Aliases for MRPL19 Gene
Aliases for MRPL19 Gene
External Ids for MRPL19 Gene
- HGNC: 14052
- Entrez Gene: 9801
- Ensembl: ENSG00000115364
- OMIM: 611832
- UniProtKB: P49406
Previous GeneCards Identifiers for MRPL19 Gene
- GC02P076011
- GC02P075831
- GC02P075848
- GC02P075785
- GC02P075727
- GC02P075873
- GC02P075611
Summaries for MRPL19 Gene
-
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for MRPL19 Gene
MRPL19 (Mitochondrial Ribosomal Protein L19) is a Protein Coding gene. Diseases associated with MRPL19 include Reading Disorder and Speech And Communication Disorders. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL19 Gene
Genomics for MRPL19 Gene
Regulatory Elements for MRPL19 Gene
Enhancers for MRPL19 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around MRPL19 on UCSC Golden Path with GeneCards custom track
Promoters for MRPL19 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around MRPL19 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MRPL19 gene promoter:
Regulatory Element Products
Genomic Location for MRPL19 Gene
- Chromosome:
- 2
- Start:
- 75,646,783 bp from pter
- End:
- 75,690,851 bp from pter
- Size:
- 44,069 bases
- Orientation:
- Plus strand
Genomic View for MRPL19 Gene
Genes around MRPL19 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p12 by Ensembl
- 2p11.1-q11.2 by Entrez Gene
- 2p11.1-q11.2 by HGNC
MRPL19 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MRPL19 Gene
Proteins for MRPL19 Gene
-
Protein details for MRPL19 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P49406-RM19_HUMAN
- Recommended name:
- 39S ribosomal protein L19, mitochondrial
- Protein Accession:
- P49406
- Q53TX9
- Q96Q52
Protein attributes for MRPL19 Gene
- Size:
- 292 amino acids
- Molecular mass:
- 33535 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAY14972.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA03494.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MRPL19 Gene
Post-translational modifications for MRPL19 Gene
Other Protein References for MRPL19 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MRPL19
- Abcam antibodies for MRPL19
- Invitrogen Antibodies for MRPL19
- antibodies-online Antibodies for MRPL19: See all 41
- GeneTex MRPL19 antibody for MRPL19
Protein Products
-
OriGene Purified Proteins for MRPL19
- Search Origene for MassSpec and Protein Over-expression Lysates for MRPL19
- Origene Custom Protein Services for MRPL19
- antibodies-online Proteins for MRPL19: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MRPL19
- Abcam proteins for MRPL19
Assay Products
- antibodies-online Kits for MRPL19: See all 8
No data available for DME Specific Peptides for MRPL19 Gene
Domains & Families for MRPL19 Gene
Gene Families for MRPL19 Gene
Protein Domains for MRPL19 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MRPL19 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P49406- Family:
-
- Belongs to the ribosomal protein L19P family.
Function for MRPL19 Gene
Phenotypes for MRPL19 Gene
- GenomeRNAi human phenotypes for MRPL19:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for MRPL19 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MRPL19 gene
- Search ViGene Biosciences for MRPL19
CRISPR Products
-
OriGene CRISPR knockouts for MRPL19
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRPL19
- GenScript: Design CRISPR guide RNA sequences for MRPL19
miRNA for MRPL19 Gene
- miRTarBase miRNAs that target MRPL19
-
- hsa-mir-374b-5p (MIRT016053)
- hsa-mir-590-3p (MIRT016214)
- hsa-mir-1-3p (MIRT023548)
- hsa-mir-19b-3p (MIRT031088)
- hsa-mir-1252-3p (MIRT303717)
- hsa-mir-4722-3p (MIRT354047)
- hsa-mir-6727-3p (MIRT354049)
- hsa-mir-7152-5p (MIRT571388)
- hsa-mir-8061 (MIRT571389)
- hsa-mir-3074-5p (MIRT571390)
- hsa-mir-4760-5p (MIRT571391)
- hsa-mir-4775 (MIRT571392)
- hsa-mir-6817-5p (MIRT571393)
- hsa-mir-4524a-3p (MIRT571394)
- hsa-mir-4769-3p (MIRT571395)
- hsa-mir-6747-3p (MIRT571396)
- hsa-mir-5580-3p (MIRT571397)
- hsa-mir-3662 (MIRT571398)
- hsa-mir-1910-5p (MIRT574213)
- hsa-mir-576-5p (MIRT721681)
- hsa-mir-4263 (MIRT721682)
- hsa-mir-4436b-5p (MIRT721683)
- hsa-mir-4764-3p (MIRT721684)
- hsa-mir-892c-3p (MIRT721685)
- hsa-mir-4676-3p (MIRT721686)
- hsa-mir-452-5p (MIRT721687)
- hsa-mir-92b-3p (MIRT727155)
- hsa-mir-32-5p (MIRT727156)
- hsa-mir-92a-3p (MIRT727157)
miRNA Products
- Search ViGene Biosciences for MRPL19
Clone Products
- OriGene clones in human for MRPL19
- OriGene ORF clones in human,mouse,rat for MRPL19
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MRPL19
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for MRPL19 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MRPL19 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MRPL19 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL19 Gene
Localization for MRPL19 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MRPL19 Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0031965 | nuclear membrane | IDA | 10942595 |
Pathways & Interactions for MRPL19 Gene
More details on SuperPathways for MRPL19| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Mitochondrial translation | ||
| 2 | Viral mRNA Translation |
.60
|
|
| 3 | Organelle biogenesis and maintenance |
Pathways by source for MRPL19 Gene
1 BioSystems pathway for MRPL19 Gene
1 KEGG pathway for MRPL19 Gene
Interacting Proteins for MRPL19 Gene
Selected Interacting proteins:
P49406-RM19_HUMAN
ENSP00000377486
for MRPL19 Gene via
MINT
STRING
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006412 | translation | IEA | -- |
| GO:0032543 | mitochondrial translation | TAS | -- |
| GO:0070124 | mitochondrial translational initiation | TAS | -- |
No data available for SIGNOR curated interactions for MRPL19 Gene
Transcripts for MRPL19 Gene
mRNA/cDNA for MRPL19 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (282) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MRPL19 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MRPL19
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRPL19
- GenScript: Design CRISPR guide RNA sequences for MRPL19
miRNA Products
- Search ViGene Biosciences for MRPL19
Clone Products
- OriGene clones in human for MRPL19
- OriGene ORF clones in human,mouse,rat for MRPL19
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MRPL19
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for MRPL19 Gene
This gene is overexpressed in Pancreas (12.5), Bone marrow stromal cell (9.6), Peripheral blood mononuclear cells (9.3), and Bone (8.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL19 Gene
SOURCE GeneReport for Unigene cluster for MRPL19 Gene Hs.44024
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for MRPL19
-
OriGene qPCR primer pairs and template standards for MRPL19
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL19 Gene
Orthologs for MRPL19 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | MRPL19 35 |
|
||
| MRPL19 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | MRPL19 35 |
|
||
| MRPL19 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Mrpl19 35 |
|
||
| Mrpl19 16 |
|
||||
| Mrpl19 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | MRPL19 35 |
|
||
| MRPL19 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Mrpl19 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MRPL19 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MRPL19 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MRPL19 35 |
|
||
| -- 36 |
|
OneToMany | |||
| -- 36 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | MRPL19 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100496116 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.22445 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mrpl19 35 |
|
||
| wufc01c05 35 |
|
||||
| mrpl19 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | mRpL19 37 |
|
|
|
| mRpL19 35 |
|
||||
| mRpL19 36 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001139 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y119C1B.4 37 |
|
|
|
| mrpl-19 35 |
|
||||
| mrpl-19 36 |
|
OneToOne | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany | |
| -- 36 |
|
OneToMany |
- Species with no ortholog for MRPL19:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MRPL19 Gene
Pseudogenes.org Pseudogenes for MRPL19 Gene
No data available for Paralogs for MRPL19 Gene
Variants for MRPL19 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs757916 | -- | 75,651,317(+) | CTCTC(C/T)TCGAC | intron-variant | |
| rs757917 | -- | 75,651,492(+) | ATCTC(A/G)GTTAC | intron-variant | |
| rs917236 | -- | 75,656,264(+) | TATAA(G/T)CACAC | utr-variant-3-prime | |
| rs1001893 | -- | 75,645,120(-) | TTAGT(C/T)TTCTT | upstream-variant-2KB | |
| rs1001894 | -- | 75,644,820(-) | ATTAG(A/T)ACAAG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1201e1 | CNV | Complex | 17122850 |
| dgv1202e1 | CNV | Complex | 17122850 |
| dgv5n43 | CNV | Gain | 19587683 |
| dgv4169n71 | CNV | Gain | 21882294 |
| esv260037 | OTHER | Complex | 20981092 |
| dgv152e55 | CNV | Gain | 17911159 |
| nsv441762 | CNV | CNV | 18776908 |
| dgv20n14 | CNV | Gain | 18776910 |
| nsv438356 | CNV | Loss | 16468122 |
| nsv834263 | CNV | Gain | 17160897 |
| nsv514988 | CNV | Complex | 21397061 |
| nsv874307 | CNV | Gain | 21882294 |
Residual Variation Intolerance Score:
49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.42;
42.69% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPL19 Gene
Disorders for MRPL19 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| reading disorder |
|
|
| speech and communication disorders |
|
|
Search MRPL19 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for MRPL19
No data available for UniProtKB/Swiss-Prot and Genatlas for MRPL19 Gene
Publications for MRPL19 Gene
- A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia. (PMID: 17309879) Anthoni H. … Peyrard-Janvid M. (Hum. Mol. Genet. 2007) 2 3 48 67
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3
- Language impairment and dyslexia genes influence language skills in children with autism spectrum disorders. (PMID: 25448322) Eicher J.D. … Gruen J.R. (Autism Res 2015) 3
- BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
- Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
Products for MRPL19 Gene
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- OriGene qPCR primer pairs for MRPL19
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- antibodies-online Antibodies for MRPL19: See all 41
- antibodies-online Kits for MRPL19: See all 8
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- GeneTex MRPL19 antibody for MRPL19
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- ViGene Biosciences adenoviral particle packaged cDNA for MRPL19 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MRPL19 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for MRPL19 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MRPL19 gene
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- Search ViGene Biosciences for MRPL19
- Search ViGene Biosciences for MRPL19
Sources for MRPL19 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon