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Aliases for NUP153 Gene

Aliases for NUP153 Gene

  • Nucleoporin 153kDa 2 3 5
  • 153 KDa Nucleoporin 3 4
  • Nucleoporin Nup153 3 4
  • Nucleoporin 153kD 2 3
  • Nuclear Pore Complex Protein Hnup153 3
  • HNUP153 3
  • N153 3

External Ids for NUP153 Gene

Previous GeneCards Identifiers for NUP153 Gene

  • GC06M017672
  • GC06M017723
  • GC06M017559

Summaries for NUP153 Gene

Entrez Gene Summary for NUP153 Gene

  • Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for NUP153 Gene

NUP153 (Nucleoporin 153kDa) is a Protein Coding gene. Diseases associated with NUP153 include hiv-1. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include identical protein binding and nucleocytoplasmic transporter activity.

UniProtKB/Swiss-Prot for NUP153 Gene

  • Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC).

Gene Wiki entry for NUP153 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP153 Gene

Genomics for NUP153 Gene

Regulatory Elements for NUP153 Gene

Promoters for NUP153 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUP153 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUP153 Gene

Chromosome:
6
Start:
17,615,035 bp from pter
End:
17,706,834 bp from pter
Size:
91,800 bases
Orientation:
Minus strand

Genomic View for NUP153 Gene

Genes around NUP153 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP153 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP153 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP153 Gene

Proteins for NUP153 Gene

  • Protein details for NUP153 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49790-NU153_HUMAN
    Recommended name:
    Nuclear pore complex protein Nup153
    Protein Accession:
    P49790
    Secondary Accessions:
    • B4DIK2
    • E7EPX5
    • F6QR24
    • Q4LE47
    • Q5T9I7
    • Q7Z743

    Protein attributes for NUP153 Gene

    Size:
    1475 amino acids
    Molecular mass:
    153938 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with RAN; the interaction occurs in a GTP- and GDP-independent manner (By similarity). Part of the nuclear pore complex (NPC). Interacts with TPR (via coiled coil region); the interaction is direct and provides a link between the core structure and the TPR-containing nuclear basket of the nuclear pore complex (NPC). Interacts with HIV-1 integrase; this interaction might play a role in nuclear import of HIV pre-integration complex. Interacts with hepatitis B virus capsid protein; this interaction probably plays a role in nuclear import of HBV genome. Interacts with C11orf73/Hikeshi, SENP2 and XPO5. Interacts with Epstein-barr virus BGLF4; this interaction allows BGLF4 nuclear entry.
    SequenceCaution:
    • Sequence=BAE06106.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP153 Gene

    Alternative splice isoforms for NUP153 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP153 Gene

Proteomics data for NUP153 Gene at MOPED

Post-translational modifications for NUP153 Gene

  • O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.
  • Phosphorylated in interphase, hyperphosphorylated during mitosis. May play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity).
  • Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains withstand degradation.
  • Ubiquitination at Lys 48, Lys 263, Lys 960, and Lys 1148
  • Glycosylation at Ser 534, Ser 544, Ser 908, Ser 909, Ser 1113, and Thr 1156
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP153 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for NUP153

No data available for DME Specific Peptides for NUP153 Gene

Domains & Families for NUP153 Gene

Gene Families for NUP153 Gene

Protein Domains for NUP153 Gene

Suggested Antigen Peptide Sequences for NUP153 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49790

UniProtKB/Swiss-Prot:

NU153_HUMAN :
  • Contains F-X-F-G repeats.
  • Belongs to the NUP153 family.
  • Contains 4 RanBP2-type zinc fingers.
Domain:
  • Contains F-X-F-G repeats.
Family:
  • Belongs to the NUP153 family.
Similarity:
  • Contains 4 RanBP2-type zinc fingers.
genes like me logo Genes that share domains with NUP153: view

Function for NUP153 Gene

Molecular function for NUP153 Gene

UniProtKB/Swiss-Prot Function:
Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC).

Gene Ontology (GO) - Molecular Function for NUP153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS --
GO:0008139 nuclear localization sequence binding IEA --
genes like me logo Genes that share ontologies with NUP153: view
genes like me logo Genes that share phenotypes with NUP153: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP153 Gene

Localization for NUP153 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP153 Gene

Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Note=Tightly associated with the nuclear membrane and lamina (By similarity). Localized to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Dissociates from the NPC structure early during prophase of mitosis. Integrated in the newly assembled nuclear envelope of postmitotic cells early in G1. Colocalized with NUP98 and TPR to the nuclear basket at the nucleoplasmic side of the NPC. Detected in diffuse and discrete intranuclear foci. Remained localized to the nuclear membrane after poliovirus (PV) infection. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP153 Gene COMPARTMENTS Subcellular localization image for NUP153 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for NUP153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031965 nuclear membrane IDA 11839768
genes like me logo Genes that share ontologies with NUP153: view

Pathways & Interactions for NUP153 Gene

SuperPathways for NUP153 Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
.48
3 SUMOylation
4 Mitotic Prophase
5 Cell Cycle, Mitotic
.61
genes like me logo Genes that share pathways with NUP153: view

Pathways by source for NUP153 Gene

SIGNOR curated interactions for NUP153 Gene

Other effect:

Gene Ontology (GO) - Biological Process for NUP153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0008645 hexose transport TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with NUP153: view

Drugs & Compounds for NUP153 Gene

(2) Drugs for NUP153 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NUP153 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NUP153: view

Transcripts for NUP153 Gene

Unigene Clusters for NUP153 Gene

Nucleoporin 153kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUP153 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:

ExUns: 22a · 22b ^ 23a · 23b ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:

Relevant External Links for NUP153 Gene

GeneLoc Exon Structure for
NUP153
ECgene alternative splicing isoforms for
NUP153

Expression for NUP153 Gene

mRNA expression in normal human tissues for NUP153 Gene

Protein differential expression in normal tissues from HIPED for NUP153 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.3) and Placenta (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP153 Gene



SOURCE GeneReport for Unigene cluster for NUP153 Gene Hs.601591

genes like me logo Genes that share expression patterns with NUP153: view

Protein tissue co-expression partners for NUP153 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP153 Gene

Orthologs for NUP153 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP153 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUP153 35
  • 88.26 (n)
  • 86.45 (a)
NUP153 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP153 35
  • 89.07 (n)
  • 87.41 (a)
NUP153 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup153 35
  • 85.66 (n)
  • 83.12 (a)
Nup153 16
Nup153 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUP153 35
  • 99.53 (n)
  • 99.23 (a)
NUP153 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup153 35
  • 85.16 (n)
  • 82.39 (a)
oppossum
(Monodelphis domestica)
Mammalia NUP153 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUP153 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUP153 35
  • 69.25 (n)
  • 65.02 (a)
NUP153 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP153 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nup153 35
  • 56.65 (n)
  • 50.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia NUP153 35
zebrafish
(Danio rerio)
Actinopterygii nup153 35
  • 52.88 (n)
  • 47.73 (a)
wufd23d09 35
nup153 36
  • 42 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12507 35
fruit fly
(Drosophila melanogaster)
Insecta Nup153 36
  • 14 (a)
OneToOne
Species with no ortholog for NUP153:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP153 Gene

ENSEMBL:
Gene Tree for NUP153 (if available)
TreeFam:
Gene Tree for NUP153 (if available)

Paralogs for NUP153 Gene

(1) SIMAP similar genes for NUP153 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NUP153: view

No data available for Paralogs for NUP153 Gene

Variants for NUP153 Gene

Sequence variations from dbSNP and Humsavar for NUP153 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs16879902 - 17,688,462(+) CTCAT(C/G/T)GGCAT reference, missense
rs2228375 - 17,675,015(-) CTTCA(A/G)TCCTT reference, missense
rs6906499 - 17,665,248(+) CACTT(C/G)TTATC reference, missense
rs6905654 - 17,637,155(+) TACCT(A/G)GTTTC reference, missense
rs2274136 - 17,632,830(+) TGAAG(C/T)AGGTA intron-variant, reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NUP153 Gene

Variant ID Type Subtype PubMed ID
nsv516012 CNV Gain+Loss 19592680
nsv883456 CNV Gain 21882294
nsv883457 CNV Gain 21882294
nsv883458 CNV Gain 21882294
nsv830596 CNV Gain 17160897
esv268526 CNV Insertion 20981092

Variation tolerance for NUP153 Gene

Residual Variation Intolerance Score: 5.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.57; 98.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP153 Gene

HapMap Linkage Disequilibrium report
NUP153

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP153 Gene

Disorders for NUP153 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUP153 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NUP153

Genetic Association Database (GAD)
NUP153
Human Genome Epidemiology (HuGE) Navigator
NUP153
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP153
genes like me logo Genes that share disorders with NUP153: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUP153 Gene

Publications for NUP153 Gene

  1. Sequence analysis of a cDNA encoding a human nuclear pore complex protein, hnup153. (PMID: 8110839) McMorrow I. … Burke B. (Biochim. Biophys. Acta 1994) 2 3 4 23 67
  2. The nucleoporin Nup153 has separable roles in both early mitotic progression and the resolution of mitosis. (PMID: 19158386) Mackay D.R. … Ullman K.S. (Mol. Biol. Cell 2009) 3 23
  3. Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1. (PMID: 19369352) Woodward C.L. … Chow S.A. (J. Virol. 2009) 3 23
  4. Oxidative stress mislocalizes and retains transport factor importin-alpha and nucleoporins Nup153 and Nup88 in nuclei where they generate high molecular mass complexes. (PMID: 18068677) Kodiha M. … Stochaj U. (Biochim. Biophys. Acta 2008) 3 23
  5. Multiple conserved domains of the nucleoporin Nup124p and its orthologs Nup1p and Nup153 are critical for nuclear import and activity of the fission yeast Tf1 retrotransposon. (PMID: 17615301) Sistla S. … Balasundaram D. (Mol. Biol. Cell 2007) 3 23

Products for NUP153 Gene

Sources for NUP153 Gene

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