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Aliases for TOX Gene

Aliases for TOX Gene

  • Thymocyte Selection-Associated High Mobility Group Box 2 3
  • Thymus High Mobility Group Box Protein TOX 3 4
  • KIAA0808 4 6
  • Thymocyte Selection-Associated High Mobility Group Box Protein TOX 3
  • TOX1 3

External Ids for TOX Gene

Previous GeneCards Identifiers for TOX Gene

  • GC08M059657
  • GC08M059441
  • GC08M059767
  • GC08M059880
  • GC08M059717
  • GC08M055205

Summaries for TOX Gene

Entrez Gene Summary for TOX Gene

  • The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009]

GeneCards Summary for TOX Gene

TOX (Thymocyte Selection-Associated High Mobility Group Box) is a Protein Coding gene. An important paralog of this gene is SSRP1.

UniProtKB/Swiss-Prot for TOX Gene

  • May play a role in regulating T-cell development.

Gene Wiki entry for TOX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOX Gene

Genomics for TOX Gene

Regulatory Elements for TOX Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TOX Gene

Start:
58,805,418 bp from pter
End:
59,119,208 bp from pter
Size:
313,791 bases
Orientation:
Minus strand

Genomic View for TOX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOX Gene

Proteins for TOX Gene

  • Protein details for TOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94900-TOX_HUMAN
    Recommended name:
    Thymocyte selection-associated high mobility group box protein TOX
    Protein Accession:
    O94900
    Secondary Accessions:
    • Q96AV5

    Protein attributes for TOX Gene

    Size:
    526 amino acids
    Molecular mass:
    57513 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34528.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TOX Gene

Proteomics data for TOX Gene at MOPED

Post-translational modifications for TOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TOX Gene

Domains for TOX Gene

Protein Domains for TOX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TOX Gene

Graphical View of Domain Structure for InterPro Entry

O94900

UniProtKB/Swiss-Prot:

TOX_HUMAN :
  • O94900
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with TOX: view

No data available for Gene Families for TOX Gene

Function for TOX Gene

Molecular function for TOX Gene

UniProtKB/Swiss-Prot Function: May play a role in regulating T-cell development.

Gene Ontology (GO) - Molecular Function for TOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA --
genes like me logo Genes that share ontologies with TOX: view
genes like me logo Genes that share phenotypes with TOX: view

Animal Models for TOX Gene

MGI Knock Outs for TOX:

Animal Model Products

CRISPR Products

miRNA for TOX Gene

miRTarBase miRNAs that target TOX

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOX

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TOX Gene

Localization for TOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOX Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOX Gene COMPARTMENTS Subcellular localization image for TOX gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TOX: view

Pathways for TOX Gene

SuperPathways for TOX Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • T Helper Cell Differentiation in human,mouse,rat

Gene Ontology (GO) - Biological Process for TOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IBA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with TOX: view

No data available for Pathways by source for TOX Gene

Transcripts for TOX Gene

mRNA/cDNA for TOX Gene

(114) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOX Gene

Thymocyte selection-associated high mobility group box:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOX

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOX Gene

No ASD Table

Relevant External Links for TOX Gene

GeneLoc Exon Structure for
TOX
ECgene alternative splicing isoforms for
TOX

Expression for TOX Gene

mRNA expression in normal human tissues for TOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TOX Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOX Gene

SOURCE GeneReport for Unigene cluster for TOX Gene Hs.491805

genes like me logo Genes that share expressions with TOX: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TOX Gene

Orthologs for TOX Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOX 35
  • 99.81 (n)
  • 100 (a)
TOX 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TOX 35
  • 91.38 (n)
  • 95.63 (a)
TOX 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOX 35
  • 93.85 (n)
  • 97.34 (a)
TOX 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tox 35
  • 89.16 (n)
  • 94.3 (a)
Tox 16
Tox 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TOX 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOX 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tox 35
  • 89.65 (n)
  • 94.67 (a)
chicken
(Gallus gallus)
Aves TOX 35
  • 85.86 (n)
  • 92.64 (a)
TOX 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOX 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1457 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tox 35
  • 78.65 (n)
  • 84.13 (a)
zebrafish
(Danio rerio)
Actinopterygii tox 35
  • 67.73 (n)
  • 67.07 (a)
tox 36
  • 62 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POB3 36
  • 6 (a)
OneToMany
Species with no ortholog for TOX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOX Gene

ENSEMBL:
Gene Tree for TOX (if available)
TreeFam:
Gene Tree for TOX (if available)

Paralogs for TOX Gene

Paralogs for TOX Gene

Selected SIMAP similar genes for TOX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TOX: view

Variants for TOX Gene

Sequence variations from dbSNP and Humsavar for TOX Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs113654 -- 59,022,883(+) GACAG(C/T)AAAAC intron-variant
rs167460 -- 59,083,895(-) GAGGG(G/T)TTTTC intron-variant
rs172652 -- 59,045,582(-) GAATT(C/T)GTCGT intron-variant
rs172653 -- 59,054,970(-) TCCCT(C/T)CCTTC intron-variant
rs172654 -- 59,056,848(-) GAGAT(C/T)TGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOX Gene

Variant ID Type Subtype PubMed ID
nsv890938 CNV Gain 21882294
nsv6213 CNV Insertion 18451855
nsv890940 CNV Loss 21882294
esv2737046 CNV Deletion 23290073
nsv526468 CNV Loss 19592680
esv2737047 CNV Deletion 23290073
esv268010 CNV Insertion 20981092
nsv525018 CNV Loss 19592680
esv1732094 CNV Insertion 17803354
esv1476730 CNV Insertion 17803354
nsv831327 CNV Loss 17160897
nsv6214 CNV Insertion 18451855

Relevant External Links for TOX Gene

HapMap Linkage Disequilibrium report
TOX
Human Gene Mutation Database (HGMD)
TOX
Locus Specific Mutation Databases (LSDB)
TOX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOX Gene

Disorders for TOX Gene

(3) University of Copenhagen DISEASES for TOX Gene

Relevant External Links for TOX

Genetic Association Database (GAD)
TOX
Human Genome Epidemiology (HuGE) Navigator
TOX
genes like me logo Genes that share disorders with TOX: view

No data available for UniProtKB/Swiss-Prot for TOX Gene

Publications for TOX Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. TOX: an HMG box protein implicated in the regulation of thymocyte selection. (PMID: 11850626) Wilkinson B. … Kaye J. (Nat. Immunol. 2002) 2 3
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Fetal hemoglobin in sickle cell anemia: Bayesian modeling of genetic associations. (PMID: 17918249) Sebastiani P. … Steinberg M.H. (Am. J. Hematol. 2008) 3 48

Products for TOX Gene

Sources for TOX Gene

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