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Aliases for DNAJC6 Gene

Aliases for DNAJC6 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 6 2 3
  • KIAA0473 4 6
  • Auxilin 2 3
  • PARK19 3 6
  • DJC6 3 6
  • Putative Tyrosine-Protein Phosphatase Auxilin 3
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 6 3
  • DnaJ Homolog Subfamily C Member 6 4
  • EC 4

External Ids for DNAJC6 Gene

Previous GeneCards Identifiers for DNAJC6 Gene

  • GC01P065681
  • GC01P064649
  • GC01P065077
  • GC01P065090
  • GC01P065145
  • GC01P065442
  • GC01P065487
  • GC01P063839
  • GC01P065714

Summaries for DNAJC6 Gene

Entrez Gene Summary for DNAJC6 Gene

  • DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DNAJC6 Gene

DNAJC6 (DnaJ (Hsp40) Homolog, Subfamily C, Member 6) is a Protein Coding gene. Diseases associated with DNAJC6 include parkinson disease 19, juvenile-onset and atypical juvenile parkinsonism. Among its related pathways are Endocytosis and Clathrin derived vesicle budding. GO annotations related to this gene include SH3 domain binding and protein tyrosine phosphatase activity. An important paralog of this gene is TNS1.

UniProtKB/Swiss-Prot for DNAJC6 Gene

  • Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity).

Gene Wiki entry for DNAJC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC6 Gene

Genomics for DNAJC6 Gene

Regulatory Elements for DNAJC6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJC6 Gene

65,248,219 bp from pter
65,415,869 bp from pter
167,651 bases
Plus strand

Genomic View for DNAJC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC6 Gene

Proteins for DNAJC6 Gene

  • Protein details for DNAJC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative tyrosine-protein phosphatase auxilin
    Protein Accession:
    Secondary Accessions:
    • B7Z3V8
    • D3DQ65
    • D3DQ66
    • Q32M66
    • Q4G0K1
    • Q5T614
    • Q5T615

    Protein attributes for DNAJC6 Gene

    913 amino acids
    Molecular mass:
    99997 Da
    Quaternary structure:
    • Interacts with HSPA8/HSC70. Interacts with CLTC. Interacts with AP2A2 (By similarity).
    • Sequence=BAA32318.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJC6 Gene


neXtProt entry for DNAJC6 Gene

Proteomics data for DNAJC6 Gene at MOPED

Post-translational modifications for DNAJC6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DNAJC6 Gene

Domains for DNAJC6 Gene

Gene Families for DNAJC6 Gene

  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Suggested Antigen Peptide Sequences for DNAJC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O75061
  • Contains 1 C2 tensin-type domain.
  • Contains 1 J domain.
  • Contains 1 phosphatase tensin-type domain.
genes like me logo Genes that share domains with DNAJC6: view

Function for DNAJC6 Gene

Molecular function for DNAJC6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot Function:
Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity).

Enzyme Numbers (IUBMB) for DNAJC6 Gene

Gene Ontology (GO) - Molecular Function for DNAJC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding --
GO:0016791 phosphatase activity --
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with DNAJC6: view
genes like me logo Genes that share phenotypes with DNAJC6: view

Animal Models for DNAJC6 Gene

MGI Knock Outs for DNAJC6:

Animal Model Products

miRNA for DNAJC6 Gene

miRTarBase miRNAs that target DNAJC6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC6

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for DNAJC6 Gene

Localization for DNAJC6 Gene

Subcellular locations from

Jensen Localization Image for DNAJC6 Gene COMPARTMENTS Subcellular localization image for DNAJC6 gene
Compartment Confidence
cytosol 4
nucleus 2
chloroplast 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DNAJC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with DNAJC6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DNAJC6 Gene

Pathways for DNAJC6 Gene

genes like me logo Genes that share pathways with DNAJC6: view

Pathways by source for DNAJC6 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DNAJC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0008219 cell death --
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with DNAJC6: view

Compounds for DNAJC6 Gene

(1) HMDB Compounds for DNAJC6 Gene

Compound Synonyms Cas Number PubMed IDs
  • NFB Orthophosphate
genes like me logo Genes that share compounds with DNAJC6: view

Transcripts for DNAJC6 Gene

Unigene Clusters for DNAJC6 Gene

DnaJ (Hsp40) homolog, subfamily C, member 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - - - - - - - - - -

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b
SP4: - - -

Relevant External Links for DNAJC6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC6 Gene

mRNA expression in normal human tissues for DNAJC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJC6 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.7), Brain - Anterior cingulate cortex (BA24) (5.6), Brain - Substantia nigra (4.6), Brain - Hypothalamus (4.5), Brain - Spinal cord (cervical c-1) (4.3), and Brain - Hippocampus (4.2).

Protein differential expression in normal tissues for DNAJC6 Gene

This gene is overexpressed in Frontal cortex (30.9), Brain (19.0), and Fetal Brain (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DNAJC6 Gene

SOURCE GeneReport for Unigene cluster for DNAJC6 Gene Hs.647643

mRNA Expression by UniProt/SwissProt for DNAJC6 Gene

Tissue specificity: Expressed in various brain regions, including cerebellum, corpus callosum, cortex, striatum, brainstem, pons, putamen, spinal cord and substantia nigra. Very low expression in non-neural tissues such as leukocytes, liver, adipose tissue, skeletal muscle and bone marrow.
genes like me logo Genes that share expressions with DNAJC6: view

Expression partners for DNAJC6 Gene

In Situ Assay Products

Orthologs for DNAJC6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNAJC6 35
  • 92.2 (n)
  • 95.6 (a)
  • 96 (a)
(Canis familiaris)
Mammalia DNAJC6 35
  • 91.99 (n)
  • 94.64 (a)
  • 95 (a)
(Mus musculus)
Mammalia Dnajc6 35
  • 87.57 (n)
  • 93.08 (a)
Dnajc6 16
Dnajc6 36
  • 93 (a)
(Pan troglodytes)
Mammalia DNAJC6 35
  • 99.28 (n)
  • 99.59 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dnajc6 35
  • 87.65 (n)
  • 93.81 (a)
(Monodelphis domestica)
Mammalia DNAJC6 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia DNAJC6 36
  • 42 (a)
(Gallus gallus)
Aves DNAJC6 35
  • 74.12 (n)
  • 77.31 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia DNAJC6 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc6 35
  • 69.98 (n)
  • 71.62 (a)
(Danio rerio)
Actinopterygii dnajc6 35
  • 65.96 (n)
  • 66.41 (a)
dnajc6 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta aux 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea tag-83 36
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWA2 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10856 36
  • 25 (a)
Species with no ortholog for DNAJC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC6 Gene

Gene Tree for DNAJC6 (if available)
Gene Tree for DNAJC6 (if available)

Paralogs for DNAJC6 Gene

Paralogs for DNAJC6 Gene

Selected SIMAP similar genes for DNAJC6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DNAJC6: view

Variants for DNAJC6 Gene

Sequence variations from dbSNP and Humsavar for DNAJC6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs488814 -- 65,272,824(+) cgtga(A/G)ccact intron-variant
rs492583 -- 65,263,188(+) TCCAC(A/T)GCCAA upstream-variant-2KB
rs501375 -- 65,267,493(-) GTTTC(A/G)GGAAA intron-variant
rs515394 -- 65,263,375(+) GCCCA(A/G)GCAGT upstream-variant-2KB
rs516504 -- 65,271,954(+) taatt(G/T)caata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC6 Gene

Variant ID Type Subtype PubMed ID
esv2676423 CNV Deletion 23128226
esv2749207 CNV Deletion 23290073
nsv830070 CNV Gain 17160897
nsv528808 CNV Gain 19592680

Relevant External Links for DNAJC6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC6 Gene

Disorders for DNAJC6 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DNAJC6 Gene in MalaCards »

(2) Diseases for DNAJC6 Gene including...

(1) OMIM Diseases for DNAJC6 Gene (608375)


  • Parkinson disease 19, juvenile-onset (PARK19) [MIM:615528]: A juvenile form of Parkinson disease, a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK19 is characterized by onset of parkinsonian symptoms in the first or second decade of life. Some patients may have additional neurologic features, including mental retardation and seizures. {ECO:0000269 PubMed:22563501, ECO:0000269 PubMed:23211418}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DNAJC6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DNAJC6: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DNAJC6 Gene

Publications for DNAJC6 Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48

Products for DNAJC6 Gene

Sources for DNAJC6 Gene

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