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Aliases for TOX4 Gene

Aliases for TOX4 Gene

  • TOX High Mobility Group Box Family Member 4 2 3 5
  • KIAA0737 2 3 4
  • Epidermal Langerhans Cell Protein LCP1 3 4
  • C14orf92 3 4
  • Chromosome 14 Open Reading Frame 92 2
  • Migration-Inducing Protein 7 3
  • LCP1 3
  • MIG7 3

External Ids for TOX4 Gene

Previous HGNC Symbols for TOX4 Gene

  • C14orf92
  • KIAA0737

Previous GeneCards Identifiers for TOX4 Gene

  • GC14P021017
  • GC14P021019
  • GC14P021944
  • GC14P002064

Summaries for TOX4 Gene

GeneCards Summary for TOX4 Gene

TOX4 (TOX High Mobility Group Box Family Member 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is TOX3.

UniProtKB/Swiss-Prot for TOX4 Gene

  • Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

Gene Wiki entry for TOX4 Gene

Additional gene information for TOX4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOX4 Gene

Genomics for TOX4 Gene

GeneHancer (GH) Regulatory Elements for TOX4 Gene

Promoters and enhancers for TOX4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I021475 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 563.1 +0.5 469 2.9 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 TOX4 RAB2B METTL17 METTL3 SUPT16H CHD8 PIR42881
GH14I021509 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.2 +34.5 34498 2.4 PKNOX1 CLOCK FOXA2 SMAD1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 METTL3 SUPT16H CHD8 HNRNPC METTL17 TOX4 PIR42881
GH14I021381 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 8.3 -92.6 -92648 4.3 HDGF PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 IRF4 SUPT16H ENSG00000260830 METTL17 METTL3 TEP1 CHD8 APEX1 TOX4 GC14M021386 MRPS17P6
GH14I020622 Enhancer 1.2 Ensembl ENCODE 13.6 -851.8 -851848 3.9 HNRNPUL1 SIN3A FEZF1 ZNF2 ZNF213 ZNF143 FOS KLF13 ZC3H11A REST PIR59363 TRL-TAG2-1 GC14P020627 METTL3 SUPT16H METTL17 ENSG00000258515 CHD8 PARP2 TEP1
GH14I021454 Promoter/Enhancer 1.5 Ensembl ENCODE 8.7 -20.6 -20590 2.9 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B CHD8 SUPT16H HNRNPC PNP METTL3 UBA52P2 SNORD8 SNORD9 ENSG00000257096 SALL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TOX4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TOX4 gene promoter:

Genomic Locations for TOX4 Gene

Genomic Locations for TOX4 Gene
22,581 bases
Plus strand

Genomic View for TOX4 Gene

Genes around TOX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOX4 Gene

Proteins for TOX4 Gene

  • Protein details for TOX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TOX high mobility group box family member 4
    Protein Accession:
    Secondary Accessions:
    • B4DPY8
    • B4DSM0
    • E7EV69

    Protein attributes for TOX4 Gene

    621 amino acids
    Molecular mass:
    66195 Da
    Quaternary structure:
    • Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS.
    • Sequence=BAA34457.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TOX4 Gene


neXtProt entry for TOX4 Gene

Post-translational modifications for TOX4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TOX4 Gene

Domains & Families for TOX4 Gene

Gene Families for TOX4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TOX4 Gene


Suggested Antigen Peptide Sequences for TOX4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TOX4: view

No data available for UniProtKB/Swiss-Prot for TOX4 Gene

Function for TOX4 Gene

Molecular function for TOX4 Gene

UniProtKB/Swiss-Prot Function:
Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

Gene Ontology (GO) - Molecular Function for TOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 20516061
genes like me logo Genes that share ontologies with TOX4: view
genes like me logo Genes that share phenotypes with TOX4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOX4 Gene

Localization for TOX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOX4 Gene

Nucleus. Note=Associated with chromatin.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOX4 gene
Compartment Confidence
nucleus 5
plasma membrane 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0000785 chromatin IDA 20516061
GO:0005634 nucleus IEA --
GO:0072357 PTW/PP1 phosphatase complex IDA 20516061
genes like me logo Genes that share ontologies with TOX4: view

Pathways & Interactions for TOX4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TOX4 Gene


No data available for Pathways by source and SIGNOR curated interactions for TOX4 Gene

Drugs & Compounds for TOX4 Gene

No Compound Related Data Available

Transcripts for TOX4 Gene

Unigene Clusters for TOX4 Gene

TOX high mobility group box family member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOX4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - -
SP6: -
SP7: - -
SP9: - -

Relevant External Links for TOX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TOX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TOX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TOX4 Gene

This gene is overexpressed in Lymph node (11.4), Testis (10.0), Fetal Brain (9.3), Pancreas (6.6), and CD8 Tcells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TOX4 Gene

Protein tissue co-expression partners for TOX4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TOX4 Gene:


SOURCE GeneReport for Unigene cluster for TOX4 Gene:


Evidence on tissue expression from TISSUES for TOX4 Gene

  • Nervous system(4.9)
  • Lung(4.4)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with TOX4: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOX4 Gene

Orthologs for TOX4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TOX4 33 34
  • 99.52 (n)
(Canis familiaris)
Mammalia TOX4 33 34
  • 94.18 (n)
(Bos Taurus)
Mammalia TOX4 33 34
  • 93.65 (n)
(Mus musculus)
Mammalia Gm5828 34
  • 91 (a)
Tox4 33 16 34
  • 89.93 (n)
(Rattus norvegicus)
Mammalia Tox4 33
  • 89.88 (n)
(Monodelphis domestica)
Mammalia TOX4 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia TOX4 34
  • 60 (a)
(Anolis carolinensis)
Reptilia TOX4 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tox4 33
  • 67.12 (n)
LOC395028 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33838 33
(Danio rerio)
Actinopterygii TOX4 (2 of 2) 34
  • 46 (a)
tox4 34
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12104 34
  • 37 (a)
(Caenorhabditis elegans)
Secernentea hmg-6 34
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POB3 34
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11202 34
  • 23 (a)
Species where no ortholog for TOX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TOX4 Gene

Gene Tree for TOX4 (if available)
Gene Tree for TOX4 (if available)

Paralogs for TOX4 Gene

Paralogs for TOX4 Gene

(2) SIMAP similar genes for TOX4 Gene using alignment to 6 proteins: Pseudogenes for TOX4 Gene

genes like me logo Genes that share paralogs with TOX4: view

Variants for TOX4 Gene

Sequence variations from dbSNP and Humsavar for TOX4 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000199939 -- 21,480,577(+) C/T intron_variant
rs1000373945 -- 21,498,838(+) C/T 3_prime_UTR_variant
rs1000401178 -- 21,495,542(+) G/A intron_variant
rs1000421889 -- 21,478,885(+) C/T intron_variant
rs1000478235 -- 21,487,391(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TOX4 Gene

Variant ID Type Subtype PubMed ID
esv2080110 CNV deletion 18987734
esv2422459 CNV duplication 17116639
esv2506236 CNV deletion 19546169
esv2666055 CNV deletion 23128226
esv2748459 CNV deletion 23290073
esv3246830 CNV deletion 24192839
esv3551214 CNV deletion 23714750
esv3633716 CNV gain 21293372
esv3633717 CNV loss 21293372
esv3633718 CNV gain 21293372
esv8853 CNV loss 19470904
esv994931 CNV deletion 20482838
nsv1069985 CNV deletion 25765185
nsv1112643 CNV deletion 24896259
nsv1144710 CNV deletion 24896259
nsv85879 CNV deletion 16902084
nsv957490 CNV deletion 24416366

Variation tolerance for TOX4 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TOX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOX4 Gene

Disorders for TOX4 Gene

Additional Disease Information for TOX4

No disorders were found for TOX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOX4 Gene

Publications for TOX4 Gene

  1. Identification and characterization of a novel human PP1 phosphatase complex. (PMID: 20516061) Lee JH … Skalnik DG (The Journal of biological chemistry 2010) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58

Products for TOX4 Gene

Sources for TOX4 Gene

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