Aliases for DAZAP2 Gene
Aliases for DAZAP2 Gene
External Ids for DAZAP2 Gene
- HGNC: 2684
- Entrez Gene: 9802
- Ensembl: ENSG00000183283
- OMIM: 607431
- UniProtKB: Q15038
Previous GeneCards Identifiers for DAZAP2 Gene
- GC02U990100
- GC12P051349
- GC12P049918
- GC12P051634
- GC12P048665
Summaries for DAZAP2 Gene
-
This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for DAZAP2 Gene
DAZAP2 (DAZ Associated Protein 2) is a Protein Coding gene. Diseases associated with DAZAP2 include Multiple Myeloma and Azoospermia. Among its related pathways are Diurnally Regulated Genes with Circadian Orthologs. GO annotations related to this gene include WW domain binding.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAZAP2 Gene
Genomics for DAZAP2 Gene
Regulatory Elements for DAZAP2 Gene
Enhancers for DAZAP2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around DAZAP2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the DAZAP2 gene promoter:
Regulatory Element Products
Genomic Location for DAZAP2 Gene
- Chromosome:
- 12
- Start:
- 51,238,292 bp from pter
- End:
- 51,271,362 bp from pter
- Size:
- 33,071 bases
- Orientation:
- Plus strand
Genomic View for DAZAP2 Gene
Genes around DAZAP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Ensembl
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
DAZAP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DAZAP2 Gene
Proteins for DAZAP2 Gene
-
Protein details for DAZAP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15038-DAZP2_HUMAN
- Recommended name:
- DAZ-associated protein 2
- Protein Accession:
- Q15038
- A8K254
- B4DDT5
- B4E1G3
- C9JA96
- C9JP84
- E9PB45
- F8VU62
Protein attributes for DAZAP2 Gene
- Size:
- 168 amino acids
- Molecular mass:
- 17319 Da
- Quaternary structure:
-
- Interacts with SOX6 (By similarity). Interacts with DAZ and DAZL. Interacts with IL17RB. May interact with FAM168B.
- SequenceCaution:
-
- Sequence=BAA06545.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for DAZAP2 Gene
Post-translational modifications for DAZAP2 Gene
- Ubiquitinated by SMURF2, leading to proteasomal degradation.
- Ubiquitination at isoforms=3, 4, 6153
- Modification sites at PhosphoSitePlus
Other Protein References for DAZAP2 Gene
Antibody Products
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- antibodies-online Antibodies for DAZAP2: See all 28
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-
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Protein Products
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- Novus Biologicals proteins for DAZAP2
- antibodies-online Proteins for DAZAP2: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for DAZAP2
Assay Products
- antibodies-online Kits for DAZAP2: See all 4
No data available for DME Specific Peptides for DAZAP2 Gene
Domains & Families for DAZAP2 Gene
Protein Domains for DAZAP2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DAZAP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for DAZAP2 Gene
Function for DAZAP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0042802 | identical protein binding | IPI | 16189514 |
| GO:0050699 | WW domain binding | IPI | 11342538 |
Phenotypes for DAZAP2 Gene
- MGI mutant phenotypes for DAZAP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DAZAP2:
Animal Model Products
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CRISPR Products
-
OriGene CRISPR knockouts for DAZAP2
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miRNA for DAZAP2 Gene
- miRTarBase miRNAs that target DAZAP2
-
- hsa-mir-302a-3p (MIRT006201)
- hsa-mir-193b-3p (MIRT016525)
- hsa-mir-375 (MIRT020036)
- hsa-mir-7-5p (MIRT025951)
- hsa-mir-455-3p (MIRT037871)
- hsa-mir-324-3p (MIRT042962)
- hsa-mir-100-5p (MIRT048456)
- hsa-mir-203a-3p (MIRT065601)
- hsa-mir-3163 (MIRT065604)
- hsa-mir-216a-3p (MIRT065606)
- hsa-mir-128-3p (MIRT065607)
- hsa-mir-140-3p (MIRT065608)
- hsa-mir-519c-3p (MIRT065609)
- hsa-mir-519b-3p (MIRT065610)
- hsa-mir-519a-3p (MIRT065611)
- hsa-mir-4280 (MIRT065612)
- hsa-mir-3681-3p (MIRT065613)
- hsa-mir-6832-5p (MIRT065615)
- hsa-mir-302b-3p (MIRT187255)
- hsa-mir-302c-3p (MIRT187256)
- hsa-mir-302d-3p (MIRT187257)
- hsa-mir-372-3p (MIRT187258)
- hsa-mir-373-3p (MIRT187259)
- hsa-mir-511-5p (MIRT187260)
- hsa-mir-512-3p (MIRT187261)
- hsa-mir-520e (MIRT187262)
- hsa-mir-520a-3p (MIRT187263)
- hsa-mir-520b (MIRT187264)
- hsa-mir-520c-3p (MIRT187265)
- hsa-mir-520d-3p (MIRT187266)
- hsa-mir-1253 (MIRT187269)
- hsa-mir-302e (MIRT187270)
- hsa-mir-4257 (MIRT187271)
- hsa-mir-4289 (MIRT187272)
- hsa-mir-4501 (MIRT187275)
- hsa-mir-219b-5p (MIRT187276)
- hsa-mir-6770-5p (MIRT187278)
- hsa-mir-6830-3p (MIRT187279)
- hsa-mir-6847-5p (MIRT187280)
- hsa-mir-153-5p (MIRT187283)
- hsa-mir-125b-2-3p (MIRT187284)
- hsa-mir-548c-3p (MIRT187285)
- hsa-mir-3692-3p (MIRT187287)
- hsa-mir-935 (MIRT273428)
- hsa-mir-491-5p (MIRT273431)
- hsa-mir-651-3p (MIRT273432)
- hsa-mir-1252-5p (MIRT273433)
- hsa-mir-3150a-3p (MIRT273434)
- hsa-mir-3175 (MIRT273435)
- hsa-mir-4434 (MIRT273436)
- hsa-mir-4516 (MIRT273438)
- hsa-mir-4737 (MIRT273439)
- hsa-mir-5703 (MIRT273441)
- hsa-mir-6763-5p (MIRT273442)
- hsa-mir-6878-5p (MIRT273443)
- hsa-mir-181a-5p (MIRT273444)
- hsa-mir-181b-5p (MIRT273445)
- hsa-mir-181c-5p (MIRT273446)
- hsa-mir-181d-5p (MIRT273449)
- hsa-mir-101-3p (MIRT338018)
- hsa-mir-1296-3p (MIRT338031)
- hsa-mir-4481 (MIRT338033)
- hsa-mir-4704-5p (MIRT338034)
- hsa-mir-4745-5p (MIRT338035)
- hsa-mir-892b (MIRT384590)
- hsa-mir-557 (MIRT478422)
- hsa-mir-507 (MIRT478423)
- hsa-mir-6739-3p (MIRT478424)
- hsa-mir-6844 (MIRT478425)
- hsa-mir-27b-3p (MIRT478426)
- hsa-mir-27a-3p (MIRT478427)
- hsa-mir-513a-5p (MIRT478428)
- hsa-mir-6715b-3p (MIRT478429)
- hsa-mir-582-5p (MIRT478430)
- hsa-mir-516a-5p (MIRT478431)
- hsa-mir-4260 (MIRT478432)
- hsa-mir-3942-3p (MIRT478433)
- hsa-mir-3611 (MIRT478434)
- hsa-mir-1227-5p (MIRT478435)
- hsa-mir-4474-5p (MIRT478436)
- hsa-mir-6825-5p (MIRT478437)
- hsa-mir-486-3p (MIRT478438)
- hsa-mir-939-5p (MIRT478439)
- hsa-mir-1343-5p (MIRT478440)
- hsa-mir-3119 (MIRT478441)
- hsa-mir-3160-5p (MIRT478442)
- hsa-mir-381-5p (MIRT478443)
- hsa-mir-494-3p (MIRT478444)
- hsa-mir-345-5p (MIRT478445)
- hsa-mir-500b-5p (MIRT478446)
- hsa-mir-362-5p (MIRT478447)
- hsa-mir-4661-3p (MIRT478448)
- hsa-mir-6856-5p (MIRT478449)
- hsa-mir-6758-5p (MIRT478450)
- hsa-mir-890 (MIRT478451)
- hsa-mir-4732-5p (MIRT485654)
- hsa-mir-767-5p (MIRT485655)
- hsa-mir-493-3p (MIRT524255)
- hsa-mir-3124-3p (MIRT524256)
- hsa-mir-502-5p (MIRT609852)
- hsa-mir-210-5p (MIRT609853)
- hsa-mir-4749-3p (MIRT609854)
- hsa-mir-324-5p (MIRT609855)
- hsa-mir-1915-5p (MIRT609856)
- hsa-mir-6841-3p (MIRT609857)
- hsa-mir-660-3p (MIRT609858)
- hsa-mir-5193 (MIRT609859)
- hsa-mir-5196-3p (MIRT609860)
- hsa-mir-5700 (MIRT609861)
miRNA Products
- Search ViGene Biosciences for DAZAP2
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Clone Products
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Cell Line Products
-
Horizon Cell Lines for DAZAP2
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DAZAP2 Gene
Localization for DAZAP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DAZAP2 Gene
- Cytoplasm. Nucleus. Note=Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| peroxisome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0016607 | nuclear speck | IDA | -- |
Pathways & Interactions for DAZAP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Diurnally Regulated Genes with Circadian Orthologs | ||
Pathways by source for DAZAP2 Gene
1 BioSystems pathway for DAZAP2 Gene
Interacting Proteins for DAZAP2 Gene
Selected Interacting proteins:
Q15038-DAZP2_HUMAN
ENSP00000448051
for DAZAP2 Gene via
MINT
STRING
UniProtKB
IID
No data available for SIGNOR curated interactions for DAZAP2 Gene
Transcripts for DAZAP2 Gene
mRNA/cDNA for DAZAP2 Gene
- (6) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (1283) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DAZAP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DAZAP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for DAZAP2
- GenScript: Design CRISPR guide RNA sequences for DAZAP2
miRNA Products
- Search ViGene Biosciences for DAZAP2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for DAZAP2
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Clone Products
-
OriGene ORF clones in human for DAZAP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DAZAP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | |||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||
| SP5: |
Expression for DAZAP2 Gene
mRNA differential expression in normal tissues according to GTEx for DAZAP2 Gene
This gene is overexpressed in Whole Blood (x5.1).
This gene is overexpressed in Placenta (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DAZAP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of DAZAP2 Gene:
DAZAP2SOURCE GeneReport for Unigene cluster for DAZAP2 Gene:
Hs.369761mRNA Expression by UniProt/SwissProt for DAZAP2 Gene:
Q15038-DAZP2_HUMAN
Tissue specificity:
Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Down-regulated in multiple myeloma.
Evidence on tissue expression from TISSUES for DAZAP2 Gene
- Nervous system(5)
- Blood(4.9)
- Lung(4.9)
- Bone marrow(4.6)
- Intestine(4.1)
- Kidney(3.9)
- Spleen(3.5)
- Pancreas(3.1)
- Eye(2.9)
- Liver(2.8)
- Skin(2.7)
- Stomach(2.7)
- Lymph node(2.4)
- Thyroid gland(2.4)
- Gall bladder(2.3)
- Heart(2.3)
- Muscle(2.3)
- Adrenal gland(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for DAZAP2
-
OriGene qPCR primer pairs for DAZAP2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DAZAP2 Gene
Orthologs for DAZAP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DAZAP2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | DAZAP2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | DAZAP2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Dazap2 34 16 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | DAZAP2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dazap2 34 |
|
||
| MGC76067 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.29509 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dazap2 34 35 |
|
||
| wufi04d04 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.345 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1706 35 |
|
OneToOne |
- Species where no ortholog for DAZAP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for DAZAP2 Gene
Pseudogenes.org Pseudogenes for DAZAP2 Gene
No data available for Paralogs for DAZAP2 Gene
Variants for DAZAP2 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000698375 | -- | 51,244,203(+) | GCTCT(-/TTTA)TTTAT | intron-variant, downstream-variant-500B | |
| rs1001518070 | -- | 51,243,616(+) | TAAAT(C/T)GTGTG | intron-variant, utr-variant-3-prime | |
| rs1001632632 | -- | 51,245,258(+) | AACAT(A/G)TGTAA | intron-variant, downstream-variant-500B | |
| rs1001734922 | -- | 51,237,808(+) | AAAAG(A/G)AAAGA | upstream-variant-2KB | |
| rs1001784234 | -- | 51,237,427(+) | CGACA(C/G)ACCAA | upstream-variant-2KB |
Residual Variation Intolerance Score:
71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.33;
7.40% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for DAZAP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DAZAP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAZAP2 Gene
Disorders for DAZAP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| multiple myeloma |
|
|
| azoospermia |
|
|
Search DAZAP2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for DAZAP2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- DAZAP2
No data available for UniProtKB/Swiss-Prot and Genatlas for DAZAP2 Gene
Publications for DAZAP2 Gene
- Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PMID: 10857750) Tsui S. … Yen P.H. (Genomics 2000) 2 3 4 64
- Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4 64
- Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2. (PMID: 22070932) Popova A. … Gratchev A. (Immunobiology 2012) 3 4 64
- Molecular features and expression of DAZAP2 in human multiple myeloma. (PMID: 17935665) Shi Y.-W. … Hu W.-X. (Chin. Med. J. 2007) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
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- antibodies-online Antibodies for DAZAP2: See all 28
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- antibodies-online Proteins for DAZAP2: See all 9
- Search antibodies-online for peptides
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for DAZAP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
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