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Aliases for GPRASP1 Gene

Aliases for GPRASP1 Gene

  • G Protein-Coupled Receptor Associated Sorting Protein 1 2 3 5
  • GASP-1 3 4
  • GASP 3 4
  • G-Protein Coupled Receptor-Associated Sorting Protein 1 3
  • KIAA0443 4
  • GASP1 3

External Ids for GPRASP1 Gene

Previous GeneCards Identifiers for GPRASP1 Gene

  • GC0XP101712
  • GC0XP101906
  • GC0XP091572

Summaries for GPRASP1 Gene

Entrez Gene Summary for GPRASP1 Gene

  • This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]

GeneCards Summary for GPRASP1 Gene

GPRASP1 (G Protein-Coupled Receptor Associated Sorting Protein 1) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is GPRASP2.

UniProtKB/Swiss-Prot for GPRASP1 Gene

  • Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.

Gene Wiki entry for GPRASP1 Gene

Additional gene information for GPRASP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRASP1 Gene

Genomics for GPRASP1 Gene

Regulatory Elements for GPRASP1 Gene

Enhancers for GPRASP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH103151 1.2 Ensembl ENCODE 42.6 +500.9 500943 1 ARNT FEZF1 GLI4 BRCA1 ZNF2 ZBTB7B TCF12 ZNF121 GLIS2 ATF7 GPRASP1 BEX4 TCEAL3 ELF2P1 TMSB15B ZCCHC18 GPRASP2 BEX3 TCEAL7 TCEAL1
GH0XH102658 1.4 FANTOM5 ENCODE 32.7 +8.0 7989 2 HDAC1 ATF1 FOXA2 ARID4B SIN3A YY1 FOS ATF7 CREM HCFC1 GPRASP1 LINC00630 ARMCX5 ENSG00000239407 TCEAL3-AS1 TCEAL9 BHLHB9 ENSG00000270050
GH0XH102598 1 ENCODE 31 -51.6 -51607 2 PKNOX1 ATF1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 ATF7 RUNX3 GPRASP1 LOC100128601 GPRASP2 ARMCX5-GPRASP2 ENSG00000227211
GH0XH102650 0.7 ENCODE 33.3 +0.6 617 2 CTCF MAZ SP3 KLF1 ZNF76 ZNF843 ATF2 RAD21 ZFHX2 ZBTB48 GPRASP1 ENSG00000270050
GH0XH102745 0.4 ENCODE 30.4 +94.7 94737 1 POLR2A GPRASP1 LINC00630 BHLHB9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPRASP1 on UCSC Golden Path with GeneCards custom track

Promoters for GPRASP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247660 335 1800 CTCF MAZ SP3 KLF1 ZNF76 ZNF843 ATF2 RAD21 ZFHX2 ZBTB48

Genomic Location for GPRASP1 Gene

Chromosome:
X
Start:
102,651,366 bp from pter
End:
102,659,083 bp from pter
Size:
7,718 bases
Orientation:
Plus strand

Genomic View for GPRASP1 Gene

Genes around GPRASP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRASP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRASP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRASP1 Gene

Proteins for GPRASP1 Gene

  • Protein details for GPRASP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JY77-GASP1_HUMAN
    Recommended name:
    G-protein coupled receptor-associated sorting protein 1
    Protein Accession:
    Q5JY77
    Secondary Accessions:
    • O43168
    • Q96LA1

    Protein attributes for GPRASP1 Gene

    Size:
    1395 amino acids
    Molecular mass:
    156865 Da
    Quaternary structure:
    • Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as D2 dopamine receptor/DRD2 (By similarity), delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4. Interacts with PER1. Interacts with BECN2; the interaction is direct.
    SequenceCaution:
    • Sequence=BAA23715.3; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPRASP1 Gene

Post-translational modifications for GPRASP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GPRASP1 Gene

Domains & Families for GPRASP1 Gene

Gene Families for GPRASP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPRASP1 Gene

Suggested Antigen Peptide Sequences for GPRASP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JY77

UniProtKB/Swiss-Prot:

GASP1_HUMAN :
  • Belongs to the GPRASP family.
Family:
  • Belongs to the GPRASP family.
genes like me logo Genes that share domains with GPRASP1: view

Function for GPRASP1 Gene

Molecular function for GPRASP1 Gene

UniProtKB/Swiss-Prot Function:
Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.

Gene Ontology (GO) - Molecular Function for GPRASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15086532
genes like me logo Genes that share ontologies with GPRASP1: view
genes like me logo Genes that share phenotypes with GPRASP1: view

Animal Models for GPRASP1 Gene

MGI Knock Outs for GPRASP1:

Animal Model Products

CRISPR Products

miRNA for GPRASP1 Gene

miRTarBase miRNAs that target GPRASP1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GPRASP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPRASP1 Gene

Localization for GPRASP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRASP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPRASP1 gene
Compartment Confidence
cytosol 5
nucleus 3
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPRASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with GPRASP1: view

Pathways & Interactions for GPRASP1 Gene

SuperPathways for GPRASP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPRASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008333 endosome to lysosome transport IMP 23954414
GO:1990172 G-protein coupled receptor catabolic process IPI 23954414
genes like me logo Genes that share ontologies with GPRASP1: view

No data available for Pathways by source and SIGNOR curated interactions for GPRASP1 Gene

Drugs & Compounds for GPRASP1 Gene

No Compound Related Data Available

Transcripts for GPRASP1 Gene

Unigene Clusters for GPRASP1 Gene

G protein-coupled receptor associated sorting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GPRASP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GPRASP1 Gene

No ASD Table

Relevant External Links for GPRASP1 Gene

GeneLoc Exon Structure for
GPRASP1
ECgene alternative splicing isoforms for
GPRASP1

Expression for GPRASP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPRASP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPRASP1 Gene

This gene is overexpressed in Pancreatic juice (43.6), Retina (15.9), and Brain (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPRASP1 Gene



Protein tissue co-expression partners for GPRASP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPRASP1 Gene:

GPRASP1

SOURCE GeneReport for Unigene cluster for GPRASP1 Gene:

Hs.729265

mRNA Expression by UniProt/SwissProt for GPRASP1 Gene:

Q5JY77-GASP1_HUMAN
Tissue specificity: Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.

Evidence on tissue expression from TISSUES for GPRASP1 Gene

  • Nervous system(4.8)
  • Heart(4.2)
genes like me logo Genes that share expression patterns with GPRASP1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPRASP1 Gene

Orthologs for GPRASP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRASP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPRASP1 33 34
  • 96.13 (n)
dog
(Canis familiaris)
Mammalia GPRASP1 33 34
  • 81.1 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 76 (a)
OneToMany
-- 34
  • 62 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gprasp1 33 16 34
  • 74.94 (n)
rat
(Rattus norvegicus)
Mammalia Gprasp1 33
  • 74.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 29 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 24 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ARMCX3 34
  • 18 (a)
OneToMany
Species where no ortholog for GPRASP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRASP1 Gene

ENSEMBL:
Gene Tree for GPRASP1 (if available)
TreeFam:
Gene Tree for GPRASP1 (if available)

Paralogs for GPRASP1 Gene

Paralogs for GPRASP1 Gene

(1) SIMAP similar genes for GPRASP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPRASP1: view

Variants for GPRASP1 Gene

Sequence variations from dbSNP and Humsavar for GPRASP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1057518762 Uncertain significance 102,657,292(+) TTCGA(C/G)AGCAT intron-variant, reference, missense
rs1000029508 -- 102,658,663(+) TATTG(A/G)TGGTG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1001381120 -- 102,656,303(+) TGAGA(C/G)TAGAG intron-variant, reference, missense
rs1002915642 -- 102,650,743(+) ATGAG(-/TC)TGGTG intron-variant, upstream-variant-2KB
rs1003156794 -- 102,654,700(+) CCTGG(C/T)TCTGG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GPRASP1 Gene

Variant ID Type Subtype PubMed ID
nsv526716 CNV gain 19592680

Variation tolerance for GPRASP1 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.51; 71.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPRASP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPRASP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRASP1 Gene

Disorders for GPRASP1 Gene

Relevant External Links for GPRASP1

Genetic Association Database (GAD)
GPRASP1
Human Genome Epidemiology (HuGE) Navigator
GPRASP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPRASP1

No disorders were found for GPRASP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPRASP1 Gene

Publications for GPRASP1 Gene

  1. Identification of a novel family of G protein-coupled receptor associated sorting proteins. (PMID: 15086532) Simonin F … Kieffer BL (Journal of neurochemistry 2004) 2 3 4 60
  2. Modulation of postendocytic sorting of G protein-coupled receptors. (PMID: 12142540) Whistler JL … Von Zastrow M (Science (New York, N.Y.) 2002) 3 4 22 60
  3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 60
  4. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. (PMID: 23954414) He C … Levine B (Cell 2013) 3 4 60
  5. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 45 60

Products for GPRASP1 Gene

Sources for GPRASP1 Gene

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