Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CD81 Gene

Aliases for CD81 Gene

  • CD81 Molecule 2 3 5
  • CD81 Antigen (Target Of Antiproliferative Antibody 1) 2 3
  • 26 KDa Cell Surface Protein TAPA-1 3 4
  • Tetraspanin-28 3 4
  • Tspan-28 3 4
  • TSPAN28 3 4
  • TAPA1 3 4
  • Target Of The Antiproliferative Antibody 1 4
  • CD81 Antigen 4
  • CVID6 3
  • S5.7 3

External Ids for CD81 Gene

Previous HGNC Symbols for CD81 Gene

  • TAPA1

Previous GeneCards Identifiers for CD81 Gene

  • GC11P002460
  • GC11P002599
  • GC11P002356
  • GC11P002363
  • GC11P002355
  • GC11P002188

Summaries for CD81 Gene

Entrez Gene Summary for CD81 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for CD81 Gene

CD81 (CD81 Molecule) is a Protein Coding gene. Diseases associated with CD81 include Immunodeficiency, Common Variable, 6 and Common Variable Immunodeficiency. Among its related pathways are Immune System and Malaria. GO annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is TSPAN9.

UniProtKB/Swiss-Prot for CD81 Gene

  • May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.

Gene Wiki entry for CD81 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD81 Gene

Genomics for CD81 Gene

Regulatory Elements for CD81 Gene

Enhancers for CD81 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CD81 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD81 Gene

2,376,177 bp from pter
2,397,419 bp from pter
21,243 bases
Plus strand

Genomic View for CD81 Gene

Genes around CD81 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD81 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD81 Gene

Proteins for CD81 Gene

  • Protein details for CD81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CD81 antigen
    Protein Accession:
    Secondary Accessions:
    • P18582
    • Q5U0J6

    Protein attributes for CD81 Gene

    236 amino acids
    Molecular mass:
    25809 Da
    Quaternary structure:
    • Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. Interacts directly with IGSF8. Interacts with CD53 and SCIMP. Interacts with IFITM1, IFITM2 and IFITM3. Part of a GPCR-tetraspanin complex consisting at least of GPR56, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of GPR56 with GNA11.

    Three dimensional structures from OCA and Proteopedia for CD81 Gene

neXtProt entry for CD81 Gene

Proteomics data for CD81 Gene at MOPED

Post-translational modifications for CD81 Gene

Antibody Products

  • Abcam antibodies for TAPA1

No data available for DME Specific Peptides for CD81 Gene

Domains & Families for CD81 Gene

Gene Families for CD81 Gene

Protein Domains for CD81 Gene

Suggested Antigen Peptide Sequences for CD81 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with CD81: view

Function for CD81 Gene

Molecular function for CD81 Gene

GENATLAS Biochemistry:
integral membrane protein (26kDa),associated with CD19,B cell surface molecule,expressed on many cell types,target of an antiproliferative antibody
UniProtKB/Swiss-Prot Function:
May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.

Gene Ontology (GO) - Molecular Function for CD81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 2398277
GO:0023026 MHC class II protein complex binding IDA 20458337
genes like me logo Genes that share ontologies with CD81: view
genes like me logo Genes that share phenotypes with CD81: view

Human Phenotype Ontology for CD81 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD81 Gene

MGI Knock Outs for CD81:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD81

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD81 Gene

Localization for CD81 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD81 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CD81 Gene COMPARTMENTS Subcellular localization image for CD81 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
endosome 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CD81 Gene

Pathways & Interactions for CD81 Gene

genes like me logo Genes that share pathways with CD81: view

Pathways by source for CD81 Gene

1 GeneGo (Thomson Reuters) pathway for CD81 Gene
1 Qiagen pathway for CD81 Gene

Gene Ontology (GO) - Biological Process for CD81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 14676841
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0008104 protein localization IDA 14676841
GO:0030890 positive regulation of B cell proliferation IDA 10400713
GO:0031647 regulation of protein stability IMP 25635054
genes like me logo Genes that share ontologies with CD81: view

No data available for SIGNOR curated interactions for CD81 Gene

Drugs & Compounds for CD81 Gene

(5) Drugs for CD81 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for CD81 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD81: view

Transcripts for CD81 Gene

Unigene Clusters for CD81 Gene

CD81 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD81 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - -
SP10: -
SP11: - - - - - - - - - -
SP12: -

Relevant External Links for CD81 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD81 Gene

mRNA expression in normal human tissues for CD81 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD81 Gene

This gene is overexpressed in Frontal cortex (7.5) and Spinal cord (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD81 Gene

SOURCE GeneReport for Unigene cluster for CD81 Gene Hs.54457

mRNA Expression by UniProt/SwissProt for CD81 Gene

Tissue specificity: Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.
genes like me logo Genes that share expression patterns with CD81: view

Protein tissue co-expression partners for CD81 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for CD81 Gene

Orthologs for CD81 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD81 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CD81 35
  • 90.68 (n)
  • 94.49 (a)
CD81 36
  • 94 (a)
(Canis familiaris)
Mammalia LOC611606 35
  • 90.67 (n)
  • 95.41 (a)
CD81 36
  • 90 (a)
(Mus musculus)
Mammalia Cd81 35
  • 86.72 (n)
  • 91.95 (a)
Cd81 16
Cd81 36
  • 92 (a)
(Pan troglodytes)
Mammalia CD81 35
  • 99.29 (n)
  • 100 (a)
CD81 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cd81 35
  • 87.01 (n)
  • 93.22 (a)
(Gallus gallus)
Aves CD81 35
  • 78.32 (n)
  • 80.37 (a)
TAPA1 36
  • 83 (a)
(Anolis carolinensis)
Reptilia CD81 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cd81 35
  • 70.5 (n)
  • 71.91 (a)
MGC75667 35
African clawed frog
(Xenopus laevis)
Amphibia cd81-prov 35
(Danio rerio)
Actinopterygii cd81 35
  • 67.53 (n)
  • 65.95 (a)
cd81 36
  • 65 (a)
CD81 (1 of 2) 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000823 35
  • 52.36 (n)
  • 34.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp96F 35
  • 47.58 (n)
  • 31.28 (a)
Tsp96F 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea tsp-9 36
  • 26 (a)
Species with no ortholog for CD81:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD81 Gene

Gene Tree for CD81 (if available)
Gene Tree for CD81 (if available)

Paralogs for CD81 Gene

Paralogs for CD81 Gene

genes like me logo Genes that share paralogs with CD81: view

Variants for CD81 Gene

Sequence variations from dbSNP and Humsavar for CD81 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs708564 -- 2,388,869(+) GGAGT(C/T)GGATG intron-variant
rs731909 -- 2,387,394(+) CAAAA(C/G)AAAAT intron-variant
rs800128 -- 2,383,847(+) GTAAG(A/G)TATGG intron-variant
rs800129 -- 2,385,682(+) CGTGC(C/T)GTGGC intron-variant, upstream-variant-2KB
rs800130 -- 2,385,663(+) TGCCC(G/T)TCGTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CD81 Gene

Variant ID Type Subtype PubMed ID
nsv467645 CNV Gain 19166990
nsv896806 CNV Loss 21882294
nsv469928 CNV Loss 18288195
nsv896808 CNV Loss 21882294
dgv1000n71 CNV Loss 21882294
nsv896811 CNV Loss 21882294
nsv896812 CNV Loss 21882294
nsv896816 CNV Loss 21882294
nsv509382 CNV Insertion 20534489
nsv896820 CNV Loss 21882294
nsv896821 CNV Loss 21882294
esv1007864 CNV Deletion 20482838
esv2744006 CNV Deletion 23290073
esv1285833 CNV Deletion 17803354

Variation tolerance for CD81 Gene

Residual Variation Intolerance Score: 17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD81 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD81 Gene

Disorders for CD81 Gene

MalaCards: The human disease database

(13) MalaCards diseases for CD81 Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency, common variable, 6
  • antibody deficiency due to cd81 defect
common variable immunodeficiency
  • acquired agammaglobulinemia
hepatitis c
  • chronic hepatitis c
  • cryoimmunoglobulinaemia
pediatric lymphoma
  • childhood lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search CD81 in MalaCards View complete list of genes associated with diseases


  • Immunodeficiency, common variable, 6 (CVID6) [MIM:613496]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:20237408}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CD81

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CD81: view

No data available for Genatlas for CD81 Gene

Publications for CD81 Gene

  1. TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. (PMID: 1695320) Oren R. … Levy S. (Mol. Cell. Biol. 1990) 3 4 23 67
  2. Tetraspanin CD81 is required for Listeria monocytogenes invasion. (PMID: 19901060) Tham T.N. … Pizarro-Cerda J. (Infect. Immun. 2010) 3 23
  3. CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas. (PMID: 20004001) Luo R.F. … Natkunam Y. (Hum. Pathol. 2010) 3 23
  4. Endothelial CD81 is a marker of early human atherosclerotic plaques and facilitates monocyte adhesion. (PMID: 18805782) Rohlena J. … Horrevoets A.J. (Cardiovasc. Res. 2009) 3 23
  5. Mutation of juxtamembrane cysteines in the tetraspanin CD81 affects palmitoylation and alters interaction with other proteins at the cell surface. (PMID: 19328198) Delandre C. … Clem R.J. (Exp. Cell Res. 2009) 3 23

Products for CD81 Gene

Sources for CD81 Gene