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Aliases for IST1 Gene

Aliases for IST1 Gene

  • Increased Sodium Tolerance 1 Homolog (Yeast) 2 3
  • Putative MAPK-Activating Protein PM28 3 4
  • KIAA0174 2 4
  • Overexpressed In Lung Cancer 1 3
  • IST1 Homolog 3
  • IRhom1 6
  • RHBDF1 6
  • HIST1 4
  • OLC1 3
  • D 6

External Ids for IST1 Gene

Previous Symbols for IST1 Gene

  • KIAA0174

Summaries for IST1 Gene

Entrez Gene Summary for IST1 Gene

  • This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for IST1 Gene

IST1 (Increased Sodium Tolerance 1 Homolog (Yeast)) is a Protein Coding gene. Diseases associated with IST1 include lung cancer. GO annotations related to this gene include protein domain specific binding and MIT domain binding.

UniProtKB/Swiss-Prot for IST1 Gene

  • Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.

Gene Wiki entry for IST1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IST1 Gene

Genomics for IST1 Gene

Genomic Location for IST1 Gene

Start:
71,845,996 bp from pter
End:
71,931,199 bp from pter
Size:
85,204 bases
Orientation:
Plus strand

Genomic View for IST1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IST1 Gene

No data available for Regulatory Elements for IST1 Gene

Proteins for IST1 Gene

  • Protein details for IST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53990-IST1_HUMAN
    Recommended name:
    IST1 homolog
    Protein Accession:
    P53990
    Secondary Accessions:
    • A8KAH5
    • J3QLU7
    • Q3SYM4
    • Q9BQ81
    • Q9BWN2

    Protein attributes for IST1 Gene

    Size:
    364 amino acids
    Molecular mass:
    39751 Da
    Quaternary structure:
    • Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4.
    SequenceCaution:
    • Sequence=BAA11491.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IST1 Gene

    Alternative splice isoforms for IST1 Gene

neXtProt entry for IST1 Gene

Proteomics data for IST1 Gene at MOPED

Post-translational modifications for IST1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys7 and Lys118

No data available for DME Specific Peptides for IST1 Gene

Domains for IST1 Gene

Protein Domains for IST1 Gene

UniProtKB/Swiss-Prot:

IST1_HUMAN
Family:
  • Belongs to the IST1 family.:
    • P53990
genes like me logo Genes that share domains with IST1: view

No data available for Gene Families for IST1 Gene

Function for IST1 Gene

Molecular function for IST1 Gene

UniProtKB/Swiss-Prot Function: Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.

Gene Ontology (GO) - Molecular Function for IST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019904 protein domain specific binding IPI 20719964
GO:0032403 protein complex binding IDA 19129479
GO:0090541 MIT domain binding IPI 19129479
genes like me logo Genes that share ontologies with IST1: view

Phenotypes for IST1 Gene

GenomeRNAi human phenotypes for IST1:
genes like me logo Genes that share phenotypes with IST1: view

miRNA for IST1 Gene

miRTarBase miRNAs that target IST1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IST1 Gene

Localization for IST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IST1 Gene

Cytoplasmic vesicle. Note=Localizes to the midbody of dividing cells.

Gene Ontology (GO) - Cellular Components for IST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 10942595
GO:0005813 centrosome IDA 19129479
GO:0005829 cytosol IDA 19129480
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0030496 midbody IDA 19129479
genes like me logo Genes that share ontologies with IST1: view

Pathways for IST1 Gene

SuperPathways for IST1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 19525971
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0008104 protein localization IMP 20719964
GO:0009838 abscission IMP 19525971
GO:0019076 viral release from host cell IDA 19129479
genes like me logo Genes that share ontologies with IST1: view

No data available for Pathways by source for IST1 Gene

Transcripts for IST1 Gene

Unigene Clusters for IST1 Gene

Increased sodium tolerance 1 homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IST1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d ^ 12a ·
SP1: - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - - -
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - -
SP14: - - - - - -
SP15: - - - - -
SP16: - - - - - - - - - - - -
SP17:
SP18: - -
SP19: - - - - - - - -
SP20: - - - - - - - - - - - - - - -
SP21:
SP22:
SP23:

ExUns: 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c · 17d
SP1: - -
SP2: - -
SP3: - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:
SP22: - - -
SP23:

Relevant External Links for IST1 Gene

GeneLoc Exon Structure for
IST1
ECgene alternative splicing isoforms for
IST1

Expression for IST1 Gene

mRNA expression in normal human tissues for IST1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IST1 Gene

SOURCE GeneReport for Unigene cluster for IST1 Gene Hs.232194

genes like me logo Genes that share expressions with IST1: view

Orthologs for IST1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IST1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IST1 36
  • 98.71 (n)
  • 98.62 (a)
cow
(Bos Taurus)
Mammalia IST1 36
  • 91.21 (n)
  • 95.6 (a)
IST1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IST1 36
  • 93.17 (n)
  • 96.99 (a)
IST1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ist1 36
  • 89.96 (n)
  • 95.58 (a)
Ist1 16
Ist1 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IST1 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IST1 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ist1 36
  • 89.84 (n)
  • 95.6 (a)
chicken
(Gallus gallus)
Aves IST1 36
  • 79.78 (n)
  • 87.98 (a)
IST1 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IST1 37
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25431 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ist1 36
  • 69.89 (n)
  • 76.14 (a)
Str.10305 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2448 36
zebrafish
(Danio rerio)
Actinopterygii Dr.1122 36
ist1 36
  • 67.15 (n)
  • 77.1 (a)
ist1 37
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005882 36
  • 52.03 (n)
  • 51.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10103 36
  • 55.21 (n)
  • 53.91 (a)
CG10103 37
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea istr-1 37
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IST1 37
  • 29 (a)
OneToOne
IST1 39
Species with no ortholog for IST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IST1 Gene

ENSEMBL:
Gene Tree for IST1 (if available)
TreeFam:
Gene Tree for IST1 (if available)

Paralogs for IST1 Gene

Pseudogenes.org Pseudogenes for IST1 Gene

genes like me logo Genes that share paralogs with IST1: view

No data available for Paralogs for IST1 Gene

Variants for IST1 Gene

Sequence variations from dbSNP and Humsavar for IST1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs6558 -- 71,928,688(+) GAGGG(C/G)TACCT utr-variant-3-prime
rs1049794 -- 71,916,547(+) GAGCA(C/T)ATTAT reference, synonymous-codon, intron-variant
rs1803857 -- 71,928,745(+) CAGAA(A/G)AATTT utr-variant-3-prime
rs1803858 -- 71,928,789(+) TTCCT(G/T)GATGG utr-variant-3-prime
rs1803859 -- 71,927,932(+) ACACT(C/T)CCTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IST1 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv906893 CNV Loss 21882294
nsv1862 CNV Insertion 18451855

Relevant External Links for IST1 Gene

HapMap Linkage Disequilibrium report
IST1

Disorders for IST1 Gene

(1) MalaCards Diseases for IST1 Gene

Search for IST1 Gene in MalaCards »
genes like me logo Genes that share disorders with IST1: view

No data available for UniProtKB/Swiss-Prot for IST1 Gene

Publications for IST1 Gene

  1. Essential role of hIST1 in cytokinesis. (PMID: 19129480) Agromayor M. … Martin-Serrano J. (Mol. Biol. Cell 2009) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4
  3. Biochemical analyses of human IST1 and its function in cytokinesis. (PMID: 19129479) Bajorek M. … Sundquist W.I. (Mol. Biol. Cell 2009) 3 4
  4. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for IST1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IST1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IST1
    • Block miRNA regulation of IST1 using miScript Target Protectors

    Sources for IST1 Gene

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