153 35
  • 99.53 (n)
  • 99.23 (a)
NUP153 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUP153 35
  • 88.26 (n)
  • 86.45 (a)
NUP153 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP153 35
  • 89.07 (n)
  • 87.41 (a)
NUP153 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup153 35
  • 85.66 (n)
  • 83.12 (a)
Nup153 16
Nup153 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUP153 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUP153 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup153 35
  • 85.16 (n)
  • 82.39 (a)
chicken
(Gallus gallus)
Aves NUP153 35
  • 69.25 (n)
  • 65.02 (a)
NUP153 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP153 36
  • 56 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia NUP153 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nup153 35
  • 56.65 (n)
  • 50.9 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12507 35
zebrafish
(Danio rerio)
Actinopterygii nup153 35
  • 52.88 (n)
  • 47.73 (a)
nup153 36
  • 42 (a)
OneToOne
wufd23d09 35
fruit fly
(Drosophila melanogaster)
Insecta Nup153 36
  • 14 (a)
OneToOne
Species with no ortholog for NUP153:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP153 Gene

ENSEMBL:
Gene Tree for NUP153 (if available)
TreeFam:
Gene Tree for NUP153 (if available)

Paralogs for NUP153 Gene

Selected SIMAP similar genes for NUP153 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NUP153: view

No data available for Paralogs for NUP153 Gene

Variants for NUP153 Gene

Sequence variations from dbSNP and Humsavar for NUP153 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs13828 -- 17,615,739(+) CGTTC(C/T)ATGAA utr-variant-3-prime
rs727557 -- 17,663,342(+) cttta(G/T)cctcg intron-variant
rs942467 -- 17,629,385(+) GAATC(A/G)GATGA reference, synonymous-codon
rs942468 -- 17,641,859(-) ttctt(C/T)ttttt intron-variant
rs942469 -- 17,638,479(-) TTATT(C/T)TGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP153 Gene

Variant ID Type Subtype PubMed ID
nsv516012 CNV Gain+Loss 19592680
nsv883456 CNV Gain 21882294
nsv883457 CNV Gain 21882294
nsv883458 CNV Gain 21882294
nsv830596 CNV Gain 17160897
esv268526 CNV Insertion 20981092

Relevant External Links for NUP153 Gene

HapMap Linkage Disequilibrium report
NUP153

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP153 Gene

Disorders for NUP153 Gene

(1) Novoseek inferred disease relationships for NUP153 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 1.21 1

Relevant External Links for NUP153

Genetic Association Database (GAD)
NUP153
Human Genome Epidemiology (HuGE) Navigator
NUP153
genes like me logo Genes that share disorders with NUP153: view

No data available for UniProtKB/Swiss-Prot for NUP153 Gene

Publications for NUP153 Gene

  1. Sequence analysis of a cDNA encoding a human nuclear pore complex protein, hnup153. (PMID: 8110839) McMorrow I. … Burke B. (Biochim. Biophys. Acta 1994) 2 3 4 23
  2. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. (PMID: 15229283) Krull S. … Cordes V.C. (Mol. Biol. Cell 2004) 3 4 23
  3. Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1. (PMID: 19369352) Woodward C.L. … Chow S.A. (J. Virol. 2009) 3 4 23
  4. Exportin-5, a novel karyopherin, mediates nuclear export of double- stranded RNA binding proteins. (PMID: 11777942) Brownawell A.M. … Macara I.G. (J. Cell Biol. 2002) 3 4
  5. Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. (PMID: 11839768) Frosst P. … Gerace L. (J. Cell Biol. 2002) 3 4

Products for NUP153 Gene

Sources for NUP153 Gene

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