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Aliases for SLC23A2 Gene

Aliases for SLC23A2 Gene

  • Solute Carrier Family 23 (Ascorbic Acid Transporter), Member 2 2 3
  • SVCT2 3 4 6
  • Solute Carrier Family 23 (Nucleobase Transporters), Member 1 2 3
  • Nucleobase Transporter-Like 1 Protein 3 4
  • Na(+)/L-Ascorbic Acid Transporter 2 3 4
  • Yolk Sac Permease-Like Molecule 2 3 4
  • SLC23A1 3 4
  • HSVCT2 3 4
  • NBTL1 3 4
  • YSPL2 3 4
  • Solute Carrier Family 23 (Nucleobase Transporters), Member 2 3
  • Sodium-Dependent Vitamin C Transporter-2 3
  • Sodium-Dependent Vitamin C Transporter 2 4
  • Solute Carrier Family 23 Member 2 3
  • KIAA0238 4

External Ids for SLC23A2 Gene

Previous HGNC Symbols for SLC23A2 Gene

  • SLC23A1

Previous GeneCards Identifiers for SLC23A2 Gene

  • GC05U990085
  • GC20M004783
  • GC20M004832
  • GC20M004828

Summaries for SLC23A2 Gene

Entrez Gene Summary for SLC23A2 Gene

  • The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC23A2 Gene

SLC23A2 (Solute Carrier Family 23 (Ascorbic Acid Transporter), Member 2) is a Protein Coding gene. Among its related pathways are Disease and PAK Pathway. GO annotations related to this gene include L-ascorbate:sodium symporter activity and nucleobase transmembrane transporter activity. An important paralog of this gene is SLC23A1.

UniProtKB/Swiss-Prot for SLC23A2 Gene

  • Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate

Gene Wiki entry for SLC23A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC23A2 Gene

Genomics for SLC23A2 Gene

Regulatory Elements for SLC23A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC23A2 Gene

Start:
4,852,356 bp from pter
End:
5,010,293 bp from pter
Size:
157,938 bases
Orientation:
Minus strand

Genomic View for SLC23A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC23A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC23A2 Gene

Proteins for SLC23A2 Gene

  • Protein details for SLC23A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGH3-S23A2_HUMAN
    Recommended name:
    Solute carrier family 23 member 2
    Protein Accession:
    Q9UGH3
    Secondary Accessions:
    • B4DJZ1
    • Q8WWR4
    • Q92512
    • Q96D54
    • Q9UNU1
    • Q9UP85

    Protein attributes for SLC23A2 Gene

    Size:
    650 amino acids
    Molecular mass:
    70337 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13244.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC23A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC23A2 Gene

Proteomics data for SLC23A2 Gene at MOPED

Post-translational modifications for SLC23A2 Gene

Other Protein References for SLC23A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC23A2 Gene

Domains for SLC23A2 Gene

Gene Families for SLC23A2 Gene

Protein Domains for SLC23A2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGH3

UniProtKB/Swiss-Prot:

S23A2_HUMAN :
  • Q9UGH3
Family:
  • Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily.
genes like me logo Genes that share domains with SLC23A2: view

Function for SLC23A2 Gene

Molecular function for SLC23A2 Gene

GENATLAS Biochemistry:
solute carrier family 23,member 2 (nucleobase transport),mainly expressed in kidney,liver,intestine
UniProtKB/Swiss-Prot Function:
Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate

Gene Ontology (GO) - Molecular Function for SLC23A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0008520 L-ascorbate:sodium symporter activity IEA --
GO:0008523 sodium-dependent multivitamin transmembrane transporter activity NAS 10471399
GO:0015205 nucleobase transmembrane transporter activity TAS 9804989
GO:0015229 L-ascorbic acid transporter activity IDA 10631088
genes like me logo Genes that share ontologies with SLC23A2: view
genes like me logo Genes that share phenotypes with SLC23A2: view

Animal Models for SLC23A2 Gene

MGI Knock Outs for SLC23A2:

Animal Model Products

CRISPR Products

miRNA for SLC23A2 Gene

miRTarBase miRNAs that target SLC23A2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC23A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC23A2 Gene

Localization for SLC23A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC23A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC23A2 Gene COMPARTMENTS Subcellular localization image for SLC23A2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC23A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0009925 basal plasma membrane IEA --
GO:0016020 membrane TAS 9804989
genes like me logo Genes that share ontologies with SLC23A2: view

Pathways for SLC23A2 Gene

SuperPathways for SLC23A2 Gene

genes like me logo Genes that share pathways with SLC23A2: view

Pathways by source for SLC23A2 Gene

Interacting Proteins for SLC23A2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000344322%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000360761%0d%0a
Selected Interacting proteins: ENSP00000344322 Q9UGH3-S23A2_HUMAN for SLC23A2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC23A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 9804989
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0006810 transport --
GO:0006814 sodium ion transport IEA --
genes like me logo Genes that share ontologies with SLC23A2: view

Compounds for SLC23A2 Gene

(2) HMDB Compounds for SLC23A2 Gene

Compound Synonyms Cas Number PubMed IDs
Ascorbic acid
  • (+)-ascorbate
50-81-7
Sodium
  • Sodium
7440-23-5

(1) IUPHAR Ligand for SLC23A2 Gene

Ligand Type Action Affinity Pubmed IDs
[14C]ascorbic acid None None

(5) Novoseek inferred chemical compound relationships for SLC23A2 Gene

Compound -log(P) Hits PubMed IDs
dehydroascorbic acid 85.9 3
ascorbic acid 83.7 75
sodium 15.2 4
adenylate 10.1 2
calcium 0 2
genes like me logo Genes that share compounds with SLC23A2: view

Transcripts for SLC23A2 Gene

Unigene Clusters for SLC23A2 Gene

Solute carrier family 23 (nucleobase transporters), member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC23A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC23A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5:
SP6:

Relevant External Links for SLC23A2 Gene

GeneLoc Exon Structure for
SLC23A2
ECgene alternative splicing isoforms for
SLC23A2

Expression for SLC23A2 Gene

mRNA expression in normal human tissues for SLC23A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC23A2 Gene

This gene is overexpressed in Adrenal Gland (4.0).

Protein differential expression in normal tissues for SLC23A2 Gene

This gene is overexpressed in CD8 Tcells (56.7) and Placenta (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC23A2 Gene

SOURCE GeneReport for Unigene cluster for SLC23A2 Gene Hs.516866

mRNA Expression by UniProt/SwissProt for SLC23A2 Gene

Q9UGH3-S23A2_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with SLC23A2: view

Expression partners for SLC23A2 Gene

In Situ Assay Products

Orthologs for SLC23A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC23A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC23A2 35
  • 91.22 (n)
  • 98.15 (a)
SLC23A2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC23A2 35
  • 90.24 (n)
  • 97.72 (a)
SLC23A2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc23a2 35
  • 88.15 (n)
  • 95.05 (a)
Slc23a2 16
Slc23a2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC23A2 35
  • 99.23 (n)
  • 100 (a)
SLC23A2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc23a2 35
  • 87.87 (n)
  • 95.2 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC23A2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC23A2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC23A2 35
  • 79.84 (n)
  • 93.83 (a)
SVCT2 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC23A2 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc23a2 35
  • 76.95 (n)
  • 88.84 (a)
Str.12033 35
zebrafish
(Danio rerio)
Actinopterygii Dr.26244 35
slc23a2 35
  • 70.7 (n)
  • 80.85 (a)
si:dkey-106n21.1 36
  • 47 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6293 37
  • 43 (a)
CG6293 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C51E3.6 37
  • 34 (a)
R11E3.2 37
  • 30 (a)
T07G12.2 37
  • 32 (a)
T07G12.4 37
  • 32 (a)
T07G12.5 37
  • 31 (a)
Y59E9AL.4 37
  • 31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G49990 35
  • 47.03 (n)
  • 37.25 (a)
rice
(Oryza sativa)
Liliopsida Os02g0741800 35
  • 47.73 (n)
  • 37.32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1254 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for SLC23A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC23A2 Gene

ENSEMBL:
Gene Tree for SLC23A2 (if available)
TreeFam:
Gene Tree for SLC23A2 (if available)

Paralogs for SLC23A2 Gene

Paralogs for SLC23A2 Gene

Selected SIMAP similar genes for SLC23A2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC23A2: view

Variants for SLC23A2 Gene

Sequence variations from dbSNP and Humsavar for SLC23A2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs939257 -- 4,926,033(+) ACACA(C/T)TTAAT intron-variant
rs939258 -- 4,926,195(+) GTCCA(A/T)GCCGC intron-variant
rs939259 -- 4,926,197(+) CCAAG(A/C)CGCTA intron-variant
rs1110277 -- 4,874,036(+) AAGAC(A/G)TCTGT synonymous-codon, reference
rs1113249 -- 4,909,615(+) GTAGT(A/G)CTATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC23A2 Gene

Variant ID Type Subtype PubMed ID
nsv912628 CNV Gain 21882294
nsv912629 CNV Gain 21882294
nsv912630 CNV Loss 21882294
nsv522948 CNV Loss 19592680
esv2722132 CNV Deletion 23290073
nsv912631 CNV Gain 21882294
nsv833902 CNV Loss 17160897
nsv179361 CNV Loss 16902084
nsv520095 CNV Loss 19592680
nsv428375 CNV Loss 18775914

Relevant External Links for SLC23A2 Gene

HapMap Linkage Disequilibrium report
SLC23A2
Human Gene Mutation Database (HGMD)
SLC23A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC23A2 Gene

Disorders for SLC23A2 Gene

Relevant External Links for SLC23A2

Genetic Association Database (GAD)
SLC23A2
Human Genome Epidemiology (HuGE) Navigator
SLC23A2

No disorders were found for SLC23A2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SLC23A2 Gene

Publications for SLC23A2 Gene

  1. A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals. (PMID: 10395795) Hogue D.L. … Ling V. (Genomics 1999) 3 4 23
  2. Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function. (PMID: 10471399) Rajan D.P. … Prasad P.D. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  3. Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. (PMID: 10556521) Daruwala R.C. … Levine M. (FEBS Lett. 1999) 3 4 23
  4. Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery. (PMID: 16357110) Erichsen H.C. … Chanock S.J. (Am. J. Epidemiol. 2006) 3 23 48
  5. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PMID: 18636124) Skibola C.F. … Smith M.T. (PLoS ONE 2008) 3 23 48

Products for SLC23A2 Gene

Sources for SLC23A2 Gene

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