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Aliases for CDC20 Gene

Aliases for CDC20 Gene

  • Cell Division Cycle 20 2 3
  • P55CDC 3 4
  • CDC20 (Cell Division Cycle 20, S. Cerevisiae, Homolog) 2
  • CDC20 Cell Division Cycle 20 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 20 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle Protein 20 Homolog 3
  • CDC20 Cell Division Cycle 20 Homolog 3
  • Cell Division Cycle 20 Homolog 3
  • BA276H19.3 3
  • CDC20A 3

External Ids for CDC20 Gene

Summaries for CDC20 Gene

Entrez Gene Summary for CDC20 Gene

  • CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC20 Gene

CDC20 (Cell Division Cycle 20) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic. GO annotations related to this gene include enzyme binding and protein C-terminus binding. An important paralog of this gene is FZR1.

UniProtKB/Swiss-Prot for CDC20 Gene

  • Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.

Gene Wiki entry for CDC20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC20 Gene

Genomics for CDC20 Gene

Genomic Location for CDC20 Gene

Start:
43,358,955 bp from pter
End:
43,363,203 bp from pter
Size:
4,249 bases
Orientation:
Plus strand

Genomic View for CDC20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC20 Gene

Regulatory Elements for CDC20 Gene

Proteins for CDC20 Gene

  • Protein details for CDC20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12834-CDC20_HUMAN
    Recommended name:
    Cell division cycle protein 20 homolog
    Protein Accession:
    Q12834
    Secondary Accessions:
    • B2R6Z6
    • D3DPJ1
    • Q5JUY4
    • Q9BW56
    • Q9UQI9

    Protein attributes for CDC20 Gene

    Size:
    499 amino acids
    Molecular mass:
    54723 Da
    Quaternary structure:
    • Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with NEUROD2 and SPATC1 (By similarity). Interacts with MAD2L1 and BUB1B. The phosphorylated form interacts with APC/C. Interacts with NINL. May interact with MAD2L2. Interacts with CDK5RAP2 and SIRT2. Interacts with isoform 1 of NEK2.

    Three dimensional structures from OCA and Proteopedia for CDC20 Gene

neXtProt entry for CDC20 Gene

Proteomics data for CDC20 Gene at MOPED

Post-translational modifications for CDC20 Gene

  • Acetylated. Deacetylated at Lys-66 by SIRT2; deacetylation enhances the interaction of CDC20 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).
  • Dephosphorylated by CTDP1
  • Phosphorylated during mitosis, probably by maturation promoting factor (MPF). Phosphorylated by BUB1 at Ser-41; Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161. Phosphorylated by NEK2.
  • Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint. Deubiquitinated by USP44, leading to stabilize the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C. Ubiquitinated at Lys-490 during prometaphase. Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C complex.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys97, Lys114, Lys129, Lys136, Lys149, Lys155, Lys259, Lys485, and Lys490

Other Protein References for CDC20 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CDC20 Gene

Domains for CDC20 Gene

Gene Families for CDC20 Gene

HGNC:
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

CDC20_HUMAN
Family:
  • Belongs to the WD repeat CDC20/Fizzy family.:
    • Q12834
Similarity:
  • Contains 7 WD repeats.:
    • Q12834
genes like me logo Genes that share domains with CDC20: view

Function for CDC20 Gene

Molecular function for CDC20 Gene

GENATLAS Biochemistry: cell division cycle 20,involved in ubiquitin mediated proteolysis,highly expressed in proliferating cells,homolog to S cerevisiae Cdc20p,mediating the association of the mitotic spindle checkpoint protein MAD1L1 with the cyclosome/anaphase-promoting complex
UniProtKB/Swiss-Prot Function: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.

Gene Ontology (GO) - Molecular Function for CDC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11030144
GO:0008022 protein C-terminus binding IPI 10700282
GO:0019899 enzyme binding IPI 17443180
genes like me logo Genes that share ontologies with CDC20: view
genes like me logo Genes that share phenotypes with CDC20: view

Animal Models for CDC20 Gene

MGI Knock Outs for CDC20:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CDC20 Gene

Localization for CDC20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC20 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC20 Gene COMPARTMENTS Subcellular localization image for CDC20 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for CDC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005680 colocalizes_with anaphase-promoting complex IDA 11459825
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CDC20: view

Pathways for CDC20 Gene

SuperPathways for CDC20 Gene

genes like me logo Genes that share pathways with CDC20: view

Pathways by source for CDC20 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for CDC20 Gene
1 Qiagen pathway for CDC20 Gene
2 Cell Signaling Technology pathways for CDC20 Gene

UniProtKB/Swiss-Prot Q12834-CDC20_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for CDC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007049 cell cycle TAS 9682218
GO:0007067 mitotic nuclear division IEA --
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with CDC20: view

Compounds for CDC20 Gene

(3) Novoseek inferred chemical compound relationships for CDC20 Gene

Compound -log(P) Hits PubMed IDs
nocodazole 50 1
serine 9.87 1
threonine 9.67 1
genes like me logo Genes that share compounds with CDC20: view

Transcripts for CDC20 Gene

mRNA/cDNA for CDC20 Gene

Unigene Clusters for CDC20 Gene

Cell division cycle 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC20 Gene

No ASD Table

Relevant External Links for CDC20 Gene

GeneLoc Exon Structure for
CDC20
ECgene alternative splicing isoforms for
CDC20

Expression for CDC20 Gene

mRNA expression in normal human tissues for CDC20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC20 Gene

This gene is overexpressed in Testis (9.1) and Esophagus - Mucosa (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC20 Gene

SOURCE GeneReport for Unigene cluster for CDC20 Gene Hs.524947

genes like me logo Genes that share expressions with CDC20: view

Orthologs for CDC20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC20 36
  • 99.8 (n)
  • 99.8 (a)
CDC20 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC20 36
  • 92.25 (n)
  • 97.39 (a)
CDC20 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC20 36
  • 91.45 (n)
  • 97.6 (a)
CDC20 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc20 36
  • 88.31 (n)
  • 94.79 (a)
Cdc20 16
Cdc20 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC20 37
  • 25 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC20 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc20 36
  • 89.25 (n)
  • 94.99 (a)
chicken
(Gallus gallus)
Aves CDC20 36
  • 77 (n)
  • 82.09 (a)
CDC20 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC20 37
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc20 36
  • 70.49 (n)
  • 77.06 (a)
MGC75919 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3615 36
zebrafish
(Danio rerio)
Actinopterygii cdc20 36
  • 63.35 (n)
  • 61.26 (a)
cdc20 37
  • 61 (a)
OneToOne
Dr.26337 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009338 36
  • 54.65 (n)
  • 51.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta fzy 36
  • 56.55 (n)
  • 54.79 (a)
fzy 37
  • 50 (a)
OneToMany
fzy 38
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea fzy-1 37
  • 23 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL014C 36
  • 48.38 (n)
  • 41.21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC20 36
  • 47.37 (n)
  • 38.92 (a)
CDC20 39
CDH1 37
  • 29 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10791g 36
  • 46.22 (n)
  • 39.86 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.7030 36
rice
(Oryza sativa)
Liliopsida Os.26575 36
Os02g0700100 36
  • 54.53 (n)
  • 50.51 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02616 36
  • 50.04 (n)
  • 47.2 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes slp1 36
  • 51.66 (n)
  • 48.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10505 37
  • 49 (a)
OneToMany
Species with no ortholog for CDC20:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC20 Gene

ENSEMBL:
Gene Tree for CDC20 (if available)
TreeFam:
Gene Tree for CDC20 (if available)

Paralogs for CDC20 Gene

Paralogs for CDC20 Gene

Selected SIMAP similar genes for CDC20 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CDC20 Gene

genes like me logo Genes that share paralogs with CDC20: view

Variants for CDC20 Gene

Sequence variations from dbSNP and Humsavar for CDC20 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs710251 -- 43,360,641(+) ACCCT(A/C)CCCTT intron-variant
rs839763 -- 43,359,973(-) TTCTG(A/G)TAACC synonymous-codon, reference
rs1051097 -- 43,359,194(+) AGGAC(C/T)CCTCC utr-variant-5-prime
rs1749960 -- 43,356,993(+) AACCA(C/T)GACAA upstream-variant-2KB
rs1749961 -- 43,356,994(+) ACCAT(C/G)ACAAC upstream-variant-2KB

Relevant External Links for CDC20 Gene

HapMap Linkage Disequilibrium report
CDC20

No data available for Structural Variations from Database of Genomic Variants (DGV) for CDC20 Gene

Disorders for CDC20 Gene

(6) Novoseek inferred disease relationships for CDC20 Gene

Disease -log(P) Hits PubMed IDs
cancer 16.7 8
cancer lung 0 1
primary tumor 0 1
breast cancer 0 1
tumors 0 9

Relevant External Links for CDC20

Genetic Association Database (GAD)
CDC20
Human Genome Epidemiology (HuGE) Navigator
CDC20
genes like me logo Genes that share disorders with CDC20: view

No data available for UniProtKB/Swiss-Prot for CDC20 Gene

Publications for CDC20 Gene

  1. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. (PMID: 9637688) Fang G. … Kirschner M.W. (Genes Dev. 1998) 3 4 23
  2. MAD2B is an inhibitor of the anaphase-promoting complex. (PMID: 11459826) Chen J. … Fang G. (Genes Dev. 2001) 3 4 23
  3. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PMID: 14657031) Kraft C. … Peters J.-M. (EMBO J. 2003) 3 4 23
  4. Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. (PMID: 15525512) Tang Z. … Yu H. (Mol. Cell 2004) 3 4 23
  5. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. (PMID: 17443180) Stegmeier F. … Elledge S.J. (Nature 2007) 3 4 23

Products for CDC20 Gene

  • Addgene plasmids for CDC20

Sources for CDC20 Gene

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