Aliases for ZEB2 Gene
External Ids for ZEB2 Gene
Previous Symbols for ZEB2 Gene
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]
GeneCards Summary for ZEB2 Gene
ZEB2 (Zinc Finger E-Box Binding Homeobox 2) is a Protein Coding gene. Diseases associated with ZEB2 include mowat-wilson syndrome and mowat-wilson syndrome due to monosomy 2q22. Among its related pathways are MicroRNAs in cancer and TGF-beta Receptor Signaling Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and SMAD binding. An important paralog of this gene is ZNF324.
UniProtKB/Swiss-Prot for ZEB2 Gene
Transcriptional inhibitor that binds to DNA sequence 5-CACCT-3 in different promoters. Represses transcription of E-cadherin.