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Aliases for IST1 Gene

Aliases for IST1 Gene

  • IST1, ESCRT-III Associated Factor 2 3
  • Increased Sodium Tolerance 1 Homolog (Yeast) 2 5
  • Putative MAPK-Activating Protein PM28 3 4
  • KIAA0174 2 4
  • IST1, Endosomal Sorting Complex Required For Transport-III Component 3
  • Endosomal Sorting Complex Required For Transport-III Component 2
  • Increased Sodium Tolerance 1 Homolog 3
  • Overexpressed In Lung Cancer 1 3
  • HIST1 4
  • IST1 2
  • OLC1 3

External Ids for IST1 Gene

Previous HGNC Symbols for IST1 Gene

  • KIAA0174

Previous GeneCards Identifiers for IST1 Gene

  • GC16P071930
  • GC16P071881

Summaries for IST1 Gene

Entrez Gene Summary for IST1 Gene

  • This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for IST1 Gene

IST1 (IST1, ESCRT-III Associated Factor) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include protein domain specific binding and MIT domain binding.

UniProtKB/Swiss-Prot for IST1 Gene

  • Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.

Gene Wiki entry for IST1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IST1 Gene

Genomics for IST1 Gene

Regulatory Elements for IST1 Gene

Promoters for IST1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IST1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IST1 Gene

Chromosome:
16
Start:
71,845,996 bp from pter
End:
71,931,199 bp from pter
Size:
85,204 bases
Orientation:
Plus strand

Genomic View for IST1 Gene

Genes around IST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IST1 Gene

Proteins for IST1 Gene

  • Protein details for IST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53990-IST1_HUMAN
    Recommended name:
    IST1 homolog
    Protein Accession:
    P53990
    Secondary Accessions:
    • A8KAH5
    • J3QLU7
    • Q3SYM4
    • Q9BQ81
    • Q9BWN2

    Protein attributes for IST1 Gene

    Size:
    364 amino acids
    Molecular mass:
    39751 Da
    Quaternary structure:
    • Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4 (PubMed:23015756). Interacts with SPG20 (via MIT domain); leading to the recruitement of SPG20 to midbodies (PubMed:20719964).
    SequenceCaution:
    • Sequence=BAA11491.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IST1 Gene

    Alternative splice isoforms for IST1 Gene

neXtProt entry for IST1 Gene

Proteomics data for IST1 Gene at MOPED

Post-translational modifications for IST1 Gene

  • Ubiquitination at Lys 118
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IST1 Gene

Domains & Families for IST1 Gene

Gene Families for IST1 Gene

Protein Domains for IST1 Gene

Suggested Antigen Peptide Sequences for IST1 Gene

Graphical View of Domain Structure for InterPro Entry

P53990

UniProtKB/Swiss-Prot:

IST1_HUMAN :
  • Belongs to the IST1 family.
Family:
  • Belongs to the IST1 family.
genes like me logo Genes that share domains with IST1: view

Function for IST1 Gene

Molecular function for IST1 Gene

UniProtKB/Swiss-Prot Function:
Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.
genes like me logo Genes that share phenotypes with IST1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IST1 Gene

Localization for IST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IST1 Gene

Cytoplasmic vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Localizes to centrosome and midbody of dividing cells (PubMed:19129480, PubMed:19129479, PubMed:20719964). Colocalized with SPG20 to the ends of Flemming bodies during cytokinesis (PubMed:20719964). {ECO:0000269 PubMed:19129479, ECO:0000269 PubMed:19129480, ECO:0000269 PubMed:20719964}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IST1 Gene COMPARTMENTS Subcellular localization image for IST1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
endosome 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with IST1: view

Pathways & Interactions for IST1 Gene

SuperPathways for IST1 Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with IST1: view

Pathways by source for IST1 Gene

1 KEGG pathway for IST1 Gene

Gene Ontology (GO) - Biological Process for IST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 19525971
GO:0045184 establishment of protein localization IMP 23015756
GO:0045862 positive regulation of proteolysis IDA 20849418
GO:0051301 cell division IMP 19129479
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with IST1: view

No data available for SIGNOR curated interactions for IST1 Gene

Drugs & Compounds for IST1 Gene

No Compound Related Data Available

Transcripts for IST1 Gene

Unigene Clusters for IST1 Gene

Increased sodium tolerance 1 homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IST1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d ^ 12a ·
SP1: - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - - -
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - -
SP14: - - - - - -
SP15: - - - - -
SP16: - - - - - - - - - - - -
SP17:
SP18: - -
SP19: - - - - - - - -
SP20: - - - - - - - - - - - - - - -
SP21:
SP22:
SP23:

ExUns: 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c · 17d
SP1: - -
SP2: - -
SP3: - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:
SP22: - - -
SP23:

Relevant External Links for IST1 Gene

GeneLoc Exon Structure for
IST1
ECgene alternative splicing isoforms for
IST1

Expression for IST1 Gene

mRNA expression in normal human tissues for IST1 Gene

Protein differential expression in normal tissues from HIPED for IST1 Gene

This gene is overexpressed in Breast (16.8) and Urine (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IST1 Gene



SOURCE GeneReport for Unigene cluster for IST1 Gene Hs.232194

genes like me logo Genes that share expression patterns with IST1: view

Protein tissue co-expression partners for IST1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IST1 Gene

Orthologs for IST1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IST1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IST1 35
  • 91.21 (n)
  • 95.6 (a)
IST1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IST1 35
  • 93.17 (n)
  • 96.99 (a)
IST1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ist1 35
  • 89.96 (n)
  • 95.58 (a)
Ist1 16
Ist1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IST1 35
  • 98.71 (n)
  • 98.62 (a)
rat
(Rattus norvegicus)
Mammalia Ist1 35
  • 89.84 (n)
  • 95.6 (a)
oppossum
(Monodelphis domestica)
Mammalia IST1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IST1 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves IST1 35
  • 79.78 (n)
  • 87.98 (a)
IST1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IST1 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ist1 35
  • 69.89 (n)
  • 76.14 (a)
Str.10305 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25431 35
zebrafish
(Danio rerio)
Actinopterygii Dr.1122 35
ist1 35
  • 67.15 (n)
  • 77.1 (a)
ist1 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2448 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005882 35
  • 52.03 (n)
  • 51.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10103 35
  • 55.21 (n)
  • 53.91 (a)
CG10103 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea istr-1 36
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IST1 36
  • 29 (a)
OneToOne
IST1 38
Species with no ortholog for IST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IST1 Gene

ENSEMBL:
Gene Tree for IST1 (if available)
TreeFam:
Gene Tree for IST1 (if available)

Paralogs for IST1 Gene

Pseudogenes.org Pseudogenes for IST1 Gene

genes like me logo Genes that share paralogs with IST1: view

No data available for Paralogs for IST1 Gene

Variants for IST1 Gene

Sequence variations from dbSNP and Humsavar for IST1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs6558 -- 71,928,688(+) GAGGG(C/G)TACCT utr-variant-3-prime
rs1049794 -- 71,916,547(+) GAGCA(C/T)ATTAT intron-variant, reference, synonymous-codon
rs1803857 -- 71,928,745(+) CAGAA(A/G)AATTT utr-variant-3-prime
rs1803858 -- 71,928,789(+) TTCCT(G/T)GATGG utr-variant-3-prime
rs1803859 -- 71,927,932(+) ACACT(C/T)CCTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IST1 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv906893 CNV Loss 21882294
nsv1862 CNV Insertion 18451855

Variation tolerance for IST1 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IST1 Gene

HapMap Linkage Disequilibrium report
IST1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IST1 Gene

Disorders for IST1 Gene

Relevant External Links for IST1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IST1

No disorders were found for IST1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IST1 Gene

Publications for IST1 Gene

  1. Essential role of hIST1 in cytokinesis. (PMID: 19129480) Agromayor M. … Martin-Serrano J. (Mol. Biol. Cell 2009) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 3
  3. Distinct mechanisms of recognizing endosomal sorting complex required for transport III (ESCRT-III) protein IST1 by different microtubule interacting and trafficking (MIT) domains. (PMID: 25657007) Guo E.Z. … Xu Z. (J. Biol. Chem. 2015) 3
  4. Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. (PMID: 26040712) Vietri M. … Stenmark H. (Nature 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for IST1 Gene

Sources for IST1 Gene

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