Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDA Gene

Aliases for CDA Gene

  • Cytidine Deaminase 2 3 5
  • Cytidine Aminohydrolase 3 4
  • CDD 3 4
  • Cytosine Nucleoside Deaminase 3
  • Small Cytidine Deaminase 3
  • EC 3.5.4.5 4

External Ids for CDA Gene

Previous GeneCards Identifiers for CDA Gene

  • GC01P020485
  • GC01P019951
  • GC01P020061
  • GC01P020385
  • GC01P020660
  • GC01P020788
  • GC01P020915
  • GC01P019161

Summaries for CDA Gene

Entrez Gene Summary for CDA Gene

  • This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDA Gene

CDA (Cytidine Deaminase) is a Protein Coding gene. Diseases associated with CDA include xeroderma pigmentosum, group d and refractory hematologic cancer. Among its related pathways are Porphyrin and chlorophyll metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and hydrolase activity.

UniProtKB/Swiss-Prot for CDA Gene

  • This enzyme scavenges exogenous and endogenous cytidine and 2-deoxycytidine for UMP synthesis.

Gene Wiki entry for CDA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDA Gene

Genomics for CDA Gene

Regulatory Elements for CDA Gene

Enhancers for CDA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDA on UCSC Golden Path with GeneCards custom track

Promoters for CDA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDA on UCSC Golden Path with GeneCards custom track

Genomic Location for CDA Gene

Chromosome:
1
Start:
20,588,948 bp from pter
End:
20,618,908 bp from pter
Size:
29,961 bases
Orientation:
Plus strand

Genomic View for CDA Gene

Genes around CDA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDA Gene

Proteins for CDA Gene

  • Protein details for CDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32320-CDD_HUMAN
    Recommended name:
    Cytidine deaminase
    Protein Accession:
    P32320

    Protein attributes for CDA Gene

    Size:
    146 amino acids
    Molecular mass:
    16185 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for CDA Gene

neXtProt entry for CDA Gene

Proteomics data for CDA Gene at MOPED

Post-translational modifications for CDA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CDA Gene

Domains & Families for CDA Gene

Suggested Antigen Peptide Sequences for CDA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32320

UniProtKB/Swiss-Prot:

CDD_HUMAN :
  • Contains 1 CMP/dCMP-type deaminase domain.
  • Belongs to the cytidine and deoxycytidylate deaminase family.
Domain:
  • Contains 1 CMP/dCMP-type deaminase domain.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.
genes like me logo Genes that share domains with CDA: view

No data available for Gene Families for CDA Gene

Function for CDA Gene

Molecular function for CDA Gene

GENATLAS Biochemistry:
cytidine deaminase,pyrimidine catabolic pathway
UniProtKB/Swiss-Prot CatalyticActivity:
Cytidine + H(2)O = uridine + NH(3).
UniProtKB/Swiss-Prot CatalyticActivity:
2deoxycytidine + H(2)O = 2-deoxyuridine + NH(3).
UniProtKB/Swiss-Prot Function:
This enzyme scavenges exogenous and endogenous cytidine and 2-deoxycytidine for UMP synthesis.

Enzyme Numbers (IUBMB) for CDA Gene

Gene Ontology (GO) - Molecular Function for CDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0042802 identical protein binding IEA --
GO:0042803 protein homodimerization activity IDA 15689149
genes like me logo Genes that share ontologies with CDA: view
genes like me logo Genes that share phenotypes with CDA: view

Animal Model Products

miRNA for CDA Gene

miRTarBase miRNAs that target CDA

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDA Gene

Localization for CDA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDA Gene COMPARTMENTS Subcellular localization image for CDA gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDA Gene

Pathways & Interactions for CDA Gene

genes like me logo Genes that share pathways with CDA: view

Gene Ontology (GO) - Biological Process for CDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009972 cytidine deamination IEA,IDA 9596658
GO:0044281 small molecule metabolic process TAS --
GO:0045980 negative regulation of nucleotide metabolic process IDA 9596658
GO:0055086 nucleobase-containing small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CDA: view

No data available for SIGNOR curated interactions for CDA Gene

Drugs & Compounds for CDA Gene

(20) Drugs for CDA Gene - From: DrugBank, PharmGKB, ApexBio, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytarabine Approved, Investigational Pharma Enzyme, substrate 1054
Gemcitabine Approved Pharma Enzyme, substrate Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1898
Capecitabine Approved, Investigational Pharma Enzyme, substrate RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1239
Azacitidine Approved, Investigational Pharma Enzyme, substrate 471
Gemzar Approved May 1996 Pharma 0

(10) Additional Compounds for CDA Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5'-Deoxy-5-fluorocytidine
5'-Deoxy-5-fluorouridine
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5

(1) ApexBio Compounds for CDA Gene

Compound Action Cas Number
Zebularine DNA methylation inhibitor 3690-10-6
genes like me logo Genes that share compounds with CDA: view

Transcripts for CDA Gene

mRNA/cDNA for CDA Gene

Unigene Clusters for CDA Gene

Cytidine deaminase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDA Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: -
SP3: - -
SP4: -
SP5: - - -
SP6: - - - -

Relevant External Links for CDA Gene

GeneLoc Exon Structure for
CDA
ECgene alternative splicing isoforms for
CDA

Expression for CDA Gene

mRNA expression in normal human tissues for CDA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDA Gene

This gene is overexpressed in Whole Blood (x32.8).

Protein differential expression in normal tissues from HIPED for CDA Gene

This gene is overexpressed in Ovary (16.2), Cervix (10.9), Neutrophil (10.7), and Monocytes (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDA Gene



SOURCE GeneReport for Unigene cluster for CDA Gene Hs.466910

mRNA Expression by UniProt/SwissProt for CDA Gene

P32320-CDD_HUMAN
Tissue specificity: Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.
genes like me logo Genes that share expression patterns with CDA: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CDA Gene

Orthologs for CDA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDA 35
  • 83.56 (n)
  • 80.82 (a)
CDA 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDA 35
  • 83.11 (n)
  • 76.71 (a)
CDA 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cda 35
  • 83.79 (n)
  • 81.51 (a)
Cda 16
Cda 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDA 35
  • 99.77 (n)
  • 100 (a)
CDA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909857 35
  • 82.88 (n)
  • 81.51 (a)
oppossum
(Monodelphis domestica)
Mammalia CDA 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDA 35
  • 73.79 (n)
  • 74.05 (a)
CDA 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDA 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cda 35
  • 69.61 (n)
  • 68.38 (a)
Str.9365 35
zebrafish
(Danio rerio)
Actinopterygii cda 35
  • 68.99 (n)
  • 72.09 (a)
Dr.16208 35
cda 36
  • 60 (a)
OneToMany
CDA (1 of 3) 36
  • 57 (a)
OneToMany
CDA (3 of 3) 36
  • 63 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7726 35
fruit fly
(Drosophila melanogaster)
Insecta CG8349 36
  • 21 (a)
OneToMany
CG8353 36
  • 37 (a)
OneToMany
CG8360 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdd-1 36
  • 34 (a)
OneToMany
cdd-2 36
  • 38 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL123W 35
  • 52.54 (n)
  • 50 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18414g 35
  • 51.36 (n)
  • 47.41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDD1 35
  • 51.88 (n)
  • 44.35 (a)
CDD1 36
  • 37 (a)
OneToOne
CDD1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU08359 35
  • 53.54 (n)
  • 44.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdd1 35
  • 50.39 (n)
  • 51.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for CDA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDA Gene

ENSEMBL:
Gene Tree for CDA (if available)
TreeFam:
Gene Tree for CDA (if available)

Paralogs for CDA Gene

No data available for Paralogs for CDA Gene

Variants for CDA Gene

Sequence variations from dbSNP and Humsavar for CDA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2072671 - 20,589,208(+) CCAAG(A/C)AGTCA reference, missense
rs471760 -- 20,590,713(-) AATGG(C/T)ACAAA intron-variant
rs472629 -- 20,590,615(-) AAGCA(C/T)GGCAG intron-variant
rs476790 -- 20,619,002(+) TGTTC(A/C/G)GAGAG downstream-variant-500B
rs477155 -- 20,609,755(+) GTGAA(A/G)AATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDA Gene

Variant ID Type Subtype PubMed ID
nsv460729 CNV Gain 19166990
nsv528156 CNV Loss 19592680
esv998962 CNV Deletion 20482838
nsv511682 CNV Loss 21212237
esv2744975 CNV Deletion 23290073
esv2662052 CNV Deletion 23128226
esv24339 CNV Loss 19812545
esv2667482 CNV Deletion 23128226
nsv834369 CNV Loss 17160897
esv270154 CNV Insertion 20981092

Variation tolerance for CDA Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDA Gene

HapMap Linkage Disequilibrium report
CDA
Human Gene Mutation Database (HGMD)
CDA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDA Gene

Disorders for CDA Gene

MalaCards: The human disease database

(7) MalaCards diseases for CDA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
xeroderma pigmentosum, group d
  • xeroderma pigmentosum, complementation group d
refractory hematologic cancer
  • refractory hematologic malignancy
refractory hairy cell leukemia
mast-cell sarcoma
  • mast cell sarcoma
plasma protein metabolism disease
- elite association - COSMIC cancer census association via MalaCards
Search CDA in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDA

Genetic Association Database (GAD)
CDA
Human Genome Epidemiology (HuGE) Navigator
CDA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDA
genes like me logo Genes that share disorders with CDA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDA Gene

Publications for CDA Gene

  1. Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples. (PMID: 18600531) Giovannetti E. … Peters G.J. (Nucleosides Nucleotides Nucleic Acids 2008) 3 23 25 26
  2. Isolation and characterization of the gene coding for human cytidine deaminase. (PMID: 9878810) Demontis S. … Garattini E. (Biochim. Biophys. Acta 1998) 2 3 4 67
  3. Impact of cytidine deaminase activity on intrinsic resistance to cytarabine in carcinoma cells. (PMID: 15492802) Ohta T. … Komada Y. (Oncol. Rep. 2004) 23 25 26
  4. Equilibrative nucleoside transporter 1 genotype, cytidine deaminase activity and age predict gemcitabine plasma clearance in patients with solid tumours. (PMID: 21284703) Gusella M. … Padrini R. (Br J Clin Pharmacol 2011) 25 26
  5. Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. (PMID: 20028759) Okazaki T. … Li D. (Clin. Cancer Res. 2010) 3 23

Products for CDA Gene

Sources for CDA Gene

Content