Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TNFSF15 Gene

Aliases for TNFSF15 Gene

  • Tumor Necrosis Factor Superfamily Member 15 2 3 5
  • Vascular Endothelial Cell Growth Inhibitor 2 3 4
  • TNF Ligand-Related Molecule 1 2 3 4
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 15 2 3
  • Vascular Endothelial Growth Inhibitor-192A 2 3
  • TNF Superfamily Ligand TL1A 2 3
  • VEGI 3 4
  • TL1 3 4
  • Tumor Necrosis Factor (Ligand) Superfamily Member 15 3
  • Tumor Necrosis Factor Ligand 1B 3
  • VEGI192A 3
  • TNLG1B 3
  • TL1A 3

External Ids for TNFSF15 Gene

Previous GeneCards Identifiers for TNFSF15 Gene

  • GC09M108349
  • GC09M109283
  • GC09M111005
  • GC09M112927
  • GC09M114632
  • GC09M116591
  • GC09M117551
  • GC09M087156

Summaries for TNFSF15 Gene

Entrez Gene Summary for TNFSF15 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for TNFSF15 Gene

TNFSF15 (Tumor Necrosis Factor Superfamily Member 15) is a Protein Coding gene. Diseases associated with TNFSF15 include Diverticulitis and Primary Biliary Cirrhosis. Among its related pathways are TNF Signaling (sino) and NF-kappaB Signaling. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNF.

UniProtKB/Swiss-Prot for TNFSF15 Gene

  • Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.

Gene Wiki entry for TNFSF15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF15 Gene

Genomics for TNFSF15 Gene

Regulatory Elements for TNFSF15 Gene

Enhancers for TNFSF15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNFSF15 on UCSC Golden Path with GeneCards custom track

Promoters for TNFSF15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNFSF15 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFSF15 Gene

Chromosome:
9
Start:
114,784,635 bp from pter
End:
114,806,128 bp from pter
Size:
21,494 bases
Orientation:
Minus strand

Genomic View for TNFSF15 Gene

Genes around TNFSF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF15 Gene

Proteins for TNFSF15 Gene

  • Protein details for TNFSF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95150-TNF15_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 15
    Protein Accession:
    O95150
    Secondary Accessions:
    • Q3SX69
    • Q5VJK8
    • Q5VWH1
    • Q8NFE9

    Protein attributes for TNFSF15 Gene

    Size:
    251 amino acids
    Molecular mass:
    28087 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for TNFSF15 Gene

    Alternative splice isoforms for TNFSF15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFSF15 Gene

Proteomics data for TNFSF15 Gene at MOPED

Post-translational modifications for TNFSF15 Gene

  • Glycosylation at Asn 133 and Asn 229

Other Protein References for TNFSF15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFSF15 (TL1A/TNFSF15)
  • Cell Signaling Technology (CST) Antibodies for TNFSF15 (TNFSF15)

No data available for DME Specific Peptides for TNFSF15 Gene

Domains & Families for TNFSF15 Gene

Gene Families for TNFSF15 Gene

Protein Domains for TNFSF15 Gene

Suggested Antigen Peptide Sequences for TNFSF15 Gene

Graphical View of Domain Structure for InterPro Entry

O95150

UniProtKB/Swiss-Prot:

TNF15_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF15: view

Function for TNFSF15 Gene

Molecular function for TNFSF15 Gene

GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 15,expressed in hematopoietic cells
UniProtKB/Swiss-Prot Function:
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL1A/interleukin-1 alpha and TNF.

Gene Ontology (GO) - Molecular Function for TNFSF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TNFSF15: view
genes like me logo Genes that share phenotypes with TNFSF15: view

Human Phenotype Ontology for TNFSF15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TNFSF15 Gene

MGI Knock Outs for TNFSF15:

Animal Model Products

  • Taconic Biosciences Mouse Models for TNFSF15

CRISPR Products

miRNA for TNFSF15 Gene

miRTarBase miRNAs that target TNFSF15

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNFSF15 Gene

Localization for TNFSF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF15 Gene

Membrane; Single-pass type II membrane protein.
Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFSF15 Gene COMPARTMENTS Subcellular localization image for TNFSF15 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TNFSF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFSF15: view

Pathways & Interactions for TNFSF15 Gene

genes like me logo Genes that share pathways with TNFSF15: view

Pathways by source for TNFSF15 Gene

3 Sino Biological pathways for TNFSF15 Gene
1 Cell Signaling Technology pathway for TNFSF15 Gene
1 BioSystems pathway for TNFSF15 Gene

Interacting Proteins for TNFSF15 Gene

SIGNOR curated interactions for TNFSF15 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TNFSF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 11911831
GO:0007165 signal transduction NAS 9872942
genes like me logo Genes that share ontologies with TNFSF15: view

Drugs & Compounds for TNFSF15 Gene

(1) Drugs for TNFSF15 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pomalidomide (CC-4047) Pharma Immunomodulator,antumor/anti-angiogenic 0

(1) ApexBio Compounds for TNFSF15 Gene

Compound Action Cas Number
Pomalidomide (CC-4047) Immunomodulator,antumor/anti-angiogenic 19171-19-8
genes like me logo Genes that share compounds with TNFSF15: view

Transcripts for TNFSF15 Gene

mRNA/cDNA for TNFSF15 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFSF15 Gene

Tumor necrosis factor (ligand) superfamily, member 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF15 Gene

No ASD Table

Relevant External Links for TNFSF15 Gene

GeneLoc Exon Structure for
TNFSF15
ECgene alternative splicing isoforms for
TNFSF15

Expression for TNFSF15 Gene

mRNA expression in normal human tissues for TNFSF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFSF15 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x5.7), Minor Salivary Gland (x5.6), Prostate (x4.8), Colon - Sigmoid (x4.7), Bladder (x4.3), and Kidney - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for TNFSF15 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFSF15 Gene



SOURCE GeneReport for Unigene cluster for TNFSF15 Gene Hs.23349

mRNA Expression by UniProt/SwissProt for TNFSF15 Gene

O95150-TNF15_HUMAN
Tissue specificity: Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.
genes like me logo Genes that share expression patterns with TNFSF15: view

Protein tissue co-expression partners for TNFSF15 Gene

- Elite partner

Primer Products

Orthologs for TNFSF15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TNFSF15 35
  • 86.27 (n)
  • 83.2 (a)
TNFSF15 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNFSF15 35
  • 87.33 (n)
  • 84.8 (a)
TNFSF15 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfsf15 35
  • 78.41 (n)
  • 67.61 (a)
Tnfsf15 16
Tnfsf15 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNFSF15 35
  • 99.34 (n)
  • 99.2 (a)
TNFSF15 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfsf15 35
  • 79.35 (n)
  • 70.85 (a)
oppossum
(Monodelphis domestica)
Mammalia TNFSF15 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFSF15 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNFSF15 35
  • 63.92 (n)
  • 55.83 (a)
CHTL1A 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFSF15 36
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfsf15 35
  • 52.43 (n)
  • 45.15 (a)
Species with no ortholog for TNFSF15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF15 Gene

ENSEMBL:
Gene Tree for TNFSF15 (if available)
TreeFam:
Gene Tree for TNFSF15 (if available)

Paralogs for TNFSF15 Gene

Paralogs for TNFSF15 Gene

genes like me logo Genes that share paralogs with TNFSF15: view

Variants for TNFSF15 Gene

Sequence variations from dbSNP and Humsavar for TNFSF15 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs16931745 - 114,790,878(+) TTTTT(A/T)AAGTG reference, missense
rs7847158 -- 114,797,985(+) GGAAG(A/G)CAGAG intron-variant
rs7848641 -- 114,806,751(+) ACCAT(C/T)GTTTA upstream-variant-2KB
rs7848647 -- 114,806,766(+) GAGTA(C/T)GAGGC upstream-variant-2KB
rs1407308 -- 114,807,943(+) AACTG(G/T)TATTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TNFSF15 Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
nsv831695 CNV Gain 17160897

Variation tolerance for TNFSF15 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFSF15 Gene

Human Gene Mutation Database (HGMD)
TNFSF15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF15 Gene

Disorders for TNFSF15 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TNFSF15 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diverticulitis
  • diverticulitis nos
primary biliary cirrhosis
  • biliary liver cirrhosis
keshan disease
  • caused by deficiency of selenium in the diet
ulcerative colitis
  • left-sided ulcerative colitis
crohn's disease
  • ileitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFSF15

Genetic Association Database (GAD)
TNFSF15
Human Genome Epidemiology (HuGE) Navigator
TNFSF15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFSF15
genes like me logo Genes that share disorders with TNFSF15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF15 Gene

Publications for TNFSF15 Gene

  1. Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells. (PMID: 9434163) Tan K.B. … Truneh A. (Gene 1997) 2 3 4 67
  2. Involvement of NF-kappa B pathway in TL1A gene expression induced by lipopolysaccharide. (PMID: 19815424) Endo K. … Shimosegawa T. (Cytokine 2010) 3 23
  3. The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro. (PMID: 20410491) McLaren J.E. … Ramji D.P. (J. Immunol. 2010) 3 23
  4. Effect of sodium butyrate on lung vascular TNFSF15 (TL1A) expression: differential expression patterns in pulmonary artery and microvascular endothelial cells. (PMID: 19251437) Safaya S. … Steinberg M.H. (Cytokine 2009) 3 23
  5. IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein. (PMID: 19262684) Michelsen K.S. … Targan S.R. (PLoS ONE 2009) 3 23

Products for TNFSF15 Gene

Sources for TNFSF15 Gene

Content