Aliases for ZEB2 Gene
External Ids for ZEB2 Gene
Previous HGNC Symbols for ZEB2 Gene
Previous GeneCards Identifiers for ZEB2 Gene
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]
GeneCards Summary for ZEB2 Gene
ZEB2 (Zinc Finger E-Box Binding Homeobox 2) is a Protein Coding gene. Diseases associated with ZEB2 include Mowat-Wilson Syndrome and Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation. Among its related pathways are TGF-beta Receptor Signaling (WikiPathways) and TGF-beta Signaling Pathway (WikiPathways). GO annotations related to this gene include nucleic acid binding and phosphatase regulator activity. An important paralog of this gene is ZEB1.
UniProtKB/Swiss-Prot for ZEB2 Gene
Transcriptional inhibitor that binds to DNA sequence 5-CACCT-3 in different promoters. Represses transcription of E-cadherin.