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Aliases for TOX Gene

Aliases for TOX Gene

  • Thymocyte Selection Associated High Mobility Group Box 2 3 5
  • Thymus High Mobility Group Box Protein TOX 3 4
  • Thymocyte Selection-Associated High Mobility Group Box Protein TOX 3
  • KIAA0808 4
  • TOX1 3

External Ids for TOX Gene

Previous GeneCards Identifiers for TOX Gene

  • GC08M059657
  • GC08M059441
  • GC08M059767
  • GC08M059880
  • GC08M059717
  • GC08M055205

Summaries for TOX Gene

Entrez Gene Summary for TOX Gene

  • The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009]

GeneCards Summary for TOX Gene

TOX (Thymocyte Selection Associated High Mobility Group Box) is a Protein Coding gene. Diseases associated with TOX include Cutaneous Diphtheria and Clostridium Difficile Colitis. Among its related pathways are Mesodermal Commitment Pathway and Development and heterogeneity of the ILC family. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is TOX3.

UniProtKB/Swiss-Prot for TOX Gene

  • May play a role in regulating T-cell development.

Gene Wiki entry for TOX Gene

Additional gene information for TOX Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOX Gene

Genomics for TOX Gene

GeneHancer (GH) Regulatory Elements for TOX Gene

Promoters and enhancers for TOX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I059115 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 555.4 +1.0 1031 5.1 CTCF MXI1 ZNF777 SIN3A E2F1 ZNF335 GLIS2 POLR2A VEZF1 ZSCAN5C TOX LOC100505501 PIR41135
GH08I058799 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13.3 +317.7 317729 3.6 ATF1 PKNOX1 IRF4 GATA2 ATF7 RUNX3 JUNB ATF4 STAT3 NBN TOX LOC100505501 RNU4-50P GC08M058815 LOC105375858
GH08I059147 Enhancer 0.9 ENCODE dbSUPER 18.8 -28.6 -28615 1 PKNOX1 BACH1 PAX8 BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 TOX LOC100505501 GC08M059138 GC08M059155 ENSG00000206853
GH08I059236 Enhancer 0.8 FANTOM5 ENCODE 16.6 -117.9 -117920 1.1 FOSL1 ZNF316 MAFG NFE2 FOS EMSY TOX GC08P059295 GC08M059177
GH08I058855 Enhancer 1.6 VISTA FANTOM5 Ensembl ENCODE dbSUPER 7.8 +261.5 261496 4.6 PKNOX1 CBX5 RCOR1 RUNX3 CEBPB SP1 MAFF NFIC IKZF1 NR2C1 TOX GC08P058884 RNU4-50P GC08M058815
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TOX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TOX gene promoter:

Genomic Locations for TOX Gene

Genomic Locations for TOX Gene
chr8:58,805,418-59,119,208
(GRCh38/hg38)
Size:
313,791 bases
Orientation:
Minus strand
chr8:59,717,977-60,031,767
(GRCh37/hg19)

Genomic View for TOX Gene

Genes around TOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOX Gene

Proteins for TOX Gene

  • Protein details for TOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94900-TOX_HUMAN
    Recommended name:
    Thymocyte selection-associated high mobility group box protein TOX
    Protein Accession:
    O94900
    Secondary Accessions:
    • Q96AV5

    Protein attributes for TOX Gene

    Size:
    526 amino acids
    Molecular mass:
    57513 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34528.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TOX Gene

Post-translational modifications for TOX Gene

No Post-translational modifications

Other Protein References for TOX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TOX Gene

Domains & Families for TOX Gene

Gene Families for TOX Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TOX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TOX Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TOX: view

No data available for UniProtKB/Swiss-Prot for TOX Gene

Function for TOX Gene

Molecular function for TOX Gene

UniProtKB/Swiss-Prot Function:
May play a role in regulating T-cell development.

Phenotypes From GWAS Catalog for TOX Gene

Gene Ontology (GO) - Molecular Function for TOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TOX: view
genes like me logo Genes that share phenotypes with TOX: view

Animal Models for TOX Gene

MGI Knock Outs for TOX:

Animal Model Products

miRNA for TOX Gene

miRTarBase miRNAs that target TOX

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TOX Gene

Localization for TOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOX Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOX gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TOX: view

Pathways & Interactions for TOX Gene

genes like me logo Genes that share pathways with TOX: view

Pathways by source for TOX Gene

Gene Ontology (GO) - Biological Process for TOX Gene

None

No data available for SIGNOR curated interactions for TOX Gene

Drugs & Compounds for TOX Gene

No Compound Related Data Available

Transcripts for TOX Gene

mRNA/cDNA for TOX Gene

Unigene Clusters for TOX Gene

Thymocyte selection-associated high mobility group box:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOX Gene

No ASD Table

Relevant External Links for TOX Gene

GeneLoc Exon Structure for
TOX
ECgene alternative splicing isoforms for
TOX

Expression for TOX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TOX Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for TOX Gene

This gene is overexpressed in CD8 Tcells (57.3) and Testis (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TOX Gene



Protein tissue co-expression partners for TOX Gene

NURSA nuclear receptor signaling pathways regulating expression of TOX Gene:

TOX

SOURCE GeneReport for Unigene cluster for TOX Gene:

Hs.491805

Evidence on tissue expression from TISSUES for TOX Gene

  • Nervous system(4.5)
  • Blood(2.4)
genes like me logo Genes that share expression patterns with TOX: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOX Gene

Orthologs for TOX Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOX 33 34
  • 99.81 (n)
oppossum
(Monodelphis domestica)
Mammalia TOX 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOX 33 34
  • 93.85 (n)
cow
(Bos Taurus)
Mammalia TOX 33 34
  • 91.38 (n)
rat
(Rattus norvegicus)
Mammalia Tox 33
  • 89.65 (n)
mouse
(Mus musculus)
Mammalia Tox 33 16 34
  • 89.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TOX 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves TOX 33 34
  • 85.86 (n)
lizard
(Anolis carolinensis)
Reptilia TOX 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tox 33
  • 78.65 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1457 33
zebrafish
(Danio rerio)
Actinopterygii tox 33 34
  • 67.73 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POB3 34
  • 6 (a)
OneToMany
Species where no ortholog for TOX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOX Gene

ENSEMBL:
Gene Tree for TOX (if available)
TreeFam:
Gene Tree for TOX (if available)

Paralogs for TOX Gene

Paralogs for TOX Gene

(3) SIMAP similar genes for TOX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TOX: view

Variants for TOX Gene

Sequence variations from dbSNP and Humsavar for TOX Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000002032 -- 58,844,565(-) C/T intron_variant
rs1000004908 -- 59,051,390(-) C/A/T intron_variant
rs1000005626 -- 59,093,634(-) C/T intron_variant
rs1000010529 -- 59,023,636(-) T/C intron_variant
rs1000025696 -- 59,104,753(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TOX Gene

Variant ID Type Subtype PubMed ID
esv1476730 CNV insertion 17803354
esv1732094 CNV insertion 17803354
esv2737046 CNV deletion 23290073
esv2737047 CNV deletion 23290073
esv3303731 CNV mobile element insertion 20981092
esv3371312 CNV insertion 20981092
esv3417134 CNV insertion 20981092
nsv1124344 CNV deletion 24896259
nsv1125946 CNV tandem duplication 24896259
nsv1133690 CNV deletion 24896259
nsv525018 CNV loss 19592680
nsv526468 CNV loss 19592680
nsv6213 CNV insertion 18451855
nsv6214 CNV insertion 18451855
nsv831327 CNV loss 17160897

Variation tolerance for TOX Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TOX Gene

Human Gene Mutation Database (HGMD)
TOX
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOX Gene

Disorders for TOX Gene

MalaCards: The human disease database

(5) MalaCards diseases for TOX Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cutaneous diphtheria
clostridium difficile colitis
  • pseudomembranous colitis
phencyclidine abuse
  • pcp abuse
refractive error
  • refractive errors
sezary's disease
  • sezary disease
- elite association - COSMIC cancer census association via MalaCards
Search TOX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TOX

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TOX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TOX Gene

Publications for TOX Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 44 58
  4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need AC … Goldstein DB (Human molecular genetics 2009) 3 44 58
  5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 44 58

Products for TOX Gene

Sources for TOX Gene

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