Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CEP170 Gene

Aliases for CEP170 Gene

  • Centrosomal Protein 170kDa 2 3
  • KIAA0470 2 3 4 6
  • KARP-1-Binding Protein 3 4
  • XRCC5 Binding Protein 2 3
  • FAM68A 3 4
  • KAB 3 4
  • Centrosomal Protein Of 170 KDa 3
  • KARP 1 Binding Protein 2
  • KARP1-Binding Protein 4
  • Cep170 4

External Ids for CEP170 Gene

Previous HGNC Symbols for CEP170 Gene

  • KIAA0470

Previous GeneCards Identifiers for CEP170 Gene

  • GC01M239615
  • GC01M241354
  • GC01M243287
  • GC01M213646

Summaries for CEP170 Gene

Entrez Gene Summary for CEP170 Gene

  • The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CEP170 Gene

CEP170 (Centrosomal Protein 170kDa) is a Protein Coding gene. An important paralog of this gene is CEP170B.

UniProtKB/Swiss-Prot for CEP170 Gene

  • Plays a role in microtubule organization.

Gene Wiki entry for CEP170 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP170 Gene

Genomics for CEP170 Gene

Regulatory Elements for CEP170 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CEP170 Gene

Start:
243,124,428 bp from pter
End:
243,255,982 bp from pter
Size:
131,555 bases
Orientation:
Minus strand

Genomic View for CEP170 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP170 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP170 Gene

Proteins for CEP170 Gene

  • Protein details for CEP170 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SW79-CE170_HUMAN
    Recommended name:
    Centrosomal protein of 170 kDa
    Protein Accession:
    Q5SW79
    Secondary Accessions:
    • O75058
    • Q5SW77
    • Q5SW78
    • Q7LGA9
    • Q86W31
    • Q9UQ08
    • Q9UQ09

    Protein attributes for CEP170 Gene

    Size:
    1584 amino acids
    Molecular mass:
    175293 Da
    Quaternary structure:
    • Interacts with PLK1.
    SequenceCaution:
    • Sequence=BAA32315.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEP170 Gene

    Alternative splice isoforms for CEP170 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP170 Gene

Proteomics data for CEP170 Gene at MOPED

Post-translational modifications for CEP170 Gene

No data available for DME Specific Peptides for CEP170 Gene

Domains for CEP170 Gene

Protein Domains for CEP170 Gene

Graphical View of Domain Structure for InterPro Entry

Q5SW79

UniProtKB/Swiss-Prot:

CE170_HUMAN :
  • Q5SW79
Domain:
  • Contains 1 FHA domain.
Family:
  • Belongs to the CEP170 family.
genes like me logo Genes that share domains with CEP170: view

No data available for Gene Families for CEP170 Gene

Function for CEP170 Gene

Molecular function for CEP170 Gene

UniProtKB/Swiss-Prot Function: Plays a role in microtubule organization.

Gene Ontology (GO) - Molecular Function for CEP170 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
genes like me logo Genes that share ontologies with CEP170: view

Phenotypes for CEP170 Gene

genes like me logo Genes that share phenotypes with CEP170: view

Animal Model Products

CRISPR Products

miRNA for CEP170 Gene

miRTarBase miRNAs that target CEP170

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP170

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEP170 Gene

Localization for CEP170 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP170 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Note=Associated with the mature mother centriole. Associated with spindle microtubules during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP170 Gene COMPARTMENTS Subcellular localization image for CEP170 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CEP170 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0005814 centriole IDA 24421332
GO:0005819 spindle IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with CEP170: view

Pathways for CEP170 Gene

SuperPathways for CEP170 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP170 Gene

None

No data available for Pathways by source for CEP170 Gene

Transcripts for CEP170 Gene

Unigene Clusters for CEP170 Gene

Centrosomal protein 170kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP170

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CEP170

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP170 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13
SP1: - - - - -
SP2: -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for CEP170 Gene

GeneLoc Exon Structure for
CEP170
ECgene alternative splicing isoforms for
CEP170

Expression for CEP170 Gene

mRNA expression in normal human tissues for CEP170 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP170 Gene

SOURCE GeneReport for Unigene cluster for CEP170 Gene Hs.533635

genes like me logo Genes that share expressions with CEP170: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP170 Gene

Orthologs for CEP170 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP170 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP170 35
  • 99.77 (n)
  • 99.87 (a)
CEP170 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEP170 35
  • 92.89 (n)
  • 93.37 (a)
CEP170 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP170 35
  • 92.2 (n)
  • 93.36 (a)
CEP170 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep170 35
  • 88.17 (n)
  • 89.95 (a)
Cep170 16
Cep170 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEP170 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP170 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep170 35
  • 86.64 (n)
  • 86.91 (a)
chicken
(Gallus gallus)
Aves CEP170 35
  • 77.86 (n)
  • 78.48 (a)
CEP170 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP170 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC779465 35
  • 66.97 (n)
  • 64.64 (a)
Str.15920 35
zebrafish
(Danio rerio)
Actinopterygii cep170a 35
  • 60.27 (n)
  • 59.08 (a)
cep170a 36
  • 52 (a)
OneToMany
cep170b 36
  • 45 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for CEP170:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP170 Gene

ENSEMBL:
Gene Tree for CEP170 (if available)
TreeFam:
Gene Tree for CEP170 (if available)

Paralogs for CEP170 Gene

Paralogs for CEP170 Gene

Pseudogenes.org Pseudogenes for CEP170 Gene

genes like me logo Genes that share paralogs with CEP170: view

Variants for CEP170 Gene

Sequence variations from dbSNP and Humsavar for CEP170 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10881 -- 243,126,485(-) AACCC(C/T)GATGG reference, synonymous-codon
rs11147 -- 243,126,493(-) ATAGA(G/T)TCAAC missense, reference
rs885166 -- 243,128,077(-) AACCC(A/C)GTATA intron-variant
rs1046118 -- 243,126,409(-) GAATG(A/G)CTAGG utr-variant-3-prime
rs1062985 -- 243,125,744(-) ATAGG(A/G)GATTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CEP170 Gene

Variant ID Type Subtype PubMed ID
nsv519429 CNV Gain 19592680
nsv470790 CNV Gain 18288195
esv32774 CNV Gain 17666407
nsv873386 CNV Gain 21882294
nsv873388 CNV Gain 21882294
nsv517939 CNV Gain 19592680

Relevant External Links for CEP170 Gene

HapMap Linkage Disequilibrium report
CEP170

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP170 Gene

Disorders for CEP170 Gene

(1) University of Copenhagen DISEASES for CEP170 Gene

Relevant External Links for CEP170

Genetic Association Database (GAD)
CEP170
Human Genome Epidemiology (HuGE) Navigator
CEP170
genes like me logo Genes that share disorders with CEP170: view

No data available for UniProtKB/Swiss-Prot for CEP170 Gene

Publications for CEP170 Gene

  1. The forkhead-associated domain protein Cep170 interacts with Polo- like kinase 1 and serves as a marker for mature centrioles. (PMID: 15616186) Guarguaglini G. … Nigg E.A. (Mol. Biol. Cell 2005) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 3 4

Products for CEP170 Gene

Sources for CEP170 Gene

Back to Top

Content