Aliases for DAZAP2 Gene
Aliases for DAZAP2 Gene
External Ids for DAZAP2 Gene
- HGNC: 2684
- Entrez Gene: 9802
- Ensembl: ENSG00000183283
- OMIM: 607431
- UniProtKB: Q15038
Previous GeneCards Identifiers for DAZAP2 Gene
- GC02U990100
- GC12P051349
- GC12P049918
- GC12P051634
- GC12P048665
Summaries for DAZAP2 Gene
-
This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for DAZAP2 Gene
DAZAP2 (DAZ Associated Protein 2) is a Protein Coding gene. Diseases associated with DAZAP2 include Multiple Myeloma and Myeloma. Among its related pathways are Diurnally regulated genes with circadian orthologs. GO annotations related to this gene include WW domain binding.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAZAP2 Gene
Genomics for DAZAP2 Gene
Regulatory Elements for DAZAP2 Gene
Enhancers for DAZAP2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around DAZAP2 on UCSC Golden Path with GeneCards custom track
Promoters for DAZAP2 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around DAZAP2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the DAZAP2 gene promoter:
Regulatory Element Products
Genomic Location for DAZAP2 Gene
- Chromosome:
- 12
- Start:
- 51,238,292 bp from pter
- End:
- 51,271,362 bp from pter
- Size:
- 33,071 bases
- Orientation:
- Plus strand
Genomic View for DAZAP2 Gene
Genes around DAZAP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Ensembl
- 12q12 by Entrez Gene
- 12q13.13 by HGNC
DAZAP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DAZAP2 Gene
Proteins for DAZAP2 Gene
-
Protein details for DAZAP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15038-DAZP2_HUMAN
- Recommended name:
- DAZ-associated protein 2
- Protein Accession:
- Q15038
- A8K254
- B4DDT5
- B4E1G3
- C9JA96
- C9JP84
- E9PB45
- F8VU62
Protein attributes for DAZAP2 Gene
- Size:
- 168 amino acids
- Molecular mass:
- 17319 Da
- Quaternary structure:
-
- Interacts with SOX6 (By similarity). Interacts with DAZ and DAZL. Interacts with IL17RB. May interact with FAM168B.
- SequenceCaution:
-
- Sequence=BAA06545.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for DAZAP2 Gene
Post-translational modifications for DAZAP2 Gene
- Ubiquitinated by SMURF2, leading to proteasomal degradation.
- Ubiquitination at Lys 153
- Modification sites at PhosphoSitePlus
Other Protein References for DAZAP2 Gene
Antibody Products
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Custom Antibody ServicesOriGene Antibodies for DAZAP2
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- antibodies-online Antibodies for DAZAP2: See all 28
- GeneTex DAZAP2 antibody for DAZAP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for DAZAP2
Protein Products
-
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- Novus Biologicals proteins for DAZAP2
- antibodies-online Proteins for DAZAP2: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for DAZAP2
Assay Products
- antibodies-online Kits for DAZAP2: See all 4
No data available for DME Specific Peptides for DAZAP2 Gene
Domains & Families for DAZAP2 Gene
Protein Domains for DAZAP2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DAZAP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for DAZAP2 Gene
Function for DAZAP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for DAZAP2 Gene
- MGI mutant phenotypes for DAZAP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DAZAP2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Search ViGene Biosciences for DAZAP2
CRISPR Products
-
OriGene CRISPR knockouts for DAZAP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for DAZAP2
- GenScript: Design CRISPR guide RNA sequences for DAZAP2
miRNA for DAZAP2 Gene
- miRTarBase miRNAs that target DAZAP2
-
- hsa-mir-302a-3p (MIRT006201)
- hsa-mir-193b-3p (MIRT016525)
- hsa-mir-375 (MIRT020036)
- hsa-mir-7-5p (MIRT025951)
- hsa-mir-455-3p (MIRT037871)
- hsa-mir-324-3p (MIRT042962)
- hsa-mir-100-5p (MIRT048456)
- hsa-mir-203a-3p (MIRT065601)
- hsa-mir-3163 (MIRT065604)
- hsa-mir-216a-3p (MIRT065606)
- hsa-mir-128-3p (MIRT065607)
- hsa-mir-140-3p (MIRT065608)
- hsa-mir-519c-3p (MIRT065609)
- hsa-mir-519b-3p (MIRT065610)
- hsa-mir-519a-3p (MIRT065611)
- hsa-mir-4280 (MIRT065612)
- hsa-mir-3681-3p (MIRT065613)
- hsa-mir-6832-5p (MIRT065615)
- hsa-mir-302b-3p (MIRT187255)
- hsa-mir-302c-3p (MIRT187256)
- hsa-mir-302d-3p (MIRT187257)
- hsa-mir-372-3p (MIRT187258)
- hsa-mir-373-3p (MIRT187259)
- hsa-mir-511-5p (MIRT187260)
- hsa-mir-512-3p (MIRT187261)
- hsa-mir-520e (MIRT187262)
- hsa-mir-520a-3p (MIRT187263)
- hsa-mir-520b (MIRT187264)
- hsa-mir-520c-3p (MIRT187265)
- hsa-mir-520d-3p (MIRT187266)
- hsa-mir-1253 (MIRT187269)
- hsa-mir-302e (MIRT187270)
- hsa-mir-4257 (MIRT187271)
- hsa-mir-4289 (MIRT187272)
- hsa-mir-4501 (MIRT187275)
- hsa-mir-219b-5p (MIRT187276)
- hsa-mir-6770-5p (MIRT187278)
- hsa-mir-6830-3p (MIRT187279)
- hsa-mir-6847-5p (MIRT187280)
- hsa-mir-153-5p (MIRT187283)
- hsa-mir-125b-2-3p (MIRT187284)
- hsa-mir-548c-3p (MIRT187285)
- hsa-mir-3692-3p (MIRT187287)
- hsa-mir-935 (MIRT273428)
- hsa-mir-491-5p (MIRT273431)
- hsa-mir-651-3p (MIRT273432)
- hsa-mir-1252-5p (MIRT273433)
- hsa-mir-3150a-3p (MIRT273434)
- hsa-mir-3175 (MIRT273435)
- hsa-mir-4434 (MIRT273436)
- hsa-mir-4516 (MIRT273438)
- hsa-mir-4737 (MIRT273439)
- hsa-mir-5703 (MIRT273441)
- hsa-mir-6763-5p (MIRT273442)
- hsa-mir-6878-5p (MIRT273443)
- hsa-mir-181a-5p (MIRT273444)
- hsa-mir-181b-5p (MIRT273445)
- hsa-mir-181c-5p (MIRT273446)
- hsa-mir-181d-5p (MIRT273449)
- hsa-mir-101-3p (MIRT338018)
- hsa-mir-1296-3p (MIRT338031)
- hsa-mir-4481 (MIRT338033)
- hsa-mir-4704-5p (MIRT338034)
- hsa-mir-4745-5p (MIRT338035)
- hsa-mir-892b (MIRT384590)
- hsa-mir-557 (MIRT478422)
- hsa-mir-507 (MIRT478423)
- hsa-mir-6739-3p (MIRT478424)
- hsa-mir-6844 (MIRT478425)
- hsa-mir-27b-3p (MIRT478426)
- hsa-mir-27a-3p (MIRT478427)
- hsa-mir-513a-5p (MIRT478428)
- hsa-mir-6715b-3p (MIRT478429)
- hsa-mir-582-5p (MIRT478430)
- hsa-mir-516a-5p (MIRT478431)
- hsa-mir-4260 (MIRT478432)
- hsa-mir-3942-3p (MIRT478433)
- hsa-mir-3611 (MIRT478434)
- hsa-mir-1227-5p (MIRT478435)
- hsa-mir-4474-5p (MIRT478436)
- hsa-mir-6825-5p (MIRT478437)
- hsa-mir-486-3p (MIRT478438)
- hsa-mir-939-5p (MIRT478439)
- hsa-mir-1343-5p (MIRT478440)
- hsa-mir-3119 (MIRT478441)
- hsa-mir-3160-5p (MIRT478442)
- hsa-mir-381-5p (MIRT478443)
- hsa-mir-494-3p (MIRT478444)
- hsa-mir-345-5p (MIRT478445)
- hsa-mir-500b-5p (MIRT478446)
- hsa-mir-362-5p (MIRT478447)
- hsa-mir-4661-3p (MIRT478448)
- hsa-mir-6856-5p (MIRT478449)
- hsa-mir-6758-5p (MIRT478450)
- hsa-mir-890 (MIRT478451)
- hsa-mir-4732-5p (MIRT485654)
- hsa-mir-767-5p (MIRT485655)
- hsa-mir-493-3p (MIRT524255)
- hsa-mir-3124-3p (MIRT524256)
- hsa-mir-502-5p (MIRT609852)
- hsa-mir-210-5p (MIRT609853)
- hsa-mir-4749-3p (MIRT609854)
- hsa-mir-324-5p (MIRT609855)
- hsa-mir-1915-5p (MIRT609856)
- hsa-mir-6841-3p (MIRT609857)
- hsa-mir-660-3p (MIRT609858)
- hsa-mir-5193 (MIRT609859)
- hsa-mir-5196-3p (MIRT609860)
- hsa-mir-5700 (MIRT609861)
miRNA Products
- Search ViGene Biosciences for DAZAP2
Inhibitory RNA Products
Clone Products
- OriGene clones in human for DAZAP2
- OriGene ORF clones in human,mouse,rat for DAZAP2
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Cell Line Products
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DAZAP2 Gene
Localization for DAZAP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DAZAP2 Gene
- Cytoplasm. Nucleus. Note=Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| cytosol | 1 |
| lysosome | 1 |
| peroxisome | 1 |
| vacuole | 1 |
No data available for Gene Ontology (GO) - Cellular Components for DAZAP2 Gene
Pathways & Interactions for DAZAP2 Gene
More details on SuperPathways for DAZAP2| Superpath | Contained pathways | |
|---|---|---|
| 1 | Diurnally regulated genes with circadian orthologs |
Pathways by source for DAZAP2 Gene
1 BioSystems pathway for DAZAP2 Gene
Interacting Proteins for DAZAP2 Gene
Selected Interacting proteins:
Q15038-DAZP2_HUMAN
ENSP00000448051
for DAZAP2 Gene via
MINT
STRING
UniProtKB
I2D
No data available for SIGNOR curated interactions for DAZAP2 Gene
Transcripts for DAZAP2 Gene
mRNA/cDNA for DAZAP2 Gene
- (6) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (1283) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DAZAP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DAZAP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for DAZAP2
- GenScript: Design CRISPR guide RNA sequences for DAZAP2
miRNA Products
- Search ViGene Biosciences for DAZAP2
Inhibitory RNA Products
Clone Products
- OriGene clones in human for DAZAP2
- OriGene ORF clones in human,mouse,rat for DAZAP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DAZAP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | |||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||
| SP5: |
Expression for DAZAP2 Gene
mRNA differential expression in normal tissues according to GTEx for DAZAP2 Gene
This gene is overexpressed in Whole Blood (x5.1).
This gene is overexpressed in Placenta (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DAZAP2 Gene
SOURCE GeneReport for Unigene cluster for DAZAP2 Gene Hs.369761
mRNA Expression by UniProt/SwissProt for DAZAP2 Gene
Q15038-DAZP2_HUMAN
Tissue specificity:
Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Down-regulated in multiple myeloma.
Primer Products
-
OriGene qPCR primer pairs for DAZAP2
-
OriGene qPCR primer pairs and template standards for DAZAP2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DAZAP2 Gene
Orthologs for DAZAP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | DAZAP2 35 |
|
||
| DAZAP2 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | DAZAP2 35 |
|
||
| DAZAP2 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Dazap2 35 |
|
||
| Dazap2 16 |
|
||||
| Dazap2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | DAZAP2 35 |
|
||
| DAZAP2 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | DAZAP2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dazap2 35 |
|
||
| MGC76067 35 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.29509 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dazap2 35 |
|
||
| wufi04d04 35 |
|
||||
| dazap2 36 |
|
OneToOne | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.345 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1706 36 |
|
OneToOne |
- Species with no ortholog for DAZAP2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for DAZAP2 Gene
Pseudogenes.org Pseudogenes for DAZAP2 Gene
No data available for Paralogs for DAZAP2 Gene
Variants for DAZAP2 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs57917280 | - | 51,241,042(+) | CTGGC(G/T)CCACA | intron-variant, reference, missense | |
| rs14678 | -- | 51,242,743(+) | TAATA(A/C)TGTAC | intron-variant, utr-variant-3-prime | |
| rs15839 | -- | 51,242,934(+) | TTGCC(C/T)CACCC | intron-variant, utr-variant-3-prime | |
| rs12823299 | -- | 51,237,818(+) | AAAAA(A/T)TTAAA | upstream-variant-2KB | |
| rs10876156 | -- | 51,243,385(+) | AAAAA(C/T)TGGTT | intron-variant, utr-variant-3-prime |
Residual Variation Intolerance Score:
71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.33;
7.40% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DAZAP2 Gene
Disorders for DAZAP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| multiple myeloma |
|
|
| myeloma |
|
|
Search DAZAP2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for DAZAP2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- DAZAP2
No data available for UniProtKB/Swiss-Prot and Genatlas for DAZAP2 Gene
Publications for DAZAP2 Gene
- Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PMID: 10857750) Tsui S. … Yen P.H. (Genomics 2000) 2 3 4 67
- Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
Products for DAZAP2 Gene
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- Custom Antibody ServicesOriGene Antibodies for DAZAP2
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- OriGene qPCR primer pairs for DAZAP2
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- antibodies-online Antibodies for DAZAP2: See all 28
- antibodies-online Kits for DAZAP2: See all 4
- antibodies-online Proteins for DAZAP2: See all 9
- Search antibodies-online for peptides
- GeneTex DAZAP2 antibody for DAZAP2
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- Santa Cruz Biotechnology (SCBT) Antibodies for DAZAP2
- Search Santa Cruz Biotechnology (SCBT) for DAZAP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DAZAP2
Sources for DAZAP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
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