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Aliases for POM121 Gene

Aliases for POM121 Gene

  • POM121 Transmembrane Nucleoporin 2 3
  • Nuclear Envelope Pore Membrane Protein POM 121A 3 4
  • POM121 Membrane Glycoprotein 2 3
  • Nucleoporin Nup121 3 4
  • POM121A 3 4
  • Nuclear Envelope Pore Membrane Protein POM 121 3
  • Nuclear Pore Membrane Protein 121 KDa 3
  • POM121 Membrane Glycoprotein (Rat) 2
  • Pore Membrane Protein Of 121 KDa 4
  • KIAA0618 4
  • NUP121 4
  • P145 3

External Ids for POM121 Gene

Previous GeneCards Identifiers for POM121 Gene

  • GC07P070990
  • GC07P071750
  • GC07P071762
  • GC07P071794
  • GC07P071987
  • GC07P072349
  • GC07M070166

Summaries for POM121 Gene

Entrez Gene Summary for POM121 Gene

  • This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]

GeneCards Summary for POM121 Gene

POM121 (POM121 Transmembrane Nucleoporin) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. An important paralog of this gene is POM121L7.

UniProtKB/Swiss-Prot for POM121 Gene

  • Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).

Gene Wiki entry for POM121 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POM121 Gene

Genomics for POM121 Gene

Regulatory Elements for POM121 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POM121 Gene

Start:
72,879,335 bp from pter
End:
72,951,440 bp from pter
Size:
72,106 bases
Orientation:
Plus strand

Genomic View for POM121 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POM121 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POM121 Gene

Proteins for POM121 Gene

  • Protein details for POM121 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HA1-P121A_HUMAN
    Recommended name:
    Nuclear envelope pore membrane protein POM 121
    Protein Accession:
    Q96HA1
    Secondary Accessions:
    • A6NFS9
    • A8CDT4
    • A8K933
    • A8MXF9
    • O75115
    • Q96DI0
    • Q9H9X1
    • Q9Y2N3
    • Q9Y4S7

    Protein attributes for POM121 Gene

    Size:
    1249 amino acids
    Molecular mass:
    127720 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA31593.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14097.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for POM121 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POM121 Gene

Proteomics data for POM121 Gene at MOPED

Post-translational modifications for POM121 Gene

  • Ubiquitination at Lys339, Lys387, and Lys428
  • Modification sites at PhosphoSitePlus

Other Protein References for POM121 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for POM121 Gene

Domains for POM121 Gene

Protein Domains for POM121 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for POM121 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96HA1

UniProtKB/Swiss-Prot:

P121A_HUMAN :
  • Q96HA1
Domain:
  • Contains F-X-F-G repeats
Family:
  • Belongs to the POM121 family.
genes like me logo Genes that share domains with POM121: view

No data available for Gene Families for POM121 Gene

Function for POM121 Gene

Molecular function for POM121 Gene

UniProtKB/Swiss-Prot Function: Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).

Gene Ontology (GO) - Molecular Function for POM121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with POM121: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POM121

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for POM121 Gene

Localization for POM121 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POM121 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POM121 Gene COMPARTMENTS Subcellular localization image for POM121 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for POM121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IEA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with POM121: view

Pathways for POM121 Gene

SuperPathways for POM121 Gene

genes like me logo Genes that share pathways with POM121: view

Pathways by source for POM121 Gene

42 Reactome pathways for POM121 Gene
1 KEGG pathway for POM121 Gene

Gene Ontology (GO) - Biological Process for POM121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0008645 hexose transport TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with POM121: view

Transcripts for POM121 Gene

Unigene Clusters for POM121 Gene

POM121 transmembrane nucleoporin:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POM121

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for POM121
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POM121 Gene

No ASD Table

Relevant External Links for POM121 Gene

GeneLoc Exon Structure for
POM121
ECgene alternative splicing isoforms for
POM121

Expression for POM121 Gene

mRNA expression in normal human tissues for POM121 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for POM121 Gene

SOURCE GeneReport for Unigene cluster for POM121 Gene Hs.655217

genes like me logo Genes that share expressions with POM121: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POM121 Gene

Orthologs for POM121 Gene

This gene was present in the common ancestor of chordates.

Orthologs for POM121 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 75 (a)
OneToMany
POM121 35
  • 98.39 (n)
  • 97.03 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 55 (a)
OneToMany
POM121C 35
  • 78.69 (n)
  • 73.78 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 46 (a)
OneToMany
POM121C 35
  • 78.16 (n)
  • 73.82 (a)
mouse
(Mus musculus)
Mammalia Pom121 35
  • 74.53 (n)
  • 69.21 (a)
Pom121 16
Pom121 36
  • 52 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pom121 35
  • 74.76 (n)
  • 68.74 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 43 (a)
OneToMany
POM121 35
  • 60.01 (n)
  • 52.9 (a)
zebrafish
(Danio rerio)
Actinopterygii pom121 36
  • 24 (a)
OneToMany
Species with no ortholog for POM121:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POM121 Gene

ENSEMBL:
Gene Tree for POM121 (if available)
TreeFam:
Gene Tree for POM121 (if available)

Paralogs for POM121 Gene

Paralogs for POM121 Gene

Selected SIMAP similar genes for POM121 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for POM121 Gene

genes like me logo Genes that share paralogs with POM121: view

Variants for POM121 Gene

Sequence variations from dbSNP and Humsavar for POM121 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs236653 -- 72,946,663(-) CTTTA(C/G)GGATA intron-variant, utr-variant-3-prime
rs236654 -- 72,946,657(+) ATGGG(C/T)TATCC intron-variant, utr-variant-3-prime
rs237926 -- 72,907,499(-) aTCCA(A/G)AAAGA intron-variant
rs237927 -- 72,911,703(-) CCCAA(C/T)AGTCC intron-variant
rs237928 -- 72,930,654(-) CCCTA(C/T)ACTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POM121 Gene

Variant ID Type Subtype PubMed ID
dgv2094e1 CNV Complex 17122850
dgv2095e1 CNV Complex 17122850
nsv520573 CNV Gain+Loss 19592680
esv34349 CNV Gain 17911159
dgv2097e1 CNV Complex 17122850
dgv2098e1 CNV Complex 17122850
nsv428171 CNV Gain 18775914
dgv2099e1 CNV Complex 17122850
nsv469793 CNV Gain 16826518
nsv888362 CNV Gain 21882294
esv1311182 CNV Deletion 17803354
nsv469664 CNV Loss 16826518
nsv888363 CNV Gain+Loss 21882294
nsv8134 CNV Loss 18304495

Relevant External Links for POM121 Gene

HapMap Linkage Disequilibrium report
POM121

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POM121 Gene

Disorders for POM121 Gene

No disorders were found for POM121 Gene.

No data available for UniProtKB/Swiss-Prot for POM121 Gene

Publications for POM121 Gene

  1. Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes. (PMID: 17900573) Funakoshi T. … Imamoto N. (FEBS Lett. 2007) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  3. An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region. (PMID: 8335683) Hallberg E. … Blobel G. (J. Cell Biol. 1993) 2 3
  4. Capture of AT-rich chromatin by ELYS recruits POM121 and NDC1 to initiate nuclear pore assembly. (PMID: 18596237) Rasala B.A. … Forbes D.J. (Mol. Biol. Cell 2008) 3 23
  5. Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo. (PMID: 19620630) Anderson D.J. … Hetzer M.W. (J. Cell Biol. 2009) 3 23

Products for POM121 Gene

Sources for POM121 Gene

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