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Aliases for ARHGAP32 Gene

Aliases for ARHGAP32 Gene

  • Rho GTPase Activating Protein 32 2 3 5
  • RhoGAP Involved In The Beta-Catenin-N-Cadherin And NMDA Receptor Signaling 3 4
  • GAB-Associated Cdc42/Rac GTPase-Activating Protein 3 4
  • Brain-Specific Rho GTPase-Activating Protein 3 4
  • Rho/Cdc42/Rac GTPase-Activating Protein RICS 3 4
  • GTPase Regulator Interacting With TrkA 3 4
  • Rho-Type GTPase-Activating Protein 32 3 4
  • P200RhoGAP 3 4
  • P250GAP 3 4
  • GC-GAP 3 4
  • GRIT 3 4
  • RICS 3 4
  • RhoGAP Involved In The -Catenin-N-Cadherin And NMDA Receptor Signaling 3
  • Brain-Specific Rho GTP-Ase-Activating Protein 3
  • GTPase-Activating Protein For Cdc42 And Rac1 3
  • Rac GTPase Activating Protein 3
  • GAB-Associated CDC42 3
  • KIAA0712 4
  • PX-RICS 3

External Ids for ARHGAP32 Gene

Previous GeneCards Identifiers for ARHGAP32 Gene

  • GC11M128834
  • GC11M124785

Summaries for ARHGAP32 Gene

Entrez Gene Summary for ARHGAP32 Gene

  • RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP32 Gene

ARHGAP32 (Rho GTPase Activating Protein 32) is a Protein Coding gene. Diseases associated with ARHGAP32 include Neuroblastoma. Among its related pathways are Signaling by Rho GTPases and G-protein signaling_RhoA regulation pathway. GO annotations related to this gene include GTPase activator activity and phosphatidylinositol binding. An important paralog of this gene is ARHGAP31.

UniProtKB/Swiss-Prot for ARHGAP32 Gene

  • GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).

Gene Wiki entry for ARHGAP32 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP32 Gene

Genomics for ARHGAP32 Gene

Regulatory Elements for ARHGAP32 Gene

Enhancers for ARHGAP32 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARHGAP32 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGAP32 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP32 Gene

Chromosome:
11
Start:
128,965,060 bp from pter
End:
129,279,324 bp from pter
Size:
314,265 bases
Orientation:
Minus strand

Genomic View for ARHGAP32 Gene

Genes around ARHGAP32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP32 Gene

Proteins for ARHGAP32 Gene

  • Protein details for ARHGAP32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A7KAX9-RHG32_HUMAN
    Recommended name:
    Rho GTPase-activating protein 32
    Protein Accession:
    A7KAX9
    Secondary Accessions:
    • I7H0B0
    • O94820
    • Q86YL6
    • Q8IUG4
    • Q9BWG3

    Protein attributes for ARHGAP32 Gene

    Size:
    2087 amino acids
    Molecular mass:
    230529 Da
    Quaternary structure:
    • Interacts with NTRK1 (via cytoplasmic domain); the interaction is independent of the phosphorylation state of NTRK1. Interacts with SHC3 (via SH2 domain). Interacts with RASA1 (via SH3 domain); the interaction is necessary for the Ras activation and cell transforming activities of ARHGAP32 (By similarity). Interacts with GAB1 and GAB2. Interacts with CRK and CRKL. Found in a complex with CRKL and BCAR1; upon EGF stimulation BCAR1 may be replaced by EGFR. Interacts with NCK1 (via SH3 domain); NCK1 recruits phosphorylated BCAR1 to the complex. Isoform 2 interacts with FYN; the interaction appears to be dependent on tyrosine phosphorylation of ARHGAP32. Interacts with EGFR; the interaction requires EGF stimulation and is increased by SHC3. Interacts with CDC42; the interaction requires constitutively active CDC42. Interacts with CTNNB1, DLG4, CDH2 and GRIN2B (By similarity).
    SequenceCaution:
    • Sequence=BAA34432.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP32 Gene

    Alternative splice isoforms for ARHGAP32 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP32 Gene

Proteomics data for ARHGAP32 Gene at MOPED

Post-translational modifications for ARHGAP32 Gene

  • Isoform 2 is phosphorylated on multiple tyrosine residues by FYN. Phosphorylated tyrosine residues undergo dephosphorylation after stimulation of NMDA receptors (By similarity). Phosphorylated in vitro by CaMK2 in the presence of calmodulin and calcium; which inhibits GAP activity (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP32 Gene

No data available for DME Specific Peptides for ARHGAP32 Gene

Domains & Families for ARHGAP32 Gene

Gene Families for ARHGAP32 Gene

Protein Domains for ARHGAP32 Gene

Suggested Antigen Peptide Sequences for ARHGAP32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A7KAX9

UniProtKB/Swiss-Prot:

RHG32_HUMAN :
  • The N-terminal PX domain interacts specifically with phosphatidylinositides.
Domain:
  • The N-terminal PX domain interacts specifically with phosphatidylinositides.
  • Belongs to the PX domain-containing GAP family.
  • Contains 1 PX (phox homology) domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with ARHGAP32: view

Function for ARHGAP32 Gene

Molecular function for ARHGAP32 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).
genes like me logo Genes that share phenotypes with ARHGAP32: view

Animal Models for ARHGAP32 Gene

MGI Knock Outs for ARHGAP32:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP32 Gene

Localization for ARHGAP32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP32 Gene

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. Cytoplasm, cell cortex. Endosome membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane. Membrane. Note=Association to membrane via PX domain (PubMed:17663722). Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic spine and postsynaptic density after differentiation (By similarity). Colocalizes with EGFR at the cell membrane upon EGF treatment (PubMed:12446789). Colocalizes with GAB2 at the cell membrane (PubMed:12819203). {ECO:0000250 UniProtKB:Q811P8, ECO:0000269 PubMed:12446789, ECO:0000269 PubMed:12819203, ECO:0000269 PubMed:17663722}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP32 Gene COMPARTMENTS Subcellular localization image for ARHGAP32 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
cytoskeleton 3
endosome 3
golgi apparatus 3
plasma membrane 3
nucleus 2

Gene Ontology (GO) - Cellular Components for ARHGAP32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005829 cytosol TAS --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with ARHGAP32: view

Pathways & Interactions for ARHGAP32 Gene

genes like me logo Genes that share pathways with ARHGAP32: view

SIGNOR curated interactions for ARHGAP32 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ARHGAP32 Gene

None

Drugs & Compounds for ARHGAP32 Gene

(4) Drugs for ARHGAP32 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
HJC 0350 Pharma 0
calcium Nutra 0

(2) Additional Compounds for ARHGAP32 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Methyl-D-aspartic acid
  • N-Me-D-Asp-OH
  • N-Methyl D-aspartate
  • N-Methyl D-aspartic acid
  • N-Methyl-D-aspartate
  • NMDA
6384-92-5

(1) ApexBio Compounds for ARHGAP32 Gene

Compound Action Cas Number
HJC 0350 885434-70-8
genes like me logo Genes that share compounds with ARHGAP32: view

Transcripts for ARHGAP32 Gene

Unigene Clusters for ARHGAP32 Gene

Rho GTPase activating protein 32:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP32 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21
SP1: - -
SP2: - -
SP3:
SP4: -

Relevant External Links for ARHGAP32 Gene

GeneLoc Exon Structure for
ARHGAP32
ECgene alternative splicing isoforms for
ARHGAP32

Expression for ARHGAP32 Gene

mRNA expression in normal human tissues for ARHGAP32 Gene

Protein differential expression in normal tissues from HIPED for ARHGAP32 Gene

This gene is overexpressed in Cervix (52.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP32 Gene



SOURCE GeneReport for Unigene cluster for ARHGAP32 Gene Hs.440379

mRNA Expression by UniProt/SwissProt for ARHGAP32 Gene

A7KAX9-RHG32_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed in other tissues such as lung, liver and spleen.
genes like me logo Genes that share expression patterns with ARHGAP32: view

Protein tissue co-expression partners for ARHGAP32 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ARHGAP32 Gene

Orthologs for ARHGAP32 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP32 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGAP32 35
  • 83.09 (n)
  • 83.59 (a)
ARHGAP32 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP32 35
  • 87.95 (n)
  • 88.97 (a)
ARHGAP32 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap32 35
  • 86.18 (n)
  • 87.96 (a)
Arhgap32 16
Arhgap32 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP32 35
  • 99.54 (n)
  • 99.43 (a)
ARHGAP32 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap32 35
  • 85.81 (n)
  • 88.45 (a)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP32 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP32 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP32 35
  • 68.16 (n)
  • 66.62 (a)
ARHGAP32 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGAP32 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap32 35
  • 65.17 (n)
  • 66.42 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34587 35
zebrafish
(Danio rerio)
Actinopterygii im:7150060 35
  • 60.52 (n)
  • 61.74 (a)
ARHGAP32 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CdGAPr 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rrc-1 36
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGD1 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for ARHGAP32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP32 Gene

ENSEMBL:
Gene Tree for ARHGAP32 (if available)
TreeFam:
Gene Tree for ARHGAP32 (if available)

Paralogs for ARHGAP32 Gene

Paralogs for ARHGAP32 Gene

(9) SIMAP similar genes for ARHGAP32 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARHGAP32: view

Variants for ARHGAP32 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP32 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs519061 -- 129,143,566(-) CATGA(A/G)AGTTG intron-variant
rs522456 -- 128,989,516(+) TTATT(A/T)CACAC intron-variant
rs525370 -- 129,037,930(-) AGAGA(C/T)GGGGT intron-variant
rs525988 -- 129,092,967(+) TGATG(A/G)GGGAA intron-variant
rs527951 -- 129,121,312(-) GTAGC(A/C)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP32 Gene

Variant ID Type Subtype PubMed ID
nsv525837 CNV Loss 19592680
esv2661820 CNV Deletion 23128226
esv274060 CNV Insertion 20981092
nsv832291 CNV Loss 17160897
esv271608 CNV Insertion 20981092
esv274658 CNV Insertion 20981092
esv2243084 CNV Deletion 18987734
esv2442229 CNV Deletion 19546169
esv269124 CNV Insertion 20981092
esv2601979 CNV Deletion 19546169
esv2287161 CNV Deletion 18987734
esv2745247 CNV Deletion 23290073
nsv826132 CNV Gain 20364138

Variation tolerance for ARHGAP32 Gene

Residual Variation Intolerance Score: 3.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.25; 70.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARHGAP32 Gene

Disorders for ARHGAP32 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGAP32 Gene - From: GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARHGAP32

Genetic Association Database (GAD)
ARHGAP32
Human Genome Epidemiology (HuGE) Navigator
ARHGAP32
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP32
genes like me logo Genes that share disorders with ARHGAP32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP32 Gene

Publications for ARHGAP32 Gene

  1. Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules. (PMID: 12446789) Nakamura T. … Mori N. (Mol. Cell. Biol. 2002) 2 3 4 23 67
  2. PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development. (PMID: 17663722) Hayashi T. … Nakamura T. (Genes Cells 2007) 2 3
  3. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. (PMID: 12819203) Zhao C. … Feng G.S. (J. Biol. Chem. 2003) 2 3
  4. Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP. (PMID: 12454018) Moon S.Y. … Zheng Y. (J. Biol. Chem. 2003) 3 23
  5. p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. (PMID: 12788081) Taniguchi S. … Yamamoto T. (Biochem. Biophys. Res. Commun. 2003) 3 23

Products for ARHGAP32 Gene

Sources for ARHGAP32 Gene

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