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Aliases for TOX4 Gene

Aliases for TOX4 Gene

  • TOX High Mobility Group Box Family Member 4 2 3
  • KIAA0737 2 3 4 6
  • Epidermal Langerhans Cell Protein LCP1 3 4
  • C14orf92 3 4
  • LCP1 3 6
  • Chromosome 14 Open Reading Frame 92 2
  • Migration-Inducing Protein 7 3
  • MIG7 3

External Ids for TOX4 Gene

Previous HGNC Symbols for TOX4 Gene

  • C14orf92
  • KIAA0737

Previous GeneCards Identifiers for TOX4 Gene

  • GC14P021017
  • GC14P021019
  • GC14P021944
  • GC14P002064

Summaries for TOX4 Gene

GeneCards Summary for TOX4 Gene

TOX4 (TOX High Mobility Group Box Family Member 4) is a Protein Coding gene. Among its related pathways are Lymphocyte Signaling. An important paralog of this gene is SSRP1.

UniProtKB/Swiss-Prot for TOX4 Gene

  • Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

Gene Wiki entry for TOX4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOX4 Gene

Genomics for TOX4 Gene

Regulatory Elements for TOX4 Gene

Genomic Location for TOX4 Gene

21,476,597 bp from pter
21,499,175 bp from pter
22,579 bases
Plus strand

Genomic View for TOX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOX4 Gene

Proteins for TOX4 Gene

  • Protein details for TOX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TOX high mobility group box family member 4
    Protein Accession:
    Secondary Accessions:
    • B4DPY8
    • B4DSM0
    • E7EV69

    Protein attributes for TOX4 Gene

    621 amino acids
    Molecular mass:
    66195 Da
    Quaternary structure:
    • Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS.
    • Sequence=BAA34457.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TOX4 Gene


neXtProt entry for TOX4 Gene

Proteomics data for TOX4 Gene at MOPED

Post-translational modifications for TOX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TOX4 Gene

Domains for TOX4 Gene

Protein Domains for TOX4 Gene


Suggested Antigen Peptide Sequences for TOX4 Gene

Graphical View of Domain Structure for InterPro Entry



  • O94842
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with TOX4: view

No data available for Gene Families for TOX4 Gene

Function for TOX4 Gene

Molecular function for TOX4 Gene

UniProtKB/Swiss-Prot Function: Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

Gene Ontology (GO) - Molecular Function for TOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA --
GO:0005515 protein binding IPI 20516061
genes like me logo Genes that share ontologies with TOX4: view

Animal Model Products

CRISPR Products

miRNA for TOX4 Gene

miRTarBase miRNAs that target TOX4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TOX4 Gene

Localization for TOX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOX4 Gene

Nucleus. Note=Associated with chromatin.

Subcellular locations from

Jensen Localization Image for TOX4 Gene COMPARTMENTS Subcellular localization image for TOX4 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for TOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 20516061
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0072357 PTW/PP1 phosphatase complex IDA 20516061
genes like me logo Genes that share ontologies with TOX4: view

Pathways for TOX4 Gene

SuperPathways for TOX4 Gene

Superpath Contained pathways
1 Lymphocyte Signaling
genes like me logo Genes that share pathways with TOX4: view

Pathways by source for TOX4 Gene

1 Cell Signaling Technology pathway for TOX4 Gene

Gene Ontology (GO) - Biological Process for TOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IBA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with TOX4: view

Transcripts for TOX4 Gene

Unigene Clusters for TOX4 Gene

TOX high mobility group box family member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOX4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOX4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - -
SP6: -
SP7: - -
SP9: - -

Relevant External Links for TOX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TOX4 Gene

mRNA expression in normal human tissues for TOX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TOX4 Gene

SOURCE GeneReport for Unigene cluster for TOX4 Gene Hs.555910

genes like me logo Genes that share expressions with TOX4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TOX4 Gene

Orthologs for TOX4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TOX4 35
  • 99.52 (n)
  • 99.52 (a)
TOX4 36
  • 100 (a)
(Bos Taurus)
Mammalia TOX4 35
  • 93.65 (n)
  • 96.45 (a)
TOX4 36
  • 96 (a)
(Canis familiaris)
Mammalia TOX4 35
  • 94.18 (n)
  • 97.9 (a)
TOX4 36
  • 98 (a)
(Mus musculus)
Mammalia Gm5828 36
  • 91 (a)
Tox4 35
  • 89.93 (n)
  • 95.32 (a)
Tox4 16
Tox4 36
  • 95 (a)
(Monodelphis domestica)
Mammalia TOX4 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia TOX4 36
  • 60 (a)
(Rattus norvegicus)
Mammalia Tox4 35
  • 89.88 (n)
  • 95.32 (a)
(Anolis carolinensis)
Reptilia TOX4 36
  • 71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33838 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC395028 35
tox4 35
  • 67.12 (n)
  • 69.74 (a)
(Danio rerio)
Actinopterygii tox4 36
  • 40 (a)
TOX4 (2 of 2) 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12104 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea hmg-6 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POB3 36
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11202 36
  • 23 (a)
Species with no ortholog for TOX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TOX4 Gene

Gene Tree for TOX4 (if available)
Gene Tree for TOX4 (if available)

Paralogs for TOX4 Gene

Paralogs for TOX4 Gene

Selected SIMAP similar genes for TOX4 Gene using alignment to 6 proteins: Pseudogenes for TOX4 Gene

genes like me logo Genes that share paralogs with TOX4: view

Variants for TOX4 Gene

Sequence variations from dbSNP and Humsavar for TOX4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7617 -- 21,492,810(+) TCCCG(A/G)GGGCT synonymous-codon, reference
rs14562 -- 21,496,853(+) AGGGA(G/T)TCTGG utr-variant-3-prime
rs933192 -- 21,495,650(+) AATAC(A/C)TTAAG intron-variant
rs1060722 -- 21,492,657(+) ACCCT(C/T)TCATC synonymous-codon, reference
rs1060887 -- 21,496,777(+) GGGCC(A/C)CTGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TOX4 Gene

Variant ID Type Subtype PubMed ID
esv2422459 CNV Duplication 17116639
esv994931 CNV Deletion 20482838
esv2506236 CNV Deletion 19546169
esv2080110 CNV Deletion 18987734
esv8853 CNV Loss 19470904
esv2748459 CNV Deletion 23290073
esv2666055 CNV Deletion 23128226
nsv85879 CNV Loss 16902084

Relevant External Links for TOX4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOX4 Gene

Disorders for TOX4 Gene

No disorders were found for TOX4 Gene.

No data available for UniProtKB/Swiss-Prot for TOX4 Gene

Publications for TOX4 Gene

  1. Identification and characterization of a novel human PP1 phosphatase complex. (PMID: 20516061) Lee J.H. … Skalnik D.G. (J. Biol. Chem. 2010) 3 4
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3

Products for TOX4 Gene

Sources for TOX4 Gene

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