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Aliases for NUAK1 Gene

Aliases for NUAK1 Gene

  • NUAK Family Kinase 1 2 3
  • NUAK Family, SNF1-Like Kinase, 1 2 3 5
  • AMP-Activated Protein Kinase Family Member 5 2 3
  • AMPK-Related Protein Kinase 5 3 4
  • Omphalocele Kinase 1 3 4
  • EC 2.7.11.1 4 63
  • ARK5 3 4
  • EC 2.7.11 63
  • KIAA0537 4
  • OMPHK1 4

External Ids for NUAK1 Gene

Previous GeneCards Identifiers for NUAK1 Gene

  • GC12M104960
  • GC12M106457
  • GC12M103517

Summaries for NUAK1 Gene

GeneCards Summary for NUAK1 Gene

NUAK1 (NUAK Family Kinase 1) is a Protein Coding gene. Diseases associated with NUAK1 include Omphalocele. Among its related pathways are Glucose / Energy Metabolism and Gene Expression. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LOC102724428.

UniProtKB/Swiss-Prot for NUAK1 Gene

  • Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of Ser-464 of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at Ser-15 and Ser-392 and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).

Gene Wiki entry for NUAK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUAK1 Gene

Genomics for NUAK1 Gene

Regulatory Elements for NUAK1 Gene

Enhancers for NUAK1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUAK1 on UCSC Golden Path with GeneCards custom track

Promoters for NUAK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUAK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUAK1 Gene

Chromosome:
12
Start:
106,063,340 bp from pter
End:
106,140,033 bp from pter
Size:
76,694 bases
Orientation:
Minus strand

Genomic View for NUAK1 Gene

Genes around NUAK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUAK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUAK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUAK1 Gene

Proteins for NUAK1 Gene

  • Protein details for NUAK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60285-NUAK1_HUMAN
    Recommended name:
    NUAK family SNF1-like kinase 1
    Protein Accession:
    O60285
    Secondary Accessions:
    • A7MD39
    • Q96KA8

    Protein attributes for NUAK1 Gene

    Size:
    661 amino acids
    Molecular mass:
    74305 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interact (via GILK motif) with PPP1CB; the interaction is direct and bridges NUAK1 and PPP1R12A. Interacts with CDKN1A.
    SequenceCaution:
    • Sequence=BAA25463.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NUAK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUAK1 Gene

Proteomics data for NUAK1 Gene at MOPED

Post-translational modifications for NUAK1 Gene

  • Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not dephosphorylated by the myosin PP1 complex when regulating its activity, due to the presence of PPP1R12A, which prevents myosin PP1 from dephosphorylating NUAK1. Phosphorylated by STK38L upon stimulation with IGF1.
  • Ubiquitinated with Lys-29- and Lys-33-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUAK1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NUAK1 (NuaK1)
  • Abcam antibodies for ARK5
  • Cloud-Clone Corp. Antibodies for NUAK1

Domains & Families for NUAK1 Gene

Gene Families for NUAK1 Gene

Suggested Antigen Peptide Sequences for NUAK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60285

UniProtKB/Swiss-Prot:

NUAK1_HUMAN :
  • The GILK motif mediates interaction with PPP1CB.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Domain:
  • The GILK motif mediates interaction with PPP1CB.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with NUAK1: view

Function for NUAK1 Gene

Molecular function for NUAK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-211. Activated by phosphorylation at Ser-600 AKT1 during glucose starvation; the relevance of such activation in normal cells is however unsure.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of Ser-464 of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at Ser-15 and Ser-392 and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).
UniProtKB/Swiss-Prot Induction:
Transcriptionally regulated by members of the MAF family.

Enzyme Numbers (IUBMB) for NUAK1 Gene

Gene Ontology (GO) - Molecular Function for NUAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 21317932
genes like me logo Genes that share ontologies with NUAK1: view
genes like me logo Genes that share phenotypes with NUAK1: view

Animal Models for NUAK1 Gene

MGI Knock Outs for NUAK1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NUAK1

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUAK1 Gene

Localization for NUAK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUAK1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUAK1 Gene COMPARTMENTS Subcellular localization image for NUAK1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for NUAK1 Gene

Pathways & Interactions for NUAK1 Gene

genes like me logo Genes that share pathways with NUAK1: view

Pathways by source for NUAK1 Gene

SIGNOR curated interactions for NUAK1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for NUAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 25329316
GO:0007155 cell adhesion IEA --
GO:0030155 regulation of cell adhesion IDA 20354225
GO:0042127 regulation of cell proliferation TAS 21317932
GO:1901796 regulation of signal transduction by p53 class mediator TAS --
genes like me logo Genes that share ontologies with NUAK1: view

Drugs & Compounds for NUAK1 Gene

(4) Drugs for NUAK1 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
HTH-01-015 Pharma NUAK1 inhibitor,highly specific and selective 0
WZ4003 Pharma 0
Magnesium Nutra 0

(1) Additional Compounds for NUAK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(2) ApexBio Compounds for NUAK1 Gene

Compound Action Cas Number
HTH-01-015 NUAK1 inhibitor,highly specific and selective 1613724-42-7
WZ4003 1214265-58-3
genes like me logo Genes that share compounds with NUAK1: view

Transcripts for NUAK1 Gene

Unigene Clusters for NUAK1 Gene

NUAK family, SNF1-like kinase, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUAK1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3:
SP4: - - -

Relevant External Links for NUAK1 Gene

GeneLoc Exon Structure for
NUAK1
ECgene alternative splicing isoforms for
NUAK1

Expression for NUAK1 Gene

mRNA expression in normal human tissues for NUAK1 Gene

mRNA differential expression in normal tissues according to GTEx for NUAK1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.2).

Protein differential expression in normal tissues from HIPED for NUAK1 Gene

This gene is overexpressed in Lung (43.1) and Liver (24.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NUAK1 Gene



SOURCE GeneReport for Unigene cluster for NUAK1 Gene Hs.524692

mRNA Expression by UniProt/SwissProt for NUAK1 Gene

O60285-NUAK1_HUMAN
Tissue specificity: Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver. Highly up-regulated in colorectal cancer cell lines.
genes like me logo Genes that share expression patterns with NUAK1: view

Protein tissue co-expression partners for NUAK1 Gene

Primer Products

Orthologs for NUAK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUAK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUAK1 35
  • 90.23 (n)
  • 94.75 (a)
NUAK1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUAK1 35
  • 89.36 (n)
  • 92.13 (a)
NUAK1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nuak1 35
  • 87.37 (n)
  • 91.48 (a)
Nuak1 16
Nuak1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUAK1 35
  • 99.55 (n)
  • 99.7 (a)
NUAK1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nuak1 35
  • 87.1 (n)
  • 91.05 (a)
oppossum
(Monodelphis domestica)
Mammalia NUAK1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUAK1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUAK1 35
  • 77.66 (n)
  • 83.13 (a)
NUAK1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUAK1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nuak1 35
  • 70.58 (n)
  • 76.51 (a)
zebrafish
(Danio rerio)
Actinopterygii nuak1 35
  • 67.18 (n)
  • 69.24 (a)
NUAK1 (1 of 2) 36
  • 61 (a)
OneToMany
NUAK1 (2 of 2) 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43143 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-82 36
  • 14 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNF1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToMany
Species with no ortholog for NUAK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUAK1 Gene

ENSEMBL:
Gene Tree for NUAK1 (if available)
TreeFam:
Gene Tree for NUAK1 (if available)

Paralogs for NUAK1 Gene

genes like me logo Genes that share paralogs with NUAK1: view

Variants for NUAK1 Gene

Sequence variations from dbSNP and Humsavar for NUAK1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs3741883 - 106,067,160(+) TTTCA(C/G/T)GGCTG reference, missense
rs55774704 - 106,067,532(+) CTACA(C/T)CTTCA reference, missense
rs1978730 -- 106,086,468(+) taaat(A/C)taaaa intron-variant
rs1991429 -- 106,105,877(+) CCCCA(C/T)GCTGC intron-variant
rs2059769 -- 106,109,292(+) GACAC(C/T)GTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUAK1 Gene

Variant ID Type Subtype PubMed ID
nsv832509 CNV Gain 17160897
esv2746333 CNV Deletion 23290073
esv25105 CNV Loss 19812545

Variation tolerance for NUAK1 Gene

Residual Variation Intolerance Score: 4.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.88; 87.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUAK1 Gene

Human Gene Mutation Database (HGMD)
NUAK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUAK1 Gene

Disorders for NUAK1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUAK1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
omphalocele
  • omphalocoele
- elite association - COSMIC cancer census association via MalaCards
Search NUAK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NUAK1

Genetic Association Database (GAD)
NUAK1
Human Genome Epidemiology (HuGE) Navigator
NUAK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUAK1
genes like me logo Genes that share disorders with NUAK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUAK1 Gene

Publications for NUAK1 Gene

  1. Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein. (PMID: 12409306) Suzuki A. … Esumi H. (J. Biol. Chem. 2003) 2 3 4 67
  2. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. (PMID: 19927127) Humbert N. … Bernard D. (EMBO J. 2010) 3 23
  3. New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. (PMID: 20354225) Zagorska A. … Alessi D.R. (Sci. Signal. 2010) 3 23
  4. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. (PMID: 18254724) Al-Hakim A.K. … Alessi D.R. (Biochem. J. 2008) 3 23
  5. ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma. (PMID: 16044163) Suzuki A. … Esumi H. (Oncogene 2005) 3 23

Products for NUAK1 Gene

Sources for NUAK1 Gene

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