Aliases for IST1 Gene
External Ids for IST1 Gene
Previous HGNC Symbols for IST1 Gene
Previous GeneCards Identifiers for IST1 Gene
This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
GeneCards Summary for IST1 Gene
IST1 (Increased Sodium Tolerance 1 Homolog (Yeast)) is a Protein Coding gene. Diseases associated with IST1 include lung cancer. GO annotations related to this gene include protein domain specific binding and MIT domain binding.
UniProtKB/Swiss-Prot for IST1 Gene
Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.