Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TNFSF15 Gene

Aliases for TNFSF15 Gene

  • Tumor Necrosis Factor (Ligand) Superfamily, Member 15 2 3
  • Vascular Endothelial Cell Growth Inhibitor 2 3 4
  • TNF Ligand-Related Molecule 1 2 3 4
  • VEGI 3 4 6
  • TL1 3 4 6
  • Vascular Endothelial Growth Inhibitor-192A 2 3
  • TNF Superfamily Ligand TL1A 2 3
  • Tumor Necrosis Factor Ligand Superfamily Member 15 3
  • VEGI192A 3
  • TL1A 3

External Ids for TNFSF15 Gene

Previous GeneCards Identifiers for TNFSF15 Gene

  • GC09M108349
  • GC09M109283
  • GC09M111005
  • GC09M112927
  • GC09M114632
  • GC09M116591
  • GC09M117551
  • GC09M087156

Summaries for TNFSF15 Gene

Entrez Gene Summary for TNFSF15 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for TNFSF15 Gene

TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15) is a Protein Coding gene. Diseases associated with TNFSF15 include primary biliary cirrhosis and irritable bowel syndrome. Among its related pathways are Apoptosis Signaling Pathways and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNF.

UniProtKB/Swiss-Prot for TNFSF15 Gene

  • Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.

Gene Wiki entry for TNFSF15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF15 Gene

Genomics for TNFSF15 Gene

Regulatory Elements for TNFSF15 Gene

Genomic Location for TNFSF15 Gene

114,784,635 bp from pter
114,806,128 bp from pter
21,494 bases
Minus strand

Genomic View for TNFSF15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFSF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF15 Gene

Proteins for TNFSF15 Gene

  • Protein details for TNFSF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor ligand superfamily member 15
    Protein Accession:
    Secondary Accessions:
    • Q3SX69
    • Q5VJK8
    • Q5VWH1
    • Q8NFE9

    Protein attributes for TNFSF15 Gene

    251 amino acids
    Molecular mass:
    28087 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for TNFSF15 Gene

    Alternative splice isoforms for TNFSF15 Gene


neXtProt entry for TNFSF15 Gene

Proteomics data for TNFSF15 Gene at MOPED

Post-translational modifications for TNFSF15 Gene

  • Glycosylation at Asn133 and Asn229

Other Protein References for TNFSF15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFSF15 (TL1A/TNFSF15)

Protein Products

  • Enzo Life Sciences proteins for TNFSF15

No data available for DME Specific Peptides for TNFSF15 Gene

Domains for TNFSF15 Gene

Gene Families for TNFSF15 Gene

  • TNFSF :Tumor necrosis factor (ligand) superfamily

Protein Domains for TNFSF15 Gene

Suggested Antigen Peptide Sequences for TNFSF15 Gene

Graphical View of Domain Structure for InterPro Entry



  • O95150
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF15: view

Function for TNFSF15 Gene

Molecular function for TNFSF15 Gene

GENATLAS Biochemistry: tumor necrosis factor (ligand) superfamily,member 15,expressed in hematopoietic cells
UniProtKB/Swiss-Prot Function: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.
UniProtKB/Swiss-Prot Induction: Up-regulated by IL1A/interleukin-1 alpha and TNF.

Gene Ontology (GO) - Molecular Function for TNFSF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 9434163
GO:0005123 death receptor binding IEA --
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TNFSF15: view

Phenotypes for TNFSF15 Gene

genes like me logo Genes that share phenotypes with TNFSF15: view

Animal Models for TNFSF15 Gene

MGI Knock Outs for TNFSF15:

Animal Model Products

CRISPR Products

miRNA for TNFSF15 Gene

miRTarBase miRNAs that target TNFSF15

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFSF15

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TNFSF15 Gene

Localization for TNFSF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF15 Gene

Membrane; Single-pass type II membrane protein.
Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted.

Subcellular locations from

Jensen Localization Image for TNFSF15 Gene COMPARTMENTS Subcellular localization image for TNFSF15 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 1
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TNFSF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IDA 11911831
GO:0005887 integral component of plasma membrane TAS 9872942
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 9872942
genes like me logo Genes that share ontologies with TNFSF15: view

Pathways for TNFSF15 Gene

genes like me logo Genes that share pathways with TNFSF15: view

Pathways by source for TNFSF15 Gene

3 Sino Biological pathways for TNFSF15 Gene
1 Qiagen pathway for TNFSF15 Gene
1 BioSystems pathway for TNFSF15 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for TNFSF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 11911831
GO:0006955 immune response IEA --
GO:0007165 signal transduction NAS 9872942
GO:0007250 activation of NF-kappaB-inducing kinase activity IDA 11911831
genes like me logo Genes that share ontologies with TNFSF15: view

Transcripts for TNFSF15 Gene

mRNA/cDNA for TNFSF15 Gene

(9) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFSF15 Gene

Tumor necrosis factor (ligand) superfamily, member 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFSF15

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TNFSF15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF15 Gene

No ASD Table

Relevant External Links for TNFSF15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFSF15 Gene

mRNA expression in normal human tissues for TNFSF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFSF15 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (5.7), Minor Salivary Gland (5.6), Prostate (4.8), Colon - Sigmoid (4.7), Bladder (4.3), and Kidney - Cortex (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNFSF15 Gene

SOURCE GeneReport for Unigene cluster for TNFSF15 Gene Hs.23349

mRNA Expression by UniProt/SwissProt for TNFSF15 Gene

Tissue specificity: Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.
genes like me logo Genes that share expressions with TNFSF15: view

In Situ Assay Products

Orthologs for TNFSF15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFSF15 35
  • 99.34 (n)
  • 99.2 (a)
TNFSF15 36
  • 99 (a)
(Bos Taurus)
Mammalia TNFSF15 35
  • 86.27 (n)
  • 83.2 (a)
TNFSF15 36
  • 81 (a)
(Canis familiaris)
Mammalia TNFSF15 35
  • 87.33 (n)
  • 84.8 (a)
TNFSF15 36
  • 79 (a)
(Mus musculus)
Mammalia Tnfsf15 35
  • 78.41 (n)
  • 67.61 (a)
Tnfsf15 16
Tnfsf15 36
  • 62 (a)
(Monodelphis domestica)
Mammalia TNFSF15 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia TNFSF15 36
  • 75 (a)
(Rattus norvegicus)
Mammalia Tnfsf15 35
  • 79.35 (n)
  • 70.85 (a)
(Gallus gallus)
Aves CHTL1A 36
  • 49 (a)
TNFSF15 35
  • 63.92 (n)
  • 55.83 (a)
(Anolis carolinensis)
Reptilia TNFSF15 36
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfsf15 35
  • 52.43 (n)
  • 45.15 (a)
Species with no ortholog for TNFSF15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF15 Gene

Gene Tree for TNFSF15 (if available)
Gene Tree for TNFSF15 (if available)

Paralogs for TNFSF15 Gene

Paralogs for TNFSF15 Gene

genes like me logo Genes that share paralogs with TNFSF15: view

Variants for TNFSF15 Gene

Sequence variations from dbSNP and Humsavar for TNFSF15 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1407308 -- 114,807,943(+) AACTG(G/T)TATTC upstream-variant-2KB
rs1857335 -- 114,789,438(-) ACTCA(A/G)GAGGC utr-variant-3-prime
rs1891836 -- 114,788,975(-) ATATG(A/G)GATTA utr-variant-3-prime
rs3810936 -- 114,790,605(+) TCGCA(C/T)ACAGA reference, synonymous-codon
rs4246905 -- 114,790,969(+) AAAAG(C/T)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFSF15 Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
nsv831695 CNV Gain 17160897

Relevant External Links for TNFSF15 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF15 Gene

Disorders for TNFSF15 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for TNFSF15 Gene including...

Search for TNFSF15 Gene in MalaCards »

(2) University of Copenhagen DISEASES for TNFSF15 Gene

(3) Novoseek inferred disease relationships for TNFSF15 Gene

Disease -log(P) Hits PubMed IDs
inflammatory bowel diseases 47.6 8
colitis ulcerative 43.6 2
inflammation 39.1 11

Relevant External Links for TNFSF15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TNFSF15: view

No data available for UniProtKB/Swiss-Prot for TNFSF15 Gene

Publications for TNFSF15 Gene

  1. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. (PMID: 11911831) Migone T.-S. … Wei P. (Immunity 2002) 3 4 23
  2. IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein. (PMID: 19262684) Michelsen K.S. … Targan S.R. (PLoS ONE 2009) 3 23 48
  3. Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells. (PMID: 9434163) Tan K.B. … Truneh A. (Gene 1997) 2 3 4
  4. VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo. (PMID: 9872942) Zhai Y. … Yu G.-L. (FASEB J. 1999) 3 4
  5. VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth. (PMID: 10597252) Haridas V. … Aggarwal B.B. (Oncogene 1999) 3 4

Products for TNFSF15 Gene

Sources for TNFSF15 Gene

Back to Top