Aliases for TNFSF15 Gene
External Ids for TNFSF15 Gene
Previous GeneCards Identifiers for TNFSF15 Gene
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for TNFSF15 Gene
TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15) is a Protein Coding gene. Diseases associated with TNFSF15 include primary biliary cirrhosis and irritable bowel syndrome. Among its related pathways are Apoptosis Signaling Pathways and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNF.
UniProtKB/Swiss-Prot for TNFSF15 Gene
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.