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Aliases for CD74 Gene

Aliases for CD74 Gene

  • CD74 Molecule 2 3 5
  • CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex, Class II Antigen-Associated) 2 3
  • CD74 Molecule, Major Histocompatibility Complex, Class II Invariant Chain 2 3
  • HLA-DR Antigens-Associated Invariant Chain 3 4
  • Gamma Chain Of Class II Antigens 2 3
  • Ia-Associated Invariant Chain 2 3
  • MHC HLA-DR Gamma Chain 2 3
  • HLA-DR-Gamma 2 3
  • DHLAG 3 4
  • P33 3 4
  • II 3 4
  • HLA Class II Histocompatibility Antigen Gamma Chain 3
  • Ia Antigen-Associated Invariant Chain 4
  • CD74 Antigen 4
  • Ia-GAMMA 3
  • HLADG 3

External Ids for CD74 Gene

Previous HGNC Symbols for CD74 Gene

  • DHLAG

Previous GeneCards Identifiers for CD74 Gene

  • GC05M149850
  • GC05M149764
  • GC05M149809
  • GC05M149753
  • GC05M144928

Summaries for CD74 Gene

Entrez Gene Summary for CD74 Gene

  • The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD74 Gene

CD74 (CD74 Molecule) is a Protein Coding gene. Diseases associated with CD74 include Mantle Cell Lymphoma and Adenosquamous Cell Lung Carcinoma. Among its related pathways are Tuberculosis and Innate Immune System. GO annotations related to this gene include identical protein binding and beta-amyloid binding.

UniProtKB/Swiss-Prot for CD74 Gene

  • Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

Gene Wiki entry for CD74 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD74 Gene

Genomics for CD74 Gene

Regulatory Elements for CD74 Gene

Enhancers for CD74 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G150404 1.7 FANTOM5 ENCODE dbSUPER 11.1 +2.2 2226 13.3 HDGF PKNOX1 MLX WRNIP1 ZFP64 SIN3A YBX1 FEZF1 YY1 ZNF207 RPS14 TCOF1 CD74 CAMK2A ZNF300P1 RBM22 SYNPO DCTN4 ZNF300 GC05M150410
GH05G151074 2.1 FANTOM5 Ensembl ENCODE dbSUPER 4.6 -668.3 -668336 13.6 CREB3L1 AGO1 DMAP1 YY1 ZNF263 SP3 MCM3 NFYC TBX21 MEF2D TNIP1 ZNF300P1 ANXA6 RBM22 CCDC69 IRGM CD74 DCTN4 SLC36A1 SMIM3
GH05G150065 1.9 FANTOM5 Ensembl ENCODE dbSUPER 3.3 +346.6 346612 2.6 FOXA2 PKNOX1 CREB3L1 ARNT ARID4B ZNF766 FOS KLF13 SP3 SP5 HMGXB3 TIGD6 PCYOX1L CSF1R PDGFRB CDX1 PDE6A ENSG00000200334 TCOF1 CAMK2A
GH05G150761 2 FANTOM5 Ensembl ENCODE dbSUPER 2.4 -350.7 -350691 4.4 FOXA2 PKNOX1 CREB3L1 MLX ARNT ARID4B ZNF766 CBX5 FOS DEK TNIP1 RBM22 RPL7P1 CCDC69 DCTN4 SMIM3 CD74
GH05G149935 2.1 FANTOM5 Ensembl ENCODE dbSUPER 2 +471.6 471602 12.4 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 SLC26A2 CARMN HMGXB3 ZNF300 RBM22 PPARGC1B CSNK1A1 CD74 ENSG00000200334 GC05M149941
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD74 on UCSC Golden Path with GeneCards custom track

Promoters for CD74 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000317910 936 2001 ATF1 MLX WRNIP1 ZFP64 SIN3A NSD2 YBX1 YY1 ZNF143 ZNF207

Genomic Location for CD74 Gene

Chromosome:
5
Start:
150,401,637 bp from pter
End:
150,412,936 bp from pter
Size:
11,300 bases
Orientation:
Minus strand

Genomic View for CD74 Gene

Genes around CD74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD74 Gene

Proteins for CD74 Gene

  • Protein details for CD74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04233-HG2A_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen gamma chain
    Protein Accession:
    P04233
    Secondary Accessions:
    • A8K7R1
    • B4DNE8
    • D3DQG3
    • D3DQG4
    • Q14597
    • Q29832
    • Q5U0J8
    • Q8SNA0
    • Q8WLP6

    Protein attributes for CD74 Gene

    Size:
    296 amino acids
    Molecular mass:
    33516 Da
    Quaternary structure:
    • Homotrimer. In the endoplasmic reticulum (ER) it forms a heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules.
    SequenceCaution:
    • Sequence=AAA36304.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD74 Gene

    Alternative splice isoforms for CD74 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD74 Gene

Post-translational modifications for CD74 Gene

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
  • Ubiquitination at Lys159 and posLast=170170
  • Glycosylation at Asn130, posLast=136136, Thr203, Asn256, and posLast=281281
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD74 (CD74)

No data available for DME Specific Peptides for CD74 Gene

Domains & Families for CD74 Gene

Gene Families for CD74 Gene

Suggested Antigen Peptide Sequences for CD74 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD74: view

No data available for UniProtKB/Swiss-Prot for CD74 Gene

Function for CD74 Gene

Molecular function for CD74 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD74,MHC class II associated invariant chain,identified by monoclonal antibodies LN2,BU-43,BU-45,chain Ii,31kDa
UniProtKB/Swiss-Prot Function:
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

Gene Ontology (GO) - Molecular Function for CD74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IPI 19849849
GO:0004896 cytokine receptor activity IDA 17045821
GO:0005515 protein binding IPI 19665027
GO:0019955 cytokine binding IPI 12782713
GO:0023026 MHC class II protein complex binding IDA 1448172
genes like me logo Genes that share ontologies with CD74: view
genes like me logo Genes that share phenotypes with CD74: view

Animal Models for CD74 Gene

MGI Knock Outs for CD74:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CD74 Gene

Localization for CD74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD74 Gene

Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD74 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
lysosome 5
golgi apparatus 5
endosome 5
cytoskeleton 3
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005622 intracellular IEA,TAS 12782713
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane TAS --
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with CD74: view

Pathways & Interactions for CD74 Gene

genes like me logo Genes that share pathways with CD74: view

SIGNOR curated interactions for CD74 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for CD74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0001516 prostaglandin biosynthetic process IDA 12782713
GO:0001934 positive regulation of protein phosphorylation IDA 24942581
GO:0001961 positive regulation of cytokine-mediated signaling pathway IMP 12782713
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with CD74: view

Drugs & Compounds for CD74 Gene

(1) Drugs for CD74 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
milatuzumab Pharma antibody Therapeutic Antibodies 0
genes like me logo Genes that share compounds with CD74: view

Transcripts for CD74 Gene

Unigene Clusters for CD74 Gene

CD74 molecule, major histocompatibility complex, class II invariant chain:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD74 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - -
SP12: -
SP13: - - - - - -
SP14: - - - - - - - - - - - -

Relevant External Links for CD74 Gene

GeneLoc Exon Structure for
CD74
ECgene alternative splicing isoforms for
CD74

Expression for CD74 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD74 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD74 Gene

This gene is overexpressed in Spleen (x5.3) and Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for CD74 Gene

This gene is overexpressed in Lymph node (16.0), Blymphocyte (12.6), and Nasal epithelium (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD74 Gene



Protein tissue co-expression partners for CD74 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD74 Gene:

CD74

SOURCE GeneReport for Unigene cluster for CD74 Gene:

Hs.436568

Evidence on tissue expression from TISSUES for CD74 Gene

  • Spleen(5)
  • Nervous system(5)
  • Heart(4.9)
  • Intestine(4.9)
  • Lung(4.9)
  • Liver(4.8)
  • Blood(4.5)
  • Stomach(4.5)
  • Pancreas(4.4)
  • Eye(3.9)
  • Lymph node(3.8)
  • Bone marrow(3.2)
  • Bone(3.1)
  • Kidney(3.1)
  • Muscle(3)
  • Skin(3)
  • Gall bladder(2.9)
  • Adrenal gland(2.7)
  • Thyroid gland(2.4)
genes like me logo Genes that share expression patterns with CD74: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD74 Gene

Orthologs for CD74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD74 34 35
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia CD74 34 35
  • 88.36 (n)
mouse
(Mus musculus)
Mammalia Cd74 34 16 35
  • 82.13 (n)
rat
(Rattus norvegicus)
Mammalia Cd74 34
  • 81.85 (n)
cow
(Bos Taurus)
Mammalia CD74 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD74 35
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD74 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD74 34
  • 60.58 (n)
II 35
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD74 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd74 34
  • 50.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10251 34
zebrafish
(Danio rerio)
Actinopterygii cd74a 35
  • 30 (a)
OneToOne
Species where no ortholog for CD74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD74 Gene

ENSEMBL:
Gene Tree for CD74 (if available)
TreeFam:
Gene Tree for CD74 (if available)

Paralogs for CD74 Gene

(4) SIMAP similar genes for CD74 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CD74: view

No data available for Paralogs for CD74 Gene

Variants for CD74 Gene

Sequence variations from dbSNP and Humsavar for CD74 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000084815 -- 150,408,399(+) TCTCT(A/G)TGCCT intron-variant
rs1000442955 -- 150,406,816(+) TCCCC(G/T)TGGCA intron-variant
rs1000519043 -- 150,412,000(+) CACTG(C/T)GTCAC intron-variant
rs1000794707 -- 150,408,768(+) GACCC(C/T)AGTCC intron-variant
rs1000860894 -- 150,402,894(+) TGACG(A/G)ATAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD74 Gene

Variant ID Type Subtype PubMed ID
nsv1022057 CNV gain 25217958
nsv599957 CNV loss 21841781
nsv599958 CNV loss 21841781

Variation tolerance for CD74 Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD74 Gene

Disorders for CD74 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CD74 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mantle cell lymphoma
  • lymphoma, mantle cell
adenosquamous cell lung carcinoma
  • adenosquamous lung carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search CD74 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HG2A_HUMAN
  • Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein. {ECO:0000269 PubMed:12661006}.

Relevant External Links for CD74

Genetic Association Database (GAD)
CD74
Human Genome Epidemiology (HuGE) Navigator
CD74
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD74
genes like me logo Genes that share disorders with CD74: view

No data available for Genatlas for CD74 Gene

Publications for CD74 Gene

  1. Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens. (PMID: 3001652) Kudo J. … Saunders G.F. (Nucleic Acids Res. 1985) 2 3 4 64
  2. cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure. (PMID: 6324166) Claesson L. … Peterson P.A. (Proc. Natl. Acad. Sci. U.S.A. 1983) 2 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PMID: 19845895) Koskinen L.L. … Saavalainen P. (Tissue Antigens 2009) 3 46 64
  5. CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. (PMID: 17045821) Shi X. … Bucala R. (Immunity 2006) 3 22 64

Products for CD74 Gene

Sources for CD74 Gene

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