Aliases for MRPL19 Gene
Aliases for MRPL19 Gene
External Ids for MRPL19 Gene
- HGNC: 14052
- Entrez Gene: 9801
- Ensembl: ENSG00000115364
- OMIM: 611832
- UniProtKB: P49406
Previous GeneCards Identifiers for MRPL19 Gene
- GC02P076011
- GC02P075831
- GC02P075848
- GC02P075785
- GC02P075727
- GC02P075873
- GC02P075611
Summaries for MRPL19 Gene
-
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for MRPL19 Gene
MRPL19 (Mitochondrial Ribosomal Protein L19) is a Protein Coding gene. Diseases associated with MRPL19 include Dyslexia and Reading Disorder. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.
Additional gene information for MRPL19 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL19 Gene
Genomics for MRPL19 Gene
GeneHancer (GH) Regulatory Elements for MRPL19 Gene
Promoters and enhancers for MRPL19 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MRPL19 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MRPL19 Gene
Genomic Locations for MRPL19 Gene
- chr2:75,646,783-75,690,851
- (GRCh38/hg38)
- Size:
- 44,069 bases
- Orientation:
- Plus strand
- chr2:75,873,909-75,917,977
- (GRCh37/hg19)
Genomic View for MRPL19 Gene
Genes around MRPL19 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p12 by Ensembl
- 2p12 by Entrez Gene
- 2p12 by HGNC
MRPL19 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MRPL19 Gene
Proteins for MRPL19 Gene
-
Protein details for MRPL19 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P49406-RM19_HUMAN
- Recommended name:
- 39S ribosomal protein L19, mitochondrial
- Protein Accession:
- P49406
- Q53TX9
- Q96Q52
Protein attributes for MRPL19 Gene
- Size:
- 292 amino acids
- Molecular mass:
- 33535 Da
- Quaternary structure:
-
- Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
- SequenceCaution:
-
- Sequence=AAY14972.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA03494.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MRPL19 Gene
Post-translational modifications for MRPL19 Gene
No Post-translational modifications
Other Protein References for MRPL19 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MRPL19
- Invitrogen Antibodies for MRPL19
- GeneTex MRPL19 antibody for MRPL19
Protein Products
-
OriGene Purified Proteins for MRPL19
- Search Origene for MassSpec and Protein Over-expression Lysates for MRPL19
- Origene Custom Protein Services for MRPL19
- antibodies-online: Search results for 2 available MRPL19 Proteins ranked by validation data
- Compare Top MRPL19 Proteins
-
Quality Products:
- Search GeneTex for Proteins for MRPL19
-
Abcam proteins for MRPL19
Assay Products
No data available for DME Specific Peptides for MRPL19 Gene
Domains & Families for MRPL19 Gene
Gene Families for MRPL19 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Ribosomal proteins
Protein Domains for MRPL19 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MRPL19 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P49406- Family:
-
- Belongs to the bacterial ribosomal protein bL19 family.
Function for MRPL19 Gene
Phenotypes From GWAS Catalog for MRPL19 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003735 | structural constituent of ribosome | IBA | -- |
Phenotypes for MRPL19 Gene
- GenomeRNAi human phenotypes for MRPL19:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for MRPL19 gene
-
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- Search ViGene Biosciences for MRPL19
CRISPR Products
-
OriGene CRISPR knockouts for MRPL19
- genomics-online: gRNA clones - Search results for available MRPL19 gene related products
- Applied Biological Materials CRISPR for MRPL19
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRPL19
- GenScript: Design CRISPR guide RNA sequences for MRPL19
miRNA for MRPL19 Gene
- miRTarBase miRNAs that target MRPL19
-
- hsa-mir-374b-5p (MIRT016053)
- hsa-mir-590-3p (MIRT016214)
- hsa-mir-1-3p (MIRT023548)
- hsa-mir-19b-3p (MIRT031088)
- hsa-mir-1252-3p (MIRT303717)
- hsa-mir-4722-3p (MIRT354047)
- hsa-mir-6727-3p (MIRT354049)
- hsa-mir-7152-5p (MIRT571388)
- hsa-mir-8061 (MIRT571389)
- hsa-mir-3074-5p (MIRT571390)
- hsa-mir-4760-5p (MIRT571391)
- hsa-mir-4775 (MIRT571392)
- hsa-mir-6817-5p (MIRT571393)
- hsa-mir-4524a-3p (MIRT571394)
- hsa-mir-4769-3p (MIRT571395)
- hsa-mir-6747-3p (MIRT571396)
- hsa-mir-5580-3p (MIRT571397)
- hsa-mir-3662 (MIRT571398)
- hsa-mir-1910-5p (MIRT574213)
- hsa-mir-576-5p (MIRT721681)
- hsa-mir-4263 (MIRT721682)
- hsa-mir-4436b-5p (MIRT721683)
- hsa-mir-4764-3p (MIRT721684)
- hsa-mir-892c-3p (MIRT721685)
- hsa-mir-4676-3p (MIRT721686)
- hsa-mir-452-5p (MIRT721687)
- hsa-mir-92b-3p (MIRT727155)
- hsa-mir-32-5p (MIRT727156)
- hsa-mir-92a-3p (MIRT727157)
miRNA Products
- Search ViGene Biosciences for MRPL19
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for available MRPL19 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MRPL19 gene
Clone Products
- Sino Biological Human cDNA Clone for MRPL19
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- VectorBuilder custom plasmid, inducible vectors for MRPL19
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MRPL19 gene related products
- orf clones - Search results for available MRPL19 gene related products
- Applied Biological Materials Clones for MRPL19
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for MRPL19 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MRPL19 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MRPL19 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL19 Gene
Localization for MRPL19 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MRPL19 Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 1 |
- Mitochondria (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IDA | 10942595 |
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005762 | mitochondrial large ribosomal subunit | IDA | 25278503 |
Pathways & Interactions for MRPL19 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Mitochondrial translation | ||
| 2 | Viral mRNA Translation |
.55
|
|
| 3 | Organelle biogenesis and maintenance | ||
Pathways by source for MRPL19 Gene
1 BioSystems pathway for MRPL19 Gene
1 KEGG pathway for MRPL19 Gene
Interacting Proteins for MRPL19 Gene
Selected Interacting proteins:
P49406-RM19_HUMAN
ENSP00000377486
for MRPL19 Gene via
IID
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006412 | translation | IEA | -- |
| GO:0070125 | mitochondrial translational elongation | TAS | -- |
| GO:0070126 | mitochondrial translational termination | TAS | -- |
No data available for SIGNOR curated interactions for MRPL19 Gene
Transcripts for MRPL19 Gene
mRNA/cDNA for MRPL19 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (282) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MRPL19 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MRPL19
- genomics-online: gRNA clones - Search results for available MRPL19 gene related products
- Applied Biological Materials CRISPR for MRPL19
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRPL19
- GenScript: Design CRISPR guide RNA sequences for MRPL19
miRNA Products
- Search ViGene Biosciences for MRPL19
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MRPL19
- Browse OriGene Inhibitory RNA Products For MRPL19
- genomics-online: shRNA clones - Search results for available MRPL19 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MRPL19 gene
Clone Products
- Sino Biological Human cDNA Clone for MRPL19
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MRPL19
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MRPL19
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MRPL19 gene related products
- orf clones - Search results for available MRPL19 gene related products
- Applied Biological Materials Clones for MRPL19
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MRPL19 Gene
This gene is overexpressed in Pancreas (12.5), Bone marrow stromal cell (9.6), Peripheral blood mononuclear cells (9.3), and Bone (8.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL19 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MRPL19 Gene:
MRPL19SOURCE GeneReport for Unigene cluster for MRPL19 Gene:
Hs.44024Evidence on tissue expression from TISSUES for MRPL19 Gene
- Bone marrow(4.1)
- Nervous system(3.2)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for MRPL19
-
OriGene qPCR primer pairs and template standards for MRPL19
- genomics-online: primer clones - Search results for available MRPL19 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL19 Gene
Orthologs for MRPL19 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MRPL19 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MRPL19 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MRPL19 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mrpl19 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Mrpl19 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MRPL19 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MRPL19 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MRPL19 33 |
|
||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | MRPL19 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100496116 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.22445 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mrpl19 33 34 |
|
||
| wufc01c05 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | mRpL19 35 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001139 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | mrpl-19 33 34 |
|
||
| Y119C1B.4 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany |
- Species where no ortholog for MRPL19 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MRPL19 Gene
Pseudogenes.org Pseudogenes for MRPL19 Gene
No data available for Paralogs for MRPL19 Gene
Variants for MRPL19 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000060991 | -- | 75,656,187(+) | G/T | 3_prime_UTR_variant | |
| rs1000581115 | -- | 75,651,202(+) | G/C | intron_variant | |
| rs1000707357 | -- | 75,651,761(+) | G/A | intron_variant | |
| rs1000779936 | -- | 75,646,770(+) | A/T | upstream_transcript_variant | |
| rs1000868574 | -- | 75,657,894(+) | T/A/C | 3_prime_UTR_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv152e55 | CNV | gain | 17911159 |
| dgv20n14 | CNV | gain | 18776910 |
| dgv5n43 | CNV | gain | 19587683 |
| dgv706e214 | CNV | gain | 21293372 |
| esv2759063 | CNV | gain+loss | 17122850 |
| esv3303063 | CNV | tandem duplication | 20981092 |
| nsv1006905 | CNV | gain | 25217958 |
| nsv438356 | CNV | loss | 16468122 |
| nsv441762 | CNV | gain | 18776908 |
| nsv514988 | CNV | loss | 21397061 |
| nsv834263 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.42;
42.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MRPL19 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MRPL19
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL19 Gene
Disorders for MRPL19 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dyslexia |
|
|
| reading disorder |
|
|
Search MRPL19 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MRPL19
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MRPL19 Gene
Publications for MRPL19 Gene
- A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia. (PMID: 17309879) Anthoni H … Peyrard-Janvid M (Human molecular genetics 2007) 2 3 44 58
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 2 3 4 58
- Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
Products for MRPL19 Gene
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- Invitrogen Antibodies for MRPL19
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for MRPL19
- VectorBuilder custom plasmid, inducible vectors for MRPL19
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MRPL19
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 48 available MRPL19 Antibodies ranked by validation data
- Compare Top MRPL19 Antibodies
- antibodies-online: Search results for available MRPL19 related products ranked by validation data
- antibodies-online: Search results for 2 available MRPL19 Proteins ranked by validation data
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- Quality Products:
- GeneTex MRPL19 antibody for MRPL19
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- Search ViGene Biosciences for MRPL19
- genomics-online: cdna clones - Search results for available MRPL19 gene related products
- orf clones - Search results for available MRPL19 gene related products
- genomics-online: gRNA clones - Search results for available MRPL19 gene related products
- genomics-online: primer clones - Search results for available MRPL19 gene related products
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Sources for MRPL19 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
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