Aliases for CD151 Gene
External Ids for CD151 Gene
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD151 Gene
CD151 (CD151 Molecule (Raph Blood Group)) is a Protein Coding gene. Diseases associated with CD151 include nephropathy with pretibial epidermolysis bullosa and deafness and nephrotic syndrome-deafness-pretibial epidermolysis bullosa syndrome. Among its related pathways are Degradation of the extracellular matrix and Cell junction organization. An important paralog of this gene is TSPAN7.
UniProtKB/Swiss-Prot for CD151 Gene
Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.