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Aliases for CDC20 Gene

Aliases for CDC20 Gene

  • Cell Division Cycle 20 2 3 5
  • P55CDC 3 4
  • CDC20 (Cell Division Cycle 20, S. Cerevisiae, Homolog) 2
  • CDC20 Cell Division Cycle 20 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 20 Homolog (S. Cerevisiae) 2
  • CDC20 Cell Division Cycle 20 Homolog 3
  • Cell Division Cycle 20 Homolog 3
  • BA276H19.3 3
  • CDC20A 3

External Ids for CDC20 Gene

Previous GeneCards Identifiers for CDC20 Gene

  • GC01P043767
  • GC01P042825
  • GC01P043254
  • GC01P043237
  • GC01P043208
  • GC01P043493
  • GC01P043597
  • GC01P043824
  • GC01P041944

Summaries for CDC20 Gene

Entrez Gene Summary for CDC20 Gene

  • CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC20 Gene

CDC20 (Cell Division Cycle 20) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include enzyme binding and protein C-terminus binding. An important paralog of this gene is FZR1.

UniProtKB/Swiss-Prot for CDC20 Gene

  • Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.

Gene Wiki entry for CDC20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC20 Gene

Genomics for CDC20 Gene

Regulatory Elements for CDC20 Gene

Promoters for CDC20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDC20 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDC20 Gene

Chromosome:
1
Start:
43,358,955 bp from pter
End:
43,363,203 bp from pter
Size:
4,249 bases
Orientation:
Plus strand

Genomic View for CDC20 Gene

Genes around CDC20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC20 Gene

Proteins for CDC20 Gene

  • Protein details for CDC20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12834-CDC20_HUMAN
    Recommended name:
    Cell division cycle protein 20 homolog
    Protein Accession:
    Q12834
    Secondary Accessions:
    • B2R6Z6
    • D3DPJ1
    • Q5JUY4
    • Q9BW56
    • Q9UQI9

    Protein attributes for CDC20 Gene

    Size:
    499 amino acids
    Molecular mass:
    54723 Da
    Quaternary structure:
    • Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with NEUROD2 and SPATC1 (By similarity). Interacts with MAD2L1 and BUB1B. The phosphorylated form interacts with APC/C. Interacts with NINL. May interact with MAD2L2. Interacts with CDK5RAP2 and SIRT2. Interacts with isoform 1 of NEK2.

    Three dimensional structures from OCA and Proteopedia for CDC20 Gene

neXtProt entry for CDC20 Gene

Proteomics data for CDC20 Gene at MOPED

Post-translational modifications for CDC20 Gene

  • Acetylated. Deacetylated at Lys-66 by SIRT2; deacetylation enhances the interaction of CDC20 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).
  • Dephosphorylated by CTDP1.
  • Phosphorylated during mitosis, probably by maturation promoting factor (MPF). Phosphorylated by BUB1 at Ser-41; Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161. Phosphorylated by NEK2.
  • Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint. Deubiquitinated by USP44, leading to stabilize the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C. Ubiquitinated at Lys-490 during prometaphase. Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C complex.
  • Ubiquitination at Lys 97, Lys 114, Lys 129, Lys 136, Lys 149, Lys 155, Lys 259, Lys 485, and Lys 490
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC20 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDC20 (CDC20)

No data available for DME Specific Peptides for CDC20 Gene

Domains & Families for CDC20 Gene

Gene Families for CDC20 Gene

Suggested Antigen Peptide Sequences for CDC20 Gene

Graphical View of Domain Structure for InterPro Entry

Q12834

UniProtKB/Swiss-Prot:

CDC20_HUMAN :
  • Belongs to the WD repeat CDC20/Fizzy family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat CDC20/Fizzy family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with CDC20: view

Function for CDC20 Gene

Molecular function for CDC20 Gene

GENATLAS Biochemistry:
cell division cycle 20,involved in ubiquitin mediated proteolysis,highly expressed in proliferating cells,homolog to S cerevisiae Cdc20p,mediating the association of the mitotic spindle checkpoint protein MAD1L1 with the cyclosome/anaphase-promoting complex
UniProtKB/Swiss-Prot Function:
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.

Gene Ontology (GO) - Molecular Function for CDC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 11030144
GO:0042826 histone deacetylase binding IEA --
genes like me logo Genes that share ontologies with CDC20: view
genes like me logo Genes that share phenotypes with CDC20: view

Animal Models for CDC20 Gene

MGI Knock Outs for CDC20:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC20 Gene

Localization for CDC20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC20 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC20 Gene COMPARTMENTS Subcellular localization image for CDC20 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for CDC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005819 spindle TAS 7513050
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with CDC20: view

Pathways & Interactions for CDC20 Gene

SuperPathways for CDC20 Gene

genes like me logo Genes that share pathways with CDC20: view

Pathways by source for CDC20 Gene

UniProtKB/Swiss-Prot Q12834-CDC20_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for CDC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with CDC20: view

No data available for SIGNOR curated interactions for CDC20 Gene

Drugs & Compounds for CDC20 Gene

(3) Drugs for CDC20 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CDC20: view

Transcripts for CDC20 Gene

Unigene Clusters for CDC20 Gene

Cell division cycle 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC20 Gene

No ASD Table

Relevant External Links for CDC20 Gene

GeneLoc Exon Structure for
CDC20
ECgene alternative splicing isoforms for
CDC20

Expression for CDC20 Gene

mRNA expression in normal human tissues for CDC20 Gene

mRNA differential expression in normal tissues according to GTEx for CDC20 Gene

This gene is overexpressed in Testis (x9.1) and Esophagus - Mucosa (x4.8).

Protein differential expression in normal tissues from HIPED for CDC20 Gene

This gene is overexpressed in Lung (67.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC20 Gene



SOURCE GeneReport for Unigene cluster for CDC20 Gene Hs.524947

genes like me logo Genes that share expression patterns with CDC20: view

Protein tissue co-expression partners for CDC20 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CDC20 Gene

Orthologs for CDC20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC20 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC20 35
  • 92.25 (n)
  • 97.39 (a)
CDC20 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC20 35
  • 91.45 (n)
  • 97.6 (a)
CDC20 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc20 35
  • 88.31 (n)
  • 94.79 (a)
Cdc20 16
Cdc20 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDC20 35
  • 99.8 (n)
  • 99.8 (a)
CDC20 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc20 35
  • 89.25 (n)
  • 94.99 (a)
oppossum
(Monodelphis domestica)
Mammalia CDC20 36
  • 25 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC20 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC20 35
  • 77 (n)
  • 82.09 (a)
CDC20 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC20 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc20 35
  • 70.49 (n)
  • 77.06 (a)
MGC75919 35
zebrafish
(Danio rerio)
Actinopterygii cdc20 35
  • 63.35 (n)
  • 61.26 (a)
Dr.26337 35
cdc20 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3615 35
fruit fly
(Drosophila melanogaster)
Insecta fzy 37
  • 49 (a)
fzy 35
  • 56.55 (n)
  • 54.79 (a)
fzy 36
  • 50 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009338 35
  • 54.65 (n)
  • 51.93 (a)
worm
(Caenorhabditis elegans)
Secernentea fzy-1 36
  • 23 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL014C 35
  • 48.38 (n)
  • 41.21 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10791g 35
  • 46.22 (n)
  • 39.86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC20 35
  • 47.37 (n)
  • 38.92 (a)
CDH1 36
  • 29 (a)
OneToMany
CDC20 38
barley
(Hordeum vulgare)
Liliopsida Hv.7030 35
rice
(Oryza sativa)
Liliopsida Os02g0700100 35
  • 54.53 (n)
  • 50.51 (a)
Os.26575 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02616 35
  • 50.04 (n)
  • 47.2 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes slp1 35
  • 51.66 (n)
  • 48.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10505 36
  • 49 (a)
OneToMany
Species with no ortholog for CDC20:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC20 Gene

ENSEMBL:
Gene Tree for CDC20 (if available)
TreeFam:
Gene Tree for CDC20 (if available)

Paralogs for CDC20 Gene

Paralogs for CDC20 Gene

(2) SIMAP similar genes for CDC20 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CDC20 Gene

genes like me logo Genes that share paralogs with CDC20: view

Variants for CDC20 Gene

Sequence variations from dbSNP and Humsavar for CDC20 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs45443196 - 43,362,195(+) CACAG(A/G)TGTGC reference, missense
VAR_030369 -
rs710251 -- 43,360,641(+) ACCCT(A/C)CCCTT intron-variant
rs1801456 -- 43,361,123(+) AGGCC(A/C/G)TAGCA reference, missense
rs2069387 -- 43,362,409(+) aatgg(G/T)tgcca intron-variant

Variation tolerance for CDC20 Gene

Residual Variation Intolerance Score: 11.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC20 Gene

HapMap Linkage Disequilibrium report
CDC20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDC20 Gene

Disorders for CDC20 Gene

Relevant External Links for CDC20

Genetic Association Database (GAD)
CDC20
Human Genome Epidemiology (HuGE) Navigator
CDC20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC20

No disorders were found for CDC20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC20 Gene

Publications for CDC20 Gene

  1. A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4. (PMID: 7513050) Weinstein J. … Baum L.G. (Mol. Cell. Biol. 1994) 2 3 4 67
  2. Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding. (PMID: 19154722) Kulukian A. … Cleveland D.W. (Dev. Cell 2009) 3 23
  3. Strong inducible knockdown of APC/CCdc20 does not cause mitotic arrest in human somatic cells. (PMID: 19197151) Baumgarten A.J. … WAosch R. (Cell Cycle 2009) 3 23
  4. [Expression of cell cycle molecules in human azoospermic testes]. (PMID: 19426592) Yang B. … Kang F.X. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2009) 3 23
  5. CDC20, a potential cancer therapeutic target, is negatively regulated by p53. (PMID: 17873905) Kidokoro T. … Matsuda K. (Oncogene 2008) 3 23

Products for CDC20 Gene

Sources for CDC20 Gene

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